Assessment of pertussis vaccination strategies using a mathematical model of disease transmission

Autores
Pesco, Pablo Sebastián; Bergero, Paula Elena; Fabricius, Gabriel; Hozbor, Daniela Flavia
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pertussis or whooping cough is a vaccinepreventable respiratory disease that has reemerged in the past decades. A higher morbidity and mortality has been recorded in infants, although cases have also been reported in adolescents and adults. The epidemiological scenario for this condition has urged to review and implement new strategies aimed at improving its control. However, many of these strategies have not been investigated in depth so as to be established as universal. In this context, mathematical models of disease transmission are useful decisionmaking tools. Using a mathematical model of pertussis, this study assessed the possible impact of the different control measures on the most vulnerable population (0-1 year old infants). In particular, the analysis focused on the impact of including a booster vaccination at 11 years old, the effect of improving the coverage provided by primary doses, and the reduction of any delay in their administration. The assessment also estimated the effect of immunizing pregnant women. Results show that including a booster dose at 11 years reduces the incidence of pertussis by 3% in infants younger than 1 year old. In addition, administering primary doses in compliance with the schedule (with no delays) reduces pertussis incidence by 16%. Increasing coverage from 80% to 95% results in a significantly decreased incidence in the vulnerable population (38%). If the percentage of immunized pregnant women reaches 50%, the reduction of the most severe infant cases could be more than 43% (0-2 monthold infants).
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Facultad de Ciencias Exactas
Materia
Biología
Booster
Bordetella pertussis
Immunization
Model
Pertussis
Pertussis vaccine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/84945

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network_name_str SEDICI (UNLP)
spelling Assessment of pertussis vaccination strategies using a mathematical model of disease transmissionEvaluación de las estrategias de vacunación contra la tos convulsa mediante un modelo matemático de transmisión de la enfermedadPesco, Pablo SebastiánBergero, Paula ElenaFabricius, GabrielHozbor, Daniela FlaviaBiologíaBoosterBordetella pertussisImmunizationModelPertussisPertussis vaccinePertussis or whooping cough is a vaccinepreventable respiratory disease that has reemerged in the past decades. A higher morbidity and mortality has been recorded in infants, although cases have also been reported in adolescents and adults. The epidemiological scenario for this condition has urged to review and implement new strategies aimed at improving its control. However, many of these strategies have not been investigated in depth so as to be established as universal. In this context, mathematical models of disease transmission are useful decisionmaking tools. Using a mathematical model of pertussis, this study assessed the possible impact of the different control measures on the most vulnerable population (0-1 year old infants). In particular, the analysis focused on the impact of including a booster vaccination at 11 years old, the effect of improving the coverage provided by primary doses, and the reduction of any delay in their administration. The assessment also estimated the effect of immunizing pregnant women. Results show that including a booster dose at 11 years reduces the incidence of pertussis by 3% in infants younger than 1 year old. In addition, administering primary doses in compliance with the schedule (with no delays) reduces pertussis incidence by 16%. Increasing coverage from 80% to 95% results in a significantly decreased incidence in the vulnerable population (38%). If the percentage of immunized pregnant women reaches 50%, the reduction of the most severe infant cases could be more than 43% (0-2 monthold infants).Instituto de Investigaciones Fisicoquímicas Teóricas y AplicadasFacultad de Ciencias Exactas2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf377-383http://sedici.unlp.edu.ar/handle/10915/84945enginfo:eu-repo/semantics/altIdentifier/issn/0325-0075info:eu-repo/semantics/altIdentifier/doi/10.5546/aap.2013.eng.377info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:16:34Zoai:sedici.unlp.edu.ar:10915/84945Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:16:34.828SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Assessment of pertussis vaccination strategies using a mathematical model of disease transmission
Evaluación de las estrategias de vacunación contra la tos convulsa mediante un modelo matemático de transmisión de la enfermedad
title Assessment of pertussis vaccination strategies using a mathematical model of disease transmission
spellingShingle Assessment of pertussis vaccination strategies using a mathematical model of disease transmission
