Prepulse inhibition predicts working memory performance while startle habituation predicts spatial reference memory retention in C57BL/6 mice

Autores
Singer, Phillipp; Hauser, Jonas; Lopez Llano, Luis; Peleg Raibstein, Daria; Feldon, Joram; Gargiulo, Pascual Angel; Yee, Benjamin K.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Prepulse inhibition (PPI) of the acoustic startle reflex refers to the attenuation of the startle response to an intense pulse stimulus when it is shortly preceded by a weak non-startling prepulse stimulus. It is a well-established high-throughput translational measure of pre-attentive sensory gating, and its impairment is detected in several neuropsychiatric diseases including schizophrenia. It has been hypothesized that PPI might be associated with, or predictive of, cognitive deficiency in such diseases, and therefore provide an efficient assay for screening drugs with potential pro-cognitive efficacy. Free from any predetermined disease models, the present study evaluated in a homogeneous cohort of inbred C57BL/6 mice the presence of a statistical link between PPI expression and cognitive performance. Performance indices in a spatial reference memory test and a working memory test conducted in the Morris water maze, and contextual fear conditioning were correlated against pre-existing baseline PPI expression. A specific correlative link between working memory and PPI induced by weak (but not strong) prepulse was revealed. In addition, a correlation between habituation of the startle reflex and reference memory was identified for the first time: a stronger overt habituation effect was associated with superior spatial search accuracy. The PPI paradigm thus provides two independent predictors of dissociable cognitive traits in normal C57BL/6 mice; and they might serve as potential markers for high-throughput evaluation of potential cognitive enhancers, especially in the context of schizophrenia where deficits in startle habituation and PPI co-exist.
Fil: Singer, Phillipp. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; Suiza
Fil: Hauser, Jonas. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; Suiza
Fil: Lopez Llano, Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Peleg Raibstein, Daria. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; Suiza
Fil: Feldon, Joram. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; Suiza
Fil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Yee, Benjamin K.. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; Suiza
Materia
Pre-Pulse
Inhibition
Cognition
Schizophrenia
Correlation
Individual Difference
Learning
Prepulse Inhibition
Sensorinotor Gating
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/18163
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/18163
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Prepulse inhibition predicts working memory performance while startle habituation predicts spatial reference memory retention in C57BL/6 miceSinger, PhillippHauser, JonasLopez Llano, LuisPeleg Raibstein, DariaFeldon, JoramGargiulo, Pascual AngelYee, Benjamin K.Pre-PulseInhibitionCognitionSchizophreniaCorrelationIndividual DifferenceLearningPrepulse InhibitionSensorinotor Gatinghttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Prepulse inhibition (PPI) of the acoustic startle reflex refers to the attenuation of the startle response to an intense pulse stimulus when it is shortly preceded by a weak non-startling prepulse stimulus. It is a well-established high-throughput translational measure of pre-attentive sensory gating, and its impairment is detected in several neuropsychiatric diseases including schizophrenia. It has been hypothesized that PPI might be associated with, or predictive of, cognitive deficiency in such diseases, and therefore provide an efficient assay for screening drugs with potential pro-cognitive efficacy. Free from any predetermined disease models, the present study evaluated in a homogeneous cohort of inbred C57BL/6 mice the presence of a statistical link between PPI expression and cognitive performance. Performance indices in a spatial reference memory test and a working memory test conducted in the Morris water maze, and contextual fear conditioning were correlated against pre-existing baseline PPI expression. A specific correlative link between working memory and PPI induced by weak (but not strong) prepulse was revealed. In addition, a correlation between habituation of the startle reflex and reference memory was identified for the first time: a stronger overt habituation effect was associated with superior spatial search accuracy. The PPI paradigm thus provides two independent predictors of dissociable cognitive traits in normal C57BL/6 mice; and they might serve as potential markers for high-throughput evaluation of potential cognitive enhancers, especially in the context of schizophrenia where deficits in startle habituation and PPI co-exist.Fil: Singer, Phillipp. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; SuizaFil: Hauser, Jonas. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; SuizaFil: Lopez Llano, Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaFil: Peleg Raibstein, Daria. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; SuizaFil: Feldon, Joram. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; SuizaFil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaFil: Yee, Benjamin K.. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; SuizaElsevier Science2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/18163Singer, Phillipp; Hauser, Jonas; Lopez Llano, Luis; Peleg Raibstein, Daria; Feldon, Joram; et al.; Prepulse inhibition predicts working memory performance while startle habituation predicts spatial reference memory retention in C57BL/6 mice; Elsevier Science; Behavioural Brain Research; 242; 1-2013; 166-1770166-4328CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2012.12.011info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0166432812007930info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:13:08Zoai:ri.conicet.gov.ar:11336/18163instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:13:08.577CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Prepulse inhibition predicts working memory performance while startle habituation predicts spatial reference memory retention in C57BL/6 mice
title Prepulse inhibition predicts working memory performance while startle habituation predicts spatial reference memory retention in C57BL/6 mice
spellingShingle Prepulse inhibition predicts working memory performance while startle habituation predicts spatial reference memory retention in C57BL/6 mice
Singer, Phillipp
Pre-Pulse
Inhