Sol gel hybrid coatings with strontium-doped 45S5 glass particles for enhancing the performance of stainless steel implants: Electrochemical, bioactive and in vivo response

Autores
Omar, Sheila Ayelén; Repp, Felix; Desimone, Paula Mariela; Weinkamer, Richard; Wagermaier, Wolfgang; Ceré, Silvia; Ballarre, Josefina
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The protection of stainless-steel implants by applying a hybrid organic–inorganic coating generates a barrier for ion migration and a potential holder for functional particles. Chemical composition of bioactive silicate-glasses (BG) can be varied to tailor their rate of dissolution in the biological environment. The substitution of calcium by strontium (Sr) generates a locally-controlled release of Sr-ions to the media. Strontium is known to reduce bone resorption and stimulate bone formation. This work presents coatings made by sol–gel method containing tetraethoxysilane, methyl-triethoxysilane and silica nanoparticles as precursors, and functionalized either with BG or Sr-substituted BG particles onto surgical grade stainless steel. The coated implants were tested in vitro for corrosion resistance and bioactivity, and in vivo to analyze bone formation. The applied coating system provided an excellent protection to aggressive fluids, even after 30 days of immersion. The presence of hydroxyapatite is shown as a first evidence of bioactivity. The evaluation of in vivo tests in Wistar–Hokkaido rat femur 4 or 8 weeks after the implantation showed slight differences in the thickness of newly formed bone measured by ESEM, and remarkable changes in bone quality characterized with Raman microscopy. The in vivo response of the coatings containing Sr-substituted bioglass is better at early times of implantation as regards the bone morphology and quality making this functionalized coatings a very promising option for implant protection and bone regeneration.
Fil: Omar, Sheila Ayelén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Repp, Felix. Institut Max Planck fuer Bioanorganische Chemie; Alemania
Fil: Desimone, Paula Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Weinkamer, Richard. Institut Max Planck fuer Bioanorganische Chemie; Alemania
Fil: Wagermaier, Wolfgang. Institut Max Planck fuer Bioanorganische Chemie; Alemania
Fil: Ceré, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Ballarre, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Materia
Stainless Steel
Coatings
Strontium
Bioactivity
Corrosion
Osseointegration
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/30042
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/30042
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sol gel hybrid coatings with strontium-doped 45S5 glass particles for enhancing the performance of stainless steel implants: Electrochemical, bioactive and in vivo responseOmar, Sheila AyelénRepp, FelixDesimone, Paula MarielaWeinkamer, RichardWagermaier, WolfgangCeré, SilviaBallarre, JosefinaStainless SteelCoatingsStrontiumBioactivityCorrosionOsseointegrationhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2The protection of stainless-steel implants by applying a hybrid organic–inorganic coating generates a barrier for ion migration and a potential holder for functional particles. Chemical composition of bioactive silicate-glasses (BG) can be varied to tailor their rate of dissolution in the biological environment. The substitution of calcium by strontium (Sr) generates a locally-controlled release of Sr-ions to the media. Strontium is known to reduce bone resorption and stimulate bone formation. This work presents coatings made by sol–gel method containing tetraethoxysilane, methyl-triethoxysilane and silica nanoparticles as precursors, and functionalized either with BG or Sr-substituted BG particles onto surgical grade stainless steel. The coated implants were tested in vitro for corrosion resistance and bioactivity, and in vivo to analyze bone formation. The applied coating system provided an excellent protection to aggressive fluids, even after 30 days of immersion. The presence of hydroxyapatite is shown as a first evidence of bioactivity. The evaluation of in vivo tests in Wistar–Hokkaido rat femur 4 or 8 weeks after the implantation showed slight differences in the thickness of newly formed bone measured by ESEM, and remarkable changes in bone quality characterized with Raman microscopy. The in vivo response of the coatings containing Sr-substituted bioglass is better at early times of implantation as regards the bone morphology and quality making this functionalized coatings a very promising option for implant protection and bone regeneration.Fil: Omar, Sheila Ayelén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Repp, Felix. Institut Max Planck fuer Bioanorganische Chemie; AlemaniaFil: Desimone, Paula Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Weinkamer, Richard. Institut Max Planck fuer Bioanorganische Chemie; AlemaniaFil: Wagermaier, Wolfgang. Institut Max Planck fuer Bioanorganische Chemie; AlemaniaFil: Ceré, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Ballarre, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaElsevier2015-05-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/30042Omar, Sheila Ayelén; Repp, Felix; Desimone, Paula Mariela; Weinkamer, Richard; Wagermaier, Wolfgang; et al.; Sol gel hybrid coatings with strontium-doped 45S5 glass particles for enhancing the performance of stainless steel implants: Electrochemical, bioactive and in vivo response; Elsevier; Journal of Non-crystalline Solids; 425; 23-5-2015; 1-100022-3093CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jnoncrysol.2015.05.024info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0022309315300442info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:20Zoai:ri.conicet.gov.ar:11336/30042instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:20.946CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sol gel hybrid coatings with strontium-doped 45S5 glass particles for enhancing the performance of stainless steel implants: Electrochemical, bioactive and in vivo response
title Sol gel hybrid coatings with strontium-doped 45S5 glass particles for enhancing the performance of stainless steel implants: Electrochemical, bioactive and in vivo response
spellingShingle Sol gel hybrid coatings with strontium-doped 45S5 glass particles for enhancing the performance of stainless steel implants: Electrochemical, bioactive and in vivo response
Omar, Sheila Ayelén
