Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model

Autores
Barp, Jaqueline; Sartório, Carmem Luiza; Campos, Cristina; Llesuy, Susana Francisca; Araujo, Alex Sander; Belló Klein, Adriane
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this study was to evaluate the potential influence of endogenous ovarian hormones on cardiac oxida-tive stress in renovascular hypertension. Female Wistar rats (N = 10 per group) were divided among 4 groups: (i) normoten-sive control; (ii) hypertensive control; (iii) normotensive ovariectomized; and (iv) hypertensive ovariectomized rats. To induce hypertension, 2-kidney 1-clip (2K1C) Goldblatt's method was followed. Blood pressure (BP) was enhanced (25%) in 2K1C and it was not further altered in hypertensive ovariectomized animals. Lipid peroxidation (measured by thiobarbituric acid reactive substances; TBARS) increased in heart homogenates after ovariectomy (253%) and was additionally augmented when associated with hypertension (by 28%). Superoxide dismutase and catalase activities were similar in both hypertensive groups. Hypertension enhanced glutathione peroxidase activity (75%), but the association with ovariectomy prevented this change. Total radical trapping antioxidant potential (TRAP) decreased in hypertensive rats (34%) and was recovered when associated with ovariectomy. However, this adaptation seems not to be sufficient to avoid the increased oxidative damage in ovariectomized hypertensive animals. These results suggest a protective role for physiological ovarian hormones in the cardiac oxidative stress induced by 2K1C hypertension.
Fil: Barp, Jaqueline. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Sartório, Carmem Luiza. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Campos, Cristina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Araujo, Alex Sander. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; Brasil
Materia
2-Kidney 1-Clip
Antioxidant Enzymes
Estrogen
Heart
Ovarian Hormones
Ovariectomy
Oxidative Stress
Renovascular Hypertension
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67296
Acceder
id CONICETDig_6f1623ef05730da42d383b87e039301e
oai_identifier_str oai:ri.conicet.gov.ar:11336/67296
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension modelBarp, JaquelineSartório, Carmem LuizaCampos, CristinaLlesuy, Susana FranciscaAraujo, Alex SanderBelló Klein, Adriane2-Kidney 1-ClipAntioxidant EnzymesEstrogenHeartOvarian HormonesOvariectomyOxidative StressRenovascular Hypertensionhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The aim of this study was to evaluate the potential influence of endogenous ovarian hormones on cardiac oxida-tive stress in renovascular hypertension. Female Wistar rats (N = 10 per group) were divided among 4 groups: (i) normoten-sive control; (ii) hypertensive control; (iii) normotensive ovariectomized; and (iv) hypertensive ovariectomized rats. To induce hypertension, 2-kidney 1-clip (2K1C) Goldblatt's method was followed. Blood pressure (BP) was enhanced (25%) in 2K1C and it was not further altered in hypertensive ovariectomized animals. Lipid peroxidation (measured by thiobarbituric acid reactive substances; TBARS) increased in heart homogenates after ovariectomy (253%) and was additionally augmented when associated with hypertension (by 28%). Superoxide dismutase and catalase activities were similar in both hypertensive groups. Hypertension enhanced glutathione peroxidase activity (75%), but the association with ovariectomy prevented this change. Total radical trapping antioxidant potential (TRAP) decreased in hypertensive rats (34%) and was recovered when associated with ovariectomy. However, this adaptation seems not to be sufficient to avoid the increased oxidative damage in ovariectomized hypertensive animals. These results suggest a protective role for physiological ovarian hormones in the cardiac oxidative stress induced by 2K1C hypertension.Fil: Barp, Jaqueline. Universidade Federal do Rio Grande do Sul; BrasilFil: Sartório, Carmem Luiza. Universidade Federal do Rio Grande do Sul; BrasilFil: Campos, Cristina. Universidade Federal do Rio Grande do Sul; BrasilFil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidade Federal do Rio Grande do Sul; BrasilFil: Araujo, Alex Sander. Universidade Federal do Rio Grande do Sul; BrasilFil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; BrasilNational Research Council Canada-NRC Research Press2012-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67296Barp, Jaqueline; Sartório, Carmem Luiza; Campos, Cristina; Llesuy, Susana Francisca; Araujo, Alex Sander; et al.; Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model; National Research Council Canada-NRC Research Press; Canadian Journal Of Physiology And Pharmacology; 90; 9; 9-2012; 1229-12340008-4212CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1139/y2012-078info:eu-repo/semantics/altIdentifier/url/http://www.nrcresearchpress.com/doi/10.1139/y2012-078info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:14:49Zoai:ri.conicet.gov.ar:11336/67296instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:14:49.785CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model
title Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model
spellingShingle Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model
Barp, Jaqueline
2-Kidney 1-Clip
Antioxidant Enzymes
Estrogen
Heart
Ovarian Hormones
Ovariectomy
Oxidative Stress
Renovascular Hypertension
