Brain activation induced by psychological stress in nonpsychotic siblings of patients with schizophrenia

Autores
Castro, Mariana Nair; Papavero, Eliana Belen; Bolotinsky, N.; Costanzo, Elsa Y.; Drucaroff, Lucas Javier; Wainsztein, A.; De Pino, G.; Fazzito, L.; García, C.; Duarte Abritta, B.; Nemeroff, Charles B.; Guinjoan, Salvador Martín; Villarreal, Mirta Fabiana
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
There is compelling evidence that environmental factors together with a large predisposing genetic component contribute to the risk for schizophrenia. Among such factors, psychosocial stress has been considered of paramount importance prior to the onset of psychotic symptoms. In order to characterize the brain response to mental arithmetic stress in individuals genetically predisposed to schizophrenia, we employed 3T-fMRI in 13 nonpsychotic siblings of patients with schizophrenia and in 13 healthy individuals. After a period of 6 min of resting state acquisition, a block design was utilized, including three blocks of a 1-min control-task, 1-min stress-task and 1-min rest after task. Nonpsychotic siblings displayed several differences in brain activity as compared with healthy individuals, including failure to engage the right hippocampus and orbitofrontal cortex (OFC) during stress and shortly thereafter. In addition, in this group hippocampal function was associated with cognitive performance rather than perceived stress. Indeed perceived stress was in contrast associated with activation of bilateral OFC and insulae. The pattern of brain activation observed may represent the CNS correlate of previous observations on heightened sensitivity to psychosocial stress in persons at increased genetic risk for schizophrenia. Its potential usefulness as a marker of increased genetic predisposition to schizophrenia requires further investigation.
Fil: Castro, Mariana Nair. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Papavero, Eliana Belen. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Bolotinsky, N.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Drucaroff, Lucas Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Wainsztein, A.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: De Pino, G.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina
Fil: Fazzito, L.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: García, C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Duarte Abritta, B.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Nemeroff, Charles B.. University of Miami; Estados Unidos
Fil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina
Fil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Schizophrenia
Siblings
Psychological Stress
Fmri
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/40761
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/40761
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Brain activation induced by psychological stress in nonpsychotic siblings of patients with schizophreniaCastro, Mariana NairPapavero, Eliana BelenBolotinsky, N.Costanzo, Elsa Y.Drucaroff, Lucas JavierWainsztein, A.De Pino, G.Fazzito, L.García, C.Duarte Abritta, B.Nemeroff, Charles B.Guinjoan, Salvador MartínVillarreal, Mirta FabianaSchizophreniaSiblingsPsychological StressFmrihttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3There is compelling evidence that environmental factors together with a large predisposing genetic component contribute to the risk for schizophrenia. Among such factors, psychosocial stress has been considered of paramount importance prior to the onset of psychotic symptoms. In order to characterize the brain response to mental arithmetic stress in individuals genetically predisposed to schizophrenia, we employed 3T-fMRI in 13 nonpsychotic siblings of patients with schizophrenia and in 13 healthy individuals. After a period of 6 min of resting state acquisition, a block design was utilized, including three blocks of a 1-min control-task, 1-min stress-task and 1-min rest after task. Nonpsychotic siblings displayed several differences in brain activity as compared with healthy individuals, including failure to engage the right hippocampus and orbitofrontal cortex (OFC) during stress and shortly thereafter. In addition, in this group hippocampal function was associated with cognitive performance rather than perceived stress. Indeed perceived stress was in contrast associated with activation of bilateral OFC and insulae. The pattern of brain activation observed may represent the CNS correlate of previous observations on heightened sensitivity to psychosocial stress in persons at increased genetic risk for schizophrenia. Its potential usefulness as a marker of increased genetic predisposition to schizophrenia requires further investigation.Fil: Castro, Mariana Nair. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Papavero, Eliana Belen. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Bolotinsky, N.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Drucaroff, Lucas Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Wainsztein, A.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: De Pino, G.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; ArgentinaFil: Fazzito, L.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: García, C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Duarte Abritta, B.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Nemeroff, Charles B.. University of Miami; Estados UnidosFil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Universidad de Buenos Aires. Facultad de Psicología; ArgentinaFil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2017-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40761Castro, Mariana Nair; Papavero, Eliana Belen; Bolotinsky, N.; Costanzo, Elsa Y.; Drucaroff, Lucas Javier; et al.; Brain activation induced by psychological stress in nonpsychotic siblings of patients with schizophrenia; Elsevier; Personalized Medicine in Psychiatry; 1-2; 4-2017; 74-802468-1717CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.pmip.2016.12.002info:eu-repo/semantics/altIdentifier/url/http://www.personalizedmedpsych.com/article/S2468-1717(16)30025-4/fulltextinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2468171716300254info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:21:23Zoai:ri.conicet.gov.ar:11336/40761instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:21:24.336CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Brain activation induced by psychological stress in nonpsychotic siblings of patients with schizophrenia
title Brain activation induced by psychological stress in nonpsychotic siblings of patients with schizophrenia
spellingShingle Brain activation induced by psychological stress in nonpsychotic siblings of patients with schizophrenia
Castro, Mariana Nair
Schizophrenia
Siblings
Psychological Stress
Fmri
title_short Brain activation induced by psychological stress in nonpsychotic siblings of patients with schizophrenia
title_full Brain activation induced by psychological stress in nonpsychotic siblings of patients with schizophrenia
title_fullStr Brain activation induced by psychological stress in nonpsychotic siblings of patients with schizophrenia
title_full_unstemmed Brain activation induced by psychological stress in nonpsychotic siblings of patients with schizophrenia
title_sort Brain activation induced by psychological stress in nonpsychotic siblings of patients with schizophrenia
dc.creator.none.fl_str_mv Castro, Mariana Nair
Papavero, Eliana Belen
Bolotinsky, N.
