Study of heart rate variability in healthy humans as a function of age: considerations on the contribution of the autonomic nervous system and the role of the sinoatrial node

Autores
Jorge Tasé, David Alejandro; Garavaglia, Leopoldo; Defeo, Magdalena Maria; Irurzun, Isabel Maria
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: This study focused on the complex structure of heart rate variability (HRV) in the healthy heart. We studied the behavior of the heart rate variability (HRV) in healthy humans as a function of age from conception, including fetal data. We calculated statistical quantities such as the mean value of RR intervals (), the standard deviation of these intervals (SD), the power of the very low frequency (VLF), low frequency (LF) and high frequency (HF) bands, and the large-scale properties of HRV. We rationalized our findings discussing previous results that identify the signatures of the sinoatrial node (SAN) and the autonomic nervous system (ANS) in the HRV. This work provides further insights into the contribution of the SAN and the ANS to the cardiac rhythm in humans.Methods: We analyzed a total of 205 HRV time series of healthy subjects. Of these time series, 195 correspond to born individuals aged between 1 month and 74 years, 50% females. The remaining ten time series correspond to healthy fetuses. The age was expressed in weeks, including gestational age to avoid finite size effects due to rounding errors. We included results previously reported in the literature.Results and discussion: followed a power law with age from gestation and throughout life. The scale factor was 0.15 ± 0.01. SD evolved during pregnancy and underwent a sudden change at birth. From birth to puberty SD followed a scale behavior with age and a scale factor equal to 0.37 ± 0.04. The power spectrum density (PSD) was calculated as a function of age. We calculated the power of the VLF, LF, and HF bands. The HF/VLF ratio followed a power law with age, and the scale factor was −0.55 ± 0.06. The power spectrum was calculated, and we analyzed the effect of age on the scale behavior. Both the scale factor and the frequency range in which it was determined depended on age. scale behavior began at low frequencies and evolved from 1/f2-like behavior to 1/f-like behavior during pregnancy. After birth, 1/f behavior extended to occupy the entire frequency range in the puberty. With aging, the frequency range regressed again toward lower frequencies. The results demonstrated that the complex structure of HRV primarily reflects the structural complexity of the SAN, which continuously evolves from the fifth month of gestation and increases until reaching its peak at puberty. There is a white noise component in HRV that can be attributed to the ANS. Therefore, the SAN, structurally evolving from its appearance in the fifth month of gestation and throughout life, could be responsible for modulating the neuronal stimulation provided by the ANS.
Fil: Jorge Tasé, David Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Simulación Computacional para Aplicaciones Tecnológicas; Argentina
Fil: Garavaglia, Leopoldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; Argentina
Fil: Defeo, Magdalena Maria. Gobierno de la Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos "prof. Dr. Rodolfo Rossi".; Argentina
Fil: Irurzun, Isabel Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Simulación Computacional para Aplicaciones Tecnológicas; Argentina
Materia
HEART
VARIABILITY
NERVOUS
SINOATRIAL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/270831

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network_name_str CONICET Digital (CONICET)
spelling Study of heart rate variability in healthy humans as a function of age: considerations on the contribution of the autonomic nervous system and the role of the sinoatrial nodeJorge Tasé, David AlejandroGaravaglia, LeopoldoDefeo, Magdalena MariaIrurzun, Isabel MariaHEARTVARIABILITYNERVOUSSINOATRIALhttps://purl.org/becyt/ford/2.6https://purl.org/becyt/ford/2Introduction: This study focused on the complex structure of heart rate variability (HRV) in the healthy heart. We studied the behavior of the heart rate variability (HRV) in healthy humans as a function of age from conception, including fetal data. We calculated statistical quantities such as the mean value of RR intervals (), the standard deviation of these intervals (SD), the power of the very low frequency (VLF), low frequency (LF) and high frequency (HF) bands, and the large-scale properties of HRV. We rationalized our findings discussing previous results that identify the signatures of the sinoatrial node (SAN) and the autonomic nervous system (ANS) in the HRV. This work provides further insights into the contribution of the SAN and the ANS to the cardiac rhythm in humans.Methods: We analyzed a total of 205 HRV time series of healthy subjects. Of these time series, 195 correspond to born individuals aged between 1 month and 74 years, 50% females. The remaining ten time series correspond to healthy fetuses. The age was expressed in weeks, including gestational age to avoid finite size effects due to rounding errors. We included results previously reported in the literature.Results and discussion: followed a power law with age from gestation and throughout life. The scale factor was 0.15 ± 0.01. SD evolved during pregnancy and underwent a sudden change at birth. From birth to puberty SD followed a scale behavior with age and a scale factor equal to 0.37 ± 0.04. The power spectrum density (PSD) was calculated as a function of age. We calculated the power of the VLF, LF, and HF bands. The HF/VLF ratio followed a power law with age, and the scale factor was −0.55 ± 0.06. The power spectrum was calculated, and we analyzed the effect of age on the scale behavior. Both the scale factor and the frequency range in which it was determined depended on age. scale behavior began at low frequencies and evolved from 1/f2-like behavior to 1/f-like behavior during pregnancy. After birth, 1/f behavior extended to occupy the entire frequency range in the puberty. With aging, the frequency range regressed again toward lower frequencies. The results demonstrated that the complex structure of HRV primarily reflects the structural complexity of the SAN, which continuously evolves from the fifth month of gestation and increases