Climatic droplet keratopathy in Argentina: involvement of environmental agents in its genesis which would open the prospect for new therapeutic interventions

Autores
Suarez, Maria Fernanda; Correa, Leandro Javier; Crim, Nicolás; Esposito, Evangelina; Monti, Jose Rodolfo; Urrets Zavalía, Julio Alberto; Serra, Horacio Marcelo
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Climatic droplet keratopathy (CDK) is a degenerative corneal disease of unknown etiology. We described CDK for the rst time in Latin America in the Argentinean Patagonia (El Cuy). A deeper knowledge of CDK pathogenic mechanisms will provide new therapeutic strategies. For that reason we investigated the prevalence of CDK in El Cuy and its existence in other 3 provinces with similar climate. Patients eyes were examined, habits throughout lives were inquired about, and serum ascorbate (sAA) was determined. All individuals work outdoors for most of the day. All regions had normal O3 levels. Individuals from regions 1, 2, and 3 had very low consumption of vegetables/fruits and low sAA levels. Conversely, region 4 individuals had balanced diet and higher sAA concentrations. CDK was only found in region 3 where individuals had partial de ciency of sAA and did not use eye protection. No CDK was found in regions 1 and 2 where individuals had similar work activities and dietary habits to those in region 3 but wear eye protection. No disease was found in region 4 where individuals work outdoors, have balanced diet, and use eye protection. To summarize, the CDK existence was related not only to climate but also to the dietary habits and lack of protection from sunlight.
Fil: Suarez, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Correa, Leandro Javier. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Crim, Nicolás. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Esposito, Evangelina. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Monti, Jose Rodolfo. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Urrets Zavalía, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Serra, Horacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Materia
CLIMATIC DROPLET KERATOPATHY
ASCORBIC ACID
ARGENTINA
UV-B RADIATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/46465
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/46465
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Climatic droplet keratopathy in Argentina: involvement of environmental agents in its genesis which would open the prospect for new therapeutic interventionsSuarez, Maria FernandaCorrea, Leandro JavierCrim, NicolásEsposito, EvangelinaMonti, Jose RodolfoUrrets Zavalía, Julio AlbertoSerra, Horacio MarceloCLIMATIC DROPLET KERATOPATHYASCORBIC ACIDARGENTINAUV-B RADIATIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Climatic droplet keratopathy (CDK) is a degenerative corneal disease of unknown etiology. We described CDK for the rst time in Latin America in the Argentinean Patagonia (El Cuy). A deeper knowledge of CDK pathogenic mechanisms will provide new therapeutic strategies. For that reason we investigated the prevalence of CDK in El Cuy and its existence in other 3 provinces with similar climate. Patients eyes were examined, habits throughout lives were inquired about, and serum ascorbate (sAA) was determined. All individuals work outdoors for most of the day. All regions had normal O3 levels. Individuals from regions 1, 2, and 3 had very low consumption of vegetables/fruits and low sAA levels. Conversely, region 4 individuals had balanced diet and higher sAA concentrations. CDK was only found in region 3 where individuals had partial de ciency of sAA and did not use eye protection. No CDK was found in regions 1 and 2 where individuals had similar work activities and dietary habits to those in region 3 but wear eye protection. No disease was found in region 4 where individuals work outdoors, have balanced diet, and use eye protection. To summarize, the CDK existence was related not only to climate but also to the dietary habits and lack of protection from sunlight.Fil: Suarez, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Correa, Leandro Javier. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; ArgentinaFil: Crim, Nicolás. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; ArgentinaFil: Esposito, Evangelina. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; ArgentinaFil: Monti, Jose Rodolfo. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; ArgentinaFil: Urrets Zavalía, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Serra, Horacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaHINDAWI2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/46465Suarez, Maria Fernanda; Correa, Leandro Javier; Crim, Nicolás; Esposito, Evangelina; Monti, Jose Rodolfo; et al.; Climatic droplet keratopathy in Argentina: involvement of environmental agents in its genesis which would open the prospect for new therapeutic interventions; HINDAWI; BioMed Research International; 2015; 9-20152314-61332314-6141CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1155/2015/527835info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2015/527835/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:31Zoai:ri.conicet.gov.ar:11336/46465instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:31.434CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Climatic droplet keratopathy in Argentina: involvement of environmental agents in its genesis which would open the prospect for new therapeutic interventions
title Climatic droplet keratopathy in Argentina: involvement of environmental agents in its genesis which would open the prospect for new therapeutic interventions
spellingShingle Climatic droplet keratopathy in Argentina: involvement of environmental agents in its genesis which would open the prospect for new therapeutic interventions
Suarez, Maria Fernanda
