Water Extract from Inflorescences of Industrial Hemp Futura 75 Variety as a Source of Anti-Inflammatory, Anti-Proliferative and Antimycotic Agents: Results from In Silico, In Vitro...

Autores: Orlando, Giustino; Recinella, Lucia; Chiavaroli, Annalisa; Brunetti, Luigi; Leone, Sheila; Carradori, Simone; Di Simone, Simonetta; Ciferri, Maria Chiara; Zengin, Gokhan; Ak, Gunes; Abdullah, Hassan H.; Cordisco, Estefanía; Sortino, Maximiliano Andrés; Svetaz, Laura Andrea; Politi, Matteo; Angelini, Paola; Covino, Stefano; Venanzoni, Roberto; Cesa, Stefania; Menghini, Luigi; Ferrante, Claudio
Año de publicación: 2020
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: Industrial hemp (Cannabis sativa) is traditionally cultivated as a valuable source of fibers and nutrients. Multiple studies also demonstrated antimicrobial, anti-proliferative, phytotoxic and insecticide effects of the essential oil from hemp female inflorescences. On the other side, only a few studies explored the potential pharmacological application of polar extracts from inflorescences. In the present study, we investigated the water extract from inflorescences of industrial hemp Futura 75 variety, from phytochemical and pharmacological point of view. The water extract was assayed for phenolic compound content, radical scavenger/reducing, chelating and anti-tyrosinase effects. Through an ex vivo model of toxicity induced by lipopolysaccharide (LPS) on isolated rat colon and liver, we explored the extract effects on serotonin, dopamine and kynurenine pathways and the production of prostaglandin (PG)E2. Anti-proliferative effects were also evaluated against human colon cancer HCT116 cell line. Additionally, antimycotic effects were investigated against Trichophyton rubrum, Trichophyton interdigitale, Microsporum gypseum. Finally, in silico studies, including bioinformatics, network pharmacology and docking approaches were conducted in order to predict the putative targets underlying the observed pharmacological and microbiological effects. Futura 75 water extract was able to blunt LPS-induced reduction of serotonin and increase of dopamine and kynurenine turnover, in rat colon. Additionally, the reduction of PGE2 levels was observed in both colon and liver specimens, as well. The extract inhibited the HCT116 cell viability, the growth of T. rubrum and T. interdigitale and the activity of tyrosinase, in vitro, whereas in silico studies highlighting the inhibitions of cyclooxygenase-1 (induced by carvacrol), carbonic anhydrase IX (induced by chlorogenic acid and gallic acid) and lanosterol 14-α-demethylase (induced by rutin) further support the observed pharmacological and antimycotic effects. The present findings suggest female inflorescences from industrial hemp as high quality by-products, thus representing promising sources of nutraceuticals and cosmeceuticals against inflammatory and infectious diseases.
Fil: Orlando, Giustino. University “G. d’Annunzio”. Department of Pharmacy; Italia
Fil: Recinella, Lucia. University “G. d’Annunzio”. Department of Pharmacy; Italia
Fil: Chiavaroli, Annalisa. University “G. d’Annunzio”. Department of Pharmacy; Italia
Fil: Brunetti, Luigi. University “G. d’Annunzio”. Department of Pharmacy; Italia
Fil: Leone, Sheila. University “G. d’Annunzio”. Department of Pharmacy; Italia
Fil: Carradori, Simone. University “G. d’Annunzio”. Department of Pharmacy; Italia
Fil: Di Simone, Simonetta. University “G. d’Annunzio”. Department of Pharmacy; Italia
Fil: Ciferri, Maria Chiara. University “G. d’Annunzio”. Department of Pharmacy; Italia
Fil: Zengin, Gokhan. Universidad de Selcuk; Turquía
Fil: Ak, Gunes. Universidad de Selcuk; Turquía
Fil: Abdullah, Hassan H.. Salahaddin University-Erbil; Iraq. Universiti Sains Malaysia; Malasia
Fil: Cordisco, Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Sortino, Maximiliano Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Svetaz, Laura Andrea. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Politi, Matteo. University “G. d’Annunzio”. Department of Pharmacy; Italia
Fil: Angelini, Paola. Università di Perugia; Italia
Fil: Covino, Stefano. Università di Perugia; Italia
