Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action

Autores
Susperreguy, Sebastian; Muñoz, Liliana; Tkalenko, Natalia Y.; Mascanfroni, Ivan Darío; Alamino, Vanina Alejandra; Montesinos, Maria del Mar; Masini, Ana María; Miras, Mirta Beatriz; Pellizas, Claudia Gabriela
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Idiopathic short stature (ISS) describes short children with normal GH secretion. Although GH treatment increases their heights, growth response to the therapy differs among patients. Thyroid hormones (TH) are essential for longitudinal growth acting mainly through TH receptors (TR) α and β. We have previously reported that GH treatment reduced peripheral TH action in Turner Syndrome by TR down-regulation. The aims of the study were to assess the effect of GH treatment to ISS on peripheral TH action and the correlation between thyroid status and growth response to the therapy. SUBJECTS, DESIGN AND MEASUREMENTS: Eighteen normal (control) and twenty-five ISS children were enrolled and evaluated before and after 12 months of life time (control) or 12 months of GH therapy (ISS). Fasting blood was used for serum biochemical evaluations, peripheral blood mononuclear cells for TR mRNA determination by QRT-PCR and growth parameters by standard methods.
Fil: Susperreguy, Sebastian. Universidad Nacional de Córdoba; Argentina
Fil: Muñoz, Liliana. Hospital de Niños de la Santísima Trinidad; Argentina
Fil: Tkalenko, Natalia Y.. Hospital de Niños de la Santísima Trinidad; Argentina
Fil: Mascanfroni, Ivan Darío. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Alamino, Vanina Alejandra. Universidad Nacional de Córdoba; Argentina
Fil: Montesinos, Maria del Mar. Universidad Nacional de Córdoba; Argentina
Fil: Masini, Ana María. Universidad Nacional de Córdoba; Argentina
Fil: Miras, Mirta Beatriz. Hospital de Niños de la Santísima Trinidad; Argentina
Fil: Pellizas, Claudia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Materia
Growth Hormone Therapy
Idiopathic Short Stature
Thyroid Hormone Receptor
Thyroid Hormone Action
Growth Hormone Therapy
Idiopathic Short Stature
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/84567
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone actionSusperreguy, SebastianMuñoz, LilianaTkalenko, Natalia Y.Mascanfroni, Ivan DaríoAlamino, Vanina AlejandraMontesinos, Maria del MarMasini, Ana MaríaMiras, Mirta BeatrizPellizas, Claudia GabrielaGrowth Hormone TherapyIdiopathic Short StatureThyroid Hormone ReceptorThyroid Hormone ActionGrowth Hormone TherapyIdiopathic Short Staturehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Idiopathic short stature (ISS) describes short children with normal GH secretion. Although GH treatment increases their heights, growth response to the therapy differs among patients. Thyroid hormones (TH) are essential for longitudinal growth acting mainly through TH receptors (TR) α and β. We have previously reported that GH treatment reduced peripheral TH action in Turner Syndrome by TR down-regulation. The aims of the study were to assess the effect of GH treatment to ISS on peripheral TH action and the correlation between thyroid status and growth response to the therapy. SUBJECTS, DESIGN AND MEASUREMENTS: Eighteen normal (control) and twenty-five ISS children were enrolled and evaluated before and after 12 months of life time (control) or 12 months of GH therapy (ISS). Fasting blood was used for serum biochemical evaluations, peripheral blood mononuclear cells for TR mRNA determination by QRT-PCR and growth parameters by standard methods.Fil: Susperreguy, Sebastian. Universidad Nacional de Córdoba; ArgentinaFil: Muñoz, Liliana. Hospital de Niños de la Santísima Trinidad; ArgentinaFil: Tkalenko, Natalia Y.. Hospital de Niños de la Santísima Trinidad; ArgentinaFil: Mascanfroni, Ivan Darío. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Alamino, Vanina Alejandra. Universidad Nacional de Córdoba; ArgentinaFil: Montesinos, Maria del Mar. Universidad Nacional de Córdoba; ArgentinaFil: Masini, Ana María. Universidad Nacional de Córdoba; ArgentinaFil: Miras, Mirta Beatriz. Hospital de Niños de la Santísima Trinidad; ArgentinaFil: Pellizas, Claudia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaWiley Blackwell Publishing, Inc2011-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/84567Susperreguy, Sebastian; Muñoz, Liliana; Tkalenko, Natalia Y.; Mascanfroni, Ivan Darío; Alamino, Vanina Alejandra; et al.; Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action; Wiley Blackwell Publishing, Inc; Clinical Endocrinology; 74; 3; 3-2011; 346-3530300-0664CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2010.03924.x/citedbyinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2265.2010.03924.xinfo:eu-repo/semantics/altIdentifier/pmid/https://www.ncbi.nlm.nih.gov/pubmed/21091751info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:17:54Zoai:ri.conicet.gov.ar:11336/84567instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:17:55.122CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action
title Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action
spellingShingle Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action
Susperreguy, Sebastian
Growth Hormone Therapy
Idiopathic Short Stature
Thyroid Hormone Receptor
Thyroid Hormone Action
Growth Hormone Therapy
Idiopathic Short Stature
title_short Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action
title_full Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action
title_fullStr Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action
title_full_unstemmed Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action
title_sort Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action
dc.creator.none.fl_str_mv Susperreguy, Sebastian
Muñoz, Liliana
Tkalenko, Natalia Y.
