Pulmonary drug delivery: A review on nanocarriers for antibacterial chemotherapy

Autores
Moreno Sastre, M.; Pastor, M.; Salomon, Claudio Javier; Esquisabel, A.; Pedraz, J. L.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
As the WHO stated, lower respiratory infections are the third leading cause of death. In addition, it is remarkable that antimicrobial resistance represents a huge threat. Thus, new therapeutic weapons are required. Among the possible alternatives, antibiotic encapsulation in nanoparticles has gained much attention in terms of improved tolerability, activity and ability to combat the resistance mechanisms of bacteria. In this regard, this reviewarticle focuses on the latest nanocarrier approaches for inhalatory therapy of antibiotics. First, the technology related to lung disposition will be reviewed. Then, nanocarrier systems will be introduced and the challenges required to perform adequate pulmonary deposition analysed. In the following part, drug delivery systems (DDSs) on the market or in clinical trials are described and, finally, new approaches of nanoparticles that have reached preclinical stage are enumerated. Altogether, this review aims at gathering together the novel nanosystems for anti-infectious therapy, underlining the potential of DDSs to improve and optimize currently available antibiotic therapies in the context of lung infections.
Fil: Moreno Sastre, M.. Universidad del País Vasco; España. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine; España
Fil: Pastor, M.. Universidad del País Vasco; España. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine; España
Fil: Salomon, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Esquisabel, A.. Universidad del País Vasco; España. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine; España
Fil: Pedraz, J. L.. Universidad del País Vasco; España. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine; España
Materia
Pulmonary Drug Delivery
Nanocarriers
Antibacterial Chemotherapy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/52387
Acceder
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spelling Pulmonary drug delivery: A review on nanocarriers for antibacterial chemotherapyMoreno Sastre, M.Pastor, M.Salomon, Claudio JavierEsquisabel, A.Pedraz, J. L.Pulmonary Drug DeliveryNanocarriersAntibacterial Chemotherapyhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1As the WHO stated, lower respiratory infections are the third leading cause of death. In addition, it is remarkable that antimicrobial resistance represents a huge threat. Thus, new therapeutic weapons are required. Among the possible alternatives, antibiotic encapsulation in nanoparticles has gained much attention in terms of improved tolerability, activity and ability to combat the resistance mechanisms of bacteria. In this regard, this reviewarticle focuses on the latest nanocarrier approaches for inhalatory therapy of antibiotics. First, the technology related to lung disposition will be reviewed. Then, nanocarrier systems will be introduced and the challenges required to perform adequate pulmonary deposition analysed. In the following part, drug delivery systems (DDSs) on the market or in clinical trials are described and, finally, new approaches of nanoparticles that have reached preclinical stage are enumerated. Altogether, this review aims at gathering together the novel nanosystems for anti-infectious therapy, underlining the potential of DDSs to improve and optimize currently available antibiotic therapies in the context of lung infections.Fil: Moreno Sastre, M.. Universidad del País Vasco; España. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine; EspañaFil: Pastor, M.. Universidad del País Vasco; España. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine; EspañaFil: Salomon, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Esquisabel, A.. Universidad del País Vasco; España. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine; EspañaFil: Pedraz, J. L.. Universidad del País Vasco; España. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine; EspañaOxford University Press2015-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/52387Moreno Sastre, M.; Pastor, M.; Salomon, Claudio Javier; Esquisabel, A.; Pedraz, J. L.; Pulmonary drug delivery: A review on nanocarriers for antibacterial chemotherapy; Oxford University Press; Journal of Antimicrobial Chemotherapy; 70; 11; 7-2015; 2945-29550305-7453CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/jac/dkv192info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jac/article/70/11/2945/2363606info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:03:24Zoai:ri.conicet.gov.ar:11336/52387instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:03:24.89CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pulmonary drug delivery: A review on nanocarriers for antibacterial chemotherapy
title Pulmonary drug delivery: A review on nanocarriers for antibacterial chemotherapy
spellingShingle Pulmonary drug delivery: A review on nanocarriers for antibacterial chemotherapy
Moreno Sastre, M.
