Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina

Autores
Fabricius, Gabriel; Bergero, Paula Elena; Ormazabal, Maximiliano Emanuel; Maltz, Alberto Leonardo; Hozbor, Daniela Flavia
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Due to the current epidemiological situation of pertussis, several countries have implemented vaccination strategies that include a booster dose for adolescents. Since there is still no evidence showing that the adolescent booster has a positive effect on the most vulnerable group represented by infants, it is difficult to universalize the recommendation to include such reinforcement. In this work we present an age-structured compartmental deterministic model that considers the outstanding epidemiological features of the disease in order to assess the impact of the booster dose at age 11 years (Tdap booster) to infants. To this end, we performed different parameterizations of the model that represent distinct possible epidemiological scenarios. The results obtained show that the inclusion of a single Tdap dose at age 11 years significantly reduces the incidence of the disease within this age group, but has a very low impact on the risk group (0–1 year). An effort to improve the coverage of the first dose would have a much greater impact on infants. These results hold in the 18 scenarios considered, which demonstrates the robustness of these conclusions.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Instituto de Biotecnologia y Biologia Molecular
Facultad de Ciencias Exactas
Materia
Biología
Epidemic
Mathematical model
Bordetella pertussis
Tdap booster
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/126189

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spelling Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in ArgentinaFabricius, GabrielBergero, Paula ElenaOrmazabal, Maximiliano EmanuelMaltz, Alberto LeonardoHozbor, Daniela FlaviaBiologíaEpidemicMathematical modelBordetella pertussisTdap boosterDue to the current epidemiological situation of pertussis, several countries have implemented vaccination strategies that include a booster dose for adolescents. Since there is still no evidence showing that the adolescent booster has a positive effect on the most vulnerable group represented by infants, it is difficult to universalize the recommendation to include such reinforcement. In this work we present an age-structured compartmental deterministic model that considers the outstanding epidemiological features of the disease in order to assess the impact of the booster dose at age 11 years (Tdap booster) to infants. To this end, we performed different parameterizations of the model that represent distinct possible epidemiological scenarios. The results obtained show that the inclusion of a single Tdap dose at age 11 years significantly reduces the incidence of the disease within this age group, but has a very low impact on the risk group (0–1 year). An effort to improve the coverage of the first dose would have a much greater impact on infants. These results hold in the 18 scenarios considered, which demonstrates the robustness of these conclusions.Instituto de Investigaciones Fisicoquímicas Teóricas y AplicadasInstituto de Biotecnologia y Biologia MolecularFacultad de Ciencias Exactas2012-07-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf718-734http://sedici.unlp.edu.ar/handle/10915/126189enginfo:eu-repo/semantics/altIdentifier/issn/1469-4409info:eu-repo/semantics/altIdentifier/issn/0950-2688info:eu-repo/semantics/altIdentifier/pmid/22874088info:eu-repo/semantics/altIdentifier/doi/10.1017/s0950268812001380info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:30:13Zoai:sedici.unlp.edu.ar:10915/126189Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:30:14.175SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
title Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
spellingShingle Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
Fabricius, Gabriel
Biología
Epidemic
Mathematical model
Bordetella pertussis
Tdap booster
title_short Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
title_full Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
title_fullStr Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
title_full_unstemmed Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
title_sort Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
dc.creator.none.fl_str_mv Fabricius, Gabriel
Bergero, Paula Elena
Ormazabal, Maximiliano Emanuel
Maltz, Alberto Leonardo
Hozbor, Daniela Flavia
author Fabricius, Gabriel
author_facet Fabricius, Gabriel
Bergero, Paula Elena
Ormazabal, Maximiliano Emanuel
Maltz, Alberto Leonardo
Hozbor, Daniela Flavia
author_role author
author2 Bergero, Paula Elena
Ormazabal, Maximiliano Emanuel
Maltz, Alberto Leonardo
Hozbor, Daniela Flavia
author2_role author
author
author
author
dc.subject.none.fl_str_mv Biología
Epidemic
Mathematical model
Bordetella pertussis
Tdap booster
topic Biología
Epidemic
Mathematical model
Bordetella pertussis
Tdap booster
dc.description.none.fl_txt_mv Due to the current epidemiological situation of pertussis, several countries have implemented vaccination strategies that include a booster dose for adolescents. Since there is still no evidence showing that the adolescent booster has a positive effect on the most vulnerable group represented by infants, it is difficult to universalize the recommendation to include such reinforcement. In this work we present an age-structured compartmental deterministic model that considers the outstanding epidemiological features of the disease in order to assess the impact of the booster dose at age 11 years (Tdap booster) to infants. To this end, we performed different parameterizations of the model that represent distinct possible epidemiological scenarios. The results obtained show that the inclusion of a single Tdap dose at age 11 years significantly reduces the incidence of the disease within this age group, but has a very low impact on the risk group (0–1 year). An effort to improve the coverage of the first dose would have a much greater impact on infants. These results hold in the 18 scenarios considered, which demonstrates the robustness of these conclusions.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Instituto de Biotecnologia y Biologia Molecular
Facultad de Ciencias Exactas
description Due to the current epidemiological situation of pertussis, several countries have implemented vaccination strategies that include a booster dose for adolescents. Since there is still no evidence showing that the adolescent booster has a positive effect on the most vulnerable group represented by infants, it is difficult to universalize the recommendation to include such reinforcement. In this work we present an age-structured compartmental deterministic model that considers the outstanding epidemiological features of the disease in order to assess the impact of the booster dose at age 11 years (Tdap booster) to infants. To this end, we performed different parameterizations of the model that represent distinct possible epidemiological scenarios. The results obtained show that the inclusion of a single Tdap dose at age 11 years significantly reduces the incidence of the disease within this age group, but has a very low impact on the risk group (0–1 year). An effort to improve the coverage of the first dose would have a much greater impact on infants. These results hold in the 18 scenarios considered, which demonstrates the robustness of these conclusions.
publishDate 2012
dc.date.none.fl_str_mv 2012-07-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/126189
url http://sedici.unlp.edu.ar/handle/10915/126189
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1469-4409
info:eu-repo/semantics/altIdentifier/issn/0950-2688
info:eu-repo/semantics/altIdentifier/pmid/22874088
info:eu-repo/semantics/altIdentifier/doi/10.1017/s0950268812001380
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
718-734
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
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instname_str Universidad Nacional de La Plata
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repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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