Actigraphic evaluation of motor fluctuations in patients with Parkinson's disease

Autores
Pérez Lloret, Santiago; Rossi, Malco Damián; Cardinali, Daniel Pedro; Merello, Marcelo Jorge
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: There is growing interest in developing inexpensive and objective motor fluctuation evaluation methods for Parkinson's disease (PD). Objectives: We aim to compare activity level in the off state, on state, and dyskinetic periods as evaluated either by a physician during a levodopa challenge or by a 72-hr onoff diary self-evaluation in the ambulatory setting. Finally, the effect of daily activities on motor activity in PD and healthy controls was further explored. Methods: The study was conducted in three consecutive phases. For phase I, in which the on state, off state, and dyskinesia were evaluated using actigraphy, recordings were made during standard acute levodopa challenge in nine dyskinetic PD patients. For phase II, a different set of 16 dyskinetic PD patients was monitored in the ambulatory setting for 72 consecutive hours by actigraphy and a standardized onoff diary. For phase III, 62 PD patients and 14 age- and sex-matched healthy controls wore an actigraph and completed a daily activities diary for 7 days. Results: No differences in activity level between on state and off state during the acute levodopa challenge (phase I) or the 72-hr ambulatory period (phase II) were found. Activity during dyskinesia periods was significantly higher than during on state periods without dyskinesia (p < .01). During the third phase, dyskinetic PD patients and healthy controls showed higher actigraphy-measured activity as compared to de novo, stable, or fluctuating PD (p < .0001), which remained unaltered by daily activities performed during the study period. Tremor UPDRS scores did not correlate with activity level. Conclusions: These results confirm the lack of specificity of simple wrist-worn actigraphy and further suggest it may be suitable for dyskinesia assessment but not for on state and off state evaluation. Copyright © 2010 Informa Healthcare USA, Inc.
Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Rossi, Malco Damián. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Merello, Marcelo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina
Materia
Actigraphy
Dyskinesia
Motor Fluctuations
Parkinson'S Disease
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/53664

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network_name_str CONICET Digital (CONICET)
spelling Actigraphic evaluation of motor fluctuations in patients with Parkinson's diseasePérez Lloret, SantiagoRossi, Malco DamiánCardinali, Daniel PedroMerello, Marcelo JorgeActigraphyDyskinesiaMotor FluctuationsParkinson'S Diseasehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: There is growing interest in developing inexpensive and objective motor fluctuation evaluation methods for Parkinson's disease (PD). Objectives: We aim to compare activity level in the off state, on state, and dyskinetic periods as evaluated either by a physician during a levodopa challenge or by a 72-hr onoff diary self-evaluation in the ambulatory setting. Finally, the effect of daily activities on motor activity in PD and healthy controls was further explored. Methods: The study was conducted in three consecutive phases. For phase I, in which the on state, off state, and dyskinesia were evaluated using actigraphy, recordings were made during standard acute levodopa challenge in nine dyskinetic PD patients. For phase II, a different set of 16 dyskinetic PD patients was monitored in the ambulatory setting for 72 consecutive hours by actigraphy and a standardized onoff diary. For phase III, 62 PD patients and 14 age- and sex-matched healthy controls wore an actigraph and completed a daily activities diary for 7 days. Results: No differences in activity level between on state and off state during the acute levodopa challenge (phase I) or the 72-hr ambulatory period (phase II) were found. Activity during dyskinesia periods was significantly higher than during on state periods without dyskinesia (p < .01). During the third phase, dyskinetic PD patients and healthy controls showed higher actigraphy-measured activity as compared to de novo, stable, or fluctuating PD (p < .0001), which remained unaltered by daily activities performed during the study period. Tremor UPDRS scores did not correlate with activity level. Conclusions: These results confirm the lack of specificity of simple wrist-worn actigraphy and further suggest it may be suitable for dyskinesia assessment but not for on state and off state evaluation. Copyright © 2010 Informa Healthcare USA, Inc.Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Rossi, Malco Damián. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Merello, Marcelo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; ArgentinaTaylor & Francis Ltd2010-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/53664Pérez Lloret, Santiago; Rossi, Malco Damián; Cardinali, Daniel Pedro; Merello, Marcelo Jorge; Actigraphic evaluation of motor fluctuations in patients with Parkinson's disease; Taylor & Francis Ltd; The International Journal Of Neuroscience.; 120; 2; 2-2010; 137-1430020-7454CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3109/00207450903139663info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.3109/00207450903139663?journalCode=ines20info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:34:03Zoai:ri.conicet.gov.ar:11336/53664instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:34:03.431CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Actigraphic evaluation of motor fluctuations in patients with Parkinson's disease
title Actigraphic evaluation of motor fluctuations in patients with Parkinson's disease
spellingShingle Actigraphic evaluation of motor fluctuations in patients with Parkinson's disease
Pérez Lloret, Santiago
Actigraphy
Dyskinesia
Motor Fluctuations
Parkinson'S Disease
