Assessment of pertussis vaccination strategies using a mathematical model of disease transmission
- Autores
- Pesco, Pablo Sebastián; Bergero, Paula Elena; Fabricius, Gabriel; Hozbor, Daniela Flavia
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Pertussis or whooping cough is a vaccinepreventable respiratory disease that has reemerged in the past decades. A higher morbidity and mortality has been recorded in infants, although cases have also been reported in adolescents and adults. The epidemiological scenario for this condition has urged to review and implement new strategies aimed at improving its control. However, many of these strategies have not been investigated in depth so as to be established as universal. In this context, mathematical models of disease transmission are useful decisionmaking tools. Using a mathematical model of pertussis, this study assessed the possible impact of the different control measures on the most vulnerable population (0-1 year old infants). In particular, the analysis focused on the impact of including a booster vaccination at 11 years old, the effect of improving the coverage provided by primary doses, and the reduction of any delay in their administration. The assessment also estimated the effect of immunizing pregnant women. Results show that including a booster dose at 11 years reduces the incidence of pertussis by 3% in infants younger than 1 year old. In addition, administering primary doses in compliance with the schedule (with no delays) reduces pertussis incidence by 16%. Increasing coverage from 80% to 95% results in a significantly decreased incidence in the vulnerable population (38%). If the percentage of immunized pregnant women reaches 50%, the reduction of the most severe infant cases could be more than 43% (0-2 monthold infants).
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Facultad de Ciencias Exactas - Materia
-
Biología
Booster
Bordetella pertussis
Immunization
Model
Pertussis
Pertussis vaccine - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/84945
Ver los metadatos del registro completo
id |
SEDICI_ec70899390061c3f3343a160e5bd7460 |
---|---|
oai_identifier_str |
oai:sedici.unlp.edu.ar:10915/84945 |
network_acronym_str |
SEDICI |
repository_id_str |
1329 |
network_name_str |
SEDICI (UNLP) |
spelling |
Assessment of pertussis vaccination strategies using a mathematical model of disease transmissionEvaluación de las estrategias de vacunación contra la tos convulsa mediante un modelo matemático de transmisión de la enfermedadPesco, Pablo SebastiánBergero, Paula ElenaFabricius, GabrielHozbor, Daniela FlaviaBiologíaBoosterBordetella pertussisImmunizationModelPertussisPertussis vaccinePertussis or whooping cough is a vaccinepreventable respiratory disease that has reemerged in the past decades. A higher morbidity and mortality has been recorded in infants, although cases have also been reported in adolescents and adults. The epidemiological scenario for this condition has urged to review and implement new strategies aimed at improving its control. However, many of these strategies have not been investigated in depth so as to be established as universal. In this context, mathematical models of disease transmission are useful decisionmaking tools. Using a mathematical model of pertussis, this study assessed the possible impact of the different control measures on the most vulnerable population (0-1 year old infants). In particular, the analysis focused on the impact of including a booster vaccination at 11 years old, the effect of improving the coverage provided by primary doses, and the reduction of any delay in their administration. The assessment also estimated the effect of immunizing pregnant women. Results show that including a booster dose at 11 years reduces the incidence of pertussis by 3% in infants younger than 1 year old. In addition, administering primary doses in compliance with the schedule (with no delays) reduces pertussis incidence by 16%. Increasing coverage from 80% to 95% results in a significantly decreased incidence in the vulnerable population (38%). If the percentage of immunized pregnant women reaches 50%, the reduction of the most severe infant cases could be more than 43% (0-2 monthold infants).Instituto de Investigaciones Fisicoquímicas Teóricas y AplicadasFacultad de Ciencias Exactas2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf377-383http://sedici.unlp.edu.ar/handle/10915/84945enginfo:eu-repo/semantics/altIdentifier/issn/0325-0075info:eu-repo/semantics/altIdentifier/doi/10.5546/aap.2013.eng.377info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:16:34Zoai:sedici.unlp.edu.ar:10915/84945Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:16:34.828SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Assessment of pertussis vaccination strategies using a mathematical model of disease transmission Evaluación de las estrategias de vacunación contra la tos convulsa mediante un modelo matemático de transmisión de la enfermedad |
title |
Assessment of pertussis vaccination strategies using a mathematical model of disease transmission |
spellingShingle |
Assessment of pertussis vaccination strategies using a mathematical model of disease transmission Pesco, Pablo Sebastián Biología Booster Bordetella pertussis Immunization Model Pertussis Pertussis vaccine |
