Geraniol delays locomotion decline in C. elegans Parkinson's disease models

Autores
Romussi, Stéfano; Andersen, Natalia Denise; Rayes, Diego Hernán; de Rosa, Maria Jose
Año de publicación
2022
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Due to the increase in life expectancy worldwide, age-related disorders such as neurodegenerative diseases (NDs) have become more prevalent. Elevated levels of oxidative stress could modulate the progression of NDs. For example, in Parkinson’s Disease (PD) it has been shown that compromising the capacity to scavenge free radicals can exacerbate αsynuclein (α-syn) aggregation and proteotoxic damage. Geraniol (GL), a plant-derived essential oil, has recognized antioxidant properties. Considering that oxidative stress contributes to proteotoxic disease progression, compounds with antioxidant activity have been postulated as potential therapeutic agents. C. elegans is widely used in biomedical research. There is a high level of homology between C. elegans and mammalian genes (including proteins involved in cytoprotective mechanisms). In fact, several NDs can be recapitulated in this animal. In this work, we use C. elegans PD models to evaluate the in vivo effects of GL. We found that GL delays age-related locomotion decline in PD worms. Interestingly, GL also decreases α-syn aggregation. These preliminary results indicate a potential antiproteotoxic effect in C. elegans models of PD. Therefore, we propose, to combine genetic, microscopy and behavioral techniques to unravel GL effect in C. elegans ND models. These studies could provide a proof of concept of the potential of GL as a promising compound to retard proteotoxic diseases
Fil: Romussi, Stéfano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Congreso Anual Sociedad Argentina de Investigación en Neurociencias 2022
Buenos Aires
Argentina
Sociedad Argentina de Investigación en Bioquímica
Materia
C. ELEGANS
GERANIOL
NEURODEGENERATION
PROTEOTOXICITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/227495
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Geraniol delays locomotion decline in C. elegans Parkinson's disease modelsRomussi, StéfanoAndersen, Natalia DeniseRayes, Diego Hernánde Rosa, Maria JoseC. ELEGANSGERANIOLNEURODEGENERATIONPROTEOTOXICITYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Due to the increase in life expectancy worldwide, age-related disorders such as neurodegenerative diseases (NDs) have become more prevalent. Elevated levels of oxidative stress could modulate the progression of NDs. For example, in Parkinson’s Disease (PD) it has been shown that compromising the capacity to scavenge free radicals can exacerbate αsynuclein (α-syn) aggregation and proteotoxic damage. Geraniol (GL), a plant-derived essential oil, has recognized antioxidant properties. Considering that oxidative stress contributes to proteotoxic disease progression, compounds with antioxidant activity have been postulated as potential therapeutic agents. C. elegans is widely used in biomedical research. There is a high level of homology between C. elegans and mammalian genes (including proteins involved in cytoprotective mechanisms). In fact, several NDs can be recapitulated in this animal. In this work, we use C. elegans PD models to evaluate the in vivo effects of GL. We found that GL delays age-related locomotion decline in PD worms. Interestingly, GL also decreases α-syn aggregation. These preliminary results indicate a potential antiproteotoxic effect in C. elegans models of PD. Therefore, we propose, to combine genetic, microscopy and behavioral techniques to unravel GL effect in C. elegans ND models. These studies could provide a proof of concept of the potential of GL as a promising compound to retard proteotoxic diseasesFil: Romussi, Stéfano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaCongreso Anual Sociedad Argentina de Investigación en Neurociencias 2022Buenos AiresArgentinaSociedad Argentina de Investigación en BioquímicaSociedad Argentina de Investigación en Neurociencias2022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/227495Geraniol delays locomotion decline in C. elegans Parkinson's disease models; Congreso Anual Sociedad Argentina de Investigación en Neurociencias 2022; Buenos Aires; Argentina; 2022; 250-250CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://saneurociencias.org.ar/wp-content/uploads/2023/07/ebook2022-07072023-1.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:02Zoai:ri.conicet.gov.ar:11336/227495instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:02.693CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Geraniol delays locomotion decline in C. elegans Parkinson's disease models
title Geraniol delays locomotion decline in C. elegans Parkinson's disease models
spellingShingle Geraniol delays locomotion decline in C. elegans Parkinson's disease models
Romussi, Stéfano
C. ELEGANS
