Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids
- Autores
- Langdon, Quinn K.; Peris, David; Eizaguirre, Juan Ignacio; Opulente, Dana A.; Buh, Kelly V.; Sylvester, Kayla; Jarzyna, Martin; Rodríguez, María Eugenia; Lopes, Christian Ariel; Libkind Frati, Diego; Hittinger, Chris
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The wild, cold-adapted parent of hybrid lager-brewing yeasts, Saccharomyces eubayanus, has a complex and understudied natural history. The exploration of this diversity can be used both to develop new brewing applications and to enlighten our understanding of the dynamics of yeast evolution in the wild. Here, we integrate whole genome sequence and phenotypic data of 200 S. eubayanus strains, the largest collection known to date. S. eubayanus has a multilayered population structure, consisting of two major populations that are further structured into six subpopulations. Four of these subpopulations are found exclusively in the Patagonian region of South America; one is found predominantly in Patagonia and sparsely in Oceania and North America; and one is specific to the Holarctic ecozone. Plant host associations differed between subpopulations and between S. eubayanus and its sister species, Saccharomyces uvarum. S. eubayanus is most abundant and genetically diverse in northern Patagonia, where some locations harbor more genetic diversity than is found outside of South America, suggesting that northern Patagonia east of the Andes was a glacial refugium for this species. All but one subpopulation shows isolation-by-distance, and gene flow between subpopulations is low. However, there are strong signals of ancient and recent outcrossing, including two admixed lineages, one that is sympatric with and one that is mostly isolated from its parental populations. Using our extensive biogeographical data, we build a robust model that predicts all known and a handful of additional regions of the globe that are climatically suitable for S. eubayanus, including Europe where host accessibility and competitive exclusion by other Saccharomyces species may explain its continued elusiveness. We conclude that this industrially relevant species has rich natural diversity with many factors contributing to its complex distribution and natural history.
Fil: Langdon, Quinn K.. University of Wisconsin; Estados Unidos
Fil: Peris, David. University of Wisconsin; Estados Unidos. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España
Fil: Eizaguirre, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; Argentina
Fil: Opulente, Dana A.. University of Wisconsin; Estados Unidos
Fil: Buh, Kelly V.. University of Wisconsin; Estados Unidos
Fil: Sylvester, Kayla. University of Wisconsin; Estados Unidos
Fil: Jarzyna, Martin. University of Wisconsin; Estados Unidos
Fil: Rodríguez, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; Argentina
Fil: Lopes, Christian Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; Argentina
Fil: Libkind Frati, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; Argentina
Fil: Hittinger, Chris. University of Wisconsin; Estados Unidos - Materia
-
BEER
SACCHARMYCES EUBAYANUS
PATAGONIA
DIVERSITY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/147187
Ver los metadatos del registro completo
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Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybridsLangdon, Quinn K.Peris, DavidEizaguirre, Juan IgnacioOpulente, Dana A.Buh, Kelly V.Sylvester, KaylaJarzyna, MartinRodríguez, María EugeniaLopes, Christian ArielLibkind Frati, DiegoHittinger, ChrisBEERSACCHARMYCES EUBAYANUSPATAGONIADIVERSITYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The wild, cold-adapted parent of hybrid lager-brewing yeasts, Saccharomyces eubayanus, has a complex and understudied natural history. The exploration of this diversity can be used both to develop new brewing applications and to enlighten our understanding of the dynamics of yeast evolution in the wild. Here, we integrate whole genome sequence and phenotypic data of 200 S. eubayanus strains, the largest collection known to date. S. eubayanus has a multilayered population structure, consisting of two major populations that are further structured into six subpopulations. Four of these subpopulations are found exclusively in the Patagonian region of South America; one is found predominantly in Patagonia and sparsely in Oceania and North America; and one is specific to the Holarctic ecozone. Plant host associations differed between subpopulations and between S. eubayanus and its sister species, Saccharomyces uvarum. S. eubayanus is most abundant and genetically diverse in northern Patagonia, where some locations harbor more genetic diversity than is found outside of South America, suggesting that northern Patagonia east of the