title_short |
Assessment of pertussis vaccination strategies using a mathematical model of disease transmission |
title_full |
Assessment of pertussis vaccination strategies using a mathematical model of disease transmission |
title_fullStr |
Assessment of pertussis vaccination strategies using a mathematical model of disease transmission |
title_full_unstemmed |
Assessment of pertussis vaccination strategies using a mathematical model of disease transmission |
title_sort |
Assessment of pertussis vaccination strategies using a mathematical model of disease transmission |
dc.creator.none.fl_str_mv |
Pesco, Pablo Sebastián Bergero, Paula Elena Fabricius, Gabriel Hozbor, Daniela Flavia |
author |
Pesco, Pablo Sebastián |
author_facet |
Pesco, Pablo Sebastián Bergero, Paula Elena Fabricius, Gabriel Hozbor, Daniela Flavia |
author_role |
author |
author2 |
Bergero, Paula Elena Fabricius, Gabriel Hozbor, Daniela Flavia |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Biología Booster Bordetella pertussis Immunization Model Pertussis Pertussis vaccine |
topic |
Biología Booster Bordetella pertussis Immunization Model Pertussis Pertussis vaccine |
dc.description.none.fl_txt_mv |
Pertussis or whooping cough is a vaccinepreventable respiratory disease that has reemerged in the past decades. A higher morbidity and mortality has been recorded in infants, although cases have also been reported in adolescents and adults. The epidemiological scenario for this condition has urged to review and implement new strategies aimed at improving its control. However, many of these strategies have not been investigated in depth so as to be established as universal. In this context, mathematical models of disease transmission are useful decisionmaking tools. Using a mathematical model of pertussis, this study assessed the possible impact of the different control measures on the most vulnerable population (0-1 year old infants). In particular, the analysis focused on the impact of including a booster vaccination at 11 years old, the effect of improving the coverage provided by primary doses, and the reduction of any delay in their administration. The assessment also estimated the effect of immunizing pregnant women. Results show that including a booster dose at 11 years reduces the incidence of pertussis by 3% in infants younger than 1 year old. In addition, administering primary doses in compliance with the schedule (with no delays) reduces pertussis incidence by 16%. Increasing coverage from 80% to 95% results in a significantly decreased incidence in the vulnerable population (38%). If the percentage of immunized pregnant women reaches 50%, the reduction of the most severe infant cases could be more than 43% (0-2 monthold infants). Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas Facultad de Ciencias Exactas |
description |
Pertussis or whooping cough is a vaccinepreventable respiratory disease that has reemerged in the past decades. A higher morbidity and mortality has been recorded in infants, although cases have also been reported in adolescents and adults. The epidemiological scenario for this condition has urged to review and implement new strategies aimed at improving its control. However, many of these strategies have not been investigated in depth so as to be established as universal. In this context, mathematical models of disease transmission are useful decisionmaking tools. Using a mathematical model of pertussis, this study assessed the possible impact of the different control measures on the most vulnerable population (0-1 year old infants). In particular, the analysis focused on the impact of including a booster vaccination at 11 years old, the effect of improving the coverage provided by primary doses, and the reduction of any delay in their administration. The assessment also estimated the effect of immunizing pregnant women. Results show that including a booster dose at 11 years reduces the incidence of pertussis by 3% in infants younger than 1 year old. In addition, administering primary doses in compliance with the schedule (with no delays) reduces pertussis incidence by 16%. Increasing coverage from 80% to 95% results in a significantly decreased incidence in the vulnerable population (38%). If the percentage of immunized pregnant women reaches 50%, the reduction of the most severe infant cases could be more than 43% (0-2 monthold infants). |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/84945 |
url |
http://sedici.unlp.edu.ar/handle/10915/84945 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/0325-0075 info:eu-repo/semantics/altIdentifier/doi/10.5546/aap.2013.eng.377 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
dc.format.none.fl_str_mv |
application/pdf 377-383 |
dc.source.none.fl_str_mv |
reponame:SEDICI (UNLP) instname:Universidad Nacional de La Plata instacron:UNLP |
reponame_str |
SEDICI (UNLP) |
collection |
SEDICI (UNLP) |
instname_str |
Universidad Nacional de La Plata |
instacron_str |
UNLP |
institution |
UNLP |
repository.name.fl_str_mv |
SEDICI (UNLP) - Universidad Nacional de La Plata |
repository.mail.fl_str_mv |
alira@sedici.unlp.edu.ar |
_version_ |
1844616038271942656 |
score |
13.070432 |