Cluster B personality symptoms in persons at genetic risk for schizophrenia are associated with social competence and activation of the right temporo-parietal junction during emoti...

Autores: Goldschmidt, Micaela Giuliana; Villarreal, Mirta Fabiana; de Achaval, Delfina; Drucaroff, Lucas Javier; Costanzo, Elsa Y.; Castro, Mariana Nair; Pahissa, Jaime; Camprodon, Joan; Nemeroff, Charles B.; Guinjoan, Salvador Martín
Año de publicación: 2014
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: Personality disorders are common in nonpsychotic siblings of patients with schizophrenia, and some personality traits in this group may be associated with an increased risk for full-blown psychosis. We sought to establish if faulty right-hemisphere activation induced by social cognitive tasks, as previously described in patients with schizophrenia, is associated with specific personality symptoms in their unaffected siblings. We observed that cluster B personality symptoms in this group were inversely related to activation in the right temporo parietal junction (rTPJ, a structure critical in social cognitive processing) in response to a basic emotion processing task and also to social competence, whereas in contrast to our initial hypothesis, cluster A traits were not associated with right hemisphere activation during emotion processing or with social competence. These findings suggest the existence of clinical traits in at-risk individuals which share a common neurobiological substrate with schizophrenia, in regards to social performance.
Fil: Goldschmidt, Micaela Giuliana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina
Fil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: de Achaval, Delfina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Drucaroff, Lucas Javier. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina
Fil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pahissa, Jaime. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Camprodon, Joan. Massachusetts General Hospital. Laboratory for Neuropsychiatry & Neuromodulation; Estados Unidos
Fil: Nemeroff, Charles B.. University of Miami; Estados Unidos
Fil: Guinjoan, Salvador Martín. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina
Materia: Fmri
Schizophrenia
Siblings
Personality
Cluster B
Temporo Parietal Junction
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/16644