Andes was a glacial refugium for this species. All but one subpopulation shows isolation-by-distance, and gene flow between subpopulations is low. However, there are strong signals of ancient and recent outcrossing, including two admixed lineages, one that is sympatric with and one that is mostly isolated from its parental populations. Using our extensive biogeographical data, we build a robust model that predicts all known and a handful of additional regions of the globe that are climatically suitable for S. eubayanus, including Europe where host accessibility and competitive exclusion by other Saccharomyces species may explain its continued elusiveness. We conclude that this industrially relevant species has rich natural diversity with many factors contributing to its complex distribution and natural history.Fil: Langdon, Quinn K.. University of Wisconsin; Estados UnidosFil: Peris, David. University of Wisconsin; Estados Unidos. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; EspañaFil: Eizaguirre, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; ArgentinaFil: Opulente, Dana A.. University of Wisconsin; Estados UnidosFil: Buh, Kelly V.. University of Wisconsin; Estados UnidosFil: Sylvester, Kayla. University of Wisconsin; Estados UnidosFil: Jarzyna, Martin. University of Wisconsin; Estados UnidosFil: Rodríguez, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; ArgentinaFil: Lopes, Christian Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; ArgentinaFil: Libkind Frati, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; ArgentinaFil: Hittinger, Chris. University of Wisconsin; Estados UnidosPublic Library of Science2020-04-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/147187Langdon, Quinn K.; Peris, David; Eizaguirre, Juan Ignacio; Opulente, Dana A.; Buh, Kelly V.; et al.; Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids; Public Library of Science; Plos Genetics; 16; 4; 6-4-2020; 1-221553-7390CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008680info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pgen.1008680info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:36:27Zoai:ri.conicet.gov.ar:11336/147187instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:36:27.644CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids |
| title |
Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids |
| spellingShingle |
Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids Langdon, Quinn K. BEER SACCHARMYCES EUBAYANUS PATAGONIA DIVERSITY |
| title_short |
Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids |
| title_full |
Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids |
| title_fullStr |
Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids |
| title_full_unstemmed |
Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids |
| title_sort |
Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids |
| dc.creator.none.fl_str_mv |
Langdon, Quinn K. Peris, David Eizaguirre, Juan Ignacio Opulente, Dana A. Buh, Kelly V. Sylvester, Kayla Jarzyna, Martin Rodríguez, María Eugenia Lopes, Christian Ariel Libkind Frati, Diego Hittinger, Chris |
| author |
Langdon, Quinn K. |
| author_facet |
Langdon, Quinn K. Peris, David Eizaguirre, Juan Ignacio Opulente, Dana A. Buh, Kelly V. Sylvester, Kayla Jarzyna, Martin Rodríguez, María Eugenia Lopes, Christian Ariel Libkind Frati, Diego Hittinger, Chris |
| author_role |
author |
| author2 |
Peris, David Eizaguirre, Juan Ignacio Opulente, Dana A. Buh, Kelly V. Sylvester, Kayla Jarzyna, Martin Rodríguez, María Eugenia Lopes, Christian Ariel Libkind Frati, Diego Hittinger, Chris |
| author2_role |
author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
BEER SACCHARMYCES EUBAYANUS PATAGONIA DIVERSITY |
| topic |
BEER SACCHARMYCES EUBAYANUS PATAGONIA DIVERSITY |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
The wild, cold-adapted parent of hybrid lager-brewing yeasts, Saccharomyces eubayanus, has a complex and understudied natural history. The exploration of this diversity can be used both to develop new brewing applications and to enlighten our understanding of the dynamics of yeast evolution in the wild. Here, we integrate whole genome sequence and phenotypic data of 200 S. eubayanus strains, the largest collection known to date. S. eubayanus has a multilayered population structure, consisting of two major populations that are further structured into six subpopulations. Four of these subpopulations are found exclusively in the Patagonian region of South America; one is found predominantly in Patagonia and sparsely in Oceania and North America; and one is specific to the Holarctic ecozone. Plant host associations differed between subpopulations and between S. eubayanus and its sister species, Saccharomyces uvarum. S. eubayanus is most abundant