MobiDB 3.0: More annotations for intrinsic disorder, conformational diversity and interactions in proteins

Autores
Piovesan, Damiano; Tabaro, Francesco; Paladin, Lisanna; Necci, Marco; Micetić, Ivan; Camilloni, Carlo; Davey, Norman; Dosztányi, Zsuzsanna; Mészáros, Bálint; Monzón, Alexander; Parisi, Gustavo Daniel; Schad, Eva; Sormanni, Pietro; Tompa, Peter; Vendruscolo, Michele; Vranken, Wim F.; Tosatto, Silvio C. E.
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The MobiDB (URL: mobidb.bio.unipd.it) database of protein disorder and mobility annotations has been significantly updated and upgraded since its last major renewal in 2014. Several curated datasets for intrinsic disorder and folding upon binding have been integrated from specialized databases. The indirect evidence has also been expanded to better capture information available in the PDB, such as high temperature residues in X-ray structures and overall conformational diversity. Novel nuclear magnetic resonance chemical shift data provides an additional experimental information layer on conformational dynamics. Predictions have been expanded to provide new types of annotation on backbone rigidity, secondary structure preference and disordered binding regions. MobiDB 3.0 contains information for the complete UniProt protein set and synchronization has been improved by covering all UniParc sequences. An advanced search function allows the creation of a wide array of custom-made datasets for download and further analysis. A large amount of information and cross-links to more specialized databases are intended to make MobiDB the central resource for the scientific community working on protein intrinsic disorder and mobility.
Fil: Piovesan, Damiano. Università di Padova; Italia
Fil: Tabaro, Francesco. Università di Padova; Italia
Fil: Paladin, Lisanna. Università di Padova; Italia
Fil: Necci, Marco. Università di Padova; Italia. Instituto Agrario San Michele all'Adige Fondazione Edmund Mach; Italia
Fil: Micetić, Ivan. Università di Padova; Italia
Fil: Camilloni, Carlo. Università degli Studi di Milano; Italia
Fil: Davey, Norman. Universidad de Dublin; Irlanda
Fil: Dosztányi, Zsuzsanna. Eötvös Loránd University; Hungría
Fil: Mészáros, Bálint. Eötvös Loránd University; Hungría
Fil: Monzón, Alexander. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Parisi, Gustavo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Schad, Eva. Hungarian Academy Of Sciences; Hungría
Fil: Sormanni, Pietro. University of Cambridge; Reino Unido
Fil: Tompa, Peter. Vrije Unviversiteit Brussel; Bélgica
Fil: Vendruscolo, Michele. University of Cambridge; Reino Unido
Fil: Vranken, Wim F.. Vrije Unviversiteit Brussel; Bélgica
Fil: Tosatto, Silvio C. E.. Università di Padova; Italia
Materia
PROTEIN DISORDER
DATABASE
INTRINSIC DISORDER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/117648
Acceder
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network_name_str CONICET Digital (CONICET)
spelling MobiDB 3.0: More annotations for intrinsic disorder, conformational diversity and interactions in proteinsPiovesan, DamianoTabaro, FrancescoPaladin, LisannaNecci, MarcoMicetić, IvanCamilloni, CarloDavey, NormanDosztányi, ZsuzsannaMészáros, BálintMonzón, AlexanderParisi, Gustavo DanielSchad, EvaSormanni, PietroTompa, PeterVendruscolo, MicheleVranken, Wim F.Tosatto, Silvio C. E.PROTEIN DISORDERDATABASEINTRINSIC DISORDERhttps://purl.org/becyt/ford/1.2https://purl.org/becyt/ford/1The MobiDB (URL: mobidb.bio.unipd.it) database of protein disorder and mobility annotations has been significantly updated and upgraded since its last major renewal in 2014. Several curated datasets for intrinsic disorder and folding upon binding have been integrated from specialized databases. The indirect evidence has also been expanded to better capture information available in the PDB, such as high temperature residues in X-ray structures and overall conformational diversity. Novel nuclear magnetic resonance chemical shift data provides an additional experimental information layer on conformational dynamics. Predictions have been expanded to provide new types of annotation on backbone rigidity, secondary structure preference