Fil: Venanzoni, Roberto. Università di Perugia; Italia
Fil: Cesa, Stefania. Università degli Studi di Roma "La Sapienza"; Italia
Fil: Menghini, Luigi. University “G. d’Annunzio”. Department of Pharmacy; Italia
Fil: Ferrante, Claudio. University “G. d’Annunzio”. Department of Pharmacy; Italia
Materia: FUTURA 75
SEROTONIN
DOPAMIN
KYNURENINE
ANTIMICOTIC
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/154175

Acceder

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repository_id_str	3498
network_name_str	CONICET Digital (CONICET)
spelling	Water Extract from Inflorescences of Industrial Hemp Futura 75 Variety as a Source of Anti-Inflammatory, Anti-Proliferative and Antimycotic Agents: Results from In Silico, In Vitro and Ex Vivo StudiesOrlando, GiustinoRecinella, LuciaChiavaroli, AnnalisaBrunetti, LuigiLeone, SheilaCarradori, SimoneDi Simone, SimonettaCiferri, Maria ChiaraZengin, GokhanAk, GunesAbdullah, Hassan H.Cordisco, EstefaníaSortino, Maximiliano AndrésSvetaz, Laura AndreaPoliti, MatteoAngelini, PaolaCovino, StefanoVenanzoni, RobertoCesa, StefaniaMenghini, LuigiFerrante, ClaudioFUTURA 75SEROTONINDOPAMINKYNURENINEANTIMICOTIChttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Industrial hemp (Cannabis sativa) is traditionally cultivated as a valuable source of fibers and nutrients. Multiple studies also demonstrated antimicrobial, anti-proliferative, phytotoxic and insecticide effects of the essential oil from hemp female inflorescences. On the other side, only a few studies explored the potential pharmacological application of polar extracts from inflorescences. In the present study, we investigated the water extract from inflorescences of industrial hemp Futura 75 variety, from phytochemical and pharmacological point of view. The water extract was assayed for phenolic compound content, radical scavenger/reducing, chelating and anti-tyrosinase effects. Through an ex vivo model of toxicity induced by lipopolysaccharide (LPS) on isolated rat colon and liver, we explored the extract effects on serotonin, dopamine and kynurenine pathways and the production of prostaglandin (PG)E2. Anti-proliferative effects were also evaluated against human colon cancer HCT116 cell line. Additionally, antimycotic effects were investigated against Trichophyton rubrum, Trichophyton interdigitale, Microsporum gypseum. Finally, in silico studies, including bioinformatics, network pharmacology and docking approaches were conducted in order to predict the putative targets underlying the observed pharmacological and microbiological effects. Futura 75 water extract was able to blunt LPS-induced reduction of serotonin and increase of dopamine and kynurenine turnover, in rat colon. Additionally, the reduction of PGE2 levels was observed in both colon and liver specimens, as well. The extract inhibited the HCT116 cell viability, the growth of T. rubrum and T. interdigitale and the activity of tyrosinase, in vitro, whereas in silico studies highlighting the inhibitions of cyclooxygenase-1 (induced by carvacrol), carbonic anhydrase IX (induced by chlorogenic acid and gallic acid) and lanosterol 14-α-demethylase (induced by rutin) further support the observed pharmacological and antimycotic effects. The present findings suggest female inflorescences from industrial hemp as high quality by-products, thus representing promising sources of nutraceuticals and cosmeceuticals against inflammatory and infectious diseases.Fil: Orlando, Giustino. University “G. d’Annunzio”. Department of Pharmacy; ItaliaFil: Recinella, Lucia. University “G. d’Annunzio”. Department of Pharmacy; ItaliaFil: Chiavaroli, Annalisa. University “G. d’Annunzio”. Department of Pharmacy; ItaliaFil: Brunetti, Luigi. University “G. d’Annunzio”. Department of Pharmacy; ItaliaFil: Leone, Sheila. University “G. d’Annunzio”. Department of Pharmacy; ItaliaFil: Carradori, Simone. University “G. d’Annunzio”. Department of Pharmacy; ItaliaFil: Di Simone, Simonetta. University “G. d’Annunzio”. Department of Pharmacy; ItaliaFil: Ciferri, Maria Chiara. University “G. d’Annunzio”. Department of Pharmacy; ItaliaFil: Zengin, Gokhan. Universidad de Selcuk; TurquíaFil: Ak, Gunes. Universidad de Selcuk; TurquíaFil: Abdullah, Hassan H.. Salahaddin University-Erbil; Iraq. Universiti Sains Malaysia; MalasiaFil: Cordisco, Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Sortino, Maximiliano Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Svetaz, Laura Andrea. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Politi, Matteo. University “G. d’Annunzio”. Department of Pharmacy; ItaliaFil: Angelini, Paola. Università di Perugia; ItaliaFil: Covino, Stefano. Università di Perugia; ItaliaFil: Venanzoni, Roberto. Università di Perugia; ItaliaFil: Cesa, Stefania. Università degli Studi di Roma "La Sapienza"; ItaliaFil: Menghini, Luigi. University “G. d’Annunzio”. Department of Pharmacy; ItaliaFil: Ferrante, Claudio. University “G. d’Annunzio”. Department of Pharmacy; ItaliaMDPI2020-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/154175Orlando, Giustino; Recinella, Lucia; Chiavaroli, Annalisa; Brunetti, Luigi; Leone, Sheila; et al.; Water Extract from Inflorescences of Industrial Hemp Futura 75 Variety as a Source of Anti-Inflammatory, Anti-Proliferative and Antimycotic Agents: Results from In Silico, In Vitro and Ex Vivo Studies; MDPI; Antioxidants; 9; 5; 5-2020; 1-192076-39212076-3921CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-3921/9/5/437info:eu-repo/semantics/altIdentifier/doi/10.3390/antiox9050437info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:18:38Zoai:ri.conicet.gov.ar:11336/154175instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:18:39.231CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	Water Extract from Inflorescences of Industrial Hemp Futura 75 Variety as a Source of Anti-Inflammatory, Anti-Proliferative and Antimycotic Agents: Results from In Silico, In Vitro and Ex Vivo Studies
title	Water Extract from Inflorescences of Industrial Hemp Futura 75 Variety as a Source of Anti-Inflammatory, Anti-Proliferative and Antimycotic Agents: Results from In Silico, In Vitro and Ex Vivo Studies
spellingShingle	Water Extract from Inflorescences of Industrial Hemp Futura 75 Variety as a Source of Anti-Inflammatory, Anti-Proliferative and Antimycotic Agents: Results from In Silico, In Vitro and Ex Vivo Studies Orlando, Giustino FUTURA 75 SEROTONIN DOPAMIN KYNURENINE ANTIMICOTIC
title_short	Water Extract from Inflorescences of Industrial Hemp Futura 75 Variety as a Source of Anti-Inflammatory, Anti-Proliferative and Antimycotic Agents: Results from In Silico, In Vitro and Ex Vivo Studies
title_full	Water Extract from Inflorescences of Industrial Hemp Futura 75 Variety as a Source of Anti-Inflammatory, Anti-Proliferative and Antimycotic Agents: Results from In Silico, In Vitro and Ex Vivo Studies
title_fullStr	Water Extract from Inflorescences of Industrial Hemp Futura 75 Variety as a Source of Anti-Inflammatory, Anti-Proliferative and Antimycotic Agents: Results from In Silico, In Vitro and Ex Vivo Studies
title_full_unstemmed	Water Extract from Inflorescences of Industrial Hemp Futura 75 Variety as a Source of Anti-Inflammatory, Anti-Proliferative and Antimycotic Agents: Results from In Silico, In Vitro and Ex Vivo Studies
title_sort	Water Extract from Inflorescences of Industrial Hemp Futura 75 Variety as a Source of Anti-Inflammatory, Anti-Proliferative and Antimycotic Agents: Results from In Silico, In Vitro and Ex Vivo Studies
dc.creator.none.fl_str_mv	Orlando, Giustino Recinella, Lucia Chiavaroli, Annalisa Brunetti, Luigi Leone, Sheila Carradori, Simone Di Simone, Simonetta Ciferri, Maria Chiara Zengin, Gokhan Ak, Gunes Abdullah, Hassan H. Cordisco, Estefanía Sortino, Maximiliano Andrés Svetaz, Laura Andrea Politi, Matteo Angelini, Paola Covino, Stefano Venanzoni, Roberto Cesa, Stefania Menghini, Luigi Ferrante, Claudio
author	Orlando, Giustino
author_facet	Orlando, Giustino Recinella, Lucia Chiavaroli, Annalisa Brunetti, Luigi Leone, Sheila Carradori, Simone Di Simone, Simonetta Ciferri, Maria Chiara Zengin, Gokhan Ak, Gunes Abdullah, Hassan H. Cordisco, Estefanía Sortino, Maximiliano Andrés Svetaz, Laura Andrea Politi, Matteo Angelini, Paola Covino, Stefano Venanzoni, Roberto Cesa, Stefania Menghini, Luigi Ferrante, Claudio
