Fermentation innovation through complex hybridization of wild and domesticated yeasts

Autores
Langdon, Quinn K.; Peris, David; Baker, Emily Clare; Opulente, Dana A.; Nguyen, Huu-Vang; Bond, Ursula; Gonçalves, Paula; Sampaio, José Paulo; Libkind Frati, Diego; Hittinger, Chris
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The most common fermented beverage, lager beer, is produced by interspecies hybrids of the brewing yeast Saccharomyces cerevisiae and its wild relative S. eubayanus. Lager-brewing yeasts are not the only example of hybrid vigour or heterosis in yeasts, but the full breadth of interspecies hybrids associated with human fermentations has received less attention. Here we present a comprehensive genomic analysis of 122 Saccharomyces hybrids and introgressed strains. These strains arose from hybridization events between two to four species. Hybrids with S. cerevisiae contributions originated from three lineages of domesticated S. cerevisiae, including the major wine-making lineage and two distinct brewing lineages. In contrast, the undomesticated parents of these interspecies hybrids were all from wild Holarctic or European lineages. Most hybrids have inherited a mitochondrial genome from a parent other than S. cerevisiae, which recent functional studies suggest could confer adaptation to colder temperatures. A subset of hybrids associated with crisp flavour profiles, including both lineages of lager-brewing yeasts, have inherited inactivated S. cerevisiae alleles of critical phenolic off-flavour genes and/or lost functional copies from the wild parent through multiple genetic mechanisms. These complex hybrids shed light on the convergent and divergent evolutionary trajectories of interspecies hybrids and their impact on innovation in lager brewing and other diverse fermentation industries.
Fil: Langdon, Quinn K.. University of Wisconsin; Estados Unidos
Fil: Peris, David. University of Wisconsin; Estados Unidos. Consejo Superior de Investigaciones Científicas; España
Fil: Baker, Emily Clare. University of Wisconsin; Estados Unidos
Fil: Opulente, Dana A.. University of Wisconsin; Estados Unidos
Fil: Nguyen, Huu-Vang. Université Paris-Saclay; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Bond, Ursula. Trinity College; Estados Unidos
Fil: Gonçalves, Paula. Universidade Nova de Lisboa; Portugal
Fil: Sampaio, José Paulo. Universidade Nova de Lisboa; Portugal
Fil: Libkind Frati, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; Argentina
Fil: Hittinger, Chris. University of Wisconsin; Estados Unidos
Materia
YEAST
HYBRIDIZATION
DOMESTICATION
BEER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/120866
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Fermentation innovation through complex hybridization of wild and domesticated yeastsLangdon, Quinn K.Peris, DavidBaker, Emily ClareOpulente, Dana A.Nguyen, Huu-VangBond, UrsulaGonçalves, PaulaSampaio, José PauloLibkind Frati, DiegoHittinger, ChrisYEASTHYBRIDIZATIONDOMESTICATIONBEERhttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2The most common fermented beverage, lager beer, is produced by interspecies hybrids of the brewing yeast Saccharomyces cerevisiae and its wild relative S. eubayanus. Lager-brewing yeasts are not the only example of hybrid vigour or heterosis in yeasts, but the full breadth of interspecies hybrids associated with human fermentations has received less attention. Here we present a comprehensive genomic analysis of 122 Saccharomyces hybrids and introgressed strains. These strains arose from hybridization events between two to four species. Hybrids with S. cerevisiae contributions originated from three lineages of domesticated S. cerevisiae, including the major wine-making lineage and two distinct brewing lineages. In contrast, the undomesticated parents of these interspecies hybrids were all from wild Holarctic or European lineages. Most hybrids have inherited a mitochondrial genome from a parent other than S. cerevisiae, which recent functional studies suggest could confer adaptation to colder temperatures. A subset of hybrids associated with crisp flavour profiles, including both lineages of lager-brewing yeasts, have inherited inactivated S. cerevisiae alleles of critical phenolic off-flavour genes and/or lost functional copies from the wild parent through multiple genetic mechanisms. These complex hybrids shed light on the convergent and divergent evolutionary trajectories of interspecies hybrids and their impact on innovation in lager brewing and other diverse fermentation industries.Fil: Langdon, Quinn K.. University of Wisconsin; Estados UnidosFil: Peris, David. University of Wisconsin; Estados Unidos. Consejo Superior de Investigaciones Científicas; EspañaFil: Baker, Emily Clare. University of Wisconsin; Estados UnidosFil: Opulente, Dana A.. University of Wisconsin; Estados UnidosFil: Nguyen, Huu-Vang. Université Paris-Saclay; Francia. Institut National de la Recherche Agronomique; FranciaFil: Bond, Ursula. Trinity College; Estados UnidosFil: Gonçalves, Paula. Universidade Nova de Lisboa; PortugalFil: Sampaio, José Paulo. Universidade Nova de Lisboa; PortugalFil: Libkind Frati, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; ArgentinaFil: Hittinger, Chris. University of Wisconsin; Estados UnidosNature Publishing Group2019-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/120866Langdon, Quinn K.; Peris, David; Baker, Emily Clare; Opulente, Dana A.; Nguyen, Huu-Vang; et al.; Fermentation innovation through complex hybridization of wild and domesticated yeasts; Nature Publishing Group; Nature Ecology and Evolution; 3; 11; 11-2019; 1576-15862397-334XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41559-019-0998-8info:eu-repo/semantics/altIdentifier/doi/10.1038/s41559-019-0998-8info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:23Zoai:ri.conicet.gov.ar:11336/120866instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:24.2CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Fermentation innovation through complex hybridization of wild and domesticated yeasts
title Fermentation innovation through complex hybridization of wild and domesticated yeasts
spellingShingle Fermentation innovation through complex hybridization of wild and domesticated yeasts
Langdon, Quinn K.
