Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass

Autores
Haro Durand, Luis Alberto; Vargas, Gabriela Elizabet; Romero, Nélida M.; Vera Mesones, Rosa; Porto Lopez, Jose Manuel; Boccaccini, Aldo R.; Zago, María Paola; Baldi, Alberto; Gorustovich, Alejandro
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In regenerative medicine of vascularized tissues, there is a great interest in the use of biomaterials that are able to stimulate angiogenesis, a process necessary for rapid revascularization to allow the transport and exchange of oxygen, nutrients, growth factors and cells that take part in tissue repair and/or regeneration. An increasing number of publications have shown that bioactive glasses stimulate angiogenesis. Because it has been established that boron (B) may play a role in angiogenesis, the aim of this study was to assess the in vivo angiogenic effects of the ionic dissolution products that from a bioactive glass (BG) in the 45S5 system doped with 2 wt% B2O3 (45S5.2B). The pro-angiogenic capacity of 45S5.2B BG was assessed on the vasculature of the embryonic quail chorioallantoic membrane (CAM). Ionic dissolution products from 45S5.2B BG increased angiogenesis. This is quantitatively evidenced by the greater expression of integrin avb3 and higher vascular density in the embryonic quail CAM. The response observed at 2 and 5 days post-treatment was equivalent to that achieved by applying 10 mg mL1 of basic fibroblast growth factor. These results show that the ionic dissolution products released from the bioactive glass 45S5.2B stimulate angiogenesis in vivo. The effects observed are attributed to the presence the ionic dissolution products, which contained 160 10 mM borate.
Fil: Haro Durand, Luis Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingenieria "Hilario Fernandez Long". Grupo Vinculado al Intecin - Grupo Interdisciplinario en Materiales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Vargas, Gabriela Elizabet. Universidad Nacional de Salta. Facultad de Cs.naturales. Escuela de Biologia; Argentina
Fil: Romero, Nélida M.. Universidad Nacional de Salta. Facultad de Cs.naturales. Escuela de Biologia; Argentina
Fil: Vera Mesones, Rosa. Universidad Nacional de Salta. Facultad de Cs.naturales. Escuela de Biologia. Catedra de Biologia de Desarrollo; Argentina
Fil: Porto Lopez, Jose Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación en Ciencia y Tecnología de Materiales (i); Argentina
Fil: Boccaccini, Aldo R.. Universitat Erlangen-Nuremberg; Alemania
Fil: Zago, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina
Fil: Baldi, Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Gorustovich, Alejandro. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingenieria "Hilario Fernandez Long". Grupo Vinculado al Intecin - Grupo Interdisciplinario en Materiales; Argentina
Materia
Angiogenesis
Boron
Bioactive Glass
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/7333
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/7333
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glassHaro Durand, Luis AlbertoVargas, Gabriela ElizabetRomero, Nélida M.Vera Mesones, RosaPorto Lopez, Jose ManuelBoccaccini, Aldo R.Zago, María PaolaBaldi, AlbertoGorustovich, AlejandroAngiogenesisBoronBioactive Glasshttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3In regenerative medicine of vascularized tissues, there is a great interest in the use of biomaterials that are able to stimulate angiogenesis, a process necessary for rapid revascularization to allow the transport and exchange of oxygen, nutrients, growth factors and cells that take part in tissue repair and/or regeneration. An increasing number of publications have shown that bioactive glasses stimulate angiogenesis. Because it has been established that boron (B) may play a role in angiogenesis, the aim of this study was to assess the in vivo angiogenic effects of the ionic dissolution products that from a bioactive glass (BG) in the 45S5 system doped with 2 wt% B2O3 (45S5.2B). The pro-angiogenic capacity of 45S5.2B BG was assessed on the vasculature of the embryonic quail chorioallantoic membrane (CAM). Ionic dissolution products from 45S5.2B BG increased angiogenesis. This is quantitatively evidenced by the greater expression of integrin avb3 and higher vascular density in the embryonic quail CAM. The response observed at 2 and 5 days post-treatment was equivalent to that achieved by applying 10 mg mL1 of basic fibroblast growth factor. These results show that the ionic dissolution products released from the bioactive glass 45S5.2B stimulate angiogenesis in vivo. The effects observed are attributed to the presence the