and genetically diverse in northern Patagonia, where some locations harbor more genetic diversity than is found outside of South America, suggesting that northern Patagonia east of the Andes was a glacial refugium for this species. All but one subpopulation shows isolation-by-distance, and gene flow between subpopulations is low. However, there are strong signals of ancient and recent outcrossing, including two admixed lineages, one that is sympatric with and one that is mostly isolated from its parental populations. Using our extensive biogeographical data, we build a robust model that predicts all known and a handful of additional regions of the globe that are climatically suitable for S. eubayanus, including Europe where host accessibility and competitive exclusion by other Saccharomyces species may explain its continued elusiveness. We conclude that this industrially relevant species has rich natural diversity with many factors contributing to its complex distribution and natural history. Fil: Langdon, Quinn K.. University of Wisconsin; Estados Unidos Fil: Peris, David. University of Wisconsin; Estados Unidos. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España Fil: Eizaguirre, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; Argentina Fil: Opulente, Dana A.. University of Wisconsin; Estados Unidos Fil: Buh, Kelly V.. University of Wisconsin; Estados Unidos Fil: Sylvester, Kayla. University of Wisconsin; Estados Unidos Fil: Jarzyna, Martin. University of Wisconsin; Estados Unidos Fil: Rodríguez, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; Argentina Fil: Lopes, Christian Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; Argentina Fil: Libkind Frati, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; Argentina Fil: Hittinger, Chris. University of Wisconsin; Estados Unidos |
| description |
The wild, cold-adapted parent of hybrid lager-brewing yeasts, Saccharomyces eubayanus, has a complex and understudied natural history. The exploration of this diversity can be used both to develop new brewing applications and to enlighten our understanding of the dynamics of yeast evolution in the wild. Here, we integrate whole genome sequence and phenotypic data of 200 S. eubayanus strains, the largest collection known to date. S. eubayanus has a multilayered population structure, consisting of two major populations that are further structured into six subpopulations. Four of these subpopulations are found exclusively in the Patagonian region of South America; one is found predominantly in Patagonia and sparsely in Oceania and North America; and one is specific to the Holarctic ecozone. Plant host associations differed between subpopulations and between S. eubayanus and its sister species, Saccharomyces uvarum. S. eubayanus is most abundant and genetically diverse in northern Patagonia, where some locations harbor more genetic diversity than is found outside of South America, suggesting that northern Patagonia east of the Andes was a glacial refugium for this species. All but one subpopulation shows isolation-by-distance, and gene flow between subpopulations is low. However, there are strong signals of ancient and recent outcrossing, including two admixed lineages, one that is sympatric with and one that is mostly isolated from its parental populations. Using our extensive biogeographical data, we build a robust model that predicts all known and a handful of additional regions of the globe that are climatically suitable for S. eubayanus, including Europe where host accessibility and competitive exclusion by other Saccharomyces species may explain its continued elusiveness. We conclude that this industrially relevant species has rich natural diversity with many factors contributing to its complex distribution and natural history. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-04-06 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/147187 Langdon, Quinn K.; Peris, David; Eizaguirre, Juan Ignacio; Opulente, Dana A.; Buh, Kelly V.; et al.; Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids; Public Library of Science; Plos Genetics; 16; 4; 6-4-2020; 1-22 1553-7390 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/147187 |
| identifier_str_mv |
Langdon, Quinn K.; Peris, David; Eizaguirre, Juan Ignacio; Opulente, Dana A.; Buh, Kelly V.; et al.; Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids; Public Library of Science; Plos Genetics; 16; 4; 6-4-2020; 1-22 1553-7390 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008680 info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pgen.1008680 |
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Public Library of Science |
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Public Library of Science |
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