Geraniol delays locomotion decline in C. elegans Parkinson's disease models
- Autores
- Romussi, Stéfano; Andersen, Natalia Denise; Rayes, Diego Hernán; de Rosa, Maria Jose
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Due to the increase in life expectancy worldwide, age-related disorders such as neurodegenerative diseases (NDs) have become more prevalent. Elevated levels of oxidative stress could modulate the progression of NDs. For example, in Parkinson’s Disease (PD) it has been shown that compromising the capacity to scavenge free radicals can exacerbate α-synuclein (α-syn) aggregation and proteotoxic damage. Geraniol (GL), a plant-derived essential oil, has recognized antioxidant properties. Considering that oxidative stress contributes to proteotoxic disease progression, compounds with antioxidant activity have been postulated as potential therapeutic agents. C. elegans is widely used in biomedical research. There is a high level of homology between C. elegans and mammalian genes (including proteins involved in cytoprotective mechanisms). In fact, several NDs can be recapitulated in this animal. In this work, we use C. elegans PD models to evaluate the in vivo effects of GL. We found that GL improves impaired locomotion in PD worms. Interestingly, GL also decreases α-syn aggregation. These preliminary results indicate a potential anti-proteotoxic effect in C. elegans models of PD. Therefore, we propose to combine genetic, microscopy and behavioral techniques to unravel GL effect in C. elegans ND models. These studies could provide a proof of concept of the potential of GL as a promising compound to retard proteotoxic diseases
Fil: Romussi, Stéfano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Third Latin American Worm Meeting
Valparaiso
Chile
Centro Interdisciplinario de Neurociencia Valparaíso - Materia
-
C. ELEGANS
GERANIOL
NEURODEGENERATION
PARKINSON - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/250871
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Geraniol delays locomotion decline in C. elegans Parkinson's disease modelsRomussi, StéfanoAndersen, Natalia DeniseRayes, Diego Hernánde Rosa, Maria JoseC. ELEGANSGERANIOLNEURODEGENERATIONPARKINSONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Due to the increase in life expectancy worldwide, age-related disorders such as neurodegenerative diseases (NDs) have become more prevalent. Elevated levels of oxidative stress could modulate the progression of NDs. For example, in Parkinson’s Disease (PD) it has been shown that compromising the capacity to scavenge free radicals can exacerbate α-synuclein (α-syn) aggregation and proteotoxic damage. Geraniol (GL), a plant-derived essential oil, has recognized antioxidant properties. Considering that oxidative stress contributes to proteotoxic disease progression, compounds with antioxidant activity have been postulated as potential therapeutic agents. C. elegans is widely used in biomedical research. There is a high level of homology between C. elegans and mammalian genes (including proteins involved in cytoprotective mechanisms). In fact, several NDs can be recapitulated in this animal. In this work, we use C. elegans PD models to evaluate the in vivo effects of GL. We found that GL improves impaired locomotion in PD worms. Interestingly, GL also decreases α-syn aggregation. These preliminary results indicate a potential anti-proteotoxic effect in C. elegans models of PD. Therefore, we propose to combine genetic, microscopy and behavioral techniques to unravel GL effect in C. elegans ND models. These studies could provide a proof of concept of the potential of GL as a promising compound to retard proteotoxic diseasesFil: Romussi, Stéfano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaThird Latin American Worm MeetingValparaisoChileCentro Interdisciplinario de Neurociencia ValparaísoLatin American Worm Meeting2023info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/250871Geraniol delays locomotion decline in C. elegans Parkinson's disease models; Third Latin American Worm Meeting; Valparaiso; Chile; 2023; 65-65CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://cinv.uv.cl/en/3rd-la-worm-meeting/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:33:17Zoai:ri.conicet.gov.ar:11336/250871instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:33:17.866CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Geraniol delays locomotion decline in C. elegans Parkinson's disease models |
title |
Geraniol delays locomotion decline in C. elegans Parkinson's disease models |
spellingShingle |
Geraniol delays locomotion decline in C. elegans Parkinson's disease models Romussi, Stéfano C. ELEGANS GERANIOL NEURODEGENERATION PARKINSON |
title_short |
Geraniol delays locomotion decline in C. elegans Parkinson's disease models |
title_full |
Geraniol delays locomotion decline in C. elegans Parkinson's disease models |
