Hydatid Disease: Current Status Of Chemotherapy And Drug Delivery Systems

Autores
Elissondo, María Celina; Bermudez, Jose Maria; Ullio Gamboa, Gabriela Veronica; Pensel, Patricia Eugenia; Cid, Alicia Graciela; Juarez, Maria Mercedes; Allemandi, Daniel Alberto; Palma, Santiago Daniel
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Human echinococcosis or hydatid disease still causes serious health problems with a worldwide geographical distribution. This parasitic infection is a chronic, complex, and still neglected disease. Currently four treatment modalities are in use: surgery, PAIR (puncture, aspiration, injection of protoscolicidal agent, reaspiration), chemotherapy and a “watch and wait” approach for inactive, clinically silent cysts. Over the past 30 years, chemotherapy with benzimidazoles (BZ), like albendazole and mebendazole, has been used increasingly to treat this pathology. Unfortunately, 20%–40% of the cases do not respond favorably to such chemotherapy and these drugs produce stabilization, rather than cure in the majority of patients. However, the overall efficacy of BZ has been overstated in the past. With regard to these difficulties, novel therapeutical tools are needed to optimize treatment of human echinococcosis. On the one hand, a number of compounds have been investigated, either using in vitro cultured parasites and/or applying to in vivo rodent models. Tested compounds include BZ derivatives such as flubendazole, and oxfendazole, as well as other anti-infective agents like ivermectin, nitazoxanide, genistein, artemisinin, timol, rapamycin, and anti-cancer agents such as 2-methoxyestradiol and cyclosporine A. Although some of these compounds showed promising activities in vitro, and also in the rodent models, they have not been yet translated to clinical applications. On the other hand, different drug delivery systems have been developed in order to improve the efficacy of several active pharmaceutical ingredients (APIs) such as oil in water emulsion, liposomes and nanoparticles among others. The present review article summarizes the chemotherapeutic state-of-the-art and the research done in the field of drug delivery systems regarded human echinococcosis.
Fil: Elissondo, María Celina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biologia. Laboratorio de Zoonosis Parasitarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación Para la Industria Química (i); Argentina
Fil: Ullio Gamboa, Gabriela Veronica. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo En Tecnologia Farmaceutica; Argentina
Fil: Pensel, Patricia Eugenia. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biologia. Laboratorio de Zoonosis Parasitarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cid, Alicia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación Para la Industria Química (i); Argentina
Fil: Juarez, Maria Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación Para la Industria Química (i); Argentina
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo En Tecnologia Farmaceutica; Argentina
Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo En Tecnologia Farmaceutica; Argentina
Materia
Chemotherapy
Drug Delivery
Hydatid Disease
Therapy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/12726
Acceder
id CONICETDig_03396ca568ff1061cfb239392b1c0728
oai_identifier_str oai:ri.conicet.gov.ar:11336/12726
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hydatid Disease: Current Status Of Chemotherapy And Drug Delivery SystemsElissondo, María CelinaBermudez, Jose MariaUllio Gamboa, Gabriela VeronicaPensel, Patricia EugeniaCid, Alicia GracielaJuarez, Maria MercedesAllemandi, Daniel AlbertoPalma, Santiago DanielChemotherapyDrug DeliveryHydatid DiseaseTherapyhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Human echinococcosis or hydatid disease still causes serious health problems with a worldwide geographical distribution. This parasitic infection is a chronic, complex, and still neglected disease. Currently four treatment modalities are in use: surgery, PAIR (puncture, aspiration, injection of protoscolicidal agent, reaspiration), chemotherapy and a “watch and wait” approach for inactive, clinically silent cysts. Over the past 30 years, chemotherapy with benzimidazoles (BZ), like albendazole and mebendazole, has been used increasingly to treat this pathology. Unfortunately, 20%–40% of the cases do not respond favorably to such chemotherapy and these drugs produce stabilization, rather than cure in the majority of patients. However, the overall efficacy of BZ has been overstated in the past. With regard to these difficulties, novel therapeutical tools are needed to optimize treatment of human echinococcosis. On the one hand, a number of compounds have been investigated, either using in vitro cultured parasites and/or applying to in vivo rodent models. Tested compounds include BZ derivatives such as flubendazole, and oxfendazole, as well as other anti-infective agents like ivermectin, nitazoxanide, genistein, artemisinin, timol, rapamycin, and anti-cancer agents such as 2-methoxyestradiol and cyclosporine A. Although some of these compounds showed promising activities in vitro, and also in the rodent models, they have not been yet translated to clinical applications. On the other hand, different drug delivery systems have been developed in order to improve the efficacy of several active pharmaceutical ingredients (APIs) such as oil in water emulsion, liposomes and nanoparticles among others. The present review article summarizes the chemotherapeutic state-of-the-art and the research done in the field of drug delivery systems regarded human echinococcosis.Fil: Elissondo, María Celina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biologia. Laboratorio de Zoonosis Parasitarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación Para la Industria Química (i); ArgentinaFil: Ullio Gamboa, Gabriela Veronica. