Offspring behavior is affected by fructuose-induced insulin resistance in wistar rat dams

Autores
Gutierrez, Bárbara Judith; Cuervo Sanchez, Marie Lucia; Prado Spalm, Facundo Heber; Furland, Natalia Edith; Valles, Ana Sofia
Año de publicación
2020
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Maternal nutrition before and during pregnancy plays a critical role in fetal brain development. Epidemiological studies have shown an association between maternal obesity and adverse neurodevelop- mental outcomes for offspring. The effects of pregestational insu- lin resistance (PIR) on intrauterine programing of fetal brain is a lesser-explored area. The goal of this study was to investigate the impact that PIR has on neurodevelopmental reflexes and behavior during adulthood. Offspring behavior was evaluated using open field (OF), marble burying, tail flick and elevated plus maze (EPM) tests. Wistar adult rats received fructose enriched water (10 % or 20% w/v) before pregnancy to induce PIR, and during gestation. No modifications on the developmental milestones nor neonates size were observed when comparing offspring of control and PIR dams. Smelling, rearing and climbing frequency as well as duration during exploratory behavior testing in the OF test decreased in PIR dams progeny. Analysis of minute-by-minute duration in the EPM assay evidenced that the PIR group spent more time in the central square and less in the closed arms compared to control group. Fur- thermore, offspring of PIR dams showed a more frequent stretch-at- tend posture in the central square. Offspring exposed to maternal fructose intake had a greater latency of tail withdraw in the tail flick test and buried more marbles in the marble test. We conclude that maternal exposure before and during gestation to fructose does not affect primitive reflexes such as body righting mechanisms, coordination, strength, sensory system maturation, and labyrinthine reflex. On the contrary, adult rat behavior was sig- nificantly altered. Particularly, our results evidence an increment on anti-anxiety like behavior; longer decision-making time and risk assessment. Obsessive-compulsive disorder behavior and altered nociception were also noted.
Fil: Gutierrez, Bárbara Judith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Cuervo Sanchez, Marie Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Prado Spalm, Facundo Heber. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Furland, Natalia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Valles, Ana Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de Ia Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología
Buenos Aires
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Inmunología
Sociedad Argentina de Fisiología
Materia
DIETA ALTA EN FRUCTOSA
INSULINORESISTENCIA
NEURODESARROLLO
PROGENIE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/184793
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Offspring behavior is affected by fructuose-induced insulin resistance in wistar rat damsGutierrez, Bárbara JudithCuervo Sanchez, Marie LuciaPrado Spalm, Facundo HeberFurland, Natalia EdithValles, Ana SofiaDIETA ALTA EN FRUCTOSAINSULINORESISTENCIANEURODESARROLLOPROGENIEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Maternal nutrition before and during pregnancy plays a critical role in fetal brain development. Epidemiological studies have shown an association between maternal obesity and adverse neurodevelop- mental outcomes for offspring. The effects of pregestational insu- lin resistance (PIR) on intrauterine programing of fetal brain is a lesser-explored area. The goal of this study was to investigate the impact that PIR has on neurodevelopmental reflexes and behavior during adulthood. Offspring behavior was evaluated using open field (OF), marble burying, tail flick and elevated plus maze (EPM) tests. Wistar adult rats received fructose enriched water (10 % or 20% w/v) before pregnancy to induce PIR, and during gestation. No modifications on the developmental milestones nor neonates size were observed when comparing offspring of control and PIR dams. Smelling, rearing and climbing frequency as well as duration during exploratory behavior testing in the OF test decreased in PIR dams progeny. Analysis of minute-by-minute duration in the EPM assay evidenced that the PIR group spent more time in the central square and less in the closed arms compared to control group. Fur- thermore, offspring of PIR dams showed a more frequent stretch-at- tend posture in the central square. Offspring exposed to maternal fructose intake had a greater latency of tail withdraw in the tail flick test and buried more marbles in the marble test. We conclude that maternal exposure before and during gestation to fructose does not affect primitive reflexes such as body righting mechanisms, coordination, strength, sensory system maturation, and labyrinthine reflex. On the contrary, adult rat behavior was sig- nificantly altered. Particularly, our results evidence an increment on anti-anxiety like behavior; longer decision-making time and risk assessment. Obsessive-compulsive disorder behavior and altered nociception were also noted.Fil: Gutierrez, Bárbara Judith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Cuervo Sanchez, Marie Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Prado Spalm, Facundo Heber. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Furland, Natalia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Valles, Ana Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaLXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de Ia Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de FisiologíaBuenos AiresArgentinaSociedad Argentina de Investigación ClínicaSociedad Argentina de InmunologíaSociedad Argentina de FisiologíaFundación Revista Medicina2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttp://hdl.handle.net/11336/184793Offspring behavior is affected by fructuose-induced insulin resistance in wistar rat dams; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de Ia Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología; Buenos Aires; Argentina; 2020; 96-960025-76801669-9106CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.saic.org.ar/revista-medicinaNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:18Zoai:ri.conicet.gov.ar:11336/184793instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:18.842CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Offspring behavior is affected by fructuose-induced insulin resistance in wistar rat dams
title Offspring behavior is affected by fructuose-induced insulin resistance in wistar rat dams
spellingShingle Offspring behavior is affected by fructuose-induced insulin resistance in wistar rat dams
Gutierrez, Bárbara Judith