until reaching its peak at puberty. There is a white noise component in HRV that can be attributed to the ANS. Therefore, the SAN, structurally evolving from its appearance in the fifth month of gestation and throughout life, could be responsible for modulating the neuronal stimulation provided by the ANS.Fil: Jorge Tasé, David Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Simulación Computacional para Aplicaciones Tecnológicas; ArgentinaFil: Garavaglia, Leopoldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; ArgentinaFil: Defeo, Magdalena Maria. Gobierno de la Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos "prof. Dr. Rodolfo Rossi".; ArgentinaFil: Irurzun, Isabel Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Simulación Computacional para Aplicaciones Tecnológicas; ArgentinaFrontiers Media2025-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/270831Jorge Tasé, David Alejandro; Garavaglia, Leopoldo; Defeo, Magdalena Maria; Irurzun, Isabel Maria; Study of heart rate variability in healthy humans as a function of age: considerations on the contribution of the autonomic nervous system and the role of the sinoatrial node; Frontiers Media; Frontiers in Medicine; 12; 8-2025; 1-92296-858XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmed.2025.1597299/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fmed.2025.1597299info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:43:54Zoai:ri.conicet.gov.ar:11336/270831instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:43:54.427CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Study of heart rate variability in healthy humans as a function of age: considerations on the contribution of the autonomic nervous system and the role of the sinoatrial node
title Study of heart rate variability in healthy humans as a function of age: considerations on the contribution of the autonomic nervous system and the role of the sinoatrial node
spellingShingle Study of heart rate variability in healthy humans as a function of age: considerations on the contribution of the autonomic nervous system and the role of the sinoatrial node
Jorge Tasé, David Alejandro
HEART
VARIABILITY
NERVOUS
SINOATRIAL
title_short Study of heart rate variability in healthy humans as a function of age: considerations on the contribution of the autonomic nervous system and the role of the sinoatrial node
title_full Study of heart rate variability in healthy humans as a function of age: considerations on the contribution of the autonomic nervous system and the role of the sinoatrial node
title_fullStr Study of heart rate variability in healthy humans as a function of age: considerations on the contribution of the autonomic nervous system and the role of the sinoatrial node
title_full_unstemmed Study of heart rate variability in healthy humans as a function of age: considerations on the contribution of the autonomic nervous system and the role of the sinoatrial node
title_sort Study of heart rate variability in healthy humans as a function of age: considerations on the contribution of the autonomic nervous system and the role of the sinoatrial node
dc.creator.none.fl_str_mv Jorge Tasé, David Alejandro
Garavaglia, Leopoldo
Defeo, Magdalena Maria
Irurzun, Isabel Maria
author Jorge Tasé, David Alejandro
author_facet Jorge Tasé, David Alejandro
Garavaglia, Leopoldo
Defeo, Magdalena Maria
Irurzun, Isabel Maria
author_role author
author2 Garavaglia, Leopoldo
Defeo, Magdalena Maria
Irurzun, Isabel Maria
author2_role author
author
author
dc.subject.none.fl_str_mv HEART
VARIABILITY
NERVOUS
SINOATRIAL
topic HEART
VARIABILITY
NERVOUS
SINOATRIAL
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.6
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Introduction: This study focused on the complex structure of heart rate variability (HRV) in the healthy heart. We studied the behavior of the heart rate variability (HRV) in healthy humans as a function of age from conception, including fetal data. We calculated statistical quantities such as the mean value of RR intervals (), the standard deviation of these intervals (SD), the power of the very low frequency (VLF), low frequency (LF) and high frequency (HF) bands, and the large-scale properties of HRV. We rationalized our findings discussing previous results that identify the signatures of the sinoatrial node (SAN) and the autonomic nervous system (ANS) in the HRV. This work provides further insights into the contribution of the SAN and the ANS to the cardiac rhythm in humans.Methods: We analyzed a total of 205 HRV time series of healthy subjects. Of these time series, 195 correspond to born individuals aged between 1 month and 74 years, 50% females. The remaining ten time series correspond to healthy fetuses. The age was expressed in weeks, including gestational age to avoid finite size effects due to rounding errors. We included results previously reported in the literature.Results and discussion: followed a power law with age from gestation and throughout life. The scale factor was 0.15 ± 0.01. SD evolved during pregnancy and underwent a sudden change at birth. From birth to puberty SD followed a scale behavior with age and a scale factor equal to 0.37 ± 0.04. The power spectrum density (PSD) was calculated as a function of age. We calculated the power of the VLF, LF, and HF bands. The HF/VLF ratio followed a power law with age, and the scale factor was −0.55 ± 0.06. The power spectrum was calculated, and we analyzed the effect of age on the scale behavior. Both the scale factor and the frequency range in which it was determined depended on age. scale behavior began at low frequencies and evolved from 1/f2-like behavior to 1/f-like behavior during pregnancy. After birth, 1/f behavior extended to occupy the entire frequency range in the puberty. With aging, the frequency range regressed again toward lower frequencies. The results demonstrated that the complex structure of HRV primarily reflects the structural complexity of the SAN, which continuously evolves from the fifth month of gestation and increases until reaching its peak at puberty. There is a white noise component in HRV that can be attributed to the ANS. Therefore, the SAN, structurally evolving from its appearance in the fifth month of gestation and throughout life, could be responsible for modulating the neuronal stimulation provided by the ANS.
