Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications

Autores
Chuffa, Luiz Gustavo de Almeida; Seiva, Fábio Rodrigues Ferreira; Novais, Adriana Alonso; Simão, Vinícius Augusto; Martín Giménez, Virna Margarita; Manucha, Walter Ariel Fernando; Zuccari, Debora Aparecida Pires de Campos; Reiter, Russel
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The use of nanosized particles has emerged to facilitate selective applications in medicine. Drug-delivery systems represent novel opportunities to provide stricter, focused, and fine-tuned therapy, enhancing the therapeutic efficacy of chemical agents at the molecular level while reducing their toxic effects. Melatonin (N-acetyl-5-methoxytriptamine) is a small indoleamine secreted essentially by the pineal gland during darkness, but also produced by most cells in a non-circadian manner from which it is not released into the blood. Although the therapeutic promise of melatonin is indisputable, aspects regarding optimal dosage, biotransformation and metabolism, route and time of administration, and targeted therapy remain to be examined for proper treatment results. Recently, prolonged release of melatonin has shown greater efficacy and safety when combined with a nanostructured formulation. This review summarizes the role of melatonin incorporated into different nanocarriers (e.g., lipid-based vesicles, polymeric vesicles, non-ionic surfactant-based vesicles, charge carriers in graphene, electro spun nanofibers, silica-based carriers, metallic and nonmetallic nanocomposites) as drug delivery system platforms or multilevel determinations in various in vivo and in vitro experimental conditions. Melatonin incorporated into nanosized materials exhibits superior effectiveness in multiple diseases and pathological processes than does free melatonin; thus, such information has functional significance for clinical intervention.
Fil: Chuffa, Luiz Gustavo de Almeida. Universidade de Sao Paulo; Brasil
Fil: Seiva, Fábio Rodrigues Ferreira. Universidade Estadual do Norte do Paraná; Brasil
Fil: Novais, Adriana Alonso. Universidade Federal do Mato Grosso do Sul; Brasil
Fil: Simão, Vinícius Augusto. Universidade de Sao Paulo; Brasil
Fil: Martín Giménez, Virna Margarita. Universidad Católica de Cuyo. Facultad de Ciencias Químicas y Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Fil: Manucha, Walter Ariel Fernando. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Zuccari, Debora Aparecida Pires de Campos. Faculdade de Medicina de São José do Rio Preto; Brasil
Fil: Reiter, Russel. University of Texas at San Antonio; Estados Unidos
Materia
MELATONIN
NANOCARRIERS
MELATONIN-LOADED NANOCARRIERS
NANOPARTICLES
DRUG-DELIVERY SYSTEM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/152856
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/152856
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic ApplicationsChuffa, Luiz Gustavo de AlmeidaSeiva, Fábio Rodrigues FerreiraNovais, Adriana AlonsoSimão, Vinícius AugustoMartín Giménez, Virna MargaritaManucha, Walter Ariel FernandoZuccari, Debora Aparecida Pires de CamposReiter, RusselMELATONINNANOCARRIERSMELATONIN-LOADED NANOCARRIERSNANOPARTICLESDRUG-DELIVERY SYSTEMhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2The use of nanosized particles has emerged to facilitate selective applications in medicine. Drug-delivery systems represent novel opportunities to provide stricter, focused, and fine-tuned therapy, enhancing the therapeutic efficacy of chemical agents at the molecular level while reducing their toxic effects. Melatonin (N-acetyl-5-methoxytriptamine) is a small indoleamine secreted essentially by the pineal gland during darkness, but also produced by most cells in a non-circadian manner from which it is not released into the blood. Although the therapeutic promise of melatonin is indisputable, aspects regarding optimal dosage, biotransformation and metabolism, route and time of administration, and targeted therapy remain to be examined for proper treatment results. Recently, prolonged release of melatonin has shown greater efficacy and safety when combined with a nanostructured formulation. This review summarizes the role of melatonin incorporated into different nanocarriers (e.g., lipid-based vesicles, polymeric vesicles, non-ionic surfactant-based vesicles, charge carriers in graphene, electro spun nanofibers, silica-based carriers, metallic and nonmetallic nanocomposites) as drug delivery system platforms or multilevel determinations in various in vivo and in vitro experimental conditions. Melatonin incorporated into nanosized materials exhibits superior effectiveness in multiple diseases and pathological processes than does free melatonin; thus, such information has functional significance for clinical intervention.Fil: Chuffa, Luiz Gustavo de Almeida. Universidade de Sao Paulo; BrasilFil: Seiva, Fábio Rodrigues Ferreira. Universidade Estadual do Norte do Paraná; BrasilFil: Novais, Adriana Alonso. Universidade Federal do Mato Grosso do Sul; BrasilFil: Simão, Vinícius Augusto. Universidade de Sao Paulo; BrasilFil: Martín Giménez, Virna Margarita. Universidad Católica de Cuyo. Facultad de Ciencias Químicas y Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Manucha, Walter Ariel Fernando. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Zuccari, Debora Aparecida Pires de Campos. Faculdade de Medicina de São José do Rio Preto; BrasilFil: Reiter, Russel. University of Texas at San Antonio; Estados UnidosMultidisciplinary Digital Publishing Institute2021-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/152856Chuffa, Luiz Gustavo de Almeida; Seiva, Fábio Rodrigues Ferreira; Novais, Adriana Alonso; Simão, Vinícius Augusto; Martín Giménez, Virna Margarita; et al.; Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications; Multidisciplinary Digital Publishing Institute; Molecules; 26; 12; 6-2021; 1-281420-3049CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/26/12/3562info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules26123562info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:12:10Zoai:ri.conicet.gov.ar:11336/152856instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:12:10.515CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications
title Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications
spellingShingle Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications
Chuffa, Luiz Gustavo de Almeida
MELATONIN
NANOCARRIERS
MELATONIN-LOADED NANOCARRIERS
NANOPARTICLES
DRUG-DELIVERY SYSTEM
title_short Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications
title_full Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications
title_fullStr Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications
title_full_unstemmed Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications
title_sort Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications
dc.creator.none.fl_str_mv Chuffa, Luiz Gustavo de Almeida
Seiva, Fábio Rodrigues Ferreira
Novais, Adriana Alonso
Simão, Vinícius Augusto
Martín Giménez, Virna Margarita
Manucha, Walter Ariel Fernando
Zuccari, Debora Aparecida Pires de Campos
Reiter, Russel
author Chuffa, Luiz Gustavo de Almeida
author_facet Chuffa, Luiz Gustavo de Almeida
Seiva, Fábio Rodrigues Ferreira
Novais, Adriana Alonso
Simão, Vinícius Augusto
Martín Giménez, Virna Margarita
Manucha, Walter Ariel Fernando
Zuccari, Debora Aparecida Pires de Campos
Reiter, Russel
author_role author
author2 Seiva, Fábio Rodrigues Ferreira
Novais, Adriana Alonso
Simão, Vinícius Augusto
Martín Giménez, Virna Margarita
Manucha, Walter Ariel Fernando
Zuccari, Debora Aparecida Pires de Campos
Reiter, Russel
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MELATONIN
NANOCARRIERS
MELATONIN-LOADED NANOCARRIERS
NANOPARTICLES
DRUG-DELIVERY SYSTEM
topic MELATONIN
NANOCARRIERS
MELATONIN-LOADED NANOCARRIERS
NANOPARTICLES
DRUG-DELIVERY SYSTEM
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The use of nanosized particles has emerged to facilitate selective applications in medicine. Drug-delivery systems represent novel opportunities to provide stricter, focused, and fine-tuned therapy, enhancing the therapeutic efficacy of chemical agents at the molecular level while reducing their toxic effects. Melatonin (N-acetyl-5-methoxytriptamine) is a small indoleamine secreted essentially by the pineal gland during darkness, but also produced by most cells in a non-circadian manner from which it is not released into the blood. Although the therapeutic promise of melatonin is indisputable, aspects regarding optimal dosage, biotransformation and metabolism, route and time of administration, and targeted therapy remain to be examined for proper treatment results. Recently, prolonged release of melatonin has shown greater efficacy and safety when combined with a nanostructured formulation. This review summarizes the role of melatonin incorporated into different nanocarriers (e.g., lipid-based vesicles, polymeric vesicles, non-ionic surfactant-based vesicles, charge carriers in graphene, electro spun nanofibers, silica-based carriers, metallic and nonmetallic nanocomposites) as drug delivery system platforms or multilevel determinations in various in vivo and in vitro experimental conditions. Melatonin incorporated into nanosized materials exhibits superior effectiveness in multiple diseases and pathological processes than does free melatonin; thus, such information has functional significance for clinical intervention.
