Osteoconductivity of strontium-doped bioactive glass particles: A histomorphometric study in rats

Autores
Gorustovich Alonso, Alejandro Adrian; Steimetz, Tammy; Cabrini, Rómulo L.; Porto Lopez, Jose Manuel
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
There is accumulating evidence that strontium (Sr)-containing bioceramics have positive effects on bone tissue repair. The aims of the present study were to evaluate the osteoconductivity of Sr-doped bioactive glass (BG) particles implanted in rat tibia bone marrow, and characterize the neoformed bone tissue by SEM-energy-dispersive X-ray microanalysis. Melt-derived BGs were prepared from a base 45S5 BG. Sr-doped glass (45S5.6Sr) was prepared using 6 wt % SrO as a substitute for the CaO. Histological analysis using undecalcified sections showed that new lamellar bone had formed along the surface of both 45S5 and 45S5.6Sr BG particles within 4 weeks. To evaluate osteoconductivity, affinity indices were calculated. At 30 days after implantation, 45S5 and 45S5.6Sr BGs had almost identical affinity indices (88% ± 7% and 87% ± 9%; p > 0.05). Strontium was not detected in the neoformed bone tissue surrounding 45S5.6Sr BG particles. These results indicate that 45S5.6Sr BG particles are osteoconductive when implanted inside the intramedullary canal of rat tibiae, and no alterations in bone mineralization, in terms of Ca/P ratio, were observed in the neoformed bone tissue around 45S5.6Sr BG particles.
Fil: Gorustovich Alonso, Alejandro Adrian. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Steimetz, Tammy. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cabrini, Rómulo L.. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Porto Lopez, Jose Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Materia
Affinity Index
Bioactive Glass
Bone
Osteoconductivity
Strontium
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/76080
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/76080
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Osteoconductivity of strontium-doped bioactive glass particles: A histomorphometric study in ratsGorustovich Alonso, Alejandro AdrianSteimetz, TammyCabrini, Rómulo L.Porto Lopez, Jose ManuelAffinity IndexBioactive GlassBoneOsteoconductivityStrontiumhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3There is accumulating evidence that strontium (Sr)-containing bioceramics have positive effects on bone tissue repair. The aims of the present study were to evaluate the osteoconductivity of Sr-doped bioactive glass (BG) particles implanted in rat tibia bone marrow, and characterize the neoformed bone tissue by SEM-energy-dispersive X-ray microanalysis. Melt-derived BGs were prepared from a base 45S5 BG. Sr-doped glass (45S5.6Sr) was prepared using 6 wt % SrO as a substitute for the CaO. Histological analysis using undecalcified sections showed that new lamellar bone had formed along the surface of both 45S5 and 45S5.6Sr BG particles within 4 weeks. To evaluate osteoconductivity, affinity indices were calculated. At 30 days after implantation, 45S5 and 45S5.6Sr BGs had almost identical affinity indices (88% ± 7% and 87% ± 9%; p > 0.05). Strontium was not detected in the neoformed bone tissue surrounding 45S5.6Sr BG particles. These results indicate that 45S5.6Sr BG particles are osteoconductive when implanted inside the intramedullary canal of rat tibiae, and no alterations in bone mineralization, in terms of Ca/P ratio, were observed in the neoformed bone tissue around 45S5.6Sr BG particles.Fil: Gorustovich Alonso, Alejandro Adrian. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Steimetz, Tammy. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cabrini, Rómulo L.. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Porto Lopez, Jose Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaWiley-liss, Div John Wiley & Sons Inc2010-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/76080Gorustovich Alonso, Alejandro Adrian; Steimetz, Tammy; Cabrini, Rómulo L.; Porto Lopez, Jose Manuel; Osteoconductivity of strontium-doped bioactive glass particles: A histomorphometric study in rats; Wiley-liss, Div John Wiley & Sons Inc; Journal of Biomedical Materials Research Part A; 92; 1; 1-2010; 232-2371549-3296CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/jbm.a.32355info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.32355info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:18:06Zoai:ri.conicet.gov.ar:11336/76080instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:18:07.272CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Osteoconductivity of strontium-doped bioactive glass particles: A histomorphometric study in rats
title Osteoconductivity of strontium-doped bioactive glass particles: A histomorphometric study in rats
spellingShingle Osteoconductivity of strontium-doped bioactive glass particles: A histomorphometric study in rats
Gorustovich Alonso, Alejandro Adrian
Affinity Index
Bioactive Glass
Bone
Osteoconductivity
Strontium
title_short Osteoconductivity of strontium-doped bioactive glass particles: A histomorphometric study in rats
title_full Osteoconductivity of strontium-doped bioactive glass particles: A histomorphometric study in rats
title_fullStr Osteoconductivity of strontium-doped bioactive glass particles: A histomorphometric study in rats
title_full_unstemmed Osteoconductivity of strontium-doped bioactive glass particles: A histomorphometric study in rats
title_sort Osteoconductivity of strontium-doped bioactive glass particles: A histomorphometric study in rats
dc.creator.none.fl_str_mv Gorustovich Alonso, Alejandro Adrian
Steimetz, Tammy
Cabrini, Rómulo L.