CLIMATIC DROPLET KERATOPATHY
ASCORBIC ACID
ARGENTINA
UV-B RADIATION
title_short Climatic droplet keratopathy in Argentina: involvement of environmental agents in its genesis which would open the prospect for new therapeutic interventions
title_full Climatic droplet keratopathy in Argentina: involvement of environmental agents in its genesis which would open the prospect for new therapeutic interventions
title_fullStr Climatic droplet keratopathy in Argentina: involvement of environmental agents in its genesis which would open the prospect for new therapeutic interventions
title_full_unstemmed Climatic droplet keratopathy in Argentina: involvement of environmental agents in its genesis which would open the prospect for new therapeutic interventions
title_sort Climatic droplet keratopathy in Argentina: involvement of environmental agents in its genesis which would open the prospect for new therapeutic interventions
dc.creator.none.fl_str_mv Suarez, Maria Fernanda
Correa, Leandro Javier
Crim, Nicolás
Esposito, Evangelina
Monti, Jose Rodolfo
Urrets Zavalía, Julio Alberto
Serra, Horacio Marcelo
author Suarez, Maria Fernanda
author_facet Suarez, Maria Fernanda
Correa, Leandro Javier
Crim, Nicolás
Esposito, Evangelina
Monti, Jose Rodolfo
Urrets Zavalía, Julio Alberto
Serra, Horacio Marcelo
author_role author
author2 Correa, Leandro Javier
Crim, Nicolás
Esposito, Evangelina
Monti, Jose Rodolfo
Urrets Zavalía, Julio Alberto
Serra, Horacio Marcelo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CLIMATIC DROPLET KERATOPATHY
ASCORBIC ACID
ARGENTINA
UV-B RADIATION
topic CLIMATIC DROPLET KERATOPATHY
ASCORBIC ACID
ARGENTINA
UV-B RADIATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Climatic droplet keratopathy (CDK) is a degenerative corneal disease of unknown etiology. We described CDK for the rst time in Latin America in the Argentinean Patagonia (El Cuy). A deeper knowledge of CDK pathogenic mechanisms will provide new therapeutic strategies. For that reason we investigated the prevalence of CDK in El Cuy and its existence in other 3 provinces with similar climate. Patients eyes were examined, habits throughout lives were inquired about, and serum ascorbate (sAA) was determined. All individuals work outdoors for most of the day. All regions had normal O3 levels. Individuals from regions 1, 2, and 3 had very low consumption of vegetables/fruits and low sAA levels. Conversely, region 4 individuals had balanced diet and higher sAA concentrations. CDK was only found in region 3 where individuals had partial de ciency of sAA and did not use eye protection. No CDK was found in regions 1 and 2 where individuals had similar work activities and dietary habits to those in region 3 but wear eye protection. No disease was found in region 4 where individuals work outdoors, have balanced diet, and use eye protection. To summarize, the CDK existence was related not only to climate but also to the dietary habits and lack of protection from sunlight.
Fil: Suarez, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Correa, Leandro Javier. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Crim, Nicolás. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Esposito, Evangelina. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Monti, Jose Rodolfo. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Urrets Zavalía, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Serra, Horacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
description Climatic droplet keratopathy (CDK) is a degenerative corneal disease of unknown etiology. We described CDK for the rst time in Latin America in the Argentinean Patagonia (El Cuy). A deeper knowledge of CDK pathogenic mechanisms will provide new therapeutic strategies. For that reason we investigated the prevalence of CDK in El Cuy and its existence in other 3 provinces with similar climate. Patients eyes were examined, habits throughout lives were inquired about, and serum ascorbate (sAA) was determined. All individuals work outdoors for most of the day. All regions had normal O3 levels. Individuals from regions 1, 2, and 3 had very low consumption of vegetables/fruits and low sAA levels. Conversely, region 4 individuals had balanced diet and higher sAA concentrations. CDK was only found in region 3 where individuals had partial de ciency of sAA and did not use eye protection. No CDK was found in regions 1 and 2 where individuals had similar work activities and dietary habits to those in region 3 but wear eye protection. No disease was found in region 4 where individuals work outdoors, have balanced diet, and use eye protection. To summarize, the CDK existence was related not only to climate but also to the dietary habits and lack of protection from sunlight.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/46465
Suarez, Maria Fernanda; Correa, Leandro Javier; Crim, Nicolás; Esposito, Evangelina; Monti, Jose Rodolfo; et al.; Climatic droplet keratopathy in Argentina: involvement of environmental agents in its genesis which would open the prospect for new therapeutic interventions; HINDAWI; BioMed Research International; 2015; 9-2015
2314-6133
2314-6141
CONICET Digital
CONICET
url http://hdl.handle.net/11336/46465
identifier_str_mv Suarez, Maria Fernanda; Correa, Leandro Javier; Crim, Nicolás; Esposito, Evangelina; Monti, Jose Rodolfo; et al.; Climatic droplet keratopathy in Argentina: involvement of environmental agents in its genesis which would open the prospect for new therapeutic interventions; HINDAWI; BioMed Research International; 2015; 9-2015
2314-6133
2314-6141
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1155/2015/527835
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2015/527835/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv HINDAWI
publisher.none.fl_str_mv HINDAWI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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