The Mauthner-cell circuit of fish as a model system for startle plasticity

Autores
Medan, Violeta; Preuss, Thomas
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The Mauthner-cell (M-cell) system of teleost fish has a long history as an experimental model for addressing a wide range of neurobiological questions. Principles derived from studies on this system have contributed significantly to our understanding at multiple levels, from mechanisms of synaptic transmission and synaptic plasticity to the concepts of a decision neuron that initiates key aspects of the startle behavior. Here we will review recent work that focuses on the neurophysiological and neuropharmacological basis for modifications in the M-cell circuit. After summarizing the main excitatory and inhibitory inputs to the M-cell, we review experiments showing startle response modulation by temperature, social status, and sensory filtering. Although very different in nature, actions of these three sources of modulation converge in the M-cell network. Mechanisms of modulation include altering the excitability of the M-cell itself as well as changes in excitatory and inhibitor drive, highlighting the role of balanced excitation and inhibition for escape decisions. One of the most extensively studied forms of startle plasticity in vertebrates is prepulse inhibition (PPI), a sensorimotor gating phenomenon, which is impaired in several information processing disorders. Finally, we review recent work in the M-cell system which focuses on the cellular mechanisms of PPI and its modulation by serotonin and dopamine.
Fil: Medan, Violeta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Preuss, Thomas. City University Of New York. Hunter College; Estados Unidos
Materia
DOPAMINE
MAUTHNER CELL
PREPULSE INHIBITION
SEROTONIN
SOCIAL STATUS
STARTLE RESPONSE
TEMPERATURE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/84949
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The Mauthner-cell circuit of fish as a model system for startle plasticityMedan, VioletaPreuss, ThomasDOPAMINEMAUTHNER CELLPREPULSE INHIBITIONSEROTONINSOCIAL STATUSSTARTLE RESPONSETEMPERATUREhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The Mauthner-cell (M-cell) system of teleost fish has a long history as an experimental model for addressing a wide range of neurobiological questions. Principles derived from studies on this system have contributed significantly to our understanding at multiple levels, from mechanisms of synaptic transmission and synaptic plasticity to the concepts of a decision neuron that initiates key aspects of the startle behavior. Here we will review recent work that focuses on the neurophysiological and neuropharmacological basis for modifications in the M-cell circuit. After summarizing the main excitatory and inhibitory inputs to the M-cell, we review experiments showing startle response modulation by temperature, social status, and sensory filtering. Although very different in nature, actions of these three sources of modulation converge in the M-cell network. Mechanisms of modulation include altering the excitability of the M-cell itself as well as changes in excitatory and inhibitor drive, highlighting the role of balanced excitation and inhibition for escape decisions. One of the most extensively studied forms of startle plasticity in vertebrates is prepulse inhibition (PPI), a sensorimotor gating phenomenon, which is impaired in several information processing disorders. Finally, we review recent work in the M-cell system which focuses on the cellular mechanisms of PPI and its modulation by serotonin and dopamine.Fil: Medan, Violeta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Preuss, Thomas. City University Of New York. Hunter College; Estados UnidosElsevier2014-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/84949Medan, Violeta; Preuss, Thomas; The Mauthner-cell circuit of fish as a model system for startle plasticity; Elsevier; Journal of Physiology; 108; 2-3; 4-2014; 129-1400928-4257CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jphysparis.2014.07.006info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0928425714000333info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:12:03Zoai:ri.conicet.gov.ar:11336/84949instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:12:03.655CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Mauthner-cell circuit of fish as a model system for startle plasticity
title The Mauthner-cell circuit of fish as a model system for startle plasticity
spellingShingle The Mauthner-cell circuit of fish as a model system for startle plasticity
Medan, Violeta
DOPAMINE
MAUTHNER CELL
PREPULSE INHIBITION
SEROTONIN
SOCIAL STATUS
STARTLE RESPONSE