GERANIOL
NEURODEGENERATION
PROTEOTOXICITY
title_short Geraniol delays locomotion decline in C. elegans Parkinson's disease models
title_full Geraniol delays locomotion decline in C. elegans Parkinson's disease models
title_fullStr Geraniol delays locomotion decline in C. elegans Parkinson's disease models
title_full_unstemmed Geraniol delays locomotion decline in C. elegans Parkinson's disease models
title_sort Geraniol delays locomotion decline in C. elegans Parkinson's disease models
dc.creator.none.fl_str_mv Romussi, Stéfano
Andersen, Natalia Denise
Rayes, Diego Hernán
de Rosa, Maria Jose
author Romussi, Stéfano
author_facet Romussi, Stéfano
Andersen, Natalia Denise
Rayes, Diego Hernán
de Rosa, Maria Jose
author_role author
author2 Andersen, Natalia Denise
Rayes, Diego Hernán
de Rosa, Maria Jose
author2_role author
author
author
dc.subject.none.fl_str_mv C. ELEGANS
GERANIOL
NEURODEGENERATION
PROTEOTOXICITY
topic C. ELEGANS
GERANIOL
NEURODEGENERATION
PROTEOTOXICITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Due to the increase in life expectancy worldwide, age-related disorders such as neurodegenerative diseases (NDs) have become more prevalent. Elevated levels of oxidative stress could modulate the progression of NDs. For example, in Parkinson’s Disease (PD) it has been shown that compromising the capacity to scavenge free radicals can exacerbate αsynuclein (α-syn) aggregation and proteotoxic damage. Geraniol (GL), a plant-derived essential oil, has recognized antioxidant properties. Considering that oxidative stress contributes to proteotoxic disease progression, compounds with antioxidant activity have been postulated as potential therapeutic agents. C. elegans is widely used in biomedical research. There is a high level of homology between C. elegans and mammalian genes (including proteins involved in cytoprotective mechanisms). In fact, several NDs can be recapitulated in this animal. In this work, we use C. elegans PD models to evaluate the in vivo effects of GL. We found that GL delays age-related locomotion decline in PD worms. Interestingly, GL also decreases α-syn aggregation. These preliminary results indicate a potential antiproteotoxic effect in C. elegans models of PD. Therefore, we propose, to combine genetic, microscopy and behavioral techniques to unravel GL effect in C. elegans ND models. These studies could provide a proof of concept of the potential of GL as a promising compound to retard proteotoxic diseases
Fil: Romussi, Stéfano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Congreso Anual Sociedad Argentina de Investigación en Neurociencias 2022
Buenos Aires
Argentina
Sociedad Argentina de Investigación en Bioquímica
description Due to the increase in life expectancy worldwide, age-related disorders such as neurodegenerative diseases (NDs) have become more prevalent. Elevated levels of oxidative stress could modulate the progression of NDs. For example, in Parkinson’s Disease (PD) it has been shown that compromising the capacity to scavenge free radicals can exacerbate αsynuclein (α-syn) aggregation and proteotoxic damage. Geraniol (GL), a plant-derived essential oil, has recognized antioxidant properties. Considering that oxidative stress contributes to proteotoxic disease progression, compounds with antioxidant activity have been postulated as potential therapeutic agents. C. elegans is widely used in biomedical research. There is a high level of homology between C. elegans and mammalian genes (including proteins involved in cytoprotective mechanisms). In fact, several NDs can be recapitulated in this animal. In this work, we use C. elegans PD models to evaluate the in vivo effects of GL. We found that GL delays age-related locomotion decline in PD worms. Interestingly, GL also decreases α-syn aggregation. These preliminary results indicate a potential antiproteotoxic effect in C. elegans models of PD. Therefore, we propose, to combine genetic, microscopy and behavioral techniques to unravel GL effect in C. elegans ND models. These studies could provide a proof of concept of the potential of GL as a promising compound to retard proteotoxic diseases
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/227495
Geraniol delays locomotion decline in C. elegans Parkinson's disease models; Congreso Anual Sociedad Argentina de Investigación en Neurociencias 2022; Buenos Aires; Argentina; 2022; 250-250
CONICET Digital
CONICET
url http://hdl.handle.net/11336/227495
identifier_str_mv Geraniol delays locomotion decline in C. elegans Parkinson's disease models; Congreso Anual Sociedad Argentina de Investigación en Neurociencias 2022; Buenos Aires; Argentina; 2022; 250-250
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://saneurociencias.org.ar/wp-content/uploads/2023/07/ebook2022-07072023-1.pdf
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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