Stainless Steel
Coatings
Strontium
Bioactivity
Corrosion
Osseointegration
title_short Sol gel hybrid coatings with strontium-doped 45S5 glass particles for enhancing the performance of stainless steel implants: Electrochemical, bioactive and in vivo response
title_full Sol gel hybrid coatings with strontium-doped 45S5 glass particles for enhancing the performance of stainless steel implants: Electrochemical, bioactive and in vivo response
title_fullStr Sol gel hybrid coatings with strontium-doped 45S5 glass particles for enhancing the performance of stainless steel implants: Electrochemical, bioactive and in vivo response
title_full_unstemmed Sol gel hybrid coatings with strontium-doped 45S5 glass particles for enhancing the performance of stainless steel implants: Electrochemical, bioactive and in vivo response
title_sort Sol gel hybrid coatings with strontium-doped 45S5 glass particles for enhancing the performance of stainless steel implants: Electrochemical, bioactive and in vivo response
dc.creator.none.fl_str_mv Omar, Sheila Ayelén
Repp, Felix
Desimone, Paula Mariela
Weinkamer, Richard
Wagermaier, Wolfgang
Ceré, Silvia
Ballarre, Josefina
author Omar, Sheila Ayelén
author_facet Omar, Sheila Ayelén
Repp, Felix
Desimone, Paula Mariela
Weinkamer, Richard
Wagermaier, Wolfgang
Ceré, Silvia
Ballarre, Josefina
author_role author
author2 Repp, Felix
Desimone, Paula Mariela
Weinkamer, Richard
Wagermaier, Wolfgang
Ceré, Silvia
Ballarre, Josefina
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Stainless Steel
Coatings
Strontium
Bioactivity
Corrosion
Osseointegration
topic Stainless Steel
Coatings
Strontium
Bioactivity
Corrosion
Osseointegration
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The protection of stainless-steel implants by applying a hybrid organic–inorganic coating generates a barrier for ion migration and a potential holder for functional particles. Chemical composition of bioactive silicate-glasses (BG) can be varied to tailor their rate of dissolution in the biological environment. The substitution of calcium by strontium (Sr) generates a locally-controlled release of Sr-ions to the media. Strontium is known to reduce bone resorption and stimulate bone formation. This work presents coatings made by sol–gel method containing tetraethoxysilane, methyl-triethoxysilane and silica nanoparticles as precursors, and functionalized either with BG or Sr-substituted BG particles onto surgical grade stainless steel. The coated implants were tested in vitro for corrosion resistance and bioactivity, and in vivo to analyze bone formation. The applied coating system provided an excellent protection to aggressive fluids, even after 30 days of immersion. The presence of hydroxyapatite is shown as a first evidence of bioactivity. The evaluation of in vivo tests in Wistar–Hokkaido rat femur 4 or 8 weeks after the implantation showed slight differences in the thickness of newly formed bone measured by ESEM, and remarkable changes in bone quality characterized with Raman microscopy. The in vivo response of the coatings containing Sr-substituted bioglass is better at early times of implantation as regards the bone morphology and quality making this functionalized coatings a very promising option for implant protection and bone regeneration.
Fil: Omar, Sheila Ayelén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Repp, Felix. Institut Max Planck fuer Bioanorganische Chemie; Alemania
Fil: Desimone, Paula Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Weinkamer, Richard. Institut Max Planck fuer Bioanorganische Chemie; Alemania
Fil: Wagermaier, Wolfgang. Institut Max Planck fuer Bioanorganische Chemie; Alemania
Fil: Ceré, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Ballarre, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
description The protection of stainless-steel implants by applying a hybrid organic–inorganic coating generates a barrier for ion migration and a potential holder for functional particles. Chemical composition of bioactive silicate-glasses (BG) can be varied to tailor their rate of dissolution in the biological environment. The substitution of calcium by strontium (Sr) generates a locally-controlled release of Sr-ions to the media. Strontium is known to reduce bone resorption and stimulate bone formation. This work presents coatings made by sol–gel method containing tetraethoxysilane, methyl-triethoxysilane and silica nanoparticles as precursors, and functionalized either with BG or Sr-substituted BG particles onto surgical grade stainless steel. The coated implants were tested in vitro for corrosion resistance and bioactivity, and in vivo to analyze bone formation. The applied coating system provided an excellent protection to aggressive fluids, even after 30 days of immersion. The presence of hydroxyapatite is shown as a first evidence of bioactivity. The evaluation of in vivo tests in Wistar–Hokkaido rat femur 4 or 8 weeks after the implantation showed slight differences in the thickness of newly formed bone measured by ESEM, and remarkable changes in bone quality characterized with Raman microscopy. The in vivo response of the coatings containing Sr-substituted bioglass is better at early times of implantation as regards the bone morphology and quality making this functionalized coatings a very promising option for implant protection and bone regeneration.
publishDate 2015
dc.date.none.fl_str_mv 2015-05-23
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/30042
Omar, Sheila Ayelén; Repp, Felix; Desimone, Paula Mariela; Weinkamer, Richard; Wagermaier, Wolfgang; et al.; Sol gel hybrid coatings with strontium-doped 45S5 glass particles for enhancing the performance of stainless steel implants: Electrochemical, bioactive and in vivo response; Elsevier; Journal of Non-crystalline Solids; 425; 23-5-2015; 1-10
0022-3093
CONICET Digital
CONICET
url http://hdl.handle.net/11336/30042
identifier_str_mv Omar, Sheila Ayelén; Repp, Felix; Desimone, Paula Mariela; Weinkamer, Richard; Wagermaier, Wolfgang; et al.; Sol gel hybrid coatings with strontium-doped 45S5 glass particles for enhancing the performance of stainless steel implants: Electrochemical, bioactive and in vivo response; Elsevier; Journal of Non-crystalline Solids; 425; 23-5-2015; 1-10
0022-3093
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jnoncrysol.2015.05.024
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0022309315300442
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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