Maternal fructose consumption impacts on the developmental outcome of its progeny

Autores
Cuervo, Sanchez Marié; Prado Spalm, Facundo Heber; Furland, Natalia Edith; Valles, Ana Sofia
Año de publicación
2021
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Recent epidemiological evidence suggests that exposure to mater- nal obesity increases the risk of neurodevelopmental disorders in offspring. Given the rise in the prevalence of metabolic syndrome (MetS), a clinical condition closely related to obesity, it is important to understand the molecular mechanisms by which maternal MetS might impact offspring behavior and brain function. Ten, two-months-old female Wistar rats from our colony were sep- arated in two groups of five rats each, control (C) and fructose 20% (F). The former drank tap water while the later drank fructose 20 % (w/v) ad libitum during 10 weeks. Both F- and C dams were mated to chow-fed male rats on the 7th week of treatment and maintained on their respective diets throughout pregnancy and sacrificed on day 4 postpartum. At postnatal day (PN) 1, the progeny from both groups were separated from their mothers and continued lactating from control nurse dams. From PN3-PN21 neurodevelopmental re- flexes were evaluated. At PN22 all pups were weaned and behav- ioral tests (open field, marble test, elevated plus maze, novel object recognition, social reciprocal interaction test, tail flick test, rotarod, Kondziela’s inverted screen test) were performed on 4- to 12-week- old female and male rats. Results were considered statistically dif- ferent between the C and the F group when a p value of 5% or lower (p< 0.05) was obtained when applying the t-student test. Our findings strongly associate maternal fructose consumption with the induction of MetS and infertility. In addition, offspring from the F group presented alterations in the developmental milestones and social behavior; decreased grip strength and increased anxiety. Fur- thermore, long term memory also showed a tendency to be reduced. No modifications were noted in compulsive like behaviors, locomo- tion nor in nociception. All in all, maternal fructose consumption im- pacts on the developmental outcome of its progeny.
Fil: Cuervo, Sanchez Marié. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Prado Spalm, Facundo Heber. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Furland, Natalia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Valles, Ana Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Reunión anual de las Sociedades de Biociencia: LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión anual de la Sociedad Argentina de Immunología; LIII Reunión anual de la Asociación Argentina de Farmacología Experimental y XI Reunión anual de la Asociación Argentina de Nanomedicinas
Buenos Aires
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Inmunología
Asociación Argentina de Farmacología Experimental
Asociación Argentina de Nanomedicinas
Materia
dieta alta en fructosa
síndrome metabólico materno
neurodesarrollo
comportamiento
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/184826
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/184826
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Maternal fructose consumption impacts on the developmental outcome of its progenyCuervo, Sanchez MariéPrado Spalm, Facundo HeberFurland, Natalia EdithValles, Ana Sofiadieta alta en fructosasíndrome metabólico maternoneurodesarrollocomportamientohttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Recent epidemiological evidence suggests that exposure to mater- nal obesity increases the risk of neurodevelopmental disorders in offspring. Given the rise in the prevalence of metabolic syndrome (MetS), a clinical condition closely related to obesity, it is important to understand the molecular mechanisms by which maternal MetS might impact offspring behavior and brain function. Ten, two-months-old female Wistar rats from our colony were sep- arated in two groups of five rats each, control (C) and fructose 20% (F). The former drank tap water while the later drank fructose 20 % (w/v) ad libitum during 10 weeks. Both F- and C dams were mated to chow-fed male rats on the 7th week of treatment and maintained on their respective diets throughout pregnancy and sacrificed on day 4 postpartum. At postnatal day (PN) 1, the progeny from both groups were separated from their mothers and continued lactating from control nurse dams. From PN3-PN21 neurodevelopmental re- flexes were evaluated. At PN22 all pups were weaned and behav- ioral tests (open field, marble test, elevated plus maze, novel object recognition, social reciprocal interaction test, tail flick test, rotarod, Kondziela’s inverted screen test) were performed on 4- to 12-week- old female and male rats. Results were considered statistically dif- ferent between the C and the F group when a p value of 5% or lower (p< 0.05) was obtained when applying the t-student test. Our findings strongly associate maternal fructose consumption with the induction of MetS and infertility. In addition, offspring from the F group presented alterations in the developmental milestones and social behavior; decreased grip strength and increased anxiety. Fur- thermore, long term memory also showed a tendency to be reduced. No modifications were noted in compulsive like behaviors, locomo- tion nor in nociception. All in all, maternal fructose consumption im- pacts on the developmental outcome of its progeny.Fil: Cuervo, Sanchez Marié. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Prado Spalm, Facundo Heber. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Furland, Natalia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Valles, Ana Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaReunión anual de las Sociedades de Biociencia: LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión anual de la Sociedad Argentina de Immunología; LIII Reunión anual de la Asociación Argentina de Farmacología Experimental y XI Reunión anual de la Asociación Argentina de NanomedicinasBuenos AiresArgentinaSociedad Argentina de Investigación ClínicaSociedad Argentina de InmunologíaAsociación Argentina de Farmacología ExperimentalAsociación Argentina de NanomedicinasFundación Revista Medicina2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/184826Maternal fructose consumption impacts on the developmental outcome of its progeny; Reunión anual de las Sociedades de Biociencia: LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión anual de la Sociedad Argentina de Immunología; LIII Reunión anual de la Asociación Argentina de Farmacología Experimental y XI Reunión anual de la Asociación Argentina de Nanomedicinas; Buenos Aires; Argentina; 2021; 171-1711669-9106CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.saic.org.ar/revista-medicinaInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:57Zoai:ri.conicet.gov.ar:11336/184826instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:57.973CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Maternal fructose consumption impacts on the developmental outcome of its progeny
title Maternal fructose consumption impacts on the developmental outcome of its progeny
spellingShingle Maternal fructose consumption impacts on the developmental outcome of its progeny
Cuervo, Sanchez Marié
dieta alta en fructosa
síndrome metabólico materno
neurodesarrollo
comportamiento
title_short Maternal fructose consumption impacts on the developmental outcome of its progeny
title_full Maternal fructose consumption impacts on the developmental outcome of its progeny
title_fullStr Maternal fructose consumption impacts on the developmental outcome of its progeny
title_full_unstemmed Maternal fructose consumption impacts on the developmental outcome of its progeny
title_sort Maternal fructose consumption impacts on the developmental outcome of its progeny
dc.creator.none.fl_str_mv Cuervo, Sanchez Marié
Prado Spalm, Facundo Heber
Furland, Natalia Edith
Valles, Ana Sofia
author Cuervo, Sanchez Marié
author_facet Cuervo, Sanchez Marié
Prado Spalm, Facundo Heber
Furland, Natalia Edith
Valles, Ana Sofia
author_role author
author2 Prado Spalm, Facundo Heber
Furland, Natalia Edith
Valles, Ana Sofia
author2_role author
author
author
dc.subject.none.fl_str_mv dieta alta en fructosa
síndrome metabólico materno
neurodesarrollo
comportamiento
topic dieta alta en fructosa
síndrome metabólico materno
neurodesarrollo
comportamiento
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Recent epidemiological evidence suggests that exposure to mater- nal obesity increases the risk of neurodevelopmental disorders in offspring. Given the rise in the prevalence of metabolic syndrome (MetS), a clinical condition closely related to obesity, it is important to understand the molecular mechanisms by which maternal MetS might impact offspring behavior and brain function. Ten, two-months-old female Wistar rats from our colony were sep- arated in two groups of five rats each, control (C) and fructose 20% (F). The former drank tap water while the later drank fructose 20 % (w/v) ad libitum during 10 weeks. Both F- and C dams were mated to chow-fed male rats on the 7th week of treatment and maintained on their respective diets throughout pregnancy and sacrificed on day 4 postpartum. At postnatal day (PN) 1, the progeny from both groups were separated from their mothers and continued lactating from control nurse dams. From PN3-PN21 neurodevelopmental re- flexes were evaluated. At PN22 all pups were weaned and behav- ioral tests (open field, marble test, elevated plus maze, novel object recognition, social reciprocal interaction test, tail flick test, rotarod, Kondziela’s inverted screen test) were performed on 4- to 12-week- old female and male rats. Results were considered statistically dif- ferent between the C and the F group when a p value of 5% or lower (p< 0.05) was obtained when applying the t-student test. Our findings strongly associate maternal fructose consumption with the induction of MetS and infertility. In addition, offspring from the F group presented alterations in the developmental milestones and social behavior; decreased grip strength and increased anxiety. Fur- thermore, long term memory also showed a tendency to be reduced. No modifications were noted in compulsive like behaviors, locomo- tion nor in nociception. All in all, maternal fructose consumption im- pacts on the developmental outcome of its progeny.