title_fullStr |
Geraniol delays locomotion decline in C. elegans Parkinson's disease models |
title_full_unstemmed |
Geraniol delays locomotion decline in C. elegans Parkinson's disease models |
title_sort |
Geraniol delays locomotion decline in C. elegans Parkinson's disease models |
dc.creator.none.fl_str_mv |
Romussi, Stéfano Andersen, Natalia Denise Rayes, Diego Hernán de Rosa, Maria Jose |
author |
Romussi, Stéfano |
author_facet |
Romussi, Stéfano Andersen, Natalia Denise Rayes, Diego Hernán de Rosa, Maria Jose |
author_role |
author |
author2 |
Andersen, Natalia Denise Rayes, Diego Hernán de Rosa, Maria Jose |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
C. ELEGANS GERANIOL NEURODEGENERATION PARKINSON |
topic |
C. ELEGANS GERANIOL NEURODEGENERATION PARKINSON |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Due to the increase in life expectancy worldwide, age-related disorders such as neurodegenerative diseases (NDs) have become more prevalent. Elevated levels of oxidative stress could modulate the progression of NDs. For example, in Parkinson’s Disease (PD) it has been shown that compromising the capacity to scavenge free radicals can exacerbate α-synuclein (α-syn) aggregation and proteotoxic damage. Geraniol (GL), a plant-derived essential oil, has recognized antioxidant properties. Considering that oxidative stress contributes to proteotoxic disease progression, compounds with antioxidant activity have been postulated as potential therapeutic agents. C. elegans is widely used in biomedical research. There is a high level of homology between C. elegans and mammalian genes (including proteins involved in cytoprotective mechanisms). In fact, several NDs can be recapitulated in this animal. In this work, we use C. elegans PD models to evaluate the in vivo effects of GL. We found that GL improves impaired locomotion in PD worms. Interestingly, GL also decreases α-syn aggregation. These preliminary results indicate a potential anti-proteotoxic effect in C. elegans models of PD. Therefore, we propose to combine genetic, microscopy and behavioral techniques to unravel GL effect in C. elegans ND models. These studies could provide a proof of concept of the potential of GL as a promising compound to retard proteotoxic diseases Fil: Romussi, Stéfano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina Fil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina Third Latin American Worm Meeting Valparaiso Chile Centro Interdisciplinario de Neurociencia Valparaíso |
description |
Due to the increase in life expectancy worldwide, age-related disorders such as neurodegenerative diseases (NDs) have become more prevalent. Elevated levels of oxidative stress could modulate the progression of NDs. For example, in Parkinson’s Disease (PD) it has been shown that compromising the capacity to scavenge free radicals can exacerbate α-synuclein (α-syn) aggregation and proteotoxic damage. Geraniol (GL), a plant-derived essential oil, has recognized antioxidant properties. Considering that oxidative stress contributes to proteotoxic disease progression, compounds with antioxidant activity have been postulated as potential therapeutic agents. C. elegans is widely used in biomedical research. There is a high level of homology between C. elegans and mammalian genes (including proteins involved in cytoprotective mechanisms). In fact, several NDs can be recapitulated in this animal. In this work, we use C. elegans PD models to evaluate the in vivo effects of GL. We found that GL improves impaired locomotion in PD worms. Interestingly, GL also decreases α-syn aggregation. These preliminary results indicate a potential anti-proteotoxic effect in C. elegans models of PD. Therefore, we propose to combine genetic, microscopy and behavioral techniques to unravel GL effect in C. elegans ND models. These studies could provide a proof of concept of the potential of GL as a promising compound to retard proteotoxic diseases |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Congreso Book http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/250871 Geraniol delays locomotion decline in C. elegans Parkinson's disease models; Third Latin American Worm Meeting; Valparaiso; Chile; 2023; 65-65 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/250871 |
identifier_str_mv |
Geraniol delays locomotion decline in C. elegans Parkinson's disease models; Third Latin American Worm Meeting; Valparaiso; Chile; 2023; 65-65 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://cinv.uv.cl/en/3rd-la-worm-meeting/ |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.coverage.none.fl_str_mv |
Internacional |
dc.publisher.none.fl_str_mv |
Latin American Worm Meeting |
publisher.none.fl_str_mv |
Latin American Worm Meeting |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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