Pesco, Pablo Sebastián
Biología
Booster
Bordetella pertussis
Immunization
Model
Pertussis
Pertussis vaccine
title_short Assessment of pertussis vaccination strategies using a mathematical model of disease transmission
title_full Assessment of pertussis vaccination strategies using a mathematical model of disease transmission
title_fullStr Assessment of pertussis vaccination strategies using a mathematical model of disease transmission
title_full_unstemmed Assessment of pertussis vaccination strategies using a mathematical model of disease transmission
title_sort Assessment of pertussis vaccination strategies using a mathematical model of disease transmission
dc.creator.none.fl_str_mv Pesco, Pablo Sebastián
Bergero, Paula Elena
Fabricius, Gabriel
Hozbor, Daniela Flavia
author Pesco, Pablo Sebastián
author_facet Pesco, Pablo Sebastián
Bergero, Paula Elena
Fabricius, Gabriel
Hozbor, Daniela Flavia
author_role author
author2 Bergero, Paula Elena
Fabricius, Gabriel
Hozbor, Daniela Flavia
author2_role author
author
author
dc.subject.none.fl_str_mv Biología
Booster
Bordetella pertussis
Immunization
Model
Pertussis
Pertussis vaccine
topic Biología
Booster
Bordetella pertussis
Immunization
Model
Pertussis
Pertussis vaccine
dc.description.none.fl_txt_mv Pertussis or whooping cough is a vaccinepreventable respiratory disease that has reemerged in the past decades. A higher morbidity and mortality has been recorded in infants, although cases have also been reported in adolescents and adults. The epidemiological scenario for this condition has urged to review and implement new strategies aimed at improving its control. However, many of these strategies have not been investigated in depth so as to be established as universal. In this context, mathematical models of disease transmission are useful decisionmaking tools. Using a mathematical model of pertussis, this study assessed the possible impact of the different control measures on the most vulnerable population (0-1 year old infants). In particular, the analysis focused on the impact of including a booster vaccination at 11 years old, the effect of improving the coverage provided by primary doses, and the reduction of any delay in their administration. The assessment also estimated the effect of immunizing pregnant women. Results show that including a booster dose at 11 years reduces the incidence of pertussis by 3% in infants younger than 1 year old. In addition, administering primary doses in compliance with the schedule (with no delays) reduces pertussis incidence by 16%. Increasing coverage from 80% to 95% results in a significantly decreased incidence in the vulnerable population (38%). If the percentage of immunized pregnant women reaches 50%, the reduction of the most severe infant cases could be more than 43% (0-2 monthold infants).
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Facultad de Ciencias Exactas
description Pertussis or whooping cough is a vaccinepreventable respiratory disease that has reemerged in the past decades. A higher morbidity and mortality has been recorded in infants, although cases have also been reported in adolescents and adults. The epidemiological scenario for this condition has urged to review and implement new strategies aimed at improving its control. However, many of these strategies have not been investigated in depth so as to be established as universal. In this context, mathematical models of disease transmission are useful decisionmaking tools. Using a mathematical model of pertussis, this study assessed the possible impact of the different control measures on the most vulnerable population (0-1 year old infants). In particular, the analysis focused on the impact of including a booster vaccination at 11 years old, the effect of improving the coverage provided by primary doses, and the reduction of any delay in their administration. The assessment also estimated the effect of immunizing pregnant women. Results show that including a booster dose at 11 years reduces the incidence of pertussis by 3% in infants younger than 1 year old. In addition, administering primary doses in compliance with the schedule (with no delays) reduces pertussis incidence by 16%. Increasing coverage from 80% to 95% results in a significantly decreased incidence in the vulnerable population (38%). If the percentage of immunized pregnant women reaches 50%, the reduction of the most severe infant cases could be more than 43% (0-2 monthold infants).
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/84945
url http://sedici.unlp.edu.ar/handle/10915/84945
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0325-0075
info:eu-repo/semantics/altIdentifier/doi/10.5546/aap.2013.eng.377
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
377-383
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instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
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repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
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