Late Fluctuations in Idiopathic Parkinson's Disease: Treatment with GM1

Autores
Dominguez, Raul Omar; Vila, José Francisco; Bianchi, Graciela Ada; Serra, Jorge Alberto; Marschoff, Enrique Ricardo
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The diagnosis and severity of Parkinson´s disease areestablished by clinical criteria. The motor manifestationspredominate while few are sensory. Initially, treatmentincludes dopaminergic drugs and/or agonists with goodresults in the first years. Later symptoms appear requiringdifferent therapeutic strategies. Here, we present the resultsof a series of patients with late fluctuations treated withmonosialo-ganglioside. Seven patients older than 70 years,treated for idiopathic Parkinson´s, presented combinedmotor and sensory fluctuations: four painful foot dystonias,one painful freezing, and two camptocormia with low backpain. After the increase in levodopa and the addition ofagonists without favorable results, gangliosides were appliedintramuscularly on alternate days, maintaining a fixed doseof levodopa and agonists, for 3 months. The Initial and finalvalues of pain, determined with the Visual Analogic Scaleand motor fluctuations with the unified Parkinson diseaserating scale and compared with the one-tailed Wilcoxonassuming the null hypothesis that the treatment was notsuccessful. In the second week of evaluation, improvementswere observed in the seven patients. The probability ofseven sucesses in seven trials under the null hypothesisis 0.0078l thus it was rejected. Dopaminergic drugs, usefulin the first years of treatment have uncertain effects on themotor and sensory fluctuations appearing later. The use ofgangliosides at this stage was useful, improving these latemanifestations, including camptocormia.
Fil: Dominguez, Raul Omar. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vila, José Francisco. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Bianchi, Graciela Ada. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Serra, Jorge Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Marschoff, Enrique Ricardo. Ministerio de Relaciones Exteriores, Comercio Interno y Culto. Dirección Nacional del Antártico. Instituto Antártico Argentino; Argentina
Materia
IDIOPATHIC PARKINSON'S
LATE FLUCTUATIONS
DYSTONIAS
FREEZING
CAMPTOCORMIA
GM1
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/227746
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/227746
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Late Fluctuations in Idiopathic Parkinson's Disease: Treatment with GM1Dominguez, Raul OmarVila, José FranciscoBianchi, Graciela AdaSerra, Jorge AlbertoMarschoff, Enrique RicardoIDIOPATHIC PARKINSON'SLATE FLUCTUATIONSDYSTONIASFREEZINGCAMPTOCORMIAGM1https://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3The diagnosis and severity of Parkinson´s disease areestablished by clinical criteria. The motor manifestationspredominate while few are sensory. Initially, treatmentincludes dopaminergic drugs and/or agonists with goodresults in the first years. Later symptoms appear requiringdifferent therapeutic strategies. Here, we present the resultsof a series of patients with late fluctuations treated withmonosialo-ganglioside. Seven patients older than 70 years,treated for idiopathic Parkinson´s, presented combinedmotor and sensory fluctuations: four painful foot dystonias,one painful freezing, and two camptocormia with low backpain. After the increase in levodopa and the addition ofagonists without favorable results, gangliosides were appliedintramuscularly on alternate days, maintaining a fixed doseof levodopa and agonists, for 3 months. The Initial and finalvalues of pain, determined with the Visual Analogic Scaleand motor fluctuations with the unified Parkinson diseaserating scale and compared with the one-tailed Wilcoxonassuming the null hypothesis that the treatment was notsuccessful. In the second week of evaluation, improvementswere observed in the seven patients. The probability ofseven sucesses in seven trials under the null hypothesisis 0.0078l thus it was rejected. Dopaminergic drugs, usefulin the first years of treatment have uncertain effects on themotor and sensory fluctuations appearing later. The use ofgangliosides at this stage was useful, improving these latemanifestations, including camptocormia.Fil: Dominguez, Raul Omar. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vila, José Francisco. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Bianchi, Graciela Ada. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Serra, Jorge Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Marschoff, Enrique Ricardo. Ministerio de Relaciones Exteriores, Comercio Interno y Culto. Dirección Nacional del Antártico. Instituto Antártico Argentino; ArgentinaClinMed International Library2023-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/227746Dominguez, Raul Omar; Vila, José Francisco; Bianchi, Graciela Ada; Serra, Jorge Alberto; Marschoff, Enrique Ricardo; Late Fluctuations in Idiopathic Parkinson's Disease: Treatment with GM1; ClinMed International Library; International Journal of Neurology and Neurotherapy; 10; 1; 6-2023; 1-42378-3001CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://clinmedjournals.org/articles/ijnn/international-journal-of-neurology-and-neurotherapy-ijnn-10-123.php?jid=ijnninfo:eu-repo/semantics/altIdentifier/doi/10.23937/2378-3001/1410123info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:47:06Zoai:ri.conicet.gov.ar:11336/227746instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:47:07.024CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Late Fluctuations in Idiopathic Parkinson's Disease: Treatment with GM1
title Late Fluctuations in Idiopathic Parkinson's Disease: Treatment with GM1
spellingShingle Late Fluctuations in Idiopathic Parkinson's Disease: Treatment with GM1
Dominguez, Raul Omar
IDIOPATHIC PARKINSON'S
LATE FLUCTUATIONS
DYSTONIAS