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spelling	Cluster B personality symptoms in persons at genetic risk for schizophrenia are associated with social competence and activation of the right temporo-parietal junction during emotion processingGoldschmidt, Micaela GiulianaVillarreal, Mirta Fabianade Achaval, DelfinaDrucaroff, Lucas JavierCostanzo, Elsa Y.Castro, Mariana NairPahissa, JaimeCamprodon, JoanNemeroff, Charles B.Guinjoan, Salvador MartínFmriSchizophreniaSiblingsPersonalityCluster BTemporo Parietal Junctionhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Personality disorders are common in nonpsychotic siblings of patients with schizophrenia, and some personality traits in this group may be associated with an increased risk for full-blown psychosis. We sought to establish if faulty right-hemisphere activation induced by social cognitive tasks, as previously described in patients with schizophrenia, is associated with specific personality symptoms in their unaffected siblings. We observed that cluster B personality symptoms in this group were inversely related to activation in the right temporo parietal junction (rTPJ, a structure critical in social cognitive processing) in response to a basic emotion processing task and also to social competence, whereas in contrast to our initial hypothesis, cluster A traits were not associated with right hemisphere activation during emotion processing or with social competence. These findings suggest the existence of clinical traits in at-risk individuals which share a common neurobiological substrate with schizophrenia, in regards to social performance.Fil: Goldschmidt, Micaela Giuliana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; ArgentinaFil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: de Achaval, Delfina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Drucaroff, Lucas Javier. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; ArgentinaFil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pahissa, Jaime. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Camprodon, Joan. Massachusetts General Hospital. Laboratory for Neuropsychiatry & Neuromodulation; Estados UnidosFil: Nemeroff, Charles B.. University of Miami; Estados UnidosFil: Guinjoan, Salvador Martín. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Psicología; ArgentinaElsevier Ireland2014-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16644Goldschmidt, Micaela Giuliana; Villarreal, Mirta Fabiana; de Achaval, Delfina; Drucaroff, Lucas Javier; Costanzo, Elsa Y.; et al.; Cluster B personality symptoms in persons at genetic risk for schizophrenia are associated with social competence and activation of the right temporo-parietal junction during emotion processing; Elsevier Ireland; Psychiatry Research: Neuroimaging; 221; 1; 1-2014; 30-360925-4927enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0925492713002795info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pscychresns.2013.10.008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:09:05Zoai:ri.conicet.gov.ar:11336/16644instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:09:05.866CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	Cluster B personality symptoms in persons at genetic risk for schizophrenia are associated with social competence and activation of the right temporo-parietal junction during emotion processing
title	Cluster B personality symptoms in persons at genetic risk for schizophrenia are associated with social competence and activation of the right temporo-parietal junction during emotion processing
spellingShingle	Cluster B personality symptoms in persons at genetic risk for schizophrenia are associated with social competence and activation of the right temporo-parietal junction during emotion processing Goldschmidt, Micaela Giuliana Fmri Schizophrenia Siblings Personality Cluster B Temporo Parietal Junction
title_short	Cluster B personality symptoms in persons at genetic risk for schizophrenia are associated with social competence and activation of the right temporo-parietal junction during emotion processing
title_full	Cluster B personality symptoms in persons at genetic risk for schizophrenia are associated with social competence and activation of the right temporo-parietal junction during emotion processing
title_fullStr	Cluster B personality symptoms in persons at genetic risk for schizophrenia are associated with social competence and activation of the right temporo-parietal junction during emotion processing
title_full_unstemmed	Cluster B personality symptoms in persons at genetic risk for schizophrenia are associated with social competence and activation of the right temporo-parietal junction during emotion processing
title_sort	Cluster B personality symptoms in persons at genetic risk for schizophrenia are associated with social competence and activation of the right temporo-parietal junction during emotion processing
dc.creator.none.fl_str_mv	Goldschmidt, Micaela Giuliana Villarreal, Mirta Fabiana de Achaval, Delfina Drucaroff, Lucas Javier Costanzo, Elsa Y. Castro, Mariana Nair Pahissa, Jaime Camprodon, Joan Nemeroff, Charles B. Guinjoan, Salvador Martín
author	Goldschmidt, Micaela Giuliana
author_facet	Goldschmidt, Micaela Giuliana Villarreal, Mirta Fabiana de Achaval, Delfina Drucaroff, Lucas Javier Costanzo, Elsa Y. Castro, Mariana Nair Pahissa, Jaime Camprodon, Joan Nemeroff, Charles B. Guinjoan, Salvador Martín
author_role	author
author2	Villarreal, Mirta Fabiana de Achaval, Delfina Drucaroff, Lucas Javier Costanzo, Elsa Y. Castro, Mariana Nair Pahissa, Jaime Camprodon, Joan Nemeroff, Charles B. Guinjoan, Salvador Martín
author2_role	author author author author author author author author author
dc.subject.none.fl_str_mv	Fmri Schizophrenia Siblings Personality Cluster B Temporo Parietal Junction
topic	Fmri Schizophrenia Siblings Personality Cluster B Temporo Parietal Junction
purl_subject.fl_str_mv	https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv	Personality disorders are common in nonpsychotic siblings of patients with schizophrenia, and some personality traits in this group may be associated with an increased risk for full-blown psychosis. We sought to establish if faulty right-hemisphere activation induced by social cognitive tasks, as previously described in patients with schizophrenia, is associated with specific personality symptoms in their unaffected siblings. We observed that cluster B personality symptoms in this group were inversely related to activation in the right temporo parietal junction (rTPJ, a structure critical in social cognitive processing) in response to a basic emotion processing task and also to social competence, whereas in contrast to our initial hypothesis, cluster A traits were not associated with right hemisphere activation during emotion processing or with social competence. These findings suggest the existence of clinical traits in at-risk individuals which share a common neurobiological substrate with schizophrenia, in regards to social performance. Fil: Goldschmidt, Micaela Giuliana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina Fil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: de Achaval, Delfina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Drucaroff, Lucas Javier. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina Fil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Pahissa, Jaime. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina Fil: Camprodon, Joan. Massachusetts General Hospital. Laboratory for Neuropsychiatry & Neuromodulation; Estados Unidos Fil: Nemeroff, Charles B.. University of Miami; Estados Unidos Fil: Guinjoan, Salvador Martín. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina
description	Personality disorders are common in nonpsychotic siblings of patients with schizophrenia, and some personality traits in this group may be associated with an increased risk for full-blown psychosis. We sought to establish if faulty right-hemisphere activation induced by social cognitive tasks, as previously described in patients with schizophrenia, is associated with specific personality symptoms in their unaffected siblings. We observed that cluster B personality symptoms in this group were inversely related to activation in the right temporo parietal junction (rTPJ, a structure critical in social cognitive processing) in response to a basic emotion processing task and also to social competence, whereas in contrast to our initial hypothesis, cluster A traits were not associated with right hemisphere activation during emotion processing or with social competence. These findings suggest the existence of clinical traits in at-risk individuals which share a common neurobiological substrate with schizophrenia, in regards to social performance.
publishDate	2014
dc.date.none.fl_str_mv	2014-01
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/16644 Goldschmidt, Micaela Giuliana; Villarreal, Mirta Fabiana; de Achaval, Delfina; Drucaroff, Lucas Javier; Costanzo, Elsa Y.; et al.; Cluster B personality symptoms in persons at genetic risk for schizophrenia are associated with social competence and activation of the right temporo-parietal junction during emotion processing; Elsevier Ireland; Psychiatry Research: Neuroimaging; 221; 1; 1-2014; 30-36 0925-4927
url	http://hdl.handle.net/11336/16644
identifier_str_mv	Goldschmidt, Micaela Giuliana; Villarreal, Mirta Fabiana; de Achaval, Delfina; Drucaroff, Lucas Javier; Costanzo, Elsa Y.; et al.; Cluster B personality symptoms in persons at genetic risk for schizophrenia are associated with social competence and activation of the right temporo-parietal junction during emotion processing; Elsevier Ireland; Psychiatry Research: Neuroimaging; 221; 1; 1-2014; 30-36 0925-4927
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0925492713002795 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pscychresns.2013.10.008
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv	openAccess
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dc.format.none.fl_str_mv	application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf
dc.publisher.none.fl_str_mv	Elsevier Ireland
publisher.none.fl_str_mv	Elsevier Ireland
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
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repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score	13.070432

Cluster B personality symptoms in persons at genetic risk for schizophrenia are associated with social competence and activation of the right temporo-parietal junction during emoti...

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