Polysaccharide-based nanocarriers for ocular drug delivery

Autores
Formica, María Lina; Calles, Javier Adrián; Palma, Santiago Daniel
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Obtaining successful ocular formulations able to support an efficient drug concentration at the target tissue for an appropriate period of time is an interesting challenge for modern pharmaceutical technology. In this sense, nanotechnology is one of the available strategies to obtain a drug carrier system that allows access to different compartments of the eye in order to deliver drugs to the desired site. Biodegradable polymers such as polysaccharides are promising biomaterials for the production of biocompatible and biodegradable nanocarriers (NCs). Different types of polysaccharide NCs are capable of improving the transport of drugs after ocular application and they can be either polysaccharide-matrix carriers or polysaccharide-coated carriers, depending on whether polysaccharide is used as a matrix or as a coating, respectively. This review focuses on recent advances achieved by polysaccharide-based NCs for the treatment of ocular disorders.
Fil: Formica, María Lina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Calles, Javier Adrián. Universidad de Valladolid; España. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Materia
Gene Therapy
Nanocarriers
Nanoparticles
Ocular Barriers
Ocular Drug Delivery
Polysaccharides
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/62953
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Polysaccharide-based nanocarriers for ocular drug deliveryFormica, María LinaCalles, Javier AdriánPalma, Santiago DanielGene TherapyNanocarriersNanoparticlesOcular BarriersOcular Drug DeliveryPolysaccharideshttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Obtaining successful ocular formulations able to support an efficient drug concentration at the target tissue for an appropriate period of time is an interesting challenge for modern pharmaceutical technology. In this sense, nanotechnology is one of the available strategies to obtain a drug carrier system that allows access to different compartments of the eye in order to deliver drugs to the desired site. Biodegradable polymers such as polysaccharides are promising biomaterials for the production of biocompatible and biodegradable nanocarriers (NCs). Different types of polysaccharide NCs are capable of improving the transport of drugs after ocular application and they can be either polysaccharide-matrix carriers or polysaccharide-coated carriers, depending on whether polysaccharide is used as a matrix or as a coating, respectively. This review focuses on recent advances achieved by polysaccharide-based NCs for the treatment of ocular disorders.Fil: Formica, María Lina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Calles, Javier Adrián. Universidad de Valladolid; España. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaBentham Science Publishers2015-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/62953Formica, María Lina; Calles, Javier Adrián; Palma, Santiago Daniel; Polysaccharide-based nanocarriers for ocular drug delivery; Bentham Science Publishers; Current Pharmaceutical Design; 21; 33; 10-2015; 4851-48681381-6128CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/134147/articleinfo:eu-repo/semantics/altIdentifier/doi/10.2174/1381612821666150820101203info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:56Zoai:ri.conicet.gov.ar:11336/62953instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:57.365CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Polysaccharide-based nanocarriers for ocular drug delivery
title Polysaccharide-based nanocarriers for ocular drug delivery
spellingShingle Polysaccharide-based nanocarriers for ocular drug delivery
Formica, María Lina
Gene Therapy
Nanocarriers
Nanoparticles
Ocular Barriers
Ocular Drug Delivery
Polysaccharides
title_short Polysaccharide-based nanocarriers for ocular drug delivery
title_full Polysaccharide-based nanocarriers for ocular drug delivery
title_fullStr Polysaccharide-based nanocarriers for ocular drug delivery
title_full_unstemmed Polysaccharide-based nanocarriers for ocular drug delivery
title_sort Polysaccharide-based nanocarriers for ocular drug delivery
dc.creator.none.fl_str_mv Formica, María Lina
Calles, Javier Adrián
Palma, Santiago Daniel
author Formica, María Lina
author_facet Formica, María Lina
Calles, Javier Adrián
Palma, Santiago Daniel
author_role author
author2 Calles, Javier Adrián
Palma, Santiago Daniel
author2_role author
author
dc.subject.none.fl_str_mv Gene Therapy
Nanocarriers
Nanoparticles
Ocular Barriers
Ocular Drug Delivery
Polysaccharides
topic Gene Therapy
Nanocarriers
Nanoparticles
Ocular Barriers
Ocular Drug Delivery
Polysaccharides
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Obtaining successful ocular formulations able to support an efficient drug concentration at the target tissue for an appropriate period of time is an interesting challenge for modern pharmaceutical technology. In this sense, nanotechnology is one of the available strategies to obtain a drug carrier system that allows access to different compartments of the eye in order to deliver drugs to the desired site. Biodegradable polymers such as polysaccharides are promising biomaterials for the production of biocompatible and biodegradable nanocarriers (NCs). Different types of polysaccharide NCs are capable of improving the transport of drugs after ocular application and they can be either polysaccharide-matrix carriers or polysaccharide-coated carriers, depending on whether polysaccharide is used as a matrix or as a coating, respectively. This review focuses on recent advances achieved by polysaccharide-based NCs for the treatment of ocular disorders.
Fil: Formica, María Lina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Calles, Javier Adrián. Universidad de Valladolid; España. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
description Obtaining successful ocular formulations able to support an efficient drug concentration at the target tissue for an appropriate period of time is an interesting challenge for modern pharmaceutical technology. In this sense, nanotechnology is one of the available strategies to obtain a drug carrier system that allows access to different compartments of the eye in order to deliver drugs to the desired site. Biodegradable polymers such as polysaccharides are promising biomaterials for the production of biocompatible and biodegradable nanocarriers (NCs). Different types of polysaccharide NCs are capable of improving the transport of drugs after ocular application and they can be either polysaccharide-matrix carriers or polysaccharide-coated carriers, depending on whether polysaccharide is used as a matrix or as a coating, respectively. This review focuses on recent advances achieved by polysaccharide-based NCs for the treatment of ocular disorders.
publishDate 2015
dc.date.none.fl_str_mv 2015-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/62953
Formica, María Lina; Calles, Javier Adrián; Palma, Santiago Daniel; Polysaccharide-based nanocarriers for ocular drug delivery; Bentham Science Publishers; Current Pharmaceutical Design; 21; 33; 10-2015; 4851-4868
1381-6128
CONICET Digital
CONICET
url http://hdl.handle.net/11336/62953
identifier_str_mv Formica, María Lina; Calles, Javier Adrián; Palma, Santiago Daniel; Polysaccharide-based nanocarriers for ocular drug delivery; Bentham Science Publishers; Current Pharmaceutical Design; 21; 33; 10-2015; 4851-4868
1381-6128
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/134147/article
info:eu-repo/semantics/altIdentifier/doi/10.2174/1381612821666150820101203
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269373812703232
score 13.13397

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