FREEZING
CAMPTOCORMIA
GM1
title_short Late Fluctuations in Idiopathic Parkinson's Disease: Treatment with GM1
title_full Late Fluctuations in Idiopathic Parkinson's Disease: Treatment with GM1
title_fullStr Late Fluctuations in Idiopathic Parkinson's Disease: Treatment with GM1
title_full_unstemmed Late Fluctuations in Idiopathic Parkinson's Disease: Treatment with GM1
title_sort Late Fluctuations in Idiopathic Parkinson's Disease: Treatment with GM1
dc.creator.none.fl_str_mv Dominguez, Raul Omar
Vila, José Francisco
Bianchi, Graciela Ada
Serra, Jorge Alberto
Marschoff, Enrique Ricardo
author Dominguez, Raul Omar
author_facet Dominguez, Raul Omar
Vila, José Francisco
Bianchi, Graciela Ada
Serra, Jorge Alberto
Marschoff, Enrique Ricardo
author_role author
author2 Vila, José Francisco
Bianchi, Graciela Ada
Serra, Jorge Alberto
Marschoff, Enrique Ricardo
author2_role author
author
author
author
dc.subject.none.fl_str_mv IDIOPATHIC PARKINSON'S
LATE FLUCTUATIONS
DYSTONIAS
FREEZING
CAMPTOCORMIA
GM1
topic IDIOPATHIC PARKINSON'S
LATE FLUCTUATIONS
DYSTONIAS
FREEZING
CAMPTOCORMIA
GM1
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The diagnosis and severity of Parkinson´s disease areestablished by clinical criteria. The motor manifestationspredominate while few are sensory. Initially, treatmentincludes dopaminergic drugs and/or agonists with goodresults in the first years. Later symptoms appear requiringdifferent therapeutic strategies. Here, we present the resultsof a series of patients with late fluctuations treated withmonosialo-ganglioside. Seven patients older than 70 years,treated for idiopathic Parkinson´s, presented combinedmotor and sensory fluctuations: four painful foot dystonias,one painful freezing, and two camptocormia with low backpain. After the increase in levodopa and the addition ofagonists without favorable results, gangliosides were appliedintramuscularly on alternate days, maintaining a fixed doseof levodopa and agonists, for 3 months. The Initial and finalvalues of pain, determined with the Visual Analogic Scaleand motor fluctuations with the unified Parkinson diseaserating scale and compared with the one-tailed Wilcoxonassuming the null hypothesis that the treatment was notsuccessful. In the second week of evaluation, improvementswere observed in the seven patients. The probability ofseven sucesses in seven trials under the null hypothesisis 0.0078l thus it was rejected. Dopaminergic drugs, usefulin the first years of treatment have uncertain effects on themotor and sensory fluctuations appearing later. The use ofgangliosides at this stage was useful, improving these latemanifestations, including camptocormia.
Fil: Dominguez, Raul Omar. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vila, José Francisco. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Bianchi, Graciela Ada. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Serra, Jorge Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Marschoff, Enrique Ricardo. Ministerio de Relaciones Exteriores, Comercio Interno y Culto. Dirección Nacional del Antártico. Instituto Antártico Argentino; Argentina
description The diagnosis and severity of Parkinson´s disease areestablished by clinical criteria. The motor manifestationspredominate while few are sensory. Initially, treatmentincludes dopaminergic drugs and/or agonists with goodresults in the first years. Later symptoms appear requiringdifferent therapeutic strategies. Here, we present the resultsof a series of patients with late fluctuations treated withmonosialo-ganglioside. Seven patients older than 70 years,treated for idiopathic Parkinson´s, presented combinedmotor and sensory fluctuations: four painful foot dystonias,one painful freezing, and two camptocormia with low backpain. After the increase in levodopa and the addition ofagonists without favorable results, gangliosides were appliedintramuscularly on alternate days, maintaining a fixed doseof levodopa and agonists, for 3 months. The Initial and finalvalues of pain, determined with the Visual Analogic Scaleand motor fluctuations with the unified Parkinson diseaserating scale and compared with the one-tailed Wilcoxonassuming the null hypothesis that the treatment was notsuccessful. In the second week of evaluation, improvementswere observed in the seven patients. The probability ofseven sucesses in seven trials under the null hypothesisis 0.0078l thus it was rejected. Dopaminergic drugs, usefulin the first years of treatment have uncertain effects on themotor and sensory fluctuations appearing later. The use ofgangliosides at this stage was useful, improving these latemanifestations, including camptocormia.
publishDate 2023
dc.date.none.fl_str_mv 2023-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/227746
Dominguez, Raul Omar; Vila, José Francisco; Bianchi, Graciela Ada; Serra, Jorge Alberto; Marschoff, Enrique Ricardo; Late Fluctuations in Idiopathic Parkinson's Disease: Treatment with GM1; ClinMed International Library; International Journal of Neurology and Neurotherapy; 10; 1; 6-2023; 1-4
2378-3001
CONICET Digital
CONICET
url http://hdl.handle.net/11336/227746
identifier_str_mv Dominguez, Raul Omar; Vila, José Francisco; Bianchi, Graciela Ada; Serra, Jorge Alberto; Marschoff, Enrique Ricardo; Late Fluctuations in Idiopathic Parkinson's Disease: Treatment with GM1; ClinMed International Library; International Journal of Neurology and Neurotherapy; 10; 1; 6-2023; 1-4
2378-3001
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://clinmedjournals.org/articles/ijnn/international-journal-of-neurology-and-neurotherapy-ijnn-10-123.php?jid=ijnn
info:eu-repo/semantics/altIdentifier/doi/10.23937/2378-3001/1410123
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv ClinMed International Library
publisher.none.fl_str_mv ClinMed International Library
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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