Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia

Autores
de Achaval, Delfina; Villarreal, Mirta Fabiana; Costanzo, Elsa Y.; Douer, Jazmín; Castro, Mariana Nair; Mora, Martina C.; Nemeroff, Charles B.; Chu, Elvina; Bär, Karl-Jürgen; Guinjoan, Salvador Martín
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
BACKGROUND: Social cognitive deficits contribute to functional disability in schizophrenia. Social cognitive tasks in healthy persons consistently evoke activation of medial prefrontal cortex, inferior frontal gyrus, temporoparietal gyrus, and posterior cingulate cortex/precuneus. We tested the hypothesis that patients with schizophrenia and their unaffected siblings share dysfunction of the same neural networks. METHODS: Neural activation during emotion processing (EP), theory of mind (ToM), and control tasks was measured using functional magnetic resonance imaging (fMRI) in 14 patients with schizophrenia, 14 nonpsychotic siblings of patients with schizophrenia, and 14 matched healthy subjects. RESULTS: Compared with healthy controls, patients with schizophrenia showed reduced activation of right hemisphere structures involved in EP and ToM including inferior frontal gyrus, middle frontal gyrus, and right temporoparietal junction. These deficits were shared, in part, by unaffected siblings. The latter group demonstrated deficits in bilateral precuneus activation during ToM, not present in patients. CONCLUSIONS: Schizophrenia appears to be associated with a deficit in activation of right hemisphere components of a ToM network. Such deficits are shared in part by those at high genetic risk but unaffected by schizophrenia.
Fil: de Achaval, Delfina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Villarreal, Mirta Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina
Fil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina
Fil: Douer, Jazmín. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina
Fil: Mora, Martina C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Nemeroff, Charles B.. University of Miami; Estados Unidos
Fil: Chu, Elvina. National Hospital for Neurology and Neurosurgery; Reino Unido
Fil: Bär, Karl-Jürgen. Universitat Jena; Alemania
Fil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina
Materia
Schizophrenia
Siblings
Social Cognition
Theory of Mind
Fmri
Lateralization
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/16381
Acceder
id CONICETDig_12ba959fb3abca18be3dce1f6fbe0065
oai_identifier_str oai:ri.conicet.gov.ar:11336/16381
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophreniade Achaval, DelfinaVillarreal, Mirta FabianaCostanzo, Elsa Y.Douer, JazmínCastro, Mariana NairMora, Martina C.Nemeroff, Charles B.Chu, ElvinaBär, Karl-JürgenGuinjoan, Salvador MartínSchizophreniaSiblingsSocial CognitionTheory of MindFmriLateralizationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3BACKGROUND: Social cognitive deficits contribute to functional disability in schizophrenia. Social cognitive tasks in healthy persons consistently evoke activation of medial prefrontal cortex, inferior frontal gyrus, temporoparietal gyrus, and posterior cingulate cortex/precuneus. We tested the hypothesis that patients with schizophrenia and their unaffected siblings share dysfunction of the same neural networks. METHODS: Neural activation during emotion processing (EP), theory of mind (ToM), and control tasks was measured using functional magnetic resonance imaging (fMRI) in 14 patients with schizophrenia, 14 nonpsychotic siblings of patients with schizophrenia, and 14 matched healthy subjects. RESULTS: Compared with healthy controls, patients with schizophrenia showed reduced activation of right hemisphere structures involved in EP and ToM including inferior frontal gyrus, middle frontal gyrus, and right temporoparietal junction. These deficits were shared, in part, by unaffected siblings. The latter group demonstrated deficits in bilateral precuneus activation during ToM, not present in patients. CONCLUSIONS: Schizophrenia appears to be associated with a deficit in activation of right hemisphere components of a ToM network. Such deficits are shared in part by those at high genetic risk but unaffected by schizophrenia.Fil: de Achaval, Delfina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Villarreal, Mirta Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; ArgentinaFil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Universidad de Buenos Aires. Facultad de Psicología; ArgentinaFil: Douer, Jazmín. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Universidad de Buenos Aires. Facultad de Psicología; ArgentinaFil: Mora, Martina C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Nemeroff, Charles B.. University of Miami; Estados UnidosFil: Chu, Elvina. National Hospital for Neurology and Neurosurgery; Reino UnidoFil: Bär, Karl-Jürgen. Universitat Jena; AlemaniaFil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Universidad de Buenos Aires. Facultad de Psicología; ArgentinaElsevier Science2012-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16381de Achaval, Delfina; Villarreal, Mirta Fabiana; Costanzo, Elsa Y.; Douer, Jazmín; Castro, Mariana Nair; et al.; Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia; Elsevier Science; Schizophrenia Research; 134; 2-3; 2-2012; 171-1790920-9964enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0920996411006049info:eu-repo/semantics/altIdentifier/doi/10.1016/j.schres.2011.11.010info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:38:28Zoai:ri.conicet.gov.ar:11336/16381instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:38:29.015CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia
title Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia
spellingShingle Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia
de Achaval, Delfina
Schizophrenia
Siblings
Social Cognition
Theory of Mind
Fmri
Lateralization
title_short Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia
title_full Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia
title_fullStr Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia
title_full_unstemmed Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia
title_sort Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia
dc.creator.none.fl_str_mv de Achaval, Delfina
Villarreal, Mirta Fabiana
Costanzo, Elsa Y.