and disordered binding regions. MobiDB 3.0 contains information for the complete UniProt protein set and synchronization has been improved by covering all UniParc sequences. An advanced search function allows the creation of a wide array of custom-made datasets for download and further analysis. A large amount of information and cross-links to more specialized databases are intended to make MobiDB the central resource for the scientific community working on protein intrinsic disorder and mobility.Fil: Piovesan, Damiano. Università di Padova; ItaliaFil: Tabaro, Francesco. Università di Padova; ItaliaFil: Paladin, Lisanna. Università di Padova; ItaliaFil: Necci, Marco. Università di Padova; Italia. Instituto Agrario San Michele all'Adige Fondazione Edmund Mach; ItaliaFil: Micetić, Ivan. Università di Padova; ItaliaFil: Camilloni, Carlo. Università degli Studi di Milano; ItaliaFil: Davey, Norman. Universidad de Dublin; IrlandaFil: Dosztányi, Zsuzsanna. Eötvös Loránd University; HungríaFil: Mészáros, Bálint. Eötvös Loránd University; HungríaFil: Monzón, Alexander. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Parisi, Gustavo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Schad, Eva. Hungarian Academy Of Sciences; HungríaFil: Sormanni, Pietro. University of Cambridge; Reino UnidoFil: Tompa, Peter. Vrije Unviversiteit Brussel; BélgicaFil: Vendruscolo, Michele. University of Cambridge; Reino UnidoFil: Vranken, Wim F.. Vrije Unviversiteit Brussel; BélgicaFil: Tosatto, Silvio C. E.. Università di Padova; ItaliaOxford University Press2018-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/117648Piovesan, Damiano; Tabaro, Francesco; Paladin, Lisanna; Necci, Marco; Micetić, Ivan; et al.; MobiDB 3.0: More annotations for intrinsic disorder, conformational diversity and interactions in proteins; Oxford University Press; Nucleic Acids Research; 46; 1; 1-2018; 471-4760305-10481362-4962CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/nar/article/46/D1/D471/4612964info:eu-repo/semantics/altIdentifier/doi/10.1093/nar/gkx1071info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:01Zoai:ri.conicet.gov.ar:11336/117648instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:02.043CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv MobiDB 3.0: More annotations for intrinsic disorder, conformational diversity and interactions in proteins
title MobiDB 3.0: More annotations for intrinsic disorder, conformational diversity and interactions in proteins
spellingShingle MobiDB 3.0: More annotations for intrinsic disorder, conformational diversity and interactions in proteins
Piovesan, Damiano
PROTEIN DISORDER
DATABASE
INTRINSIC DISORDER
title_short MobiDB 3.0: More annotations for intrinsic disorder, conformational diversity and interactions in proteins
title_full MobiDB 3.0: More annotations for intrinsic disorder, conformational diversity and interactions in proteins
title_fullStr MobiDB 3.0: More annotations for intrinsic disorder, conformational diversity and interactions in proteins
title_full_unstemmed MobiDB 3.0: More annotations for intrinsic disorder, conformational diversity and interactions in proteins
title_sort MobiDB 3.0: More annotations for intrinsic disorder, conformational diversity and interactions in proteins
dc.creator.none.fl_str_mv Piovesan, Damiano
Tabaro, Francesco
Paladin, Lisanna
Necci, Marco
Micetić, Ivan
Camilloni, Carlo
Davey, Norman
Dosztányi, Zsuzsanna
Mészáros, Bálint
Monzón, Alexander
Parisi, Gustavo Daniel
Schad, Eva
Sormanni, Pietro
Tompa, Peter
Vendruscolo, Michele
Vranken, Wim F.
Tosatto, Silvio C. E.
author Piovesan, Damiano
author_facet Piovesan, Damiano
Tabaro, Francesco
Paladin, Lisanna
Necci, Marco
Micetić, Ivan
Camilloni, Carlo
Davey, Norman
Dosztányi, Zsuzsanna
Mészáros, Bálint
Monzón, Alexander
Parisi, Gustavo Daniel
Schad, Eva
Sormanni, Pietro
Tompa, Peter
Vendruscolo, Michele
Vranken, Wim F.
Tosatto, Silvio C. E.
author_role author
author2 Tabaro, Francesco
Paladin, Lisanna
Necci, Marco
Micetić, Ivan
Camilloni, Carlo
Davey, Norman
Dosztányi, Zsuzsanna
Mészáros, Bálint
Monzón, Alexander
Parisi, Gustavo Daniel
Schad, Eva
Sormanni, Pietro
Tompa, Peter
Vendruscolo, Michele
Vranken, Wim F.
