Apomorphine for the treatment of refractory motor fluctuations in late stage Parkinson's disease : an old drug revisited

Autores
Pérez Lloret, Santiago
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión enviada
Descripción
Fil: Pérez Lloret, Santiago. Hospital Universitario de Toulouse. Departamento de Farmacología Clínica; Francia
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Laboratorio de Farmacología Clínica y Epidemiología; Argentina
Abstract: pomorphine is the oldest dopaminergic agent and was initially known for its emetic properties. Although Weill suggested using it to treat Parkinson’s disease (PD) in 1884, evidence about its antiparkinsonian efficacy was provided initially by Schwab and colleagues in 1951 and then by Cotzias and co-workers in 1970. Subcutaneous injection of the drug displayed potent but short-live antiparkinsonian effects usually at the expense of vomiting and postural hypotension. These limitations coupled with the advent of orally-active dopamine receptor agonists led to a waning in the interest in the drug...
Fuente
Preprint del documento publicado en European Journal of Neurology, 2013
Materia
APOMORFINA
TRATAMIENTO
ENFERMEDAD DE PARKINSON
ENFERMEDADES NEUROGENERATIVAS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/1635
Acceder
id RIUCA_8edeb5cf4a360a9c7593f002136a983f
oai_identifier_str oai:ucacris:123456789/1635
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Apomorphine for the treatment of refractory motor fluctuations in late stage Parkinson's disease : an old drug revisitedPérez Lloret, SantiagoAPOMORFINATRATAMIENTOENFERMEDAD DE PARKINSONENFERMEDADES NEUROGENERATIVASFil: Pérez Lloret, Santiago. Hospital Universitario de Toulouse. Departamento de Farmacología Clínica; FranciaFil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Laboratorio de Farmacología Clínica y Epidemiología; ArgentinaAbstract: pomorphine is the oldest dopaminergic agent and was initially known for its emetic properties. Although Weill suggested using it to treat Parkinson’s disease (PD) in 1884, evidence about its antiparkinsonian efficacy was provided initially by Schwab and colleagues in 1951 and then by Cotzias and co-workers in 1970. Subcutaneous injection of the drug displayed potent but short-live antiparkinsonian effects usually at the expense of vomiting and postural hypotension. These limitations coupled with the advent of orally-active dopamine receptor agonists led to a waning in the interest in the drug...2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/16351468-1331 (online)1351-5101 (impreso)10.1111/ene.12113Pérez Lloret, S. Apomorphine for the treatment of refractory motor fluctuations in late stage Parkinson's disease : an old drug revisited [en línea]. Preprint del documento publicado en European Journal of Neurology. 2013. doi:10.1111/ene.12113. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1635Preprint del documento publicado en European Journal of Neurology, 2013reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaengenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:55:21Zoai:ucacris:123456789/1635instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:55:21.806Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Apomorphine for the treatment of refractory motor fluctuations in late stage Parkinson's disease : an old drug revisited
title Apomorphine for the treatment of refractory motor fluctuations in late stage Parkinson's disease : an old drug revisited
spellingShingle Apomorphine for the treatment of refractory motor fluctuations in late stage Parkinson's disease : an old drug revisited
Pérez Lloret, Santiago
APOMORFINA
TRATAMIENTO
ENFERMEDAD DE PARKINSON
ENFERMEDADES NEUROGENERATIVAS
title_short Apomorphine for the treatment of refractory motor fluctuations in late stage Parkinson's disease : an old drug revisited
title_full Apomorphine for the treatment of refractory motor fluctuations in late stage Parkinson's disease : an old drug revisited
title_fullStr Apomorphine for the treatment of refractory motor fluctuations in late stage Parkinson's disease : an old drug revisited
title_full_unstemmed Apomorphine for the treatment of refractory motor fluctuations in late stage Parkinson's disease : an old drug revisited
title_sort Apomorphine for the treatment of refractory motor fluctuations in late stage Parkinson's disease : an old drug revisited
dc.creator.none.fl_str_mv Pérez Lloret, Santiago
author Pérez Lloret, Santiago
author_facet Pérez Lloret, Santiago
author_role author
dc.subject.none.fl_str_mv APOMORFINA
TRATAMIENTO
ENFERMEDAD DE PARKINSON
ENFERMEDADES NEUROGENERATIVAS
topic APOMORFINA
TRATAMIENTO
ENFERMEDAD DE PARKINSON
ENFERMEDADES NEUROGENERATIVAS
dc.description.none.fl_txt_mv Fil: Pérez Lloret, Santiago. Hospital Universitario de Toulouse. Departamento de Farmacología Clínica; Francia
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Laboratorio de Farmacología Clínica y Epidemiología; Argentina
Abstract: pomorphine is the oldest dopaminergic agent and was initially known for its emetic properties. Although Weill suggested using it to treat Parkinson’s disease (PD) in 1884, evidence about its antiparkinsonian efficacy was provided initially by Schwab and colleagues in 1951 and then by Cotzias and co-workers in 1970. Subcutaneous injection of the drug displayed potent but short-live antiparkinsonian effects usually at the expense of vomiting and postural hypotension. These limitations coupled with the advent of orally-active dopamine receptor agonists led to a waning in the interest in the drug...
description Fil: Pérez Lloret, Santiago. Hospital Universitario de Toulouse. Departamento de Farmacología Clínica; Francia
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/1635
1468-1331 (online)
1351-5101 (impreso)
10.1111/ene.12113
Pérez Lloret, S. Apomorphine for the treatment of refractory motor fluctuations in late stage Parkinson's disease : an old drug revisited [en línea]. Preprint del documento publicado en European Journal of Neurology. 2013. doi:10.1111/ene.12113. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1635
url https://repositorio.uca.edu.ar/handle/123456789/1635
identifier_str_mv 1468-1331 (online)
1351-5101 (impreso)
10.1111/ene.12113
Pérez Lloret, S. Apomorphine for the treatment of refractory motor fluctuations in late stage Parkinson's disease : an old drug revisited [en línea]. Preprint del documento publicado en European Journal of Neurology. 2013. doi:10.1111/ene.12113. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1635
dc.language.none.fl_str_mv eng
eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Preprint del documento publicado en European Journal of Neurology, 2013
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.13397

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