Douer, Jazmín
Castro, Mariana Nair
Mora, Martina C.
Nemeroff, Charles B.
Chu, Elvina
Bär, Karl-Jürgen
Guinjoan, Salvador Martín
author de Achaval, Delfina
author_facet de Achaval, Delfina
Villarreal, Mirta Fabiana
Costanzo, Elsa Y.
Douer, Jazmín
Castro, Mariana Nair
Mora, Martina C.
Nemeroff, Charles B.
Chu, Elvina
Bär, Karl-Jürgen
Guinjoan, Salvador Martín
author_role author
author2 Villarreal, Mirta Fabiana
Costanzo, Elsa Y.
Douer, Jazmín
Castro, Mariana Nair
Mora, Martina C.
Nemeroff, Charles B.
Chu, Elvina
Bär, Karl-Jürgen
Guinjoan, Salvador Martín
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Schizophrenia
Siblings
Social Cognition
Theory of Mind
Fmri
Lateralization
topic Schizophrenia
Siblings
Social Cognition
Theory of Mind
Fmri
Lateralization
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv BACKGROUND: Social cognitive deficits contribute to functional disability in schizophrenia. Social cognitive tasks in healthy persons consistently evoke activation of medial prefrontal cortex, inferior frontal gyrus, temporoparietal gyrus, and posterior cingulate cortex/precuneus. We tested the hypothesis that patients with schizophrenia and their unaffected siblings share dysfunction of the same neural networks. METHODS: Neural activation during emotion processing (EP), theory of mind (ToM), and control tasks was measured using functional magnetic resonance imaging (fMRI) in 14 patients with schizophrenia, 14 nonpsychotic siblings of patients with schizophrenia, and 14 matched healthy subjects. RESULTS: Compared with healthy controls, patients with schizophrenia showed reduced activation of right hemisphere structures involved in EP and ToM including inferior frontal gyrus, middle frontal gyrus, and right temporoparietal junction. These deficits were shared, in part, by unaffected siblings. The latter group demonstrated deficits in bilateral precuneus activation during ToM, not present in patients. CONCLUSIONS: Schizophrenia appears to be associated with a deficit in activation of right hemisphere components of a ToM network. Such deficits are shared in part by those at high genetic risk but unaffected by schizophrenia.
Fil: de Achaval, Delfina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Villarreal, Mirta Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina
Fil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina
Fil: Douer, Jazmín. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina
Fil: Mora, Martina C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Nemeroff, Charles B.. University of Miami; Estados Unidos
Fil: Chu, Elvina. National Hospital for Neurology and Neurosurgery; Reino Unido
Fil: Bär, Karl-Jürgen. Universitat Jena; Alemania
Fil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina
description BACKGROUND: Social cognitive deficits contribute to functional disability in schizophrenia. Social cognitive tasks in healthy persons consistently evoke activation of medial prefrontal cortex, inferior frontal gyrus, temporoparietal gyrus, and posterior cingulate cortex/precuneus. We tested the hypothesis that patients with schizophrenia and their unaffected siblings share dysfunction of the same neural networks. METHODS: Neural activation during emotion processing (EP), theory of mind (ToM), and control tasks was measured using functional magnetic resonance imaging (fMRI) in 14 patients with schizophrenia, 14 nonpsychotic siblings of patients with schizophrenia, and 14 matched healthy subjects. RESULTS: Compared with healthy controls, patients with schizophrenia showed reduced activation of right hemisphere structures involved in EP and ToM including inferior frontal gyrus, middle frontal gyrus, and right temporoparietal junction. These deficits were shared, in part, by unaffected siblings. The latter group demonstrated deficits in bilateral precuneus activation during ToM, not present in patients. CONCLUSIONS: Schizophrenia appears to be associated with a deficit in activation of right hemisphere components of a ToM network. Such deficits are shared in part by those at high genetic risk but unaffected by schizophrenia.
publishDate 2012
dc.date.none.fl_str_mv 2012-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/16381
de Achaval, Delfina; Villarreal, Mirta Fabiana; Costanzo, Elsa Y.; Douer, Jazmín; Castro, Mariana Nair; et al.; Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia; Elsevier Science; Schizophrenia Research; 134; 2-3; 2-2012; 171-179
0920-9964
url http://hdl.handle.net/11336/16381
identifier_str_mv de Achaval, Delfina; Villarreal, Mirta Fabiana; Costanzo, Elsa Y.; Douer, Jazmín; Castro, Mariana Nair; et al.; Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia; Elsevier Science; Schizophrenia Research; 134; 2-3; 2-2012; 171-179
0920-9964
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0920996411006049
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.schres.2011.11.010
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082863834857472
score 13.221938

Publicaciones similares