title_short Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model
title_full Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model
title_fullStr Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model
title_full_unstemmed Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model
title_sort Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model
dc.creator.none.fl_str_mv Barp, Jaqueline
Sartório, Carmem Luiza
Campos, Cristina
Llesuy, Susana Francisca
Araujo, Alex Sander
Belló Klein, Adriane
author Barp, Jaqueline
author_facet Barp, Jaqueline
Sartório, Carmem Luiza
Campos, Cristina
Llesuy, Susana Francisca
Araujo, Alex Sander
Belló Klein, Adriane
author_role author
author2 Sartório, Carmem Luiza
Campos, Cristina
Llesuy, Susana Francisca
Araujo, Alex Sander
Belló Klein, Adriane
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv 2-Kidney 1-Clip
Antioxidant Enzymes
Estrogen
Heart
Ovarian Hormones
Ovariectomy
Oxidative Stress
Renovascular Hypertension
topic 2-Kidney 1-Clip
Antioxidant Enzymes
Estrogen
Heart
Ovarian Hormones
Ovariectomy
Oxidative Stress
Renovascular Hypertension
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of this study was to evaluate the potential influence of endogenous ovarian hormones on cardiac oxida-tive stress in renovascular hypertension. Female Wistar rats (N = 10 per group) were divided among 4 groups: (i) normoten-sive control; (ii) hypertensive control; (iii) normotensive ovariectomized; and (iv) hypertensive ovariectomized rats. To induce hypertension, 2-kidney 1-clip (2K1C) Goldblatt's method was followed. Blood pressure (BP) was enhanced (25%) in 2K1C and it was not further altered in hypertensive ovariectomized animals. Lipid peroxidation (measured by thiobarbituric acid reactive substances; TBARS) increased in heart homogenates after ovariectomy (253%) and was additionally augmented when associated with hypertension (by 28%). Superoxide dismutase and catalase activities were similar in both hypertensive groups. Hypertension enhanced glutathione peroxidase activity (75%), but the association with ovariectomy prevented this change. Total radical trapping antioxidant potential (TRAP) decreased in hypertensive rats (34%) and was recovered when associated with ovariectomy. However, this adaptation seems not to be sufficient to avoid the increased oxidative damage in ovariectomized hypertensive animals. These results suggest a protective role for physiological ovarian hormones in the cardiac oxidative stress induced by 2K1C hypertension.
Fil: Barp, Jaqueline. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Sartório, Carmem Luiza. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Campos, Cristina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Araujo, Alex Sander. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; Brasil
description The aim of this study was to evaluate the potential influence of endogenous ovarian hormones on cardiac oxida-tive stress in renovascular hypertension. Female Wistar rats (N = 10 per group) were divided among 4 groups: (i) normoten-sive control; (ii) hypertensive control; (iii) normotensive ovariectomized; and (iv) hypertensive ovariectomized rats. To induce hypertension, 2-kidney 1-clip (2K1C) Goldblatt's method was followed. Blood pressure (BP) was enhanced (25%) in 2K1C and it was not further altered in hypertensive ovariectomized animals. Lipid peroxidation (measured by thiobarbituric acid reactive substances; TBARS) increased in heart homogenates after ovariectomy (253%) and was additionally augmented when associated with hypertension (by 28%). Superoxide dismutase and catalase activities were similar in both hypertensive groups. Hypertension enhanced glutathione peroxidase activity (75%), but the association with ovariectomy prevented this change. Total radical trapping antioxidant potential (TRAP) decreased in hypertensive rats (34%) and was recovered when associated with ovariectomy. However, this adaptation seems not to be sufficient to avoid the increased oxidative damage in ovariectomized hypertensive animals. These results suggest a protective role for physiological ovarian hormones in the cardiac oxidative stress induced by 2K1C hypertension.
publishDate 2012
dc.date.none.fl_str_mv 2012-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67296
Barp, Jaqueline; Sartório, Carmem Luiza; Campos, Cristina; Llesuy, Susana Francisca; Araujo, Alex Sander; et al.; Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model; National Research Council Canada-NRC Research Press; Canadian Journal Of Physiology And Pharmacology; 90; 9; 9-2012; 1229-1234
0008-4212
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67296
identifier_str_mv Barp, Jaqueline; Sartório, Carmem Luiza; Campos, Cristina; Llesuy, Susana Francisca; Araujo, Alex Sander; et al.; Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model; National Research Council Canada-NRC Research Press; Canadian Journal Of Physiology And Pharmacology; 90; 9; 9-2012; 1229-1234
0008-4212
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1139/y2012-078
info:eu-repo/semantics/altIdentifier/url/http://www.nrcresearchpress.com/doi/10.1139/y2012-078
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Research Council Canada-NRC Research Press
publisher.none.fl_str_mv National Research Council Canada-NRC Research Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614079699746816
score 13.070432

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