ionic dissolution products, which contained 160 10 mM borate.Fil: Haro Durand, Luis Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingenieria "Hilario Fernandez Long". Grupo Vinculado al Intecin - Grupo Interdisciplinario en Materiales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Vargas, Gabriela Elizabet. Universidad Nacional de Salta. Facultad de Cs.naturales. Escuela de Biologia; ArgentinaFil: Romero, Nélida M.. Universidad Nacional de Salta. Facultad de Cs.naturales. Escuela de Biologia; ArgentinaFil: Vera Mesones, Rosa. Universidad Nacional de Salta. Facultad de Cs.naturales. Escuela de Biologia. Catedra de Biologia de Desarrollo; ArgentinaFil: Porto Lopez, Jose Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación en Ciencia y Tecnología de Materiales (i); ArgentinaFil: Boccaccini, Aldo R.. Universitat Erlangen-Nuremberg; AlemaniaFil: Zago, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; ArgentinaFil: Baldi, Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Gorustovich, Alejandro. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingenieria "Hilario Fernandez Long". Grupo Vinculado al Intecin - Grupo Interdisciplinario en Materiales; ArgentinaRoyal Society Of Chemistry2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7333Haro Durand, Luis Alberto; Vargas, Gabriela Elizabet; Romero, Nélida M.; Vera Mesones, Rosa; Porto Lopez, Jose Manuel; et al.; Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass; Royal Society Of Chemistry; Journal Of Materials Chemistry; 3; 6; 1-2015; 1142-11480959-9428enginfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/C4TB01840K#!divAbstractinfo:eu-repo/semantics/altIdentifier/doi/10.1039/C4TB01840Kinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:39:06Zoai:ri.conicet.gov.ar:11336/7333instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:39:07.204CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass
title Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass
spellingShingle Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass
Haro Durand, Luis Alberto
Angiogenesis
Boron
Bioactive Glass
title_short Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass
title_full Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass
title_fullStr Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass
title_full_unstemmed Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass
title_sort Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass
dc.creator.none.fl_str_mv Haro Durand, Luis Alberto
Vargas, Gabriela Elizabet
Romero, Nélida M.
Vera Mesones, Rosa
Porto Lopez, Jose Manuel
Boccaccini, Aldo R.
Zago, María Paola
Baldi, Alberto
Gorustovich, Alejandro
author Haro Durand, Luis Alberto
author_facet Haro Durand, Luis Alberto
Vargas, Gabriela Elizabet
Romero, Nélida M.
Vera Mesones, Rosa
Porto Lopez, Jose Manuel
Boccaccini, Aldo R.
Zago, María Paola
Baldi, Alberto
Gorustovich, Alejandro
author_role author
author2 Vargas, Gabriela Elizabet
Romero, Nélida M.
Vera Mesones, Rosa
Porto Lopez, Jose Manuel
Boccaccini, Aldo R.
Zago, María Paola
Baldi, Alberto
Gorustovich, Alejandro
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Angiogenesis
Boron
Bioactive Glass
topic Angiogenesis
Boron
Bioactive Glass
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In regenerative medicine of vascularized tissues, there is a great interest in the use of biomaterials that are able to stimulate angiogenesis, a process necessary for rapid revascularization to allow the transport and exchange of oxygen, nutrients, growth factors and cells that take part in tissue repair and/or regeneration. An increasing number of publications have shown that bioactive glasses stimulate angiogenesis. Because it has been established that boron (B) may play a role in angiogenesis, the aim of this study was to assess the in vivo angiogenic effects of the ionic dissolution products that from a bioactive glass (BG) in the 45S5 system doped with 2 wt% B2O3 (45S5.2B). The pro-angiogenic capacity of 45S5.2B BG was assessed on the vasculature of the embryonic quail chorioallantoic membrane (CAM). Ionic dissolution products from 45S5.2B BG increased angiogenesis. This is quantitatively evidenced by the greater expression of integrin avb3 and higher vascular density in the embryonic quail CAM. The response observed at 2 and 5 days post-treatment was equivalent to that achieved by applying 10 mg mL1 of basic fibroblast growth factor. These results show that the ionic dissolution products released from the bioactive glass 45S5.2B stimulate angiogenesis in vivo. The effects observed are attributed to the presence the ionic dissolution products, which contained 160 10 mM borate.