Fil: Cuervo, Sanchez Marié. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Prado Spalm, Facundo Heber. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Furland, Natalia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Valles, Ana Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Reunión anual de las Sociedades de Biociencia: LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión anual de la Sociedad Argentina de Immunología; LIII Reunión anual de la Asociación Argentina de Farmacología Experimental y XI Reunión anual de la Asociación Argentina de Nanomedicinas
Buenos Aires
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Inmunología
Asociación Argentina de Farmacología Experimental
Asociación Argentina de Nanomedicinas
description Recent epidemiological evidence suggests that exposure to mater- nal obesity increases the risk of neurodevelopmental disorders in offspring. Given the rise in the prevalence of metabolic syndrome (MetS), a clinical condition closely related to obesity, it is important to understand the molecular mechanisms by which maternal MetS might impact offspring behavior and brain function. Ten, two-months-old female Wistar rats from our colony were sep- arated in two groups of five rats each, control (C) and fructose 20% (F). The former drank tap water while the later drank fructose 20 % (w/v) ad libitum during 10 weeks. Both F- and C dams were mated to chow-fed male rats on the 7th week of treatment and maintained on their respective diets throughout pregnancy and sacrificed on day 4 postpartum. At postnatal day (PN) 1, the progeny from both groups were separated from their mothers and continued lactating from control nurse dams. From PN3-PN21 neurodevelopmental re- flexes were evaluated. At PN22 all pups were weaned and behav- ioral tests (open field, marble test, elevated plus maze, novel object recognition, social reciprocal interaction test, tail flick test, rotarod, Kondziela’s inverted screen test) were performed on 4- to 12-week- old female and male rats. Results were considered statistically dif- ferent between the C and the F group when a p value of 5% or lower (p< 0.05) was obtained when applying the t-student test. Our findings strongly associate maternal fructose consumption with the induction of MetS and infertility. In addition, offspring from the F group presented alterations in the developmental milestones and social behavior; decreased grip strength and increased anxiety. Fur- thermore, long term memory also showed a tendency to be reduced. No modifications were noted in compulsive like behaviors, locomo- tion nor in nociception. All in all, maternal fructose consumption im- pacts on the developmental outcome of its progeny.
publishDate 2021
dc.date.none.fl_str_mv 2021
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info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/184826
Maternal fructose consumption impacts on the developmental outcome of its progeny; Reunión anual de las Sociedades de Biociencia: LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión anual de la Sociedad Argentina de Immunología; LIII Reunión anual de la Asociación Argentina de Farmacología Experimental y XI Reunión anual de la Asociación Argentina de Nanomedicinas; Buenos Aires; Argentina; 2021; 171-171
1669-9106
CONICET Digital
CONICET
url http://hdl.handle.net/11336/184826
identifier_str_mv Maternal fructose consumption impacts on the developmental outcome of its progeny; Reunión anual de las Sociedades de Biociencia: LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión anual de la Sociedad Argentina de Immunología; LIII Reunión anual de la Asociación Argentina de Farmacología Experimental y XI Reunión anual de la Asociación Argentina de Nanomedicinas; Buenos Aires; Argentina; 2021; 171-171
1669-9106
CONICET Digital
CONICET
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dc.publisher.none.fl_str_mv Fundación Revista Medicina
publisher.none.fl_str_mv Fundación Revista Medicina
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