Geraniol protects against proteotoxicity and neurodegeneration in C. elegans Parkinson's disease models through SKN-1/Nrf2 and DAF-16/FOXO activation

Autores
Romussi, Stéfano; Rayes, Diego Hernán; de Rosa, Maria Jose
Año de publicación
2025
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
As life expectancy increases, the prevalence of age-related disorders, including neurodegenerative diseases (ND), is also rising. Oxidative stress (OS) is a key factor accelerating ND progression. For instance, in Parkinson’s disease (PD), impaired free radical scavenging promotes α-synuclein (α- syn) aggregation and neuronal damage. Therefore, antioxidant compounds are considered promising therapeutic candidates. In this study, we investigated the biological effects of Geraniol (GER), a plant-derived compound with antioxidant properties. Caenorhabditis elegans is a valuable model in biomedical research due to its genetic conservation with mammals and ease of manipulation. We evaluated GER’s effects in C. elegans PD models and explored the conserved molecular mechanisms involved. In wild-type animals, GER increased survival under OS, confirming its antioxidant activity in vivo. To elucidate the underlying mechanisms, we used mutants in key stress-response pathways and found that SKN-1/NRF2 mediates GER’s protective effect. Given the connection between OS and PD, we assessed GER in a muscle-expressed α-syn model, where it improved locomotion and reduced protein aggregation. In a neuronal α-syn model, GER significantly preserved dopaminergic neuron morphology and function. Overall, our results show that GER exerts antioxidant, antiproteotoxic, and neuroprotective effects in C. elegans PD models, supporting its potential as a therapeutic candidate for neurodegenerative diseases.
Fil: Romussi, Stéfano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
XL Meeting de la Sociedad Argentina de Investigación en Neurociencias
Buenos Aires
Argentina
Sociedad Argentina de Investigación en Neurociencias
Materia
C ELEGANS
NEURODEGENERATION
PROTEOTOXICITY
GERANIOL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/280586
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Geraniol protects against proteotoxicity and neurodegeneration in C. elegans Parkinson's disease models through SKN-1/Nrf2 and DAF-16/FOXO activationRomussi, StéfanoRayes, Diego Hernánde Rosa, Maria JoseC ELEGANSNEURODEGENERATIONPROTEOTOXICITYGERANIOLhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1As life expectancy increases, the prevalence of age-related disorders, including neurodegenerative diseases (ND), is also rising. Oxidative stress (OS) is a key factor accelerating ND progression. For instance, in Parkinson’s disease (PD), impaired free radical scavenging promotes α-synuclein (α- syn) aggregation and neuronal damage. Therefore, antioxidant compounds are considered promising therapeutic candidates. In this study, we investigated the biological effects of Geraniol (GER), a plant-derived compound with antioxidant properties. Caenorhabditis elegans is a valuable model in biomedical research due to its genetic conservation with mammals and ease of manipulation. We evaluated GER’s effects in C. elegans PD models and explored the conserved molecular mechanisms involved. In wild-type animals, GER increased survival under OS, confirming its antioxidant activity in vivo. To elucidate the underlying mechanisms, we used mutants in key stress-response pathways and found that SKN-1/NRF2 mediates GER’s protective effect. Given the connection between OS and PD, we assessed GER in a muscle-expressed α-syn model, where it improved locomotion and reduced protein aggregation. In a neuronal α-syn model, GER significantly preserved dopaminergic neuron morphology and function. Overall, our results show that GER exerts antioxidant, antiproteotoxic, and neuroprotective effects in C. elegans PD models, supporting its potential as a therapeutic candidate for neurodegenerative diseases.Fil: Romussi, Stéfano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaXL Meeting de la Sociedad Argentina de Investigación en NeurocienciasBuenos AiresArgentinaSociedad Argentina de Investigación en NeurocienciasSociedad Argentina de Investigación en Neurociencias2025info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/280586Geraniol protects against proteotoxicity and neurodegeneration in C. elegans Parkinson's disease models through SKN-1/Nrf2 and DAF-16/FOXO activation; XL Meeting de la Sociedad Argentina de Investigación en Neurociencias; Buenos Aires; Argentina; 2025; 238-238CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://csan2025.saneurociencias.org.ar/wp-content/uploads/2025/10/SAN2025-Poster-EBOOK-.pdfInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-06T12:23:13Zoai:ri.conicet.gov.ar:11336/280586instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-06 12:23:14.299CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Geraniol protects against proteotoxicity and neurodegeneration in C. elegans Parkinson's disease models through SKN-1/Nrf2 and DAF-16/FOXO activation
title Geraniol protects against proteotoxicity and neurodegeneration in C. elegans Parkinson's disease models through SKN-1/Nrf2 and DAF-16/FOXO activation
spellingShingle Geraniol protects against proteotoxicity and neurodegeneration in C. elegans Parkinson's disease models through SKN-1/Nrf2 and DAF-16/FOXO activation
Romussi, Stéfano
C ELEGANS
