Clinical, Functional and Structural Studies of Humans and Merino Sheep Corneas from Two Different Regions of Argentina
- Autores
- Suarez, Maria Fernanda; Crim, Nicolás; Monti, Rodolfo; Esposito, Evangelina; Urrets Zavalía, Julio Alberto; Serra, Horacio Marcelo
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Objective: The purpose of our work was to study and compare the cornea and tear film of people and sheep inhabiting in a region of Argentinean Patagonia (PATG), and in a geographically and climatically different region in the Argentinean Pampa (CAPT).Methods: Using cross sectional study, corneal examinations were performed in people and Merino sheep inhabiting PATG and CAPT regions, respectively. All people completed a questionnaire related to work activity, diet, and the use of hats or sunglasses during their life. Eyes from all participants were examined with a portable hand- held slit-lamp biomicroscope (BM) to evaluate corneal appearance, epithelium integrity, and transparency. Later on, in a subgroup of participants we studied eye blinking frequency (EBF), ocular surface staining (FS), breakup time (BUT), Schirmer Tear Test (STT), corneal structure using confocal laser scanning microscopy (CLSM) and light microscopy (LM), and concentrations of serum ascorbate (sAA).Results: BM studies revealed numerous cases of climatic droplet keratopathy (CDK) only in people inhabiting the PATG region. CLSM studies confirmed typical punctate deposits at the Bowman ́s layer in CDK patients living in that region. CLSM images from sheep did not show any abnormalities at the Bowman ́s layer but exhibited small hyper reflective dots at the epithelium only in animals pasturing in the PATG region. FS and EBF mean values were significant higher in sheep grazing in the PATG region (p <0.05). No differences were found in surface eye tests when people from both regions were analyzed. Low sAA levels were found only in CDK people living in PATG region.Conclusions: CDK is a multi-factorial disease not only associated to harsh climate. We provide data that low sAA levels can play a role in its genesis in Patagonia patients?... Sheep pasturing in this region with a high prevalence of CDK have high concentration of sAA and did not present any sub epithelial corneal abnormalities.
Fil: Suarez, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Crim, Nicolás. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Monti, Rodolfo. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Esposito, Evangelina. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Urrets Zavalía, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Serra, Horacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina - Materia
-
CLIMATIC DROPLET KERATOPATHY
CORNEAL DEGENERATION
ARGENTINIAN PATAGONIA
ARGENTINIAN PAMPA
HUMAN
SHEEP
OCULAR SURGACE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/46689
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Clinical, Functional and Structural Studies of Humans and Merino Sheep Corneas from Two Different Regions of ArgentinaSuarez, Maria FernandaCrim, NicolásMonti, RodolfoEsposito, EvangelinaUrrets Zavalía, Julio AlbertoSerra, Horacio MarceloCLIMATIC DROPLET KERATOPATHYCORNEAL DEGENERATIONARGENTINIAN PATAGONIAARGENTINIAN PAMPAHUMANSHEEPOCULAR SURGACEhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective: The purpose of our work was to study and compare the cornea and tear film of people and sheep inhabiting in a region of Argentinean Patagonia (PATG), and in a geographically and climatically different region in the Argentinean Pampa (CAPT).Methods: Using cross sectional study, corneal examinations were performed in people and Merino sheep inhabiting PATG and CAPT regions, respectively. All people completed a questionnaire related to work activity, diet, and the use of hats or sunglasses during their life. Eyes from all participants were examined with a portable hand- held slit-lamp biomicroscope (BM) to evaluate corneal appearance, epithelium integrity, and transparency. Later on, in a subgroup of participants we studied eye blinking frequency (EBF), ocular surface staining (FS), breakup time (BUT), Schirmer Tear Test (STT), corneal structure using confocal laser scanning microscopy (CLSM) and light microscopy (LM), and concentrations of serum ascorbate (sAA).Results: BM studies revealed numerous cases of climatic droplet keratopathy (CDK) only in people inhabiting the PATG region. CLSM studies confirmed typical punctate deposits at the Bowman ́s layer in CDK patients living in that region. CLSM images from sheep did not show any abnormalities at the Bowman ́s layer but exhibited small hyper reflective dots at the epithelium only in animals pasturing in the PATG region. FS and EBF mean values were significant higher in sheep grazing in the PATG region (p <0.05). No differences were found in surface eye tests when people from both regions were analyzed. Low sAA levels were found only in CDK people living in PATG region.Conclusions: CDK is a multi-factorial disease not only associated to harsh climate. We provide data that low sAA levels can play a role in its genesis in Patagonia patients?... Sheep pasturing in this region with a high prevalence of CDK have high concentration of sAA and did not present any sub epithelial corneal abnormalities.Fil: Suarez, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Crim, Nicolás. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; ArgentinaFil: Monti, Rodolfo. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; ArgentinaFil: Esposito, Evangelina. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; ArgentinaFil: Urrets Zavalía, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; ArgentinaFil: Serra, Horacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaWiley Blackwell Publishing, Inc2015-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/46689Suarez, Maria Fernanda; Crim, Nicolás; Monti, Rodolfo; Esposito, Evangelina; Urrets Zavalía, Julio Alberto; et al.; Clinical, Functional and Structural Studies of Humans and Merino Sheep Corneas from Two Different Regions of Argentina; Wiley Blackwell Publishing, Inc; Journal of Clinical & Experimental Ophthalmology; 06; 06; 11-2015; 1-82155-95701442-6404CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.4172/2155-9570.1000499info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/clinical-functional-and-structural-studies-of-humans-and-merino-sheepcorneas-from-two-different-regions-of-argentina-2155-9570-1000499.php?aid=66076info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:58Zoai:ri.conicet.gov.ar:11336/46689instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:58.894CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Clinical, Functional and Structural Studies of Humans and Merino Sheep Corneas from Two Different Regions of Argentina |
title |
Clinical, Functional and Structural Studies of Humans and Merino Sheep Corneas from Two Different Regions of Argentina |
spellingShingle |
Clinical, Functional and Structural Studies of Humans and Merino Sheep Corneas from Two Different Regions of Argentina Suarez, Maria Fernanda CLIMATIC DROPLET KERATOPATHY CORNEAL DEGENERATION ARGENTINIAN PATAGONIA ARGENTINIAN PAMPA HUMAN SHEEP OCULAR SURGACE |
title_short |
Clinical, Functional and Structural Studies of Humans and Merino Sheep Corneas from Two Different Regions of Argentina |
title_full |
Clinical, Functional and Structural Studies of Humans and Merino Sheep Corneas from Two Different Regions of Argentina |
title_fullStr |
Clinical, Functional and Structural Studies of Humans and Merino Sheep Corneas from Two Different Regions of Argentina |
title_full_unstemmed |
Clinical, Functional and Structural Studies of Humans and Merino Sheep Corneas from Two Different Regions of Argentina |
title_sort |
Clinical, Functional and Structural Studies of Humans and Merino Sheep Corneas from Two Different Regions of Argentina |
dc.creator.none.fl_str_mv |
Suarez, Maria Fernanda Crim, Nicolás Monti, Rodolfo Esposito, Evangelina Urrets Zavalía, Julio Alberto Serra, Horacio Marcelo |
author |
Suarez, Maria Fernanda |
author_facet |
Suarez, Maria Fernanda Crim, Nicolás Monti, Rodolfo Esposito, Evangelina Urrets Zavalía, Julio Alberto Serra, Horacio Marcelo |
author_role |
author |
author2 |
Crim, Nicolás Monti, Rodolfo Esposito, Evangelina Urrets Zavalía, Julio Alberto Serra, Horacio Marcelo |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
CLIMATIC DROPLET KERATOPATHY CORNEAL DEGENERATION ARGENTINIAN PATAGONIA ARGENTINIAN PAMPA HUMAN SHEEP OCULAR SURGACE |
topic |
CLIMATIC DROPLET KERATOPATHY CORNEAL DEGENERATION ARGENTINIAN PATAGONIA ARGENTINIAN PAMPA HUMAN SHEEP OCULAR SURGACE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Objective: The purpose of our work was to study and compare the cornea and tear film of people and sheep inhabiting in a region of Argentinean Patagonia (PATG), and in a geographically and climatically different region in the Argentinean Pampa (CAPT).Methods: Using cross sectional study, corneal examinations were performed in people and Merino sheep inhabiting PATG and CAPT regions, respectively. All people completed a questionnaire related to work activity, diet, and the use of hats or sunglasses during their life. Eyes from all participants were examined with a portable hand- held slit-lamp biomicroscope (BM) to evaluate corneal appearance, epithelium integrity, and transparency. Later on, in a subgroup of participants we studied eye blinking frequency (EBF), ocular surface staining (FS), breakup time (BUT), Schirmer Tear Test (STT), corneal structure using confocal laser scanning microscopy (CLSM) and light microscopy (LM), and concentrations of serum ascorbate (sAA).Results: BM studies revealed numerous cases of climatic droplet keratopathy (CDK) only in people inhabiting the PATG region. CLSM studies confirmed typical punctate deposits at the Bowman ́s layer in CDK patients living in that region. CLSM images from sheep did not show any abnormalities at the Bowman ́s layer but exhibited small hyper reflective dots at the epithelium only in animals pasturing in the PATG region. FS and EBF mean values were significant higher in sheep grazing in the PATG region (p <0.05). No differences were found in surface eye tests when people from both regions were analyzed. Low sAA levels were found only in CDK people living in PATG region.Conclusions: CDK is a multi-factorial disease not only associated to harsh climate. We provide data that low sAA levels can play a role in its genesis in Patagonia patients?... Sheep pasturing in this region with a high prevalence of CDK have high concentration of sAA and did not present any sub epithelial corneal abnormalities. Fil: Suarez, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina Fil: Crim, Nicolás. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina Fil: Monti, Rodolfo. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina Fil: Esposito, Evangelina. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina Fil: Urrets Zavalía, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina Fil: Serra, Horacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina |
description |
Objective: The purpose of our work was to study and compare the cornea and tear film of people and sheep inhabiting in a region of Argentinean Patagonia (PATG), and in a geographically and climatically different region in the Argentinean Pampa (CAPT).Methods: Using cross sectional study, corneal examinations were performed in people and Merino sheep inhabiting PATG and CAPT regions, respectively. All people completed a questionnaire related to work activity, diet, and the use of hats or sunglasses during their life. Eyes from all participants were examined with a portable hand- held slit-lamp biomicroscope (BM) to evaluate corneal appearance, epithelium integrity, and transparency. Later on, in a subgroup of participants we studied eye blinking frequency (EBF), ocular surface staining (FS), breakup time (BUT), Schirmer Tear Test (STT), corneal structure using confocal laser scanning microscopy (CLSM) and light microscopy (LM), and concentrations of serum ascorbate (sAA).Results: BM studies revealed numerous cases of climatic droplet keratopathy (CDK) only in people inhabiting the PATG region. CLSM studies confirmed typical punctate deposits at the Bowman ́s layer in CDK patients living in that region. CLSM images from sheep did not show any abnormalities at the Bowman ́s layer but exhibited small hyper reflective dots at the epithelium only in animals pasturing in the PATG region. FS and EBF mean values were significant higher in sheep grazing in the PATG region (p <0.05). No differences were found in surface eye tests when people from both regions were analyzed. Low sAA levels were found only in CDK people living in PATG region.Conclusions: CDK is a multi-factorial disease not only associated to harsh climate. We provide data that low sAA levels can play a role in its genesis in Patagonia patients?... Sheep pasturing in this region with a high prevalence of CDK have high concentration of sAA and did not present any sub epithelial corneal abnormalities. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/46689 Suarez, Maria Fernanda; Crim, Nicolás; Monti, Rodolfo; Esposito, Evangelina; Urrets Zavalía, Julio Alberto; et al.; Clinical, Functional and Structural Studies of Humans and Merino Sheep Corneas from Two Different Regions of Argentina; Wiley Blackwell Publishing, Inc; Journal of Clinical & Experimental Ophthalmology; 06; 06; 11-2015; 1-8 2155-9570 1442-6404 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/46689 |
identifier_str_mv |
Suarez, Maria Fernanda; Crim, Nicolás; Monti, Rodolfo; Esposito, Evangelina; Urrets Zavalía, Julio Alberto; et al.; Clinical, Functional and Structural Studies of Humans and Merino Sheep Corneas from Two Different Regions of Argentina; Wiley Blackwell Publishing, Inc; Journal of Clinical & Experimental Ophthalmology; 06; 06; 11-2015; 1-8 2155-9570 1442-6404 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.4172/2155-9570.1000499 info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/clinical-functional-and-structural-studies-of-humans-and-merino-sheepcorneas-from-two-different-regions-of-argentina-2155-9570-1000499.php?aid=66076 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Wiley Blackwell Publishing, Inc |
publisher.none.fl_str_mv |
Wiley Blackwell Publishing, Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613009446535168 |
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13.070432 |