Histidine-rich glycoprotein and idiopathic pulmonary fibrosis

Autores
Ernst, G.; Dantas, Ezequiel Carlos; Sabatte, Juan Atilio; Caro, F.; Salvado, A.; Grynblat Pipman, Luciana; Geffner, Jorge Raúl
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Histidine-rich glycoprotein (HRG) is an enigmatic glycoprotein able to interact with a variety of ligands such as IgG, complement components, heparan sulfate, thrombospondin, fibrinogen and plasminogen. HRG is present at high concentrations in plasma and there is evidence indicating that it is able to modulate the course of biological processes such as angiogenesis, fibroblast proliferation, complement activation, coagulation and fibrinolysis. Because these processes are involved in the pathogeneses of lung fibrosis we here analyzed a possible link between HRG and idiopathic pulmonary fibrosis (IPF). We found that plasma concentrations of HRG are significantly diminished in IPF patients compared to healthy subjects. Moreover, we found a positive correlation between HRG plasma levels and forced vital capacity (FVC) values, suggesting that plasma concentration of HRG would be a useful indicator of disease activity in IPF. HRG has been described as a negative acute phase reactant able to accumulate at sites of tissue injury. Hence, we also measured the concentrations of HRG in BAL samples from IPF patients. We found that the concentrations of HRG in samples from IPF patients were significantly higher compared to controls, suggesting that the reduced concentration of HRG in plasma from IPF patients could be due, at least in part, to an enhanced uptake of this protein in the lung.
Fil: Ernst, G.. Ciudad Autónoma de Buenos Aires. María Ferrer; Argentina. Hospital Británico de Buenos Aires; Argentina
Fil: Dantas, Ezequiel Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Sabatte, Juan Atilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Caro, F.. Ciudad Autónoma de Buenos Aires. María Ferrer; Argentina
Fil: Salvado, A.. Hospital Británico de Buenos Aires; Argentina
Fil: Grynblat Pipman, Luciana. Ciudad Autónoma de Buenos Aires. María Ferrer; Argentina
Fil: Geffner, Jorge Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Materia
Bal
Forced Vital Capacity
Histidine-Rich Glycoprotein
Idiopathic Pulmonary Fibrosis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38859
Acceder
id CONICETDig_27386e8043845ba6095cff444693f24b
oai_identifier_str oai:ri.conicet.gov.ar:11336/38859
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Histidine-rich glycoprotein and idiopathic pulmonary fibrosisErnst, G.Dantas, Ezequiel CarlosSabatte, Juan AtilioCaro, F.Salvado, A.Grynblat Pipman, LucianaGeffner, Jorge RaúlBalForced Vital CapacityHistidine-Rich GlycoproteinIdiopathic Pulmonary Fibrosishttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Histidine-rich glycoprotein (HRG) is an enigmatic glycoprotein able to interact with a variety of ligands such as IgG, complement components, heparan sulfate, thrombospondin, fibrinogen and plasminogen. HRG is present at high concentrations in plasma and there is evidence indicating that it is able to modulate the course of biological processes such as angiogenesis, fibroblast proliferation, complement activation, coagulation and fibrinolysis. Because these processes are involved in the pathogeneses of lung fibrosis we here analyzed a possible link between HRG and idiopathic pulmonary fibrosis (IPF). We found that plasma concentrations of HRG are significantly diminished in IPF patients compared to healthy subjects. Moreover, we found a positive correlation between HRG plasma levels and forced vital capacity (FVC) values, suggesting that plasma concentration of HRG would be a useful indicator of disease activity in IPF. HRG has been described as a negative acute phase reactant able to accumulate at sites of tissue injury. Hence, we also measured the concentrations of HRG in BAL samples from IPF patients. We found that the concentrations of HRG in samples from IPF patients were significantly higher compared to controls, suggesting that the reduced concentration of HRG in plasma from IPF patients could be due, at least in part, to an enhanced uptake of this protein in the lung.Fil: Ernst, G.. Ciudad Autónoma de Buenos Aires. María Ferrer; Argentina. Hospital Británico de Buenos Aires; ArgentinaFil: Dantas, Ezequiel Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Sabatte, Juan Atilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Caro, F.. Ciudad Autónoma de Buenos Aires. María Ferrer; ArgentinaFil: Salvado, A.. Hospital Británico de Buenos Aires; ArgentinaFil: Grynblat Pipman, Luciana. Ciudad Autónoma de Buenos Aires. María Ferrer; ArgentinaFil: Geffner, Jorge Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaW B Saunders Co Ltd2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38859Ernst, G.; Dantas, Ezequiel Carlos; Sabatte, Juan Atilio; Caro, F.; Salvado, A.; et al.; Histidine-rich glycoprotein and idiopathic pulmonary fibrosis; W B Saunders Co Ltd; Respiratory Medicine.; 109; 12; 12-2015; 1589-15910954-6111CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.rmed.2015.10.010info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0954611115300743info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:30Zoai:ri.conicet.gov.ar:11336/38859instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:30.448CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Histidine-rich glycoprotein and idiopathic pulmonary fibrosis
title Histidine-rich glycoprotein and idiopathic pulmonary fibrosis
spellingShingle Histidine-rich glycoprotein and idiopathic pulmonary fibrosis
Ernst, G.