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo En Tecnologia Farmaceutica; ArgentinaFil: Pensel, Patricia Eugenia. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biologia. Laboratorio de Zoonosis Parasitarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cid, Alicia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación Para la Industria Química (i); ArgentinaFil: Juarez, Maria Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación Para la Industria Química (i); ArgentinaFil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo En Tecnologia Farmaceutica; ArgentinaFil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo En Tecnologia Farmaceutica; ArgentinaBetham Science2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12726Elissondo, María Celina; Bermudez, Jose Maria; Ullio Gamboa, Gabriela Veronica; Pensel, Patricia Eugenia; Cid, Alicia Graciela; et al.; Hydatid Disease: Current Status Of Chemotherapy And Drug Delivery Systems; Betham Science; Current Drug Therapy; 8; 3; 7-2013; 197-2051574-88552212-3903enginfo:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/ben/cdth/2013/00000008/00000003/art00007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:50:52Zoai:ri.conicet.gov.ar:11336/12726instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:50:52.677CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hydatid Disease: Current Status Of Chemotherapy And Drug Delivery Systems
title Hydatid Disease: Current Status Of Chemotherapy And Drug Delivery Systems
spellingShingle Hydatid Disease: Current Status Of Chemotherapy And Drug Delivery Systems
Elissondo, María Celina
Chemotherapy
Drug Delivery
Hydatid Disease
Therapy
title_short Hydatid Disease: Current Status Of Chemotherapy And Drug Delivery Systems
title_full Hydatid Disease: Current Status Of Chemotherapy And Drug Delivery Systems
title_fullStr Hydatid Disease: Current Status Of Chemotherapy And Drug Delivery Systems
title_full_unstemmed Hydatid Disease: Current Status Of Chemotherapy And Drug Delivery Systems
title_sort Hydatid Disease: Current Status Of Chemotherapy And Drug Delivery Systems
dc.creator.none.fl_str_mv Elissondo, María Celina
Bermudez, Jose Maria
Ullio Gamboa, Gabriela Veronica
Pensel, Patricia Eugenia
Cid, Alicia Graciela
Juarez, Maria Mercedes
Allemandi, Daniel Alberto
Palma, Santiago Daniel
author Elissondo, María Celina
author_facet Elissondo, María Celina
Bermudez, Jose Maria
Ullio Gamboa, Gabriela Veronica
Pensel, Patricia Eugenia
Cid, Alicia Graciela
Juarez, Maria Mercedes
Allemandi, Daniel Alberto
Palma, Santiago Daniel
author_role author
author2 Bermudez, Jose Maria
Ullio Gamboa, Gabriela Veronica
Pensel, Patricia Eugenia
Cid, Alicia Graciela
Juarez, Maria Mercedes
Allemandi, Daniel Alberto
Palma, Santiago Daniel
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Chemotherapy
Drug Delivery
Hydatid Disease
Therapy
topic Chemotherapy
Drug Delivery
Hydatid Disease
Therapy
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Human echinococcosis or hydatid disease still causes serious health problems with a worldwide geographical distribution. This parasitic infection is a chronic, complex, and still neglected disease. Currently four treatment modalities are in use: surgery, PAIR (puncture, aspiration, injection of protoscolicidal agent, reaspiration), chemotherapy and a “watch and wait” approach for inactive, clinically silent cysts. Over the past 30 years, chemotherapy with benzimidazoles (BZ), like albendazole and mebendazole, has been used increasingly to treat this pathology. Unfortunately, 20%–40% of the cases do not respond favorably to such chemotherapy and these drugs produce stabilization, rather than cure in the majority of patients. However, the overall efficacy of BZ has been overstated in the past. With regard to these difficulties, novel therapeutical tools are needed to optimize treatment of human echinococcosis. On the one hand, a number of compounds have been investigated, either using in vitro cultured parasites and/or applying to in vivo rodent models. Tested compounds include BZ derivatives such as flubendazole, and oxfendazole, as well as other anti-infective agents like ivermectin, nitazoxanide, genistein, artemisinin, timol, rapamycin, and anti-cancer agents such as 2-methoxyestradiol and cyclosporine A. Although some of these compounds showed promising activities in vitro, and also in the rodent models, they have not been yet translated to clinical applications. On the other hand, different drug delivery systems have been developed in order to improve the efficacy of several active pharmaceutical ingredients (APIs) such as oil in water emulsion, liposomes and nanoparticles among others. The present review article summarizes the chemotherapeutic state-of-the-art and the research done in the field of drug delivery systems regarded human echinococcosis.
