Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
- Autores
- Fabricius, Gabriel; Bergero, Paula Elena; Ormazabal, Maximiliano Emanuel; Maltz, Alberto Leonardo; Hozbor, Daniela Flavia
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Due to the current epidemiological situation of pertussis, several countries have implemented vaccination strategies that include a booster dose for adolescents. Since there is still no evidence showing that the adolescent booster has a positive effect on the most vulnerable group represented by infants, it is difficult to universalize the recommendation to include such reinforcement. In this work we present an age-structured compartmental deterministic model that considers the outstanding epidemiological features of the disease in order to assess the impact of the booster dose at age 11 years (Tdap booster) to infants. To this end, we performed different parameterizations of the model that represent distinct possible epidemiological scenarios. The results obtained show that the inclusion of a single Tdap dose at age 11 years significantly reduces the incidence of the disease within this age group, but has a very low impact on the risk group (0–1 year). An effort to improve the coverage of the first dose would have a much greater impact on infants. These results hold in the 18 scenarios considered, which demonstrates the robustness of these conclusions.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Instituto de Biotecnologia y Biologia Molecular
Facultad de Ciencias Exactas - Materia
-
Biología
Epidemic
Mathematical model
Bordetella pertussis
Tdap booster - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/126189
Ver los metadatos del registro completo
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Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in ArgentinaFabricius, GabrielBergero, Paula ElenaOrmazabal, Maximiliano EmanuelMaltz, Alberto LeonardoHozbor, Daniela FlaviaBiologíaEpidemicMathematical modelBordetella pertussisTdap boosterDue to the current epidemiological situation of pertussis, several countries have implemented vaccination strategies that include a booster dose for adolescents. Since there is still no evidence showing that the adolescent booster has a positive effect on the most vulnerable group represented by infants, it is difficult to universalize the recommendation to include such reinforcement. In this work we present an age-structured compartmental deterministic model that considers the outstanding epidemiological features of the disease in order to assess the impact of the booster dose at age 11 years (Tdap booster) to infants. To this end, we performed different parameterizations of the model that represent distinct possible epidemiological scenarios. The results obtained show that the inclusion of a single Tdap dose at age 11 years significantly reduces the incidence of the disease within this age group, but has a very low impact on the risk group (0–1 year). An effort to improve the coverage of the first dose would have a much greater impact on infants. These results hold in the 18 scenarios considered, which demonstrates the robustness of these conclusions.Instituto de Investigaciones Fisicoquímicas Teóricas y AplicadasInstituto de Biotecnologia y Biologia MolecularFacultad de Ciencias Exactas2012-07-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf718-734http://sedici.unlp.edu.ar/handle/10915/126189enginfo:eu-repo/semantics/altIdentifier/issn/1469-4409info:eu-repo/semantics/altIdentifier/issn/0950-2688info:eu-repo/semantics/altIdentifier/pmid/22874088info:eu-repo/semantics/altIdentifier/doi/10.1017/s0950268812001380info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:30:13Zoai:sedici.unlp.edu.ar:10915/126189Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:30:14.175SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina |
title |
Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina |
spellingShingle |
Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina Fabricius, Gabriel Biología Epidemic Mathematical model Bordetella pertussis Tdap booster |
title_short |
Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina |
title_full |
Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina |
title_fullStr |
Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina |
title_full_unstemmed |
Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina |
title_sort |
Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina |
dc.creator.none.fl_str_mv |
Fabricius, Gabriel Bergero, Paula Elena Ormazabal, Maximiliano Emanuel Maltz, Alberto Leonardo Hozbor, Daniela Flavia |
author |
Fabricius, Gabriel |
author_facet |
Fabricius, Gabriel Bergero, Paula Elena Ormazabal, Maximiliano Emanuel Maltz, Alberto Leonardo Hozbor, Daniela Flavia |
author_role |
author |
author2 |
Bergero, Paula Elena Ormazabal, Maximiliano Emanuel Maltz, Alberto Leonardo Hozbor, Daniela Flavia |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Biología Epidemic Mathematical model Bordetella pertussis Tdap booster |
topic |
Biología Epidemic Mathematical model Bordetella pertussis Tdap booster |
dc.description.none.fl_txt_mv |
Due to the current epidemiological situation of pertussis, several countries have implemented vaccination strategies that include a booster dose for adolescents. Since there is still no evidence showing that the adolescent booster has a positive effect on the most vulnerable group represented by infants, it is difficult to universalize the recommendation to include such reinforcement. In this work we present an age-structured compartmental deterministic model that considers the outstanding epidemiological features of the disease in order to assess the impact of the booster dose at age 11 years (Tdap booster) to infants. To this end, we performed different parameterizations of the model that represent distinct possible epidemiological scenarios. The results obtained show that the inclusion of a single Tdap dose at age 11 years significantly reduces the incidence of the disease within this age group, but has a very low impact on the risk group (0–1 year). An effort to improve the coverage of the first dose would have a much greater impact on infants. These results hold in the 18 scenarios considered, which demonstrates the robustness of these conclusions. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas Instituto de Biotecnologia y Biologia Molecular Facultad de Ciencias Exactas |
description |
Due to the current epidemiological situation of pertussis, several countries have implemented vaccination strategies that include a booster dose for adolescents. Since there is still no evidence showing that the adolescent booster has a positive effect on the most vulnerable group represented by infants, it is difficult to universalize the recommendation to include such reinforcement. In this work we present an age-structured compartmental deterministic model that considers the outstanding epidemiological features of the disease in order to assess the impact of the booster dose at age 11 years (Tdap booster) to infants. To this end, we performed different parameterizations of the model that represent distinct possible epidemiological scenarios. The results obtained show that the inclusion of a single Tdap dose at age 11 years significantly reduces the incidence of the disease within this age group, but has a very low impact on the risk group (0–1 year). An effort to improve the coverage of the first dose would have a much greater impact on infants. These results hold in the 18 scenarios considered, which demonstrates the robustness of these conclusions. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-07-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/126189 |
url |
http://sedici.unlp.edu.ar/handle/10915/126189 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/1469-4409 info:eu-repo/semantics/altIdentifier/issn/0950-2688 info:eu-repo/semantics/altIdentifier/pmid/22874088 info:eu-repo/semantics/altIdentifier/doi/10.1017/s0950268812001380 |
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openAccess |
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http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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application/pdf 718-734 |
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