Fil: Haro Durand, Luis Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingenieria "Hilario Fernandez Long". Grupo Vinculado al Intecin - Grupo Interdisciplinario en Materiales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Vargas, Gabriela Elizabet. Universidad Nacional de Salta. Facultad de Cs.naturales. Escuela de Biologia; Argentina
Fil: Romero, Nélida M.. Universidad Nacional de Salta. Facultad de Cs.naturales. Escuela de Biologia; Argentina
Fil: Vera Mesones, Rosa. Universidad Nacional de Salta. Facultad de Cs.naturales. Escuela de Biologia. Catedra de Biologia de Desarrollo; Argentina
Fil: Porto Lopez, Jose Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación en Ciencia y Tecnología de Materiales (i); Argentina
Fil: Boccaccini, Aldo R.. Universitat Erlangen-Nuremberg; Alemania
Fil: Zago, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina
Fil: Baldi, Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Gorustovich, Alejandro. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingenieria "Hilario Fernandez Long". Grupo Vinculado al Intecin - Grupo Interdisciplinario en Materiales; Argentina
description In regenerative medicine of vascularized tissues, there is a great interest in the use of biomaterials that are able to stimulate angiogenesis, a process necessary for rapid revascularization to allow the transport and exchange of oxygen, nutrients, growth factors and cells that take part in tissue repair and/or regeneration. An increasing number of publications have shown that bioactive glasses stimulate angiogenesis. Because it has been established that boron (B) may play a role in angiogenesis, the aim of this study was to assess the in vivo angiogenic effects of the ionic dissolution products that from a bioactive glass (BG) in the 45S5 system doped with 2 wt% B2O3 (45S5.2B). The pro-angiogenic capacity of 45S5.2B BG was assessed on the vasculature of the embryonic quail chorioallantoic membrane (CAM). Ionic dissolution products from 45S5.2B BG increased angiogenesis. This is quantitatively evidenced by the greater expression of integrin avb3 and higher vascular density in the embryonic quail CAM. The response observed at 2 and 5 days post-treatment was equivalent to that achieved by applying 10 mg mL1 of basic fibroblast growth factor. These results show that the ionic dissolution products released from the bioactive glass 45S5.2B stimulate angiogenesis in vivo. The effects observed are attributed to the presence the ionic dissolution products, which contained 160 10 mM borate.
publishDate 2015
dc.date.none.fl_str_mv 2015-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7333
Haro Durand, Luis Alberto; Vargas, Gabriela Elizabet; Romero, Nélida M.; Vera Mesones, Rosa; Porto Lopez, Jose Manuel; et al.; Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass; Royal Society Of Chemistry; Journal Of Materials Chemistry; 3; 6; 1-2015; 1142-1148
0959-9428
url http://hdl.handle.net/11336/7333
identifier_str_mv Haro Durand, Luis Alberto; Vargas, Gabriela Elizabet; Romero, Nélida M.; Vera Mesones, Rosa; Porto Lopez, Jose Manuel; et al.; Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass; Royal Society Of Chemistry; Journal Of Materials Chemistry; 3; 6; 1-2015; 1142-1148
0959-9428
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/C4TB01840K#!divAbstract
info:eu-repo/semantics/altIdentifier/doi/10.1039/C4TB01840K
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society Of Chemistry
publisher.none.fl_str_mv Royal Society Of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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