Fil: Elissondo, María Celina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biologia. Laboratorio de Zoonosis Parasitarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación Para la Industria Química (i); Argentina
Fil: Ullio Gamboa, Gabriela Veronica. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo En Tecnologia Farmaceutica; Argentina
Fil: Pensel, Patricia Eugenia. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biologia. Laboratorio de Zoonosis Parasitarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cid, Alicia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación Para la Industria Química (i); Argentina
Fil: Juarez, Maria Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación Para la Industria Química (i); Argentina
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo En Tecnologia Farmaceutica; Argentina
Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo En Tecnologia Farmaceutica; Argentina
description Human echinococcosis or hydatid disease still causes serious health problems with a worldwide geographical distribution. This parasitic infection is a chronic, complex, and still neglected disease. Currently four treatment modalities are in use: surgery, PAIR (puncture, aspiration, injection of protoscolicidal agent, reaspiration), chemotherapy and a “watch and wait” approach for inactive, clinically silent cysts. Over the past 30 years, chemotherapy with benzimidazoles (BZ), like albendazole and mebendazole, has been used increasingly to treat this pathology. Unfortunately, 20%–40% of the cases do not respond favorably to such chemotherapy and these drugs produce stabilization, rather than cure in the majority of patients. However, the overall efficacy of BZ has been overstated in the past. With regard to these difficulties, novel therapeutical tools are needed to optimize treatment of human echinococcosis. On the one hand, a number of compounds have been investigated, either using in vitro cultured parasites and/or applying to in vivo rodent models. Tested compounds include BZ derivatives such as flubendazole, and oxfendazole, as well as other anti-infective agents like ivermectin, nitazoxanide, genistein, artemisinin, timol, rapamycin, and anti-cancer agents such as 2-methoxyestradiol and cyclosporine A. Although some of these compounds showed promising activities in vitro, and also in the rodent models, they have not been yet translated to clinical applications. On the other hand, different drug delivery systems have been developed in order to improve the efficacy of several active pharmaceutical ingredients (APIs) such as oil in water emulsion, liposomes and nanoparticles among others. The present review article summarizes the chemotherapeutic state-of-the-art and the research done in the field of drug delivery systems regarded human echinococcosis.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12726
Elissondo, María Celina; Bermudez, Jose Maria; Ullio Gamboa, Gabriela Veronica; Pensel, Patricia Eugenia; Cid, Alicia Graciela; et al.; Hydatid Disease: Current Status Of Chemotherapy And Drug Delivery Systems; Betham Science; Current Drug Therapy; 8; 3; 7-2013; 197-205
1574-8855
2212-3903
url http://hdl.handle.net/11336/12726
identifier_str_mv Elissondo, María Celina; Bermudez, Jose Maria; Ullio Gamboa, Gabriela Veronica; Pensel, Patricia Eugenia; Cid, Alicia Graciela; et al.; Hydatid Disease: Current Status Of Chemotherapy And Drug Delivery Systems; Betham Science; Current Drug Therapy; 8; 3; 7-2013; 197-205
1574-8855
2212-3903
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/ben/cdth/2013/00000008/00000003/art00007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Betham Science
publisher.none.fl_str_mv Betham Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782192239247360
score 12.982451

Publicaciones similares