Tosatto, Silvio C. E.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv PROTEIN DISORDER
DATABASE
INTRINSIC DISORDER
topic PROTEIN DISORDER
DATABASE
INTRINSIC DISORDER
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The MobiDB (URL: mobidb.bio.unipd.it) database of protein disorder and mobility annotations has been significantly updated and upgraded since its last major renewal in 2014. Several curated datasets for intrinsic disorder and folding upon binding have been integrated from specialized databases. The indirect evidence has also been expanded to better capture information available in the PDB, such as high temperature residues in X-ray structures and overall conformational diversity. Novel nuclear magnetic resonance chemical shift data provides an additional experimental information layer on conformational dynamics. Predictions have been expanded to provide new types of annotation on backbone rigidity, secondary structure preference and disordered binding regions. MobiDB 3.0 contains information for the complete UniProt protein set and synchronization has been improved by covering all UniParc sequences. An advanced search function allows the creation of a wide array of custom-made datasets for download and further analysis. A large amount of information and cross-links to more specialized databases are intended to make MobiDB the central resource for the scientific community working on protein intrinsic disorder and mobility.
Fil: Piovesan, Damiano. Università di Padova; Italia
Fil: Tabaro, Francesco. Università di Padova; Italia
Fil: Paladin, Lisanna. Università di Padova; Italia
Fil: Necci, Marco. Università di Padova; Italia. Instituto Agrario San Michele all'Adige Fondazione Edmund Mach; Italia
Fil: Micetić, Ivan. Università di Padova; Italia
Fil: Camilloni, Carlo. Università degli Studi di Milano; Italia
Fil: Davey, Norman. Universidad de Dublin; Irlanda
Fil: Dosztányi, Zsuzsanna. Eötvös Loránd University; Hungría
Fil: Mészáros, Bálint. Eötvös Loránd University; Hungría
Fil: Monzón, Alexander. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Parisi, Gustavo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Schad, Eva. Hungarian Academy Of Sciences; Hungría
Fil: Sormanni, Pietro. University of Cambridge; Reino Unido
Fil: Tompa, Peter. Vrije Unviversiteit Brussel; Bélgica
Fil: Vendruscolo, Michele. University of Cambridge; Reino Unido
Fil: Vranken, Wim F.. Vrije Unviversiteit Brussel; Bélgica
Fil: Tosatto, Silvio C. E.. Università di Padova; Italia
description The MobiDB (URL: mobidb.bio.unipd.it) database of protein disorder and mobility annotations has been significantly updated and upgraded since its last major renewal in 2014. Several curated datasets for intrinsic disorder and folding upon binding have been integrated from specialized databases. The indirect evidence has also been expanded to better capture information available in the PDB, such as high temperature residues in X-ray structures and overall conformational diversity. Novel nuclear magnetic resonance chemical shift data provides an additional experimental information layer on conformational dynamics. Predictions have been expanded to provide new types of annotation on backbone rigidity, secondary structure preference and disordered binding regions. MobiDB 3.0 contains information for the complete UniProt protein set and synchronization has been improved by covering all UniParc sequences. An advanced search function allows the creation of a wide array of custom-made datasets for download and further analysis. A large amount of information and cross-links to more specialized databases are intended to make MobiDB the central resource for the scientific community working on protein intrinsic disorder and mobility.
publishDate 2018
dc.date.none.fl_str_mv 2018-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/117648
Piovesan, Damiano; Tabaro, Francesco; Paladin, Lisanna; Necci, Marco; Micetić, Ivan; et al.; MobiDB 3.0: More annotations for intrinsic disorder, conformational diversity and interactions in proteins; Oxford University Press; Nucleic Acids Research; 46; 1; 1-2018; 471-476
0305-1048
1362-4962
CONICET Digital
CONICET
url http://hdl.handle.net/11336/117648
identifier_str_mv Piovesan, Damiano; Tabaro, Francesco; Paladin, Lisanna; Necci, Marco; Micetić, Ivan; et al.; MobiDB 3.0: More annotations for intrinsic disorder, conformational diversity and interactions in proteins; Oxford University Press; Nucleic Acids Research; 46; 1; 1-2018; 471-476
0305-1048
1362-4962
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/nar/article/46/D1/D471/4612964
info:eu-repo/semantics/altIdentifier/doi/10.1093/nar/gkx1071
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269615519956992
score 13.13397

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