Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina

Autores
Fabricius, Gabriel; Bergero, Paula Elena; Ormazabal, Maximiliano Emanuel; Maltz, Alberto; Hozbor, Daniela Flavia
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Due to the current epidemiological situation of pertussis, several countries have implemented vaccination strategies that include a booster dose for adolescents. Since there is still no evidence showing that the adolescent booster has a positive effect on the most vulnerable group represented by infants, it is difficult to universalize the recommendation to include such reinforcement. In this work we present an age-structured compartmental deterministic model that considers the outstanding epidemiological features of the disease in order to assess the impact of the booster dose at age 11 years (Tdap booster) to infants. To this end, we performed different parameterizations of the model that represent distinct possible epidemiological scenarios. The results obtained show that the inclusion of a single Tdap dose at age 11 years significantly reduces the incidence of the disease within this age group, but has a very low impact on the risk group (0-1 year). An effort to improve the coverage of the first dose would have a much greater impact on infants. These results hold in the 18 scenarios considered, which demonstrates the robustness of these conclusions.
Fil: Fabricius, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Bergero, Paula Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Ormazabal, Maximiliano Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Biotecnología y Biología Molecular; Argentina
Fil: Maltz, Alberto. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Matematicas; Argentina
Fil: Hozbor, Daniela Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Biotecnología y Biología Molecular; Argentina
Materia
Epidemic
Mathematical Modelling
Pertussis
Tdap Booster
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/5335
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/5335
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in ArgentinaFabricius, GabrielBergero, Paula ElenaOrmazabal, Maximiliano EmanuelMaltz, AlbertoHozbor, Daniela FlaviaEpidemicMathematical ModellingPertussisTdap Boosterhttps://purl.org/becyt/ford/1.1https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Due to the current epidemiological situation of pertussis, several countries have implemented vaccination strategies that include a booster dose for adolescents. Since there is still no evidence showing that the adolescent booster has a positive effect on the most vulnerable group represented by infants, it is difficult to universalize the recommendation to include such reinforcement. In this work we present an age-structured compartmental deterministic model that considers the outstanding epidemiological features of the disease in order to assess the impact of the booster dose at age 11 years (Tdap booster) to infants. To this end, we performed different parameterizations of the model that represent distinct possible epidemiological scenarios. The results obtained show that the inclusion of a single Tdap dose at age 11 years significantly reduces the incidence of the disease within this age group, but has a very low impact on the risk group (0-1 year). An effort to improve the coverage of the first dose would have a much greater impact on infants. These results hold in the 18 scenarios considered, which demonstrates the robustness of these conclusions.Fil: Fabricius, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Bergero, Paula Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Ormazabal, Maximiliano Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Biotecnología y Biología Molecular; ArgentinaFil: Maltz, Alberto. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Matematicas; ArgentinaFil: Hozbor, Daniela Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Biotecnología y Biología Molecular; ArgentinaCambridge University Press2012-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/5335Fabricius, Gabriel; Bergero, Paula Elena; Ormazabal, Maximiliano Emanuel; Maltz, Alberto; Hozbor, Daniela Flavia; Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina; Cambridge University Press; Epidemiology and Infection; 141; 4; 6-2012; 718-7340950-2688enginfo:eu-repo/semantics/altIdentifier/url/http://journals.cambridge.org/abstract_S0950268812001380info:eu-repo/semantics/altIdentifier/doi/10.1017/S0950268812001380info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/pmid/22874088info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:38:01Zoai:ri.conicet.gov.ar:11336/5335instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:38:02.192CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
title Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
spellingShingle Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
Fabricius, Gabriel
Epidemic
Mathematical Modelling
Pertussis
Tdap Booster
title_short Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
title_full Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
title_fullStr Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
title_full_unstemmed Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
title_sort Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
dc.creator.none.fl_str_mv Fabricius, Gabriel
Bergero, Paula Elena
Ormazabal, Maximiliano Emanuel
Maltz, Alberto
Hozbor, Daniela Flavia
author Fabricius, Gabriel
author_facet Fabricius, Gabriel
Bergero, Paula Elena
Ormazabal, Maximiliano Emanuel
Maltz, Alberto
Hozbor, Daniela Flavia
author_role author
author2 Bergero, Paula Elena
Ormazabal, Maximiliano Emanuel
Maltz, Alberto
Hozbor, Daniela Flavia
author2_role author
author
author
author
dc.subject.none.fl_str_mv Epidemic
Mathematical Modelling
Pertussis
Tdap Booster
topic Epidemic
Mathematical Modelling
Pertussis
Tdap Booster
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.1
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Due to the current epidemiological situation of pertussis, several countries have implemented vaccination strategies that include a booster dose for adolescents. Since there is still no evidence showing that the adolescent booster has a positive effect on the most vulnerable group represented by infants, it is difficult to universalize the recommendation to include such reinforcement. In this work we present an age-structured compartmental deterministic model that considers the outstanding epidemiological features of the disease in order to assess the impact of the booster dose at age 11 years (Tdap booster) to infants. To this end, we performed different parameterizations of the model that represent distinct possible epidemiological scenarios. The results obtained show that the inclusion of a single Tdap dose at age 11 years significantly reduces the incidence of the disease within this age group, but has a very low impact on the risk group (0-1 year). An effort to improve the coverage of the first dose would have a much greater impact on infants. These results hold in the 18 scenarios considered, which demonstrates the robustness of these conclusions.
Fil: Fabricius, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Bergero, Paula Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Ormazabal, Maximiliano Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Biotecnología y Biología Molecular; Argentina
Fil: Maltz, Alberto. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Matematicas; Argentina
Fil: Hozbor, Daniela Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Biotecnología y Biología Molecular; Argentina
description Due to the current epidemiological situation of pertussis, several countries have implemented vaccination strategies that include a booster dose for adolescents. Since there is still no evidence showing that the adolescent booster has a positive effect on the most vulnerable group represented by infants, it is difficult to universalize the recommendation to include such reinforcement. In this work we present an age-structured compartmental deterministic model that considers the outstanding epidemiological features of the disease in order to assess the impact of the booster dose at age 11 years (Tdap booster) to infants. To this end, we performed different parameterizations of the model that represent distinct possible epidemiological scenarios. The results obtained show that the inclusion of a single Tdap dose at age 11 years significantly reduces the incidence of the disease within this age group, but has a very low impact on the risk group (0-1 year). An effort to improve the coverage of the first dose would have a much greater impact on infants. These results hold in the 18 scenarios considered, which demonstrates the robustness of these conclusions.
publishDate 2012
dc.date.none.fl_str_mv 2012-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/5335
Fabricius, Gabriel; Bergero, Paula Elena; Ormazabal, Maximiliano Emanuel; Maltz, Alberto; Hozbor, Daniela Flavia; Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina; Cambridge University Press; Epidemiology and Infection; 141; 4; 6-2012; 718-734
0950-2688
url http://hdl.handle.net/11336/5335
identifier_str_mv Fabricius, Gabriel; Bergero, Paula Elena; Ormazabal, Maximiliano Emanuel; Maltz, Alberto; Hozbor, Daniela Flavia; Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina; Cambridge University Press; Epidemiology and Infection; 141; 4; 6-2012; 718-734
0950-2688
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journals.cambridge.org/abstract_S0950268812001380
info:eu-repo/semantics/altIdentifier/doi/10.1017/S0950268812001380
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/pmid/22874088
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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