author_role	author
author2	Recinella, Lucia Chiavaroli, Annalisa Brunetti, Luigi Leone, Sheila Carradori, Simone Di Simone, Simonetta Ciferri, Maria Chiara Zengin, Gokhan Ak, Gunes Abdullah, Hassan H. Cordisco, Estefanía Sortino, Maximiliano Andrés Svetaz, Laura Andrea Politi, Matteo Angelini, Paola Covino, Stefano Venanzoni, Roberto Cesa, Stefania Menghini, Luigi Ferrante, Claudio
author2_role	author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	FUTURA 75 SEROTONIN DOPAMIN KYNURENINE ANTIMICOTIC
topic	FUTURA 75 SEROTONIN DOPAMIN KYNURENINE ANTIMICOTIC
purl_subject.fl_str_mv	https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv	Industrial hemp (Cannabis sativa) is traditionally cultivated as a valuable source of fibers and nutrients. Multiple studies also demonstrated antimicrobial, anti-proliferative, phytotoxic and insecticide effects of the essential oil from hemp female inflorescences. On the other side, only a few studies explored the potential pharmacological application of polar extracts from inflorescences. In the present study, we investigated the water extract from inflorescences of industrial hemp Futura 75 variety, from phytochemical and pharmacological point of view. The water extract was assayed for phenolic compound content, radical scavenger/reducing, chelating and anti-tyrosinase effects. Through an ex vivo model of toxicity induced by lipopolysaccharide (LPS) on isolated rat colon and liver, we explored the extract effects on serotonin, dopamine and kynurenine pathways and the production of prostaglandin (PG)E2. Anti-proliferative effects were also evaluated against human colon cancer HCT116 cell line. Additionally, antimycotic effects were investigated against Trichophyton rubrum, Trichophyton interdigitale, Microsporum gypseum. Finally, in silico studies, including bioinformatics, network pharmacology and docking approaches were conducted in order to predict the putative targets underlying the observed pharmacological and microbiological effects. Futura 75 water extract was able to blunt LPS-induced reduction of serotonin and increase of dopamine and kynurenine turnover, in rat colon. Additionally, the reduction of PGE2 levels was observed in both colon and liver specimens, as well. The extract inhibited the HCT116 cell viability, the growth of T. rubrum and T. interdigitale and the activity of tyrosinase, in vitro, whereas in silico studies highlighting the inhibitions of cyclooxygenase-1 (induced by carvacrol), carbonic anhydrase IX (induced by chlorogenic acid and gallic acid) and lanosterol 14-α-demethylase (induced by rutin) further support the observed pharmacological and antimycotic effects. The present findings suggest female inflorescences from industrial hemp as high quality by-products, thus representing promising sources of nutraceuticals and cosmeceuticals against inflammatory and infectious diseases. Fil: Orlando, Giustino. University “G. d’Annunzio”. Department of Pharmacy; Italia Fil: Recinella, Lucia. University “G. d’Annunzio”. Department of Pharmacy; Italia Fil: Chiavaroli, Annalisa. University “G. d’Annunzio”. Department of Pharmacy; Italia Fil: Brunetti, Luigi. University “G. d’Annunzio”. Department of Pharmacy; Italia Fil: Leone, Sheila. University “G. d’Annunzio”. Department of Pharmacy; Italia Fil: Carradori, Simone. University “G. d’Annunzio”. Department of Pharmacy; Italia Fil: Di Simone, Simonetta. University “G. d’Annunzio”. Department of Pharmacy; Italia Fil: Ciferri, Maria Chiara. University “G. d’Annunzio”. Department of Pharmacy; Italia Fil: Zengin, Gokhan. Universidad de Selcuk; Turquía Fil: Ak, Gunes. Universidad de Selcuk; Turquía Fil: Abdullah, Hassan H.. Salahaddin University-Erbil; Iraq. Universiti Sains Malaysia; Malasia Fil: Cordisco, Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina Fil: Sortino, Maximiliano Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina Fil: Svetaz, Laura Andrea. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina Fil: Politi, Matteo. University “G. d’Annunzio”. Department of Pharmacy; Italia Fil: Angelini, Paola. Università di Perugia; Italia Fil: Covino, Stefano. Università di Perugia; Italia Fil: Venanzoni, Roberto. Università di Perugia; Italia Fil: Cesa, Stefania. Università degli Studi di Roma "La Sapienza"; Italia Fil: Menghini, Luigi. University “G. d’Annunzio”. Department of Pharmacy; Italia Fil: Ferrante, Claudio. University “G. d’Annunzio”. Department of Pharmacy; Italia