Pulmonary Drug Delivery
Nanocarriers
Antibacterial Chemotherapy
title_short Pulmonary drug delivery: A review on nanocarriers for antibacterial chemotherapy
title_full Pulmonary drug delivery: A review on nanocarriers for antibacterial chemotherapy
title_fullStr Pulmonary drug delivery: A review on nanocarriers for antibacterial chemotherapy
title_full_unstemmed Pulmonary drug delivery: A review on nanocarriers for antibacterial chemotherapy
title_sort Pulmonary drug delivery: A review on nanocarriers for antibacterial chemotherapy
dc.creator.none.fl_str_mv Moreno Sastre, M.
Pastor, M.
Salomon, Claudio Javier
Esquisabel, A.
Pedraz, J. L.
author Moreno Sastre, M.
author_facet Moreno Sastre, M.
Pastor, M.
Salomon, Claudio Javier
Esquisabel, A.
Pedraz, J. L.
author_role author
author2 Pastor, M.
Salomon, Claudio Javier
Esquisabel, A.
Pedraz, J. L.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Pulmonary Drug Delivery
Nanocarriers
Antibacterial Chemotherapy
topic Pulmonary Drug Delivery
Nanocarriers
Antibacterial Chemotherapy
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv As the WHO stated, lower respiratory infections are the third leading cause of death. In addition, it is remarkable that antimicrobial resistance represents a huge threat. Thus, new therapeutic weapons are required. Among the possible alternatives, antibiotic encapsulation in nanoparticles has gained much attention in terms of improved tolerability, activity and ability to combat the resistance mechanisms of bacteria. In this regard, this reviewarticle focuses on the latest nanocarrier approaches for inhalatory therapy of antibiotics. First, the technology related to lung disposition will be reviewed. Then, nanocarrier systems will be introduced and the challenges required to perform adequate pulmonary deposition analysed. In the following part, drug delivery systems (DDSs) on the market or in clinical trials are described and, finally, new approaches of nanoparticles that have reached preclinical stage are enumerated. Altogether, this review aims at gathering together the novel nanosystems for anti-infectious therapy, underlining the potential of DDSs to improve and optimize currently available antibiotic therapies in the context of lung infections.
Fil: Moreno Sastre, M.. Universidad del País Vasco; España. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine; España
Fil: Pastor, M.. Universidad del País Vasco; España. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine; España
Fil: Salomon, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Esquisabel, A.. Universidad del País Vasco; España. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine; España
Fil: Pedraz, J. L.. Universidad del País Vasco; España. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine; España
description As the WHO stated, lower respiratory infections are the third leading cause of death. In addition, it is remarkable that antimicrobial resistance represents a huge threat. Thus, new therapeutic weapons are required. Among the possible alternatives, antibiotic encapsulation in nanoparticles has gained much attention in terms of improved tolerability, activity and ability to combat the resistance mechanisms of bacteria. In this regard, this reviewarticle focuses on the latest nanocarrier approaches for inhalatory therapy of antibiotics. First, the technology related to lung disposition will be reviewed. Then, nanocarrier systems will be introduced and the challenges required to perform adequate pulmonary deposition analysed. In the following part, drug delivery systems (DDSs) on the market or in clinical trials are described and, finally, new approaches of nanoparticles that have reached preclinical stage are enumerated. Altogether, this review aims at gathering together the novel nanosystems for anti-infectious therapy, underlining the potential of DDSs to improve and optimize currently available antibiotic therapies in the context of lung infections.
publishDate 2015
dc.date.none.fl_str_mv 2015-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/52387
Moreno Sastre, M.; Pastor, M.; Salomon, Claudio Javier; Esquisabel, A.; Pedraz, J. L.; Pulmonary drug delivery: A review on nanocarriers for antibacterial chemotherapy; Oxford University Press; Journal of Antimicrobial Chemotherapy; 70; 11; 7-2015; 2945-2955
0305-7453
CONICET Digital
CONICET
url http://hdl.handle.net/11336/52387
identifier_str_mv Moreno Sastre, M.; Pastor, M.; Salomon, Claudio Javier; Esquisabel, A.; Pedraz, J. L.; Pulmonary drug delivery: A review on nanocarriers for antibacterial chemotherapy; Oxford University Press; Journal of Antimicrobial Chemotherapy; 70; 11; 7-2015; 2945-2955
0305-7453
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/jac/dkv192
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jac/article/70/11/2945/2363606
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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