Bal
Forced Vital Capacity
Histidine-Rich Glycoprotein
Idiopathic Pulmonary Fibrosis
title_short Histidine-rich glycoprotein and idiopathic pulmonary fibrosis
title_full Histidine-rich glycoprotein and idiopathic pulmonary fibrosis
title_fullStr Histidine-rich glycoprotein and idiopathic pulmonary fibrosis
title_full_unstemmed Histidine-rich glycoprotein and idiopathic pulmonary fibrosis
title_sort Histidine-rich glycoprotein and idiopathic pulmonary fibrosis
dc.creator.none.fl_str_mv Ernst, G.
Dantas, Ezequiel Carlos
Sabatte, Juan Atilio
Caro, F.
Salvado, A.
Grynblat Pipman, Luciana
Geffner, Jorge Raúl
author Ernst, G.
author_facet Ernst, G.
Dantas, Ezequiel Carlos
Sabatte, Juan Atilio
Caro, F.
Salvado, A.
Grynblat Pipman, Luciana
Geffner, Jorge Raúl
author_role author
author2 Dantas, Ezequiel Carlos
Sabatte, Juan Atilio
Caro, F.
Salvado, A.
Grynblat Pipman, Luciana
Geffner, Jorge Raúl
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Bal
Forced Vital Capacity
Histidine-Rich Glycoprotein
Idiopathic Pulmonary Fibrosis
topic Bal
Forced Vital Capacity
Histidine-Rich Glycoprotein
Idiopathic Pulmonary Fibrosis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Histidine-rich glycoprotein (HRG) is an enigmatic glycoprotein able to interact with a variety of ligands such as IgG, complement components, heparan sulfate, thrombospondin, fibrinogen and plasminogen. HRG is present at high concentrations in plasma and there is evidence indicating that it is able to modulate the course of biological processes such as angiogenesis, fibroblast proliferation, complement activation, coagulation and fibrinolysis. Because these processes are involved in the pathogeneses of lung fibrosis we here analyzed a possible link between HRG and idiopathic pulmonary fibrosis (IPF). We found that plasma concentrations of HRG are significantly diminished in IPF patients compared to healthy subjects. Moreover, we found a positive correlation between HRG plasma levels and forced vital capacity (FVC) values, suggesting that plasma concentration of HRG would be a useful indicator of disease activity in IPF. HRG has been described as a negative acute phase reactant able to accumulate at sites of tissue injury. Hence, we also measured the concentrations of HRG in BAL samples from IPF patients. We found that the concentrations of HRG in samples from IPF patients were significantly higher compared to controls, suggesting that the reduced concentration of HRG in plasma from IPF patients could be due, at least in part, to an enhanced uptake of this protein in the lung.
Fil: Ernst, G.. Ciudad Autónoma de Buenos Aires. María Ferrer; Argentina. Hospital Británico de Buenos Aires; Argentina
Fil: Dantas, Ezequiel Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Sabatte, Juan Atilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Caro, F.. Ciudad Autónoma de Buenos Aires. María Ferrer; Argentina
Fil: Salvado, A.. Hospital Británico de Buenos Aires; Argentina
Fil: Grynblat Pipman, Luciana. Ciudad Autónoma de Buenos Aires. María Ferrer; Argentina
Fil: Geffner, Jorge Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
description Histidine-rich glycoprotein (HRG) is an enigmatic glycoprotein able to interact with a variety of ligands such as IgG, complement components, heparan sulfate, thrombospondin, fibrinogen and plasminogen. HRG is present at high concentrations in plasma and there is evidence indicating that it is able to modulate the course of biological processes such as angiogenesis, fibroblast proliferation, complement activation, coagulation and fibrinolysis. Because these processes are involved in the pathogeneses of lung fibrosis we here analyzed a possible link between HRG and idiopathic pulmonary fibrosis (IPF). We found that plasma concentrations of HRG are significantly diminished in IPF patients compared to healthy subjects. Moreover, we found a positive correlation between HRG plasma levels and forced vital capacity (FVC) values, suggesting that plasma concentration of HRG would be a useful indicator of disease activity in IPF. HRG has been described as a negative acute phase reactant able to accumulate at sites of tissue injury. Hence, we also measured the concentrations of HRG in BAL samples from IPF patients. We found that the concentrations of HRG in samples from IPF patients were significantly higher compared to controls, suggesting that the reduced concentration of HRG in plasma from IPF patients could be due, at least in part, to an enhanced uptake of this protein in the lung.
publishDate 2015
dc.date.none.fl_str_mv 2015-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38859
Ernst, G.; Dantas, Ezequiel Carlos; Sabatte, Juan Atilio; Caro, F.; Salvado, A.; et al.; Histidine-rich glycoprotein and idiopathic pulmonary fibrosis; W B Saunders Co Ltd; Respiratory Medicine.; 109; 12; 12-2015; 1589-1591
0954-6111
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38859
identifier_str_mv Ernst, G.; Dantas, Ezequiel Carlos; Sabatte, Juan Atilio; Caro, F.; Salvado, A.; et al.; Histidine-rich glycoprotein and idiopathic pulmonary fibrosis; W B Saunders Co Ltd; Respiratory Medicine.; 109; 12; 12-2015; 1589-1591
0954-6111
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.rmed.2015.10.010
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0954611115300743
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv W B Saunders Co Ltd
publisher.none.fl_str_mv W B Saunders Co Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270083607429120
score 13.13397

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