DIETA ALTA EN FRUCTOSA
INSULINORESISTENCIA
NEURODESARROLLO
PROGENIE
title_short Offspring behavior is affected by fructuose-induced insulin resistance in wistar rat dams
title_full Offspring behavior is affected by fructuose-induced insulin resistance in wistar rat dams
title_fullStr Offspring behavior is affected by fructuose-induced insulin resistance in wistar rat dams
title_full_unstemmed Offspring behavior is affected by fructuose-induced insulin resistance in wistar rat dams
title_sort Offspring behavior is affected by fructuose-induced insulin resistance in wistar rat dams
dc.creator.none.fl_str_mv Gutierrez, Bárbara Judith
Cuervo Sanchez, Marie Lucia
Prado Spalm, Facundo Heber
Furland, Natalia Edith
Valles, Ana Sofia
author Gutierrez, Bárbara Judith
author_facet Gutierrez, Bárbara Judith
Cuervo Sanchez, Marie Lucia
Prado Spalm, Facundo Heber
Furland, Natalia Edith
Valles, Ana Sofia
author_role author
author2 Cuervo Sanchez, Marie Lucia
Prado Spalm, Facundo Heber
Furland, Natalia Edith
Valles, Ana Sofia
author2_role author
author
author
author
dc.subject.none.fl_str_mv DIETA ALTA EN FRUCTOSA
INSULINORESISTENCIA
NEURODESARROLLO
PROGENIE
topic DIETA ALTA EN FRUCTOSA
INSULINORESISTENCIA
NEURODESARROLLO
PROGENIE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Maternal nutrition before and during pregnancy plays a critical role in fetal brain development. Epidemiological studies have shown an association between maternal obesity and adverse neurodevelop- mental outcomes for offspring. The effects of pregestational insu- lin resistance (PIR) on intrauterine programing of fetal brain is a lesser-explored area. The goal of this study was to investigate the impact that PIR has on neurodevelopmental reflexes and behavior during adulthood. Offspring behavior was evaluated using open field (OF), marble burying, tail flick and elevated plus maze (EPM) tests. Wistar adult rats received fructose enriched water (10 % or 20% w/v) before pregnancy to induce PIR, and during gestation. No modifications on the developmental milestones nor neonates size were observed when comparing offspring of control and PIR dams. Smelling, rearing and climbing frequency as well as duration during exploratory behavior testing in the OF test decreased in PIR dams progeny. Analysis of minute-by-minute duration in the EPM assay evidenced that the PIR group spent more time in the central square and less in the closed arms compared to control group. Fur- thermore, offspring of PIR dams showed a more frequent stretch-at- tend posture in the central square. Offspring exposed to maternal fructose intake had a greater latency of tail withdraw in the tail flick test and buried more marbles in the marble test. We conclude that maternal exposure before and during gestation to fructose does not affect primitive reflexes such as body righting mechanisms, coordination, strength, sensory system maturation, and labyrinthine reflex. On the contrary, adult rat behavior was sig- nificantly altered. Particularly, our results evidence an increment on anti-anxiety like behavior; longer decision-making time and risk assessment. Obsessive-compulsive disorder behavior and altered nociception were also noted.
Fil: Gutierrez, Bárbara Judith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Cuervo Sanchez, Marie Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Prado Spalm, Facundo Heber. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Furland, Natalia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Valles, Ana Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de Ia Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología
Buenos Aires
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Inmunología
Sociedad Argentina de Fisiología
description Maternal nutrition before and during pregnancy plays a critical role in fetal brain development. Epidemiological studies have shown an association between maternal obesity and adverse neurodevelop- mental outcomes for offspring. The effects of pregestational insu- lin resistance (PIR) on intrauterine programing of fetal brain is a lesser-explored area. The goal of this study was to investigate the impact that PIR has on neurodevelopmental reflexes and behavior during adulthood. Offspring behavior was evaluated using open field (OF), marble burying, tail flick and elevated plus maze (EPM) tests. Wistar adult rats received fructose enriched water (10 % or 20% w/v) before pregnancy to induce PIR, and during gestation. No modifications on the developmental milestones nor neonates size were observed when comparing offspring of control and PIR dams. Smelling, rearing and climbing frequency as well as duration during exploratory behavior testing in the OF test decreased in PIR dams progeny. Analysis of minute-by-minute duration in the EPM assay evidenced that the PIR group spent more time in the central square and less in the closed arms compared to control group. Fur- thermore, offspring of PIR dams showed a more frequent stretch-at- tend posture in the central square. Offspring exposed to maternal fructose intake had a greater latency of tail withdraw in the tail flick test and buried more marbles in the marble test. We conclude that maternal exposure before and during gestation to fructose does not affect primitive reflexes such as body righting mechanisms, coordination, strength, sensory system maturation, and labyrinthine reflex. On the contrary, adult rat behavior was sig- nificantly altered. Particularly, our results evidence an increment on anti-anxiety like behavior; longer decision-making time and risk assessment. Obsessive-compulsive disorder behavior and altered nociception were also noted.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/184793
Offspring behavior is affected by fructuose-induced insulin resistance in wistar rat dams; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de Ia Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología; Buenos Aires; Argentina; 2020; 96-96
0025-7680
1669-9106
CONICET Digital
CONICET
url http://hdl.handle.net/11336/184793
identifier_str_mv Offspring behavior is affected by fructuose-induced insulin resistance in wistar rat dams; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de Ia Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología; Buenos Aires; Argentina; 2020; 96-96
0025-7680
1669-9106
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.saic.org.ar/revista-medicina
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/vnd.openxmlformats-officedocument.wordprocessingml.document
application/pdf
dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Fundación Revista Medicina
publisher.none.fl_str_mv Fundación Revista Medicina
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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