Geraniol Protects Against Oxidative Stress And Proteotoxicity In C. Elegans Parkinson’s Disease Models

Autores
Romussi, Stéfano; Andersen, Natalia Denise; Ibarguren, Sofia; Rayes, Diego Hernán; de Rosa, Maria Jose
Año de publicación
2024
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
The rise in life expectancy has led to an increase in age-related disorders, including neurodegenerative diseases (ND). Oxidative stress (OS) plays a crucial role in the progression of these conditions. For instance, in Parkinson’s disease (PD), impaired free radical scavenging results in α-synuclein (α-syn) aggregation and subsequent proteotoxic damage. Geraniol (GER), a plant-derived essential oil, is well-known for its potent antioxidant properties. Given the association between OS and ND, antioxidant compounds are attractive as potential therapeutic agents. In this study, we investigated the effects of GER in C. elegans models of PD, where α-syn is expressed either in muscle or dopaminergic neurons. Our findings show that GER treatment improves locomotion, reduces α-syn accumulation, and protects dopaminergic neurons from degeneration. Thus, these results demonstrate GER’s protective effect against proteotoxicity caused by α-syn aggregation. Additionally, GER enhances OS resistance in C. elegans. To further explore GER’s protective mechanisms, we analyzed null mutants in key OS-related pathways. Our results indicate that the transcription factors SKN1/NRF2 and HSF1 play crucial roles in mediating GER’s antioxidant effects. Preliminary data also suggest that GER may modulate autophagy, contributing to its neuroprotective actions. In conclusion, this work demonstrates the potential anti neurodegenerative effects of GER in vivo, which should be validated in other models
Fil: Romussi, Stéfano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Ibarguren, Sofia. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
XXXIX Annual Meeting
Buenos Aires
Argentina
Sociedad Argentina de Investigación en Neurociencias
Materia
PROTEOTOXICITY
OXIDATIVE STRESS
C ELEGANS
NEUROBIOLOGY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/252921
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Geraniol Protects Against Oxidative Stress And Proteotoxicity In C. Elegans Parkinson’s Disease ModelsRomussi, StéfanoAndersen, Natalia DeniseIbarguren, SofiaRayes, Diego Hernánde Rosa, Maria JosePROTEOTOXICITYOXIDATIVE STRESSC ELEGANSNEUROBIOLOGYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The rise in life expectancy has led to an increase in age-related disorders, including neurodegenerative diseases (ND). Oxidative stress (OS) plays a crucial role in the progression of these conditions. For instance, in Parkinson’s disease (PD), impaired free radical scavenging results in α-synuclein (α-syn) aggregation and subsequent proteotoxic damage. Geraniol (GER), a plant-derived essential oil, is well-known for its potent antioxidant properties. Given the association between OS and ND, antioxidant compounds are attractive as potential therapeutic agents. In this study, we investigated the effects of GER in C. elegans models of PD, where α-syn is expressed either in muscle or dopaminergic neurons. Our findings show that GER treatment improves locomotion, reduces α-syn accumulation, and protects dopaminergic neurons from degeneration. Thus, these results demonstrate GER’s protective effect against proteotoxicity caused by α-syn aggregation. Additionally, GER enhances OS resistance in C. elegans. To further explore GER’s protective mechanisms, we analyzed null mutants in key OS-related pathways. Our results indicate that the transcription factors SKN1/NRF2 and HSF1 play crucial roles in mediating GER’s antioxidant effects. Preliminary data also suggest that GER may modulate autophagy, contributing to its neuroprotective actions. In conclusion, this work demonstrates the potential anti neurodegenerative effects of GER in vivo, which should be validated in other modelsFil: Romussi, Stéfano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Ibarguren, Sofia. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaXXXIX Annual MeetingBuenos AiresArgentinaSociedad Argentina de Investigación en NeurocienciasSociedad Argentina de Investigación en Neurociencias2024info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/252921Geraniol Protects Against Oxidative Stress And Proteotoxicity In C. Elegans Parkinson’s Disease Models; XXXIX Annual Meeting; Buenos Aires; Argentina; 2024; 466-466CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://csan2024.saneurociencias.org.ar/posters-complete-list/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:08:42Zoai:ri.conicet.gov.ar:11336/252921instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:08:42.509CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Geraniol Protects Against Oxidative Stress And Proteotoxicity In C. Elegans Parkinson’s Disease Models
title Geraniol Protects Against Oxidative Stress And Proteotoxicity In C. Elegans Parkinson’s Disease Models
spellingShingle Geraniol Protects Against Oxidative Stress And Proteotoxicity In C. Elegans Parkinson’s Disease Models