title_short Actigraphic evaluation of motor fluctuations in patients with Parkinson's disease
title_full Actigraphic evaluation of motor fluctuations in patients with Parkinson's disease
title_fullStr Actigraphic evaluation of motor fluctuations in patients with Parkinson's disease
title_full_unstemmed Actigraphic evaluation of motor fluctuations in patients with Parkinson's disease
title_sort Actigraphic evaluation of motor fluctuations in patients with Parkinson's disease
dc.creator.none.fl_str_mv Pérez Lloret, Santiago
Rossi, Malco Damián
Cardinali, Daniel Pedro
Merello, Marcelo Jorge
author Pérez Lloret, Santiago
author_facet Pérez Lloret, Santiago
Rossi, Malco Damián
Cardinali, Daniel Pedro
Merello, Marcelo Jorge
author_role author
author2 Rossi, Malco Damián
Cardinali, Daniel Pedro
Merello, Marcelo Jorge
author2_role author
author
author
dc.subject.none.fl_str_mv Actigraphy
Dyskinesia
Motor Fluctuations
Parkinson'S Disease
topic Actigraphy
Dyskinesia
Motor Fluctuations
Parkinson'S Disease
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: There is growing interest in developing inexpensive and objective motor fluctuation evaluation methods for Parkinson's disease (PD). Objectives: We aim to compare activity level in the off state, on state, and dyskinetic periods as evaluated either by a physician during a levodopa challenge or by a 72-hr onoff diary self-evaluation in the ambulatory setting. Finally, the effect of daily activities on motor activity in PD and healthy controls was further explored. Methods: The study was conducted in three consecutive phases. For phase I, in which the on state, off state, and dyskinesia were evaluated using actigraphy, recordings were made during standard acute levodopa challenge in nine dyskinetic PD patients. For phase II, a different set of 16 dyskinetic PD patients was monitored in the ambulatory setting for 72 consecutive hours by actigraphy and a standardized onoff diary. For phase III, 62 PD patients and 14 age- and sex-matched healthy controls wore an actigraph and completed a daily activities diary for 7 days. Results: No differences in activity level between on state and off state during the acute levodopa challenge (phase I) or the 72-hr ambulatory period (phase II) were found. Activity during dyskinesia periods was significantly higher than during on state periods without dyskinesia (p < .01). During the third phase, dyskinetic PD patients and healthy controls showed higher actigraphy-measured activity as compared to de novo, stable, or fluctuating PD (p < .0001), which remained unaltered by daily activities performed during the study period. Tremor UPDRS scores did not correlate with activity level. Conclusions: These results confirm the lack of specificity of simple wrist-worn actigraphy and further suggest it may be suitable for dyskinesia assessment but not for on state and off state evaluation. Copyright © 2010 Informa Healthcare USA, Inc.
Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Rossi, Malco Damián. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Merello, Marcelo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina
description Background: There is growing interest in developing inexpensive and objective motor fluctuation evaluation methods for Parkinson's disease (PD). Objectives: We aim to compare activity level in the off state, on state, and dyskinetic periods as evaluated either by a physician during a levodopa challenge or by a 72-hr onoff diary self-evaluation in the ambulatory setting. Finally, the effect of daily activities on motor activity in PD and healthy controls was further explored. Methods: The study was conducted in three consecutive phases. For phase I, in which the on state, off state, and dyskinesia were evaluated using actigraphy, recordings were made during standard acute levodopa challenge in nine dyskinetic PD patients. For phase II, a different set of 16 dyskinetic PD patients was monitored in the ambulatory setting for 72 consecutive hours by actigraphy and a standardized onoff diary. For phase III, 62 PD patients and 14 age- and sex-matched healthy controls wore an actigraph and completed a daily activities diary for 7 days. Results: No differences in activity level between on state and off state during the acute levodopa challenge (phase I) or the 72-hr ambulatory period (phase II) were found. Activity during dyskinesia periods was significantly higher than during on state periods without dyskinesia (p < .01). During the third phase, dyskinetic PD patients and healthy controls showed higher actigraphy-measured activity as compared to de novo, stable, or fluctuating PD (p < .0001), which remained unaltered by daily activities performed during the study period. Tremor UPDRS scores did not correlate with activity level. Conclusions: These results confirm the lack of specificity of simple wrist-worn actigraphy and further suggest it may be suitable for dyskinesia assessment but not for on state and off state evaluation. Copyright © 2010 Informa Healthcare USA, Inc.
publishDate 2010
dc.date.none.fl_str_mv 2010-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/53664
Pérez Lloret, Santiago; Rossi, Malco Damián; Cardinali, Daniel Pedro; Merello, Marcelo Jorge; Actigraphic evaluation of motor fluctuations in patients with Parkinson's disease; Taylor & Francis Ltd; The International Journal Of Neuroscience.; 120; 2; 2-2010; 137-143
0020-7454
CONICET Digital
CONICET
url http://hdl.handle.net/11336/53664
identifier_str_mv Pérez Lloret, Santiago; Rossi, Malco Damián; Cardinali, Daniel Pedro; Merello, Marcelo Jorge; Actigraphic evaluation of motor fluctuations in patients with Parkinson's disease; Taylor & Francis Ltd; The International Journal Of Neuroscience.; 120; 2; 2-2010; 137-143
0020-7454
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3109/00207450903139663
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.3109/00207450903139663?journalCode=ines20
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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