Geraniol protects against oxidative stress and proteotoxicity in Caenorhabditis elegans Parkinson's disease models

Autores
Romussi, Stéfano; Andersen, Natalia Denise; Ibarguren, Sofia; Rayes, Diego Hernán; de Rosa, Maria Jose
Año de publicación
2023
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Due to the increase in life expectancy worldwide, age-related disorders such as neurodegenerative diseases have become more prevalent. Elevated levels of oxidative stress could modulate the progression of neurodegenerative diseases. For example, in Parkinson’s disease it has been shown that compromising the capacity to scavenge free radicals can exacerbate α-synuclein (α-syn) aggregation and proteotoxic damage. Geraniol, a plant-derived essential oil, has recognized antioxidant properties. Considering that oxidative stress contributes to proteotoxic disease progression, compounds with antioxidant activity have been postulated as potential therapeutic agents. C.elegans is widely used in biomedical research. There is a high level of homology between C. elegans and mammalian genes (including proteins involved in cytoprotective mechanisms). In fact, several neurodegenerative diseases can be recapitulated in this animal. In this work, we use C. elegans Parkinson’s disease models to evaluate the in vivo effect of geraniol. We found that geraniol improves impaired locomotion in these animal models. Interestingly, geraniol also decreases α-syn aggregation. In addition, our last preliminary results suggest that DAF-16 is not involved in geraniol activity. So far, these results indicate a potential antiproteotoxic effect of this drug in C. elegans Parkinson’s disease models. Therefore, we propose to combine genetic, microscopy and behavioral techniques to unravel geraniol effect in C. elegans neurodegenerative diseases models. These studies could provide a proof of concept of the potential of geraniol as a promising compound to retard proteotoxic diseases.
Fil: Romussi, Stéfano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Ibarguren, Sofia. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
24th International C. elegans Conference
Glasgow
Reino Unido
Genetics Society of America
Materia
C.ELEGANS
GERANIOL
PROTEOTOXIC
PARKINSON
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/226155
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/226155
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Geraniol protects against oxidative stress and proteotoxicity in Caenorhabditis elegans Parkinson's disease modelsRomussi, StéfanoAndersen, Natalia DeniseIbarguren, SofiaRayes, Diego Hernánde Rosa, Maria JoseC.ELEGANSGERANIOLPROTEOTOXICPARKINSONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Due to the increase in life expectancy worldwide, age-related disorders such as neurodegenerative diseases have become more prevalent. Elevated levels of oxidative stress could modulate the progression of neurodegenerative diseases. For example, in Parkinson’s disease it has been shown that compromising the capacity to scavenge free radicals can exacerbate α-synuclein (α-syn) aggregation and proteotoxic damage. Geraniol, a plant-derived essential oil, has recognized antioxidant properties. Considering that oxidative stress contributes to proteotoxic disease progression, compounds with antioxidant activity have been postulated as potential therapeutic agents. C.elegans is widely used in biomedical research. There is a high level of homology between C. elegans and mammalian genes (including proteins involved in cytoprotective mechanisms). In fact, several neurodegenerative diseases can be recapitulated in this animal. In this work, we use C. elegans Parkinson’s disease models to evaluate the in vivo effect of geraniol. We found that geraniol improves impaired locomotion in these animal models. Interestingly, geraniol also decreases α-syn aggregation. In addition, our last preliminary results suggest that DAF-16 is not involved in geraniol activity. So far, these results indicate a potential antiproteotoxic effect of this drug in C. elegans Parkinson’s disease models. Therefore, we propose to combine genetic, microscopy and behavioral techniques to unravel geraniol effect in C. elegans neurodegenerative diseases models. These studies could provide a proof of concept of the potential of geraniol as a promising compound to retard proteotoxic diseases.Fil: Romussi, Stéfano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Ibarguren, Sofia. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina24th International C. elegans ConferenceGlasgowReino UnidoGenetics Society of AmericaGenetics Society of America2023info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/226155Geraniol protects against oxidative stress and proteotoxicity in Caenorhabditis elegans Parkinson's disease models; 24th International C. elegans Conference; Glasgow; Reino Unido; 2023; 388-389CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://genetics-gsa.org/celegans2023/program-and-abstract-books/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:23:14Zoai:ri.conicet.gov.ar:11336/226155instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:23:15.119CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Geraniol protects against oxidative stress and proteotoxicity in Caenorhabditis elegans Parkinson's disease models
title Geraniol protects against oxidative stress and proteotoxicity in Caenorhabditis elegans Parkinson's disease models
spellingShingle Geraniol protects against oxidative stress and proteotoxicity in Caenorhabditis elegans Parkinson's disease models
Romussi, Stéfano
C.ELEGANS
GERANIOL
PROTEOTOXIC
PARKINSON
title_short Geraniol protects against oxidative stress and proteotoxicity in Caenorhabditis elegans Parkinson's disease models
title_full Geraniol protects against oxidative stress and proteotoxicity in Caenorhabditis elegans Parkinson's disease models
title_fullStr Geraniol protects against oxidative stress and proteotoxicity in Caenorhabditis elegans Parkinson's disease models
title_full_unstemmed Geraniol protects against oxidative stress and proteotoxicity in Caenorhabditis elegans Parkinson's disease models
title_sort Geraniol protects against oxidative stress and proteotoxicity in Caenorhabditis elegans Parkinson's disease models
dc.creator.none.fl_str_mv Romussi, Stéfano
Andersen, Natalia Denise
Ibarguren, Sofia
Rayes, Diego Hernán
de Rosa, Maria Jose
author Romussi, Stéfano
author_facet Romussi, Stéfano
Andersen, Natalia Denise
Ibarguren, Sofia
Rayes, Diego Hernán
de Rosa, Maria Jose
author_role author
author2 Andersen, Natalia Denise
Ibarguren, Sofia
Rayes, Diego Hernán
de Rosa, Maria Jose
author2_role author
author
author
author
dc.subject.none.fl_str_mv C.ELEGANS
GERANIOL
PROTEOTOXIC
PARKINSON
topic C.ELEGANS
GERANIOL
PROTEOTOXIC
PARKINSON
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Due to the increase in life expectancy worldwide, age-related disorders such as neurodegenerative diseases have become more prevalent. Elevated levels of oxidative stress could modulate the progression of neurodegenerative diseases. For example, in Parkinson’s disease it has been shown that compromising the capacity to scavenge free radicals can exacerbate α-synuclein (α-syn) aggregation and proteotoxic damage. Geraniol, a plant-derived essential oil, has recognized antioxidant properties. Considering that oxidative stress contributes to proteotoxic disease progression, compounds with antioxidant activity have been postulated as potential therapeutic agents. C.elegans is widely used in biomedical research. There is a high level of homology between C. elegans and mammalian genes (including proteins involved in cytoprotective mechanisms). In fact, several neurodegenerative diseases can be recapitulated in this animal. In this work, we use C. elegans Parkinson’s disease models to evaluate the in vivo effect of geraniol. We found that geraniol improves impaired locomotion in these animal models. Interestingly, geraniol also decreases α-syn aggregation. In addition, our last preliminary results suggest that DAF-16 is not involved in geraniol activity. So far, these results indicate a potential antiproteotoxic effect of this drug in C. elegans Parkinson’s disease models. Therefore, we propose to combine genetic, microscopy and behavioral techniques to unravel geraniol effect in C. elegans neurodegenerative diseases models. These studies could provide a proof of concept of the potential of geraniol as a promising compound to retard proteotoxic diseases.
Fil: Romussi, Stéfano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Ibarguren, Sofia. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
24th International C. elegans Conference
Glasgow
Reino Unido
Genetics Society of America
description Due to the increase in life expectancy worldwide, age-related disorders such as neurodegenerative diseases have become more prevalent. Elevated levels of oxidative stress could modulate the progression of neurodegenerative diseases. For example, in Parkinson’s disease it has been shown that compromising the capacity to scavenge free radicals can exacerbate α-synuclein (α-syn) aggregation and proteotoxic damage. Geraniol, a plant-derived essential oil, has recognized antioxidant properties. Considering that oxidative stress contributes to proteotoxic disease progression, compounds with antioxidant activity have been postulated as potential therapeutic agents. C.elegans is widely used in biomedical research. There is a high level of homology between C. elegans and mammalian genes (including proteins involved in cytoprotective mechanisms). In fact, several neurodegenerative diseases can be recapitulated in this animal. In this work, we use C. elegans Parkinson’s disease models to evaluate the in vivo effect of geraniol. We found that geraniol improves impaired locomotion in these animal models. Interestingly, geraniol also decreases α-syn aggregation. In addition, our last preliminary results suggest that DAF-16 is not involved in geraniol activity. So far, these results indicate a potential antiproteotoxic effect of this drug in C. elegans Parkinson’s disease models. Therefore, we propose to combine genetic, microscopy and behavioral techniques to unravel geraniol effect in C. elegans neurodegenerative diseases models. These studies could provide a proof of concept of the potential of geraniol as a promising compound to retard proteotoxic diseases.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/226155
Geraniol protects against oxidative stress and proteotoxicity in Caenorhabditis elegans Parkinson's disease models; 24th International C. elegans Conference; Glasgow; Reino Unido; 2023; 388-389
CONICET Digital
CONICET
url http://hdl.handle.net/11336/226155
identifier_str_mv Geraniol protects against oxidative stress and proteotoxicity in Caenorhabditis elegans Parkinson's disease models; 24th International C. elegans Conference; Glasgow; Reino Unido; 2023; 388-389
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://genetics-gsa.org/celegans2023/program-and-abstract-books/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Genetics Society of America
publisher.none.fl_str_mv Genetics Society of America
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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