Romussi, Stéfano
PROTEOTOXICITY
OXIDATIVE STRESS
C ELEGANS
NEUROBIOLOGY
title_short Geraniol Protects Against Oxidative Stress And Proteotoxicity In C. Elegans Parkinson’s Disease Models
title_full Geraniol Protects Against Oxidative Stress And Proteotoxicity In C. Elegans Parkinson’s Disease Models
title_fullStr Geraniol Protects Against Oxidative Stress And Proteotoxicity In C. Elegans Parkinson’s Disease Models
title_full_unstemmed Geraniol Protects Against Oxidative Stress And Proteotoxicity In C. Elegans Parkinson’s Disease Models
title_sort Geraniol Protects Against Oxidative Stress And Proteotoxicity In C. Elegans Parkinson’s Disease Models
dc.creator.none.fl_str_mv Romussi, Stéfano
Andersen, Natalia Denise
Ibarguren, Sofia
Rayes, Diego Hernán
de Rosa, Maria Jose
author Romussi, Stéfano
author_facet Romussi, Stéfano
Andersen, Natalia Denise
Ibarguren, Sofia
Rayes, Diego Hernán
de Rosa, Maria Jose
author_role author
author2 Andersen, Natalia Denise
Ibarguren, Sofia
Rayes, Diego Hernán
de Rosa, Maria Jose
author2_role author
author
author
author
dc.subject.none.fl_str_mv PROTEOTOXICITY
OXIDATIVE STRESS
C ELEGANS
NEUROBIOLOGY
topic PROTEOTOXICITY
OXIDATIVE STRESS
C ELEGANS
NEUROBIOLOGY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The rise in life expectancy has led to an increase in age-related disorders, including neurodegenerative diseases (ND). Oxidative stress (OS) plays a crucial role in the progression of these conditions. For instance, in Parkinson’s disease (PD), impaired free radical scavenging results in α-synuclein (α-syn) aggregation and subsequent proteotoxic damage. Geraniol (GER), a plant-derived essential oil, is well-known for its potent antioxidant properties. Given the association between OS and ND, antioxidant compounds are attractive as potential therapeutic agents. In this study, we investigated the effects of GER in C. elegans models of PD, where α-syn is expressed either in muscle or dopaminergic neurons. Our findings show that GER treatment improves locomotion, reduces α-syn accumulation, and protects dopaminergic neurons from degeneration. Thus, these results demonstrate GER’s protective effect against proteotoxicity caused by α-syn aggregation. Additionally, GER enhances OS resistance in C. elegans. To further explore GER’s protective mechanisms, we analyzed null mutants in key OS-related pathways. Our results indicate that the transcription factors SKN1/NRF2 and HSF1 play crucial roles in mediating GER’s antioxidant effects. Preliminary data also suggest that GER may modulate autophagy, contributing to its neuroprotective actions. In conclusion, this work demonstrates the potential anti neurodegenerative effects of GER in vivo, which should be validated in other models
Fil: Romussi, Stéfano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Ibarguren, Sofia. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
XXXIX Annual Meeting
Buenos Aires
Argentina
Sociedad Argentina de Investigación en Neurociencias
description The rise in life expectancy has led to an increase in age-related disorders, including neurodegenerative diseases (ND). Oxidative stress (OS) plays a crucial role in the progression of these conditions. For instance, in Parkinson’s disease (PD), impaired free radical scavenging results in α-synuclein (α-syn) aggregation and subsequent proteotoxic damage. Geraniol (GER), a plant-derived essential oil, is well-known for its potent antioxidant properties. Given the association between OS and ND, antioxidant compounds are attractive as potential therapeutic agents. In this study, we investigated the effects of GER in C. elegans models of PD, where α-syn is expressed either in muscle or dopaminergic neurons. Our findings show that GER treatment improves locomotion, reduces α-syn accumulation, and protects dopaminergic neurons from degeneration. Thus, these results demonstrate GER’s protective effect against proteotoxicity caused by α-syn aggregation. Additionally, GER enhances OS resistance in C. elegans. To further explore GER’s protective mechanisms, we analyzed null mutants in key OS-related pathways. Our results indicate that the transcription factors SKN1/NRF2 and HSF1 play crucial roles in mediating GER’s antioxidant effects. Preliminary data also suggest that GER may modulate autophagy, contributing to its neuroprotective actions. In conclusion, this work demonstrates the potential anti neurodegenerative effects of GER in vivo, which should be validated in other models
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/252921
Geraniol Protects Against Oxidative Stress And Proteotoxicity In C. Elegans Parkinson’s Disease Models; XXXIX Annual Meeting; Buenos Aires; Argentina; 2024; 466-466
CONICET Digital
CONICET
url http://hdl.handle.net/11336/252921
identifier_str_mv Geraniol Protects Against Oxidative Stress And Proteotoxicity In C. Elegans Parkinson’s Disease Models; XXXIX Annual Meeting; Buenos Aires; Argentina; 2024; 466-466
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://csan2024.saneurociencias.org.ar/posters-complete-list/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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