YEAST
HYBRIDIZATION
DOMESTICATION
BEER
title_short Fermentation innovation through complex hybridization of wild and domesticated yeasts
title_full Fermentation innovation through complex hybridization of wild and domesticated yeasts
title_fullStr Fermentation innovation through complex hybridization of wild and domesticated yeasts
title_full_unstemmed Fermentation innovation through complex hybridization of wild and domesticated yeasts
title_sort Fermentation innovation through complex hybridization of wild and domesticated yeasts
dc.creator.none.fl_str_mv Langdon, Quinn K.
Peris, David
Baker, Emily Clare
Opulente, Dana A.
Nguyen, Huu-Vang
Bond, Ursula
Gonçalves, Paula
Sampaio, José Paulo
Libkind Frati, Diego
Hittinger, Chris
author Langdon, Quinn K.
author_facet Langdon, Quinn K.
Peris, David
Baker, Emily Clare
Opulente, Dana A.
Nguyen, Huu-Vang
Bond, Ursula
Gonçalves, Paula
Sampaio, José Paulo
Libkind Frati, Diego
Hittinger, Chris
author_role author
author2 Peris, David
Baker, Emily Clare
Opulente, Dana A.
Nguyen, Huu-Vang
Bond, Ursula
Gonçalves, Paula
Sampaio, José Paulo
Libkind Frati, Diego
Hittinger, Chris
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv YEAST
HYBRIDIZATION
DOMESTICATION
BEER
topic YEAST
HYBRIDIZATION
DOMESTICATION
BEER
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The most common fermented beverage, lager beer, is produced by interspecies hybrids of the brewing yeast Saccharomyces cerevisiae and its wild relative S. eubayanus. Lager-brewing yeasts are not the only example of hybrid vigour or heterosis in yeasts, but the full breadth of interspecies hybrids associated with human fermentations has received less attention. Here we present a comprehensive genomic analysis of 122 Saccharomyces hybrids and introgressed strains. These strains arose from hybridization events between two to four species. Hybrids with S. cerevisiae contributions originated from three lineages of domesticated S. cerevisiae, including the major wine-making lineage and two distinct brewing lineages. In contrast, the undomesticated parents of these interspecies hybrids were all from wild Holarctic or European lineages. Most hybrids have inherited a mitochondrial genome from a parent other than S. cerevisiae, which recent functional studies suggest could confer adaptation to colder temperatures. A subset of hybrids associated with crisp flavour profiles, including both lineages of lager-brewing yeasts, have inherited inactivated S. cerevisiae alleles of critical phenolic off-flavour genes and/or lost functional copies from the wild parent through multiple genetic mechanisms. These complex hybrids shed light on the convergent and divergent evolutionary trajectories of interspecies hybrids and their impact on innovation in lager brewing and other diverse fermentation industries.
Fil: Langdon, Quinn K.. University of Wisconsin; Estados Unidos
Fil: Peris, David. University of Wisconsin; Estados Unidos. Consejo Superior de Investigaciones Científicas; España
Fil: Baker, Emily Clare. University of Wisconsin; Estados Unidos
Fil: Opulente, Dana A.. University of Wisconsin; Estados Unidos
Fil: Nguyen, Huu-Vang. Université Paris-Saclay; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Bond, Ursula. Trinity College; Estados Unidos
Fil: Gonçalves, Paula. Universidade Nova de Lisboa; Portugal
Fil: Sampaio, José Paulo. Universidade Nova de Lisboa; Portugal
Fil: Libkind Frati, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; Argentina
Fil: Hittinger, Chris. University of Wisconsin; Estados Unidos
description The most common fermented beverage, lager beer, is produced by interspecies hybrids of the brewing yeast Saccharomyces cerevisiae and its wild relative S. eubayanus. Lager-brewing yeasts are not the only example of hybrid vigour or heterosis in yeasts, but the full breadth of interspecies hybrids associated with human fermentations has received less attention. Here we present a comprehensive genomic analysis of 122 Saccharomyces hybrids and introgressed strains. These strains arose from hybridization events between two to four species. Hybrids with S. cerevisiae contributions originated from three lineages of domesticated S. cerevisiae, including the major wine-making lineage and two distinct brewing lineages. In contrast, the undomesticated parents of these interspecies hybrids were all from wild Holarctic or European lineages. Most hybrids have inherited a mitochondrial genome from a parent other than S. cerevisiae, which recent functional studies suggest could confer adaptation to colder temperatures. A subset of hybrids associated with crisp flavour profiles, including both lineages of lager-brewing yeasts, have inherited inactivated S. cerevisiae alleles of critical phenolic off-flavour genes and/or lost functional copies from the wild parent through multiple genetic mechanisms. These complex hybrids shed light on the convergent and divergent evolutionary trajectories of interspecies hybrids and their impact on innovation in lager brewing and other diverse fermentation industries.
publishDate 2019
dc.date.none.fl_str_mv 2019-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/120866
Langdon, Quinn K.; Peris, David; Baker, Emily Clare; Opulente, Dana A.; Nguyen, Huu-Vang; et al.; Fermentation innovation through complex hybridization of wild and domesticated yeasts; Nature Publishing Group; Nature Ecology and Evolution; 3; 11; 11-2019; 1576-1586
2397-334X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/120866
identifier_str_mv Langdon, Quinn K.; Peris, David; Baker, Emily Clare; Opulente, Dana A.; Nguyen, Huu-Vang; et al.; Fermentation innovation through complex hybridization of wild and domesticated yeasts; Nature Publishing Group; Nature Ecology and Evolution; 3; 11; 11-2019; 1576-1586
2397-334X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41559-019-0998-8
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41559-019-0998-8
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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