NEURODEGENERATION
PROTEOTOXICITY
GERANIOL
title_short Geraniol protects against proteotoxicity and neurodegeneration in C. elegans Parkinson's disease models through SKN-1/Nrf2 and DAF-16/FOXO activation
title_full Geraniol protects against proteotoxicity and neurodegeneration in C. elegans Parkinson's disease models through SKN-1/Nrf2 and DAF-16/FOXO activation
title_fullStr Geraniol protects against proteotoxicity and neurodegeneration in C. elegans Parkinson's disease models through SKN-1/Nrf2 and DAF-16/FOXO activation
title_full_unstemmed Geraniol protects against proteotoxicity and neurodegeneration in C. elegans Parkinson's disease models through SKN-1/Nrf2 and DAF-16/FOXO activation
title_sort Geraniol protects against proteotoxicity and neurodegeneration in C. elegans Parkinson's disease models through SKN-1/Nrf2 and DAF-16/FOXO activation
dc.creator.none.fl_str_mv Romussi, Stéfano
Rayes, Diego Hernán
de Rosa, Maria Jose
author Romussi, Stéfano
author_facet Romussi, Stéfano
Rayes, Diego Hernán
de Rosa, Maria Jose
author_role author
author2 Rayes, Diego Hernán
de Rosa, Maria Jose
author2_role author
author
dc.subject.none.fl_str_mv C ELEGANS
NEURODEGENERATION
PROTEOTOXICITY
GERANIOL
topic C ELEGANS
NEURODEGENERATION
PROTEOTOXICITY
GERANIOL
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv As life expectancy increases, the prevalence of age-related disorders, including neurodegenerative diseases (ND), is also rising. Oxidative stress (OS) is a key factor accelerating ND progression. For instance, in Parkinson’s disease (PD), impaired free radical scavenging promotes α-synuclein (α- syn) aggregation and neuronal damage. Therefore, antioxidant compounds are considered promising therapeutic candidates. In this study, we investigated the biological effects of Geraniol (GER), a plant-derived compound with antioxidant properties. Caenorhabditis elegans is a valuable model in biomedical research due to its genetic conservation with mammals and ease of manipulation. We evaluated GER’s effects in C. elegans PD models and explored the conserved molecular mechanisms involved. In wild-type animals, GER increased survival under OS, confirming its antioxidant activity in vivo. To elucidate the underlying mechanisms, we used mutants in key stress-response pathways and found that SKN-1/NRF2 mediates GER’s protective effect. Given the connection between OS and PD, we assessed GER in a muscle-expressed α-syn model, where it improved locomotion and reduced protein aggregation. In a neuronal α-syn model, GER significantly preserved dopaminergic neuron morphology and function. Overall, our results show that GER exerts antioxidant, antiproteotoxic, and neuroprotective effects in C. elegans PD models, supporting its potential as a therapeutic candidate for neurodegenerative diseases.
Fil: Romussi, Stéfano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
XL Meeting de la Sociedad Argentina de Investigación en Neurociencias
Buenos Aires
Argentina
Sociedad Argentina de Investigación en Neurociencias
description As life expectancy increases, the prevalence of age-related disorders, including neurodegenerative diseases (ND), is also rising. Oxidative stress (OS) is a key factor accelerating ND progression. For instance, in Parkinson’s disease (PD), impaired free radical scavenging promotes α-synuclein (α- syn) aggregation and neuronal damage. Therefore, antioxidant compounds are considered promising therapeutic candidates. In this study, we investigated the biological effects of Geraniol (GER), a plant-derived compound with antioxidant properties. Caenorhabditis elegans is a valuable model in biomedical research due to its genetic conservation with mammals and ease of manipulation. We evaluated GER’s effects in C. elegans PD models and explored the conserved molecular mechanisms involved. In wild-type animals, GER increased survival under OS, confirming its antioxidant activity in vivo. To elucidate the underlying mechanisms, we used mutants in key stress-response pathways and found that SKN-1/NRF2 mediates GER’s protective effect. Given the connection between OS and PD, we assessed GER in a muscle-expressed α-syn model, where it improved locomotion and reduced protein aggregation. In a neuronal α-syn model, GER significantly preserved dopaminergic neuron morphology and function. Overall, our results show that GER exerts antioxidant, antiproteotoxic, and neuroprotective effects in C. elegans PD models, supporting its potential as a therapeutic candidate for neurodegenerative diseases.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/280586
Geraniol protects against proteotoxicity and neurodegeneration in C. elegans Parkinson's disease models through SKN-1/Nrf2 and DAF-16/FOXO activation; XL Meeting de la Sociedad Argentina de Investigación en Neurociencias; Buenos Aires; Argentina; 2025; 238-238
CONICET Digital
CONICET
url http://hdl.handle.net/11336/280586
identifier_str_mv Geraniol protects against proteotoxicity and neurodegeneration in C. elegans Parkinson's disease models through SKN-1/Nrf2 and DAF-16/FOXO activation; XL Meeting de la Sociedad Argentina de Investigación en Neurociencias; Buenos Aires; Argentina; 2025; 238-238
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://csan2025.saneurociencias.org.ar/wp-content/uploads/2025/10/SAN2025-Poster-EBOOK-.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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