Revealing alterations in heart rate fluctuations during the progression of Chagas disease

Autores
Defeo, Magdalena Maria; Delaplace, Laura Andrea; Goin, Juan Carlos; Tersigni, Carina Laura; Garavaglia, Leopoldo; Irurzun, Isabel Maria
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: The heart rate variability (HRV) continually evolves throughout life,reflecting modifications in the architecture of the sinoatrial node (SAN) and inthe regulation of heart rate by the autonomic nervous system (ANS). Both canbe considerably aected by Chagas disease, causing important changes in thecomplex nature of HRV. We aim to evaluate the ability of an index based on thefalse nearest neighbors method (FN10) to reflect these changes during diseaseprogression.Methods: We perform a retrospective, descriptive, and cross-sectional studyanalyzing HRV time series of participants with Chagas disease. We determine thedependence of FN10 on age and sex in a healthy population, and then evaluateFN10 in individuals with Chagas disease.Results and discussion: In the healthy population, FN10 has a scaling behaviorwith age, which is independent of sex. In Chagas disease, some individualsshow FN10 values significantly above those seen in the healthy population. Werelate the findings to the pathophysiological mechanisms that determine theprogression of the disease. The results indicate that FN10 may be a candidateprognostic biomarker for heart disease
Fil: Defeo, Magdalena Maria. Gobierno de la Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos "prof. Dr. Rodolfo Rossi".; Argentina
Fil: Delaplace, Laura Andrea. Universidad Nacional de la Plata. Facultad de Cs.exactas. Laboratorio de Salud Publica.;
Fil: Goin, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Tersigni, Carina Laura. Universidad Nacional de la Plata. Facultad de Cs.exactas. Laboratorio de Salud Publica.;
Fil: Garavaglia, Leopoldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; Argentina
Fil: Irurzun, Isabel Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Simulación Computacional para Aplicaciones Tecnológicas; Argentina
Materia
CHAGAS DISEASE
HEART RATE VARIABILITY
SINOATRIAL NODE
AUTONOMIC NERVOUS SYSTEM
FIBROSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/261000
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/261000
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Revealing alterations in heart rate fluctuations during the progression of Chagas diseaseDefeo, Magdalena MariaDelaplace, Laura AndreaGoin, Juan CarlosTersigni, Carina LauraGaravaglia, LeopoldoIrurzun, Isabel MariaCHAGAS DISEASEHEART RATE VARIABILITYSINOATRIAL NODEAUTONOMIC NERVOUS SYSTEMFIBROSIShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction: The heart rate variability (HRV) continually evolves throughout life,reflecting modifications in the architecture of the sinoatrial node (SAN) and inthe regulation of heart rate by the autonomic nervous system (ANS). Both canbe considerably aected by Chagas disease, causing important changes in thecomplex nature of HRV. We aim to evaluate the ability of an index based on thefalse nearest neighbors method (FN10) to reflect these changes during diseaseprogression.Methods: We perform a retrospective, descriptive, and cross-sectional studyanalyzing HRV time series of participants with Chagas disease. We determine thedependence of FN10 on age and sex in a healthy population, and then evaluateFN10 in individuals with Chagas disease.Results and discussion: In the healthy population, FN10 has a scaling behaviorwith age, which is independent of sex. In Chagas disease, some individualsshow FN10 values significantly above those seen in the healthy population. Werelate the findings to the pathophysiological mechanisms that determine theprogression of the disease. The results indicate that FN10 may be a candidateprognostic biomarker for heart diseaseFil: Defeo, Magdalena Maria. Gobierno de la Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos "prof. Dr. Rodolfo Rossi".; ArgentinaFil: Delaplace, Laura Andrea. Universidad Nacional de la Plata. Facultad de Cs.exactas. Laboratorio de Salud Publica.;Fil: Goin, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Tersigni, Carina Laura. Universidad Nacional de la Plata. Facultad de Cs.exactas. Laboratorio de Salud Publica.;Fil: Garavaglia, Leopoldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; ArgentinaFil: Irurzun, Isabel Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Simulación Computacional para Aplicaciones Tecnológicas; ArgentinaFrontiers Media2024-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/261000Defeo, Magdalena Maria; Delaplace, Laura Andrea; Goin, Juan Carlos; Tersigni, Carina Laura; Garavaglia, Leopoldo; et al.; Revealing alterations in heart rate fluctuations during the progression of Chagas disease; Frontiers Media; Frontiers in Medicine; 11; 9-2024; 1-82296-858XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmed.2024.1438077/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fmed.2024.1438077info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:41Zoai:ri.conicet.gov.ar:11336/261000instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:41.556CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Revealing alterations in heart rate fluctuations during the progression of Chagas disease
title Revealing alterations in heart rate fluctuations during the progression of Chagas disease