Fil: Chuffa, Luiz Gustavo de Almeida. Universidade de Sao Paulo; Brasil
Fil: Seiva, Fábio Rodrigues Ferreira. Universidade Estadual do Norte do Paraná; Brasil
Fil: Novais, Adriana Alonso. Universidade Federal do Mato Grosso do Sul; Brasil
Fil: Simão, Vinícius Augusto. Universidade de Sao Paulo; Brasil
Fil: Martín Giménez, Virna Margarita. Universidad Católica de Cuyo. Facultad de Ciencias Químicas y Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Fil: Manucha, Walter Ariel Fernando. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Zuccari, Debora Aparecida Pires de Campos. Faculdade de Medicina de São José do Rio Preto; Brasil
Fil: Reiter, Russel. University of Texas at San Antonio; Estados Unidos
description The use of nanosized particles has emerged to facilitate selective applications in medicine. Drug-delivery systems represent novel opportunities to provide stricter, focused, and fine-tuned therapy, enhancing the therapeutic efficacy of chemical agents at the molecular level while reducing their toxic effects. Melatonin (N-acetyl-5-methoxytriptamine) is a small indoleamine secreted essentially by the pineal gland during darkness, but also produced by most cells in a non-circadian manner from which it is not released into the blood. Although the therapeutic promise of melatonin is indisputable, aspects regarding optimal dosage, biotransformation and metabolism, route and time of administration, and targeted therapy remain to be examined for proper treatment results. Recently, prolonged release of melatonin has shown greater efficacy and safety when combined with a nanostructured formulation. This review summarizes the role of melatonin incorporated into different nanocarriers (e.g., lipid-based vesicles, polymeric vesicles, non-ionic surfactant-based vesicles, charge carriers in graphene, electro spun nanofibers, silica-based carriers, metallic and nonmetallic nanocomposites) as drug delivery system platforms or multilevel determinations in various in vivo and in vitro experimental conditions. Melatonin incorporated into nanosized materials exhibits superior effectiveness in multiple diseases and pathological processes than does free melatonin; thus, such information has functional significance for clinical intervention.
publishDate 2021
dc.date.none.fl_str_mv 2021-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/152856
Chuffa, Luiz Gustavo de Almeida; Seiva, Fábio Rodrigues Ferreira; Novais, Adriana Alonso; Simão, Vinícius Augusto; Martín Giménez, Virna Margarita; et al.; Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications; Multidisciplinary Digital Publishing Institute; Molecules; 26; 12; 6-2021; 1-28
1420-3049
CONICET Digital
CONICET
url http://hdl.handle.net/11336/152856
identifier_str_mv Chuffa, Luiz Gustavo de Almeida; Seiva, Fábio Rodrigues Ferreira; Novais, Adriana Alonso; Simão, Vinícius Augusto; Martín Giménez, Virna Margarita; et al.; Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications; Multidisciplinary Digital Publishing Institute; Molecules; 26; 12; 6-2021; 1-28
1420-3049
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/26/12/3562
info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules26123562
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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