Porto Lopez, Jose Manuel
author Gorustovich Alonso, Alejandro Adrian
author_facet Gorustovich Alonso, Alejandro Adrian
Steimetz, Tammy
Cabrini, Rómulo L.
Porto Lopez, Jose Manuel
author_role author
author2 Steimetz, Tammy
Cabrini, Rómulo L.
Porto Lopez, Jose Manuel
author2_role author
author
author
dc.subject.none.fl_str_mv Affinity Index
Bioactive Glass
Bone
Osteoconductivity
Strontium
topic Affinity Index
Bioactive Glass
Bone
Osteoconductivity
Strontium
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv There is accumulating evidence that strontium (Sr)-containing bioceramics have positive effects on bone tissue repair. The aims of the present study were to evaluate the osteoconductivity of Sr-doped bioactive glass (BG) particles implanted in rat tibia bone marrow, and characterize the neoformed bone tissue by SEM-energy-dispersive X-ray microanalysis. Melt-derived BGs were prepared from a base 45S5 BG. Sr-doped glass (45S5.6Sr) was prepared using 6 wt % SrO as a substitute for the CaO. Histological analysis using undecalcified sections showed that new lamellar bone had formed along the surface of both 45S5 and 45S5.6Sr BG particles within 4 weeks. To evaluate osteoconductivity, affinity indices were calculated. At 30 days after implantation, 45S5 and 45S5.6Sr BGs had almost identical affinity indices (88% ± 7% and 87% ± 9%; p > 0.05). Strontium was not detected in the neoformed bone tissue surrounding 45S5.6Sr BG particles. These results indicate that 45S5.6Sr BG particles are osteoconductive when implanted inside the intramedullary canal of rat tibiae, and no alterations in bone mineralization, in terms of Ca/P ratio, were observed in the neoformed bone tissue around 45S5.6Sr BG particles.
Fil: Gorustovich Alonso, Alejandro Adrian. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Steimetz, Tammy. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cabrini, Rómulo L.. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Porto Lopez, Jose Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
description There is accumulating evidence that strontium (Sr)-containing bioceramics have positive effects on bone tissue repair. The aims of the present study were to evaluate the osteoconductivity of Sr-doped bioactive glass (BG) particles implanted in rat tibia bone marrow, and characterize the neoformed bone tissue by SEM-energy-dispersive X-ray microanalysis. Melt-derived BGs were prepared from a base 45S5 BG. Sr-doped glass (45S5.6Sr) was prepared using 6 wt % SrO as a substitute for the CaO. Histological analysis using undecalcified sections showed that new lamellar bone had formed along the surface of both 45S5 and 45S5.6Sr BG particles within 4 weeks. To evaluate osteoconductivity, affinity indices were calculated. At 30 days after implantation, 45S5 and 45S5.6Sr BGs had almost identical affinity indices (88% ± 7% and 87% ± 9%; p > 0.05). Strontium was not detected in the neoformed bone tissue surrounding 45S5.6Sr BG particles. These results indicate that 45S5.6Sr BG particles are osteoconductive when implanted inside the intramedullary canal of rat tibiae, and no alterations in bone mineralization, in terms of Ca/P ratio, were observed in the neoformed bone tissue around 45S5.6Sr BG particles.
publishDate 2010
dc.date.none.fl_str_mv 2010-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/76080
Gorustovich Alonso, Alejandro Adrian; Steimetz, Tammy; Cabrini, Rómulo L.; Porto Lopez, Jose Manuel; Osteoconductivity of strontium-doped bioactive glass particles: A histomorphometric study in rats; Wiley-liss, Div John Wiley & Sons Inc; Journal of Biomedical Materials Research Part A; 92; 1; 1-2010; 232-237
1549-3296
CONICET Digital
CONICET
url http://hdl.handle.net/11336/76080
identifier_str_mv Gorustovich Alonso, Alejandro Adrian; Steimetz, Tammy; Cabrini, Rómulo L.; Porto Lopez, Jose Manuel; Osteoconductivity of strontium-doped bioactive glass particles: A histomorphometric study in rats; Wiley-liss, Div John Wiley & Sons Inc; Journal of Biomedical Materials Research Part A; 92; 1; 1-2010; 232-237
1549-3296
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/jbm.a.32355
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.32355
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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