Climatic droplet keratopathy: An old disease in new clothes

Autores
Serra, Horacio Marcelo; Holopainen, Juha M.; Beuerman, Roger; Kaarniranta, Kai; Suarez, Maria Fernanda; Urrets Zavalía, Julio Alberto
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Climatic droplet keratopathy (CDK) is an acquired and potentially handicapping cornea degenerative disease that is highly prevalent in certain rural communities around the world. It predominantly affects males over their forties. It has many other names such as Bietti's band-shaped nodular dystrophy, Labrador keratopathy, spheroidal degeneration, chronic actinic keratopathy, oil droplet degeneration, elastoid degeneration and keratinoid corneal degeneration. CDK is characterized by the haziness and opalescence of the cornea's most anterior layers which go through three stages with increasing severity. Globular deposits of different sizes may be histopathologically observed under the corneal epithelium by means of light and electron microscopy. The coalescence and increased volume of these spherules may cause the disruption of Bowman's membrane and the elevation and thinning of the corneal epithelium. The exact aetiology and pathogenesis of CDK are unknown, but they are possibly multifactorial. The only treatment in CDK advanced cases is a corneal transplantation, which in different impoverished regions of the world is not an available option. Many years ago, the clinical and histological aspects of this disease were described in several articles. This review highlights new scientific evidence of the expanding knowledge on CDK's pathogenesis which will open the prospect for new therapeutic interventions.
Fil: Serra, Horacio Marcelo. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Holopainen, Juha M.. University of Helsinski; Finlandia
Fil: Beuerman, Roger. Singapore Eye Research Institute; Singapur. Yong Loo Lin School of Medicine; Singapur
Fil: Kaarniranta, Kai. University of Eastern Finland and Kuopio University Hospital; Finlandia
Fil: Suarez, Maria Fernanda. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Urrets Zavalía, Julio Alberto. Universidad Católica de Córdoba. Facultad de Medicina. Clínica Universitaria Reina Fabiola; Argentina
Materia
ASCORBATE
ENVIRONMENT
HUMAN
KERATOPATHY
UV-B
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/185952
Acceder
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spelling Climatic droplet keratopathy: An old disease in new clothesSerra, Horacio MarceloHolopainen, Juha M.Beuerman, RogerKaarniranta, KaiSuarez, Maria FernandaUrrets Zavalía, Julio AlbertoASCORBATEENVIRONMENTHUMANKERATOPATHYUV-Bhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Climatic droplet keratopathy (CDK) is an acquired and potentially handicapping cornea degenerative disease that is highly prevalent in certain rural communities around the world. It predominantly affects males over their forties. It has many other names such as Bietti's band-shaped nodular dystrophy, Labrador keratopathy, spheroidal degeneration, chronic actinic keratopathy, oil droplet degeneration, elastoid degeneration and keratinoid corneal degeneration. CDK is characterized by the haziness and opalescence of the cornea's most anterior layers which go through three stages with increasing severity. Globular deposits of different sizes may be histopathologically observed under the corneal epithelium by means of light and electron microscopy. The coalescence and increased volume of these spherules may cause the disruption of Bowman's membrane and the elevation and thinning of the corneal epithelium. The exact aetiology and pathogenesis of CDK are unknown, but they are possibly multifactorial. The only treatment in CDK advanced cases is a corneal transplantation, which in different impoverished regions of the world is not an available option. Many years ago, the clinical and histological aspects of this disease were described in several articles. This review highlights new scientific evidence of the expanding knowledge on CDK's pathogenesis which will open the prospect for new therapeutic interventions.Fil: Serra, Horacio Marcelo. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Holopainen, Juha M.. University of Helsinski; FinlandiaFil: Beuerman, Roger. Singapore Eye Research Institute; Singapur. Yong Loo Lin School of Medicine; SingapurFil: Kaarniranta, Kai. University of Eastern Finland and Kuopio University Hospital; FinlandiaFil: Suarez, Maria Fernanda. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Urrets Zavalía, Julio Alberto. Universidad Católica de Córdoba. Facultad de Medicina. Clínica Universitaria Reina Fabiola; ArgentinaWiley Blackwell Publishing, Inc2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/185952Serra, Horacio Marcelo; Holopainen, Juha M.; Beuerman, Roger; Kaarniranta, Kai; Suarez, Maria Fernanda; et al.; Climatic droplet keratopathy: An old disease in new clothes; Wiley Blackwell Publishing, Inc; Acta Ophthalmologica; 93; 6; 9-2015; 496-5041755-375X1755-3768CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/aos.12628info:eu-repo/semantics/altIdentifier/doi/10.1111/aos.12628info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:01:42Zoai:ri.conicet.gov.ar:11336/185952instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:01:42.413CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Climatic droplet keratopathy: An old disease in new clothes
title Climatic droplet keratopathy: An old disease in new clothes
spellingShingle Climatic droplet keratopathy: An old disease in new clothes
Serra, Horacio Marcelo
ASCORBATE
ENVIRONMENT
HUMAN
KERATOPATHY
UV-B
title_short Climatic droplet keratopathy: An old disease in new clothes
title_full Climatic droplet keratopathy: An old disease in new clothes
title_fullStr Climatic droplet keratopathy: An old disease in new clothes
title_full_unstemmed Climatic droplet keratopathy: An old disease in new clothes
title_sort Climatic droplet keratopathy: An old disease in new clothes
dc.creator.none.fl_str_mv Serra, Horacio Marcelo
Holopainen, Juha M.