spellingShingle Revealing alterations in heart rate fluctuations during the progression of Chagas disease
Defeo, Magdalena Maria
CHAGAS DISEASE
HEART RATE VARIABILITY
SINOATRIAL NODE
AUTONOMIC NERVOUS SYSTEM
FIBROSIS
title_short Revealing alterations in heart rate fluctuations during the progression of Chagas disease
title_full Revealing alterations in heart rate fluctuations during the progression of Chagas disease
title_fullStr Revealing alterations in heart rate fluctuations during the progression of Chagas disease
title_full_unstemmed Revealing alterations in heart rate fluctuations during the progression of Chagas disease
title_sort Revealing alterations in heart rate fluctuations during the progression of Chagas disease
dc.creator.none.fl_str_mv Defeo, Magdalena Maria
Delaplace, Laura Andrea
Goin, Juan Carlos
Tersigni, Carina Laura
Garavaglia, Leopoldo
Irurzun, Isabel Maria
author Defeo, Magdalena Maria
author_facet Defeo, Magdalena Maria
Delaplace, Laura Andrea
Goin, Juan Carlos
Tersigni, Carina Laura
Garavaglia, Leopoldo
Irurzun, Isabel Maria
author_role author
author2 Delaplace, Laura Andrea
Goin, Juan Carlos
Tersigni, Carina Laura
Garavaglia, Leopoldo
Irurzun, Isabel Maria
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CHAGAS DISEASE
HEART RATE VARIABILITY
SINOATRIAL NODE
AUTONOMIC NERVOUS SYSTEM
FIBROSIS
topic CHAGAS DISEASE
HEART RATE VARIABILITY
SINOATRIAL NODE
AUTONOMIC NERVOUS SYSTEM
FIBROSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: The heart rate variability (HRV) continually evolves throughout life,reflecting modifications in the architecture of the sinoatrial node (SAN) and inthe regulation of heart rate by the autonomic nervous system (ANS). Both canbe considerably aected by Chagas disease, causing important changes in thecomplex nature of HRV. We aim to evaluate the ability of an index based on thefalse nearest neighbors method (FN10) to reflect these changes during diseaseprogression.Methods: We perform a retrospective, descriptive, and cross-sectional studyanalyzing HRV time series of participants with Chagas disease. We determine thedependence of FN10 on age and sex in a healthy population, and then evaluateFN10 in individuals with Chagas disease.Results and discussion: In the healthy population, FN10 has a scaling behaviorwith age, which is independent of sex. In Chagas disease, some individualsshow FN10 values significantly above those seen in the healthy population. Werelate the findings to the pathophysiological mechanisms that determine theprogression of the disease. The results indicate that FN10 may be a candidateprognostic biomarker for heart disease
Fil: Defeo, Magdalena Maria. Gobierno de la Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos "prof. Dr. Rodolfo Rossi".; Argentina
Fil: Delaplace, Laura Andrea. Universidad Nacional de la Plata. Facultad de Cs.exactas. Laboratorio de Salud Publica.;
Fil: Goin, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Tersigni, Carina Laura. Universidad Nacional de la Plata. Facultad de Cs.exactas. Laboratorio de Salud Publica.;
Fil: Garavaglia, Leopoldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; Argentina
Fil: Irurzun, Isabel Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Simulación Computacional para Aplicaciones Tecnológicas; Argentina
description Introduction: The heart rate variability (HRV) continually evolves throughout life,reflecting modifications in the architecture of the sinoatrial node (SAN) and inthe regulation of heart rate by the autonomic nervous system (ANS). Both canbe considerably aected by Chagas disease, causing important changes in thecomplex nature of HRV. We aim to evaluate the ability of an index based on thefalse nearest neighbors method (FN10) to reflect these changes during diseaseprogression.Methods: We perform a retrospective, descriptive, and cross-sectional studyanalyzing HRV time series of participants with Chagas disease. We determine thedependence of FN10 on age and sex in a healthy population, and then evaluateFN10 in individuals with Chagas disease.Results and discussion: In the healthy population, FN10 has a scaling behaviorwith age, which is independent of sex. In Chagas disease, some individualsshow FN10 values significantly above those seen in the healthy population. Werelate the findings to the pathophysiological mechanisms that determine theprogression of the disease. The results indicate that FN10 may be a candidateprognostic biomarker for heart disease
publishDate 2024
dc.date.none.fl_str_mv 2024-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/261000
Defeo, Magdalena Maria; Delaplace, Laura Andrea; Goin, Juan Carlos; Tersigni, Carina Laura; Garavaglia, Leopoldo; et al.; Revealing alterations in heart rate fluctuations during the progression of Chagas disease; Frontiers Media; Frontiers in Medicine; 11; 9-2024; 1-8
2296-858X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/261000
identifier_str_mv Defeo, Magdalena Maria; Delaplace, Laura Andrea; Goin, Juan Carlos; Tersigni, Carina Laura; Garavaglia, Leopoldo; et al.; Revealing alterations in heart rate fluctuations during the progression of Chagas disease; Frontiers Media; Frontiers in Medicine; 11; 9-2024; 1-8
2296-858X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmed.2024.1438077/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fmed.2024.1438077
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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