Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids

Autores
Langdon, Quinn K.; Peris, David; Eizaguirre, Juan Ignacio; Opulente, Dana A.; Buh, Kelly V.; Sylvester, Kayla; Jarzyna, Martin; Rodríguez, María Eugenia; Lopes, Christian Ariel; Libkind Frati, Diego; Hittinger, Chris
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The wild, cold-adapted parent of hybrid lager-brewing yeasts, Saccharomyces eubayanus, has a complex and understudied natural history. The exploration of this diversity can be used both to develop new brewing applications and to enlighten our understanding of the dynamics of yeast evolution in the wild. Here, we integrate whole genome sequence and phenotypic data of 200 S. eubayanus strains, the largest collection known to date. S. eubayanus has a multilayered population structure, consisting of two major populations that are further structured into six subpopulations. Four of these subpopulations are found exclusively in the Patagonian region of South America; one is found predominantly in Patagonia and sparsely in Oceania and North America; and one is specific to the Holarctic ecozone. Plant host associations differed between subpopulations and between S. eubayanus and its sister species, Saccharomyces uvarum. S. eubayanus is most abundant and genetically diverse in northern Patagonia, where some locations harbor more genetic diversity than is found outside of South America, suggesting that northern Patagonia east of the Andes was a glacial refugium for this species. All but one subpopulation shows isolation-by-distance, and gene flow between subpopulations is low. However, there are strong signals of ancient and recent outcrossing, including two admixed lineages, one that is sympatric with and one that is mostly isolated from its parental populations. Using our extensive biogeographical data, we build a robust model that predicts all known and a handful of additional regions of the globe that are climatically suitable for S. eubayanus, including Europe where host accessibility and competitive exclusion by other Saccharomyces species may explain its continued elusiveness. We conclude that this industrially relevant species has rich natural diversity with many factors contributing to its complex distribution and natural history.
Fil: Langdon, Quinn K.. University of Wisconsin; Estados Unidos
Fil: Peris, David. University of Wisconsin; Estados Unidos. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España
Fil: Eizaguirre, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; Argentina
Fil: Opulente, Dana A.. University of Wisconsin; Estados Unidos
Fil: Buh, Kelly V.. University of Wisconsin; Estados Unidos
Fil: Sylvester, Kayla. University of Wisconsin; Estados Unidos
Fil: Jarzyna, Martin. University of Wisconsin; Estados Unidos
Fil: Rodríguez, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; Argentina
Fil: Lopes, Christian Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; Argentina
Fil: Libkind Frati, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; Argentina
Fil: Hittinger, Chris. University of Wisconsin; Estados Unidos
Materia
BEER
SACCHARMYCES EUBAYANUS
PATAGONIA
DIVERSITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/147187
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybridsLangdon, Quinn K.Peris, DavidEizaguirre, Juan IgnacioOpulente, Dana A.Buh, Kelly V.Sylvester, KaylaJarzyna, MartinRodríguez, María EugeniaLopes, Christian ArielLibkind Frati, DiegoHittinger, ChrisBEERSACCHARMYCES EUBAYANUSPATAGONIADIVERSITYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The wild, cold-adapted parent of hybrid lager-brewing yeasts, Saccharomyces eubayanus, has a complex and understudied natural history. The exploration of this diversity can be used both to develop new brewing applications and to enlighten our understanding of the dynamics of yeast evolution in the wild. Here, we integrate whole genome sequence and phenotypic data of 200 S. eubayanus strains, the largest collection known to date. S. eubayanus has a multilayered population structure, consisting of two major populations that are further structured into six subpopulations. Four of these subpopulations are found exclusively in the Patagonian region of South America; one is found predominantly in Patagonia and sparsely in Oceania and North America; and one is specific to the Holarctic ecozone. Plant host associations differed between subpopulations and between S. eubayanus and its sister species, Saccharomyces uvarum. S. eubayanus is most abundant and genetically diverse in northern Patagonia, where some locations harbor more genetic diversity than is found outside of South America, suggesting that northern Patagonia east of the Andes was a glacial refugium for this species. All but one subpopulation shows isolation-by-distance, and gene flow between subpopulations is low. However, there are strong signals of ancient and recent outcrossing, including two admixed lineages, one that is sympatric with and one that is mostly isolated from its parental populations. Using our extensive biogeographical data, we build a robust model that predicts all known and a handful of additional regions of the globe that are climatically suitable for S. eubayanus, including Europe where host accessibility and competitive exclusion by other Saccharomyces species may explain its continued elusiveness. We conclude that this industrially relevant species has rich natural diversity with many factors contributing to its complex distribution and natural history.Fil: Langdon, Quinn K.. University of Wisconsin; Estados UnidosFil: Peris, David. University of Wisconsin; Estados Unidos. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; EspañaFil: Eizaguirre, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; ArgentinaFil: Opulente, Dana A.. University of Wisconsin; Estados UnidosFil: Buh, Kelly V.. University of Wisconsin; Estados UnidosFil: Sylvester, Kayla. University of Wisconsin; Estados UnidosFil: Jarzyna, Martin. University of Wisconsin; Estados UnidosFil: Rodríguez, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; ArgentinaFil: Lopes, Christian Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; ArgentinaFil: Libkind Frati, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; ArgentinaFil: Hittinger, Chris. University of Wisconsin; Estados UnidosPublic Library of Science2020-04-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/147187Langdon, Quinn K.; Peris, David; Eizaguirre, Juan Ignacio; Opulente, Dana A.; Buh, Kelly V.; et al.; Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids; Public Library of Science; Plos Genetics; 16; 4; 6-4-2020; 1-221553-7390CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008680info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pgen.1008680info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:08:18Zoai:ri.conicet.gov.ar:11336/147187instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:08:18.889CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids
title Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids
spellingShingle Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids
Langdon, Quinn K.
BEER
SACCHARMYCES EUBAYANUS
PATAGONIA
DIVERSITY
title_short Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids
title_full Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids
title_fullStr Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids
title_full_unstemmed Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids
title_sort Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids
dc.creator.none.fl_str_mv Langdon, Quinn K.
Peris, David
Eizaguirre, Juan Ignacio
Opulente, Dana A.
Buh, Kelly V.
Sylvester, Kayla
Jarzyna, Martin
Rodríguez, María Eugenia
Lopes, Christian Ariel
Libkind Frati, Diego
Hittinger, Chris
author Langdon, Quinn K.
author_facet Langdon, Quinn K.
Peris, David
Eizaguirre, Juan Ignacio
Opulente, Dana A.
Buh, Kelly V.
Sylvester, Kayla
Jarzyna, Martin
Rodríguez, María Eugenia
Lopes, Christian Ariel
Libkind Frati, Diego
Hittinger, Chris
author_role author
author2 Peris, David
Eizaguirre, Juan Ignacio
Opulente, Dana A.
Buh, Kelly V.
Sylvester, Kayla
Jarzyna, Martin
Rodríguez, María Eugenia
Lopes, Christian Ariel
Libkind Frati, Diego
Hittinger, Chris
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BEER
SACCHARMYCES EUBAYANUS
PATAGONIA
DIVERSITY
topic BEER
SACCHARMYCES EUBAYANUS
PATAGONIA
DIVERSITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The wild, cold-adapted parent of hybrid lager-brewing yeasts, Saccharomyces eubayanus, has a complex and understudied natural history. The exploration of this diversity can be used both to develop new brewing applications and to enlighten our understanding of the dynamics of yeast evolution in the wild. Here, we integrate whole genome sequence and phenotypic data of 200 S. eubayanus strains, the largest collection known to date. S. eubayanus has a multilayered population structure, consisting of two major populations that are further structured into six subpopulations. Four of these subpopulations are found exclusively in the Patagonian region of South America; one is found predominantly in Patagonia and sparsely in Oceania and North America; and one is specific to the Holarctic ecozone. Plant host associations differed between subpopulations and between S. eubayanus and its sister species, Saccharomyces uvarum. S. eubayanus is most abundant and genetically diverse in northern Patagonia, where some locations harbor more genetic diversity than is found outside of South America, suggesting that northern Patagonia east of the Andes was a glacial refugium for this species. All but one subpopulation shows isolation-by-distance, and gene flow between subpopulations is low. However, there are strong signals of ancient and recent outcrossing, including two admixed lineages, one that is sympatric with and one that is mostly isolated from its parental populations. Using our extensive biogeographical data, we build a robust model that predicts all known and a handful of additional regions of the globe that are climatically suitable for S. eubayanus, including Europe where host accessibility and competitive exclusion by other Saccharomyces species may explain its continued elusiveness. We conclude that this industrially relevant species has rich natural diversity with many factors contributing to its complex distribution and natural history.