Beuerman, Roger
Kaarniranta, Kai
Suarez, Maria Fernanda
Urrets Zavalía, Julio Alberto
author Serra, Horacio Marcelo
author_facet Serra, Horacio Marcelo
Holopainen, Juha M.
Beuerman, Roger
Kaarniranta, Kai
Suarez, Maria Fernanda
Urrets Zavalía, Julio Alberto
author_role author
author2 Holopainen, Juha M.
Beuerman, Roger
Kaarniranta, Kai
Suarez, Maria Fernanda
Urrets Zavalía, Julio Alberto
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ASCORBATE
ENVIRONMENT
HUMAN
KERATOPATHY
UV-B
topic ASCORBATE
ENVIRONMENT
HUMAN
KERATOPATHY
UV-B
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Climatic droplet keratopathy (CDK) is an acquired and potentially handicapping cornea degenerative disease that is highly prevalent in certain rural communities around the world. It predominantly affects males over their forties. It has many other names such as Bietti's band-shaped nodular dystrophy, Labrador keratopathy, spheroidal degeneration, chronic actinic keratopathy, oil droplet degeneration, elastoid degeneration and keratinoid corneal degeneration. CDK is characterized by the haziness and opalescence of the cornea's most anterior layers which go through three stages with increasing severity. Globular deposits of different sizes may be histopathologically observed under the corneal epithelium by means of light and electron microscopy. The coalescence and increased volume of these spherules may cause the disruption of Bowman's membrane and the elevation and thinning of the corneal epithelium. The exact aetiology and pathogenesis of CDK are unknown, but they are possibly multifactorial. The only treatment in CDK advanced cases is a corneal transplantation, which in different impoverished regions of the world is not an available option. Many years ago, the clinical and histological aspects of this disease were described in several articles. This review highlights new scientific evidence of the expanding knowledge on CDK's pathogenesis which will open the prospect for new therapeutic interventions.
Fil: Serra, Horacio Marcelo. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Holopainen, Juha M.. University of Helsinski; Finlandia
Fil: Beuerman, Roger. Singapore Eye Research Institute; Singapur. Yong Loo Lin School of Medicine; Singapur
Fil: Kaarniranta, Kai. University of Eastern Finland and Kuopio University Hospital; Finlandia
Fil: Suarez, Maria Fernanda. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Urrets Zavalía, Julio Alberto. Universidad Católica de Córdoba. Facultad de Medicina. Clínica Universitaria Reina Fabiola; Argentina
description Climatic droplet keratopathy (CDK) is an acquired and potentially handicapping cornea degenerative disease that is highly prevalent in certain rural communities around the world. It predominantly affects males over their forties. It has many other names such as Bietti's band-shaped nodular dystrophy, Labrador keratopathy, spheroidal degeneration, chronic actinic keratopathy, oil droplet degeneration, elastoid degeneration and keratinoid corneal degeneration. CDK is characterized by the haziness and opalescence of the cornea's most anterior layers which go through three stages with increasing severity. Globular deposits of different sizes may be histopathologically observed under the corneal epithelium by means of light and electron microscopy. The coalescence and increased volume of these spherules may cause the disruption of Bowman's membrane and the elevation and thinning of the corneal epithelium. The exact aetiology and pathogenesis of CDK are unknown, but they are possibly multifactorial. The only treatment in CDK advanced cases is a corneal transplantation, which in different impoverished regions of the world is not an available option. Many years ago, the clinical and histological aspects of this disease were described in several articles. This review highlights new scientific evidence of the expanding knowledge on CDK's pathogenesis which will open the prospect for new therapeutic interventions.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/185952
Serra, Horacio Marcelo; Holopainen, Juha M.; Beuerman, Roger; Kaarniranta, Kai; Suarez, Maria Fernanda; et al.; Climatic droplet keratopathy: An old disease in new clothes; Wiley Blackwell Publishing, Inc; Acta Ophthalmologica; 93; 6; 9-2015; 496-504
1755-375X
1755-3768
CONICET Digital
CONICET
url http://hdl.handle.net/11336/185952
identifier_str_mv Serra, Horacio Marcelo; Holopainen, Juha M.; Beuerman, Roger; Kaarniranta, Kai; Suarez, Maria Fernanda; et al.; Climatic droplet keratopathy: An old disease in new clothes; Wiley Blackwell Publishing, Inc; Acta Ophthalmologica; 93; 6; 9-2015; 496-504
1755-375X
1755-3768
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/aos.12628
info:eu-repo/semantics/altIdentifier/doi/10.1111/aos.12628
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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