Costanzo, Elsa Y.
Drucaroff, Lucas Javier
Wainsztein, A.
De Pino, G.
Fazzito, L.
García, C.
Duarte Abritta, B.
Nemeroff, Charles B.
Guinjoan, Salvador Martín
Villarreal, Mirta Fabiana
author Castro, Mariana Nair
author_facet Castro, Mariana Nair
Papavero, Eliana Belen
Bolotinsky, N.
Costanzo, Elsa Y.
Drucaroff, Lucas Javier
Wainsztein, A.
De Pino, G.
Fazzito, L.
García, C.
Duarte Abritta, B.
Nemeroff, Charles B.
Guinjoan, Salvador Martín
Villarreal, Mirta Fabiana
author_role author
author2 Papavero, Eliana Belen
Bolotinsky, N.
Costanzo, Elsa Y.
Drucaroff, Lucas Javier
Wainsztein, A.
De Pino, G.
Fazzito, L.
García, C.
Duarte Abritta, B.
Nemeroff, Charles B.
Guinjoan, Salvador Martín
Villarreal, Mirta Fabiana
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Schizophrenia
Siblings
Psychological Stress
Fmri
topic Schizophrenia
Siblings
Psychological Stress
Fmri
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv There is compelling evidence that environmental factors together with a large predisposing genetic component contribute to the risk for schizophrenia. Among such factors, psychosocial stress has been considered of paramount importance prior to the onset of psychotic symptoms. In order to characterize the brain response to mental arithmetic stress in individuals genetically predisposed to schizophrenia, we employed 3T-fMRI in 13 nonpsychotic siblings of patients with schizophrenia and in 13 healthy individuals. After a period of 6 min of resting state acquisition, a block design was utilized, including three blocks of a 1-min control-task, 1-min stress-task and 1-min rest after task. Nonpsychotic siblings displayed several differences in brain activity as compared with healthy individuals, including failure to engage the right hippocampus and orbitofrontal cortex (OFC) during stress and shortly thereafter. In addition, in this group hippocampal function was associated with cognitive performance rather than perceived stress. Indeed perceived stress was in contrast associated with activation of bilateral OFC and insulae. The pattern of brain activation observed may represent the CNS correlate of previous observations on heightened sensitivity to psychosocial stress in persons at increased genetic risk for schizophrenia. Its potential usefulness as a marker of increased genetic predisposition to schizophrenia requires further investigation.
Fil: Castro, Mariana Nair. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Papavero, Eliana Belen. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Bolotinsky, N.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Drucaroff, Lucas Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Wainsztein, A.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: De Pino, G.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina
Fil: Fazzito, L.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: García, C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Duarte Abritta, B.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Nemeroff, Charles B.. University of Miami; Estados Unidos
Fil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina
Fil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description There is compelling evidence that environmental factors together with a large predisposing genetic component contribute to the risk for schizophrenia. Among such factors, psychosocial stress has been considered of paramount importance prior to the onset of psychotic symptoms. In order to characterize the brain response to mental arithmetic stress in individuals genetically predisposed to schizophrenia, we employed 3T-fMRI in 13 nonpsychotic siblings of patients with schizophrenia and in 13 healthy individuals. After a period of 6 min of resting state acquisition, a block design was utilized, including three blocks of a 1-min control-task, 1-min stress-task and 1-min rest after task. Nonpsychotic siblings displayed several differences in brain activity as compared with healthy individuals, including failure to engage the right hippocampus and orbitofrontal cortex (OFC) during stress and shortly thereafter. In addition, in this group hippocampal function was associated with cognitive performance rather than perceived stress. Indeed perceived stress was in contrast associated with activation of bilateral OFC and insulae. The pattern of brain activation observed may represent the CNS correlate of previous observations on heightened sensitivity to psychosocial stress in persons at increased genetic risk for schizophrenia. Its potential usefulness as a marker of increased genetic predisposition to schizophrenia requires further investigation.
publishDate 2017
dc.date.none.fl_str_mv 2017-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/40761
Castro, Mariana Nair; Papavero, Eliana Belen; Bolotinsky, N.; Costanzo, Elsa Y.; Drucaroff, Lucas Javier; et al.; Brain activation induced by psychological stress in nonpsychotic siblings of patients with schizophrenia; Elsevier; Personalized Medicine in Psychiatry; 1-2; 4-2017; 74-80
2468-1717
CONICET Digital
CONICET
url http://hdl.handle.net/11336/40761
identifier_str_mv Castro, Mariana Nair; Papavero, Eliana Belen; Bolotinsky, N.; Costanzo, Elsa Y.; Drucaroff, Lucas Javier; et al.; Brain activation induced by psychological stress in nonpsychotic siblings of patients with schizophrenia; Elsevier; Personalized Medicine in Psychiatry; 1-2; 4-2017; 74-80
2468-1717
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pmip.2016.12.002
info:eu-repo/semantics/altIdentifier/url/http://www.personalizedmedpsych.com/article/S2468-1717(16)30025-4/fulltext
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2468171716300254
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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