Fil: Langdon, Quinn K.. University of Wisconsin; Estados Unidos
Fil: Peris, David. University of Wisconsin; Estados Unidos. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España
Fil: Eizaguirre, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; Argentina
Fil: Opulente, Dana A.. University of Wisconsin; Estados Unidos
Fil: Buh, Kelly V.. University of Wisconsin; Estados Unidos
Fil: Sylvester, Kayla. University of Wisconsin; Estados Unidos
Fil: Jarzyna, Martin. University of Wisconsin; Estados Unidos
Fil: Rodríguez, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; Argentina
Fil: Lopes, Christian Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; Argentina
Fil: Libkind Frati, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; Argentina
Fil: Hittinger, Chris. University of Wisconsin; Estados Unidos
description The wild, cold-adapted parent of hybrid lager-brewing yeasts, Saccharomyces eubayanus, has a complex and understudied natural history. The exploration of this diversity can be used both to develop new brewing applications and to enlighten our understanding of the dynamics of yeast evolution in the wild. Here, we integrate whole genome sequence and phenotypic data of 200 S. eubayanus strains, the largest collection known to date. S. eubayanus has a multilayered population structure, consisting of two major populations that are further structured into six subpopulations. Four of these subpopulations are found exclusively in the Patagonian region of South America; one is found predominantly in Patagonia and sparsely in Oceania and North America; and one is specific to the Holarctic ecozone. Plant host associations differed between subpopulations and between S. eubayanus and its sister species, Saccharomyces uvarum. S. eubayanus is most abundant and genetically diverse in northern Patagonia, where some locations harbor more genetic diversity than is found outside of South America, suggesting that northern Patagonia east of the Andes was a glacial refugium for this species. All but one subpopulation shows isolation-by-distance, and gene flow between subpopulations is low. However, there are strong signals of ancient and recent outcrossing, including two admixed lineages, one that is sympatric with and one that is mostly isolated from its parental populations. Using our extensive biogeographical data, we build a robust model that predicts all known and a handful of additional regions of the globe that are climatically suitable for S. eubayanus, including Europe where host accessibility and competitive exclusion by other Saccharomyces species may explain its continued elusiveness. We conclude that this industrially relevant species has rich natural diversity with many factors contributing to its complex distribution and natural history.
publishDate 2020
dc.date.none.fl_str_mv 2020-04-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/147187
Langdon, Quinn K.; Peris, David; Eizaguirre, Juan Ignacio; Opulente, Dana A.; Buh, Kelly V.; et al.; Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids; Public Library of Science; Plos Genetics; 16; 4; 6-4-2020; 1-22
1553-7390
CONICET Digital
CONICET
url http://hdl.handle.net/11336/147187
identifier_str_mv Langdon, Quinn K.; Peris, David; Eizaguirre, Juan Ignacio; Opulente, Dana A.; Buh, Kelly V.; et al.; Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids; Public Library of Science; Plos Genetics; 16; 4; 6-4-2020; 1-22
1553-7390
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pgen.1008680
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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