description	Industrial hemp (Cannabis sativa) is traditionally cultivated as a valuable source of fibers and nutrients. Multiple studies also demonstrated antimicrobial, anti-proliferative, phytotoxic and insecticide effects of the essential oil from hemp female inflorescences. On the other side, only a few studies explored the potential pharmacological application of polar extracts from inflorescences. In the present study, we investigated the water extract from inflorescences of industrial hemp Futura 75 variety, from phytochemical and pharmacological point of view. The water extract was assayed for phenolic compound content, radical scavenger/reducing, chelating and anti-tyrosinase effects. Through an ex vivo model of toxicity induced by lipopolysaccharide (LPS) on isolated rat colon and liver, we explored the extract effects on serotonin, dopamine and kynurenine pathways and the production of prostaglandin (PG)E2. Anti-proliferative effects were also evaluated against human colon cancer HCT116 cell line. Additionally, antimycotic effects were investigated against Trichophyton rubrum, Trichophyton interdigitale, Microsporum gypseum. Finally, in silico studies, including bioinformatics, network pharmacology and docking approaches were conducted in order to predict the putative targets underlying the observed pharmacological and microbiological effects. Futura 75 water extract was able to blunt LPS-induced reduction of serotonin and increase of dopamine and kynurenine turnover, in rat colon. Additionally, the reduction of PGE2 levels was observed in both colon and liver specimens, as well. The extract inhibited the HCT116 cell viability, the growth of T. rubrum and T. interdigitale and the activity of tyrosinase, in vitro, whereas in silico studies highlighting the inhibitions of cyclooxygenase-1 (induced by carvacrol), carbonic anhydrase IX (induced by chlorogenic acid and gallic acid) and lanosterol 14-α-demethylase (induced by rutin) further support the observed pharmacological and antimycotic effects. The present findings suggest female inflorescences from industrial hemp as high quality by-products, thus representing promising sources of nutraceuticals and cosmeceuticals against inflammatory and infectious diseases.
publishDate	2020
dc.date.none.fl_str_mv	2020-05
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/154175 Orlando, Giustino; Recinella, Lucia; Chiavaroli, Annalisa; Brunetti, Luigi; Leone, Sheila; et al.; Water Extract from Inflorescences of Industrial Hemp Futura 75 Variety as a Source of Anti-Inflammatory, Anti-Proliferative and Antimycotic Agents: Results from In Silico, In Vitro and Ex Vivo Studies; MDPI; Antioxidants; 9; 5; 5-2020; 1-19 2076-3921 2076-3921 CONICET Digital CONICET
url	http://hdl.handle.net/11336/154175
identifier_str_mv	Orlando, Giustino; Recinella, Lucia; Chiavaroli, Annalisa; Brunetti, Luigi; Leone, Sheila; et al.; Water Extract from Inflorescences of Industrial Hemp Futura 75 Variety as a Source of Anti-Inflammatory, Anti-Proliferative and Antimycotic Agents: Results from In Silico, In Vitro and Ex Vivo Studies; MDPI; Antioxidants; 9; 5; 5-2020; 1-19 2076-3921 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-3921/9/5/437 info:eu-repo/semantics/altIdentifier/doi/10.3390/antiox9050437
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv	openAccess
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dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
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repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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Water Extract from Inflorescences of Industrial Hemp Futura 75 Variety as a Source of Anti-Inflammatory, Anti-Proliferative and Antimycotic Agents: Results from In Silico, In Vitro...

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