Mascanfroni, Ivan Darío
Alamino, Vanina Alejandra
Montesinos, Maria del Mar
Masini, Ana María
Miras, Mirta Beatriz
Pellizas, Claudia Gabriela
author Susperreguy, Sebastian
author_facet Susperreguy, Sebastian
Muñoz, Liliana
Tkalenko, Natalia Y.
Mascanfroni, Ivan Darío
Alamino, Vanina Alejandra
Montesinos, Maria del Mar
Masini, Ana María
Miras, Mirta Beatriz
Pellizas, Claudia Gabriela
author_role author
author2 Muñoz, Liliana
Tkalenko, Natalia Y.
Mascanfroni, Ivan Darío
Alamino, Vanina Alejandra
Montesinos, Maria del Mar
Masini, Ana María
Miras, Mirta Beatriz
Pellizas, Claudia Gabriela
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Growth Hormone Therapy
Idiopathic Short Stature
Thyroid Hormone Receptor
Thyroid Hormone Action
Growth Hormone Therapy
Idiopathic Short Stature
topic Growth Hormone Therapy
Idiopathic Short Stature
Thyroid Hormone Receptor
Thyroid Hormone Action
Growth Hormone Therapy
Idiopathic Short Stature
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Idiopathic short stature (ISS) describes short children with normal GH secretion. Although GH treatment increases their heights, growth response to the therapy differs among patients. Thyroid hormones (TH) are essential for longitudinal growth acting mainly through TH receptors (TR) α and β. We have previously reported that GH treatment reduced peripheral TH action in Turner Syndrome by TR down-regulation. The aims of the study were to assess the effect of GH treatment to ISS on peripheral TH action and the correlation between thyroid status and growth response to the therapy. SUBJECTS, DESIGN AND MEASUREMENTS: Eighteen normal (control) and twenty-five ISS children were enrolled and evaluated before and after 12 months of life time (control) or 12 months of GH therapy (ISS). Fasting blood was used for serum biochemical evaluations, peripheral blood mononuclear cells for TR mRNA determination by QRT-PCR and growth parameters by standard methods.
Fil: Susperreguy, Sebastian. Universidad Nacional de Córdoba; Argentina
Fil: Muñoz, Liliana. Hospital de Niños de la Santísima Trinidad; Argentina
Fil: Tkalenko, Natalia Y.. Hospital de Niños de la Santísima Trinidad; Argentina
Fil: Mascanfroni, Ivan Darío. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Alamino, Vanina Alejandra. Universidad Nacional de Córdoba; Argentina
Fil: Montesinos, Maria del Mar. Universidad Nacional de Córdoba; Argentina
Fil: Masini, Ana María. Universidad Nacional de Córdoba; Argentina
Fil: Miras, Mirta Beatriz. Hospital de Niños de la Santísima Trinidad; Argentina
Fil: Pellizas, Claudia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
description Idiopathic short stature (ISS) describes short children with normal GH secretion. Although GH treatment increases their heights, growth response to the therapy differs among patients. Thyroid hormones (TH) are essential for longitudinal growth acting mainly through TH receptors (TR) α and β. We have previously reported that GH treatment reduced peripheral TH action in Turner Syndrome by TR down-regulation. The aims of the study were to assess the effect of GH treatment to ISS on peripheral TH action and the correlation between thyroid status and growth response to the therapy. SUBJECTS, DESIGN AND MEASUREMENTS: Eighteen normal (control) and twenty-five ISS children were enrolled and evaluated before and after 12 months of life time (control) or 12 months of GH therapy (ISS). Fasting blood was used for serum biochemical evaluations, peripheral blood mononuclear cells for TR mRNA determination by QRT-PCR and growth parameters by standard methods.
publishDate 2011
dc.date.none.fl_str_mv 2011-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/84567
Susperreguy, Sebastian; Muñoz, Liliana; Tkalenko, Natalia Y.; Mascanfroni, Ivan Darío; Alamino, Vanina Alejandra; et al.; Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action; Wiley Blackwell Publishing, Inc; Clinical Endocrinology; 74; 3; 3-2011; 346-353
0300-0664
CONICET Digital
CONICET
url http://hdl.handle.net/11336/84567
identifier_str_mv Susperreguy, Sebastian; Muñoz, Liliana; Tkalenko, Natalia Y.; Mascanfroni, Ivan Darío; Alamino, Vanina Alejandra; et al.; Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action; Wiley Blackwell Publishing, Inc; Clinical Endocrinology; 74; 3; 3-2011; 346-353
0300-0664
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2010.03924.x/citedby
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2265.2010.03924.x
info:eu-repo/semantics/altIdentifier/pmid/https://www.ncbi.nlm.nih.gov/pubmed/21091751
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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