Fil: Jorge Tasé, David Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Simulación Computacional para Aplicaciones Tecnológicas; Argentina
Fil: Garavaglia, Leopoldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; Argentina
Fil: Defeo, Magdalena Maria. Gobierno de la Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos "prof. Dr. Rodolfo Rossi".; Argentina
Fil: Irurzun, Isabel Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Simulación Computacional para Aplicaciones Tecnológicas; Argentina
description Introduction: This study focused on the complex structure of heart rate variability (HRV) in the healthy heart. We studied the behavior of the heart rate variability (HRV) in healthy humans as a function of age from conception, including fetal data. We calculated statistical quantities such as the mean value of RR intervals (), the standard deviation of these intervals (SD), the power of the very low frequency (VLF), low frequency (LF) and high frequency (HF) bands, and the large-scale properties of HRV. We rationalized our findings discussing previous results that identify the signatures of the sinoatrial node (SAN) and the autonomic nervous system (ANS) in the HRV. This work provides further insights into the contribution of the SAN and the ANS to the cardiac rhythm in humans.Methods: We analyzed a total of 205 HRV time series of healthy subjects. Of these time series, 195 correspond to born individuals aged between 1 month and 74 years, 50% females. The remaining ten time series correspond to healthy fetuses. The age was expressed in weeks, including gestational age to avoid finite size effects due to rounding errors. We included results previously reported in the literature.Results and discussion: followed a power law with age from gestation and throughout life. The scale factor was 0.15 ± 0.01. SD evolved during pregnancy and underwent a sudden change at birth. From birth to puberty SD followed a scale behavior with age and a scale factor equal to 0.37 ± 0.04. The power spectrum density (PSD) was calculated as a function of age. We calculated the power of the VLF, LF, and HF bands. The HF/VLF ratio followed a power law with age, and the scale factor was −0.55 ± 0.06. The power spectrum was calculated, and we analyzed the effect of age on the scale behavior. Both the scale factor and the frequency range in which it was determined depended on age. scale behavior began at low frequencies and evolved from 1/f2-like behavior to 1/f-like behavior during pregnancy. After birth, 1/f behavior extended to occupy the entire frequency range in the puberty. With aging, the frequency range regressed again toward lower frequencies. The results demonstrated that the complex structure of HRV primarily reflects the structural complexity of the SAN, which continuously evolves from the fifth month of gestation and increases until reaching its peak at puberty. There is a white noise component in HRV that can be attributed to the ANS. Therefore, the SAN, structurally evolving from its appearance in the fifth month of gestation and throughout life, could be responsible for modulating the neuronal stimulation provided by the ANS.
publishDate 2025
dc.date.none.fl_str_mv 2025-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/270831
Jorge Tasé, David Alejandro; Garavaglia, Leopoldo; Defeo, Magdalena Maria; Irurzun, Isabel Maria; Study of heart rate variability in healthy humans as a function of age: considerations on the contribution of the autonomic nervous system and the role of the sinoatrial node; Frontiers Media; Frontiers in Medicine; 12; 8-2025; 1-9
2296-858X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/270831
identifier_str_mv Jorge Tasé, David Alejandro; Garavaglia, Leopoldo; Defeo, Magdalena Maria; Irurzun, Isabel Maria; Study of heart rate variability in healthy humans as a function of age: considerations on the contribution of the autonomic nervous system and the role of the sinoatrial node; Frontiers Media; Frontiers in Medicine; 12; 8-2025; 1-9
2296-858X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmed.2025.1597299/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fmed.2025.1597299
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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