TEMPERATURE
title_short The Mauthner-cell circuit of fish as a model system for startle plasticity
title_full The Mauthner-cell circuit of fish as a model system for startle plasticity
title_fullStr The Mauthner-cell circuit of fish as a model system for startle plasticity
title_full_unstemmed The Mauthner-cell circuit of fish as a model system for startle plasticity
title_sort The Mauthner-cell circuit of fish as a model system for startle plasticity
dc.creator.none.fl_str_mv Medan, Violeta
Preuss, Thomas
author Medan, Violeta
author_facet Medan, Violeta
Preuss, Thomas
author_role author
author2 Preuss, Thomas
author2_role author
dc.subject.none.fl_str_mv DOPAMINE
MAUTHNER CELL
PREPULSE INHIBITION
SEROTONIN
SOCIAL STATUS
STARTLE RESPONSE
TEMPERATURE
topic DOPAMINE
MAUTHNER CELL
PREPULSE INHIBITION
SEROTONIN
SOCIAL STATUS
STARTLE RESPONSE
TEMPERATURE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The Mauthner-cell (M-cell) system of teleost fish has a long history as an experimental model for addressing a wide range of neurobiological questions. Principles derived from studies on this system have contributed significantly to our understanding at multiple levels, from mechanisms of synaptic transmission and synaptic plasticity to the concepts of a decision neuron that initiates key aspects of the startle behavior. Here we will review recent work that focuses on the neurophysiological and neuropharmacological basis for modifications in the M-cell circuit. After summarizing the main excitatory and inhibitory inputs to the M-cell, we review experiments showing startle response modulation by temperature, social status, and sensory filtering. Although very different in nature, actions of these three sources of modulation converge in the M-cell network. Mechanisms of modulation include altering the excitability of the M-cell itself as well as changes in excitatory and inhibitor drive, highlighting the role of balanced excitation and inhibition for escape decisions. One of the most extensively studied forms of startle plasticity in vertebrates is prepulse inhibition (PPI), a sensorimotor gating phenomenon, which is impaired in several information processing disorders. Finally, we review recent work in the M-cell system which focuses on the cellular mechanisms of PPI and its modulation by serotonin and dopamine.
Fil: Medan, Violeta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Preuss, Thomas. City University Of New York. Hunter College; Estados Unidos
description The Mauthner-cell (M-cell) system of teleost fish has a long history as an experimental model for addressing a wide range of neurobiological questions. Principles derived from studies on this system have contributed significantly to our understanding at multiple levels, from mechanisms of synaptic transmission and synaptic plasticity to the concepts of a decision neuron that initiates key aspects of the startle behavior. Here we will review recent work that focuses on the neurophysiological and neuropharmacological basis for modifications in the M-cell circuit. After summarizing the main excitatory and inhibitory inputs to the M-cell, we review experiments showing startle response modulation by temperature, social status, and sensory filtering. Although very different in nature, actions of these three sources of modulation converge in the M-cell network. Mechanisms of modulation include altering the excitability of the M-cell itself as well as changes in excitatory and inhibitor drive, highlighting the role of balanced excitation and inhibition for escape decisions. One of the most extensively studied forms of startle plasticity in vertebrates is prepulse inhibition (PPI), a sensorimotor gating phenomenon, which is impaired in several information processing disorders. Finally, we review recent work in the M-cell system which focuses on the cellular mechanisms of PPI and its modulation by serotonin and dopamine.
publishDate 2014
dc.date.none.fl_str_mv 2014-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/84949
Medan, Violeta; Preuss, Thomas; The Mauthner-cell circuit of fish as a model system for startle plasticity; Elsevier; Journal of Physiology; 108; 2-3; 4-2014; 129-140
0928-4257
CONICET Digital
CONICET
url http://hdl.handle.net/11336/84949
identifier_str_mv Medan, Violeta; Preuss, Thomas; The Mauthner-cell circuit of fish as a model system for startle plasticity; Elsevier; Journal of Physiology; 108; 2-3; 4-2014; 129-140
0928-4257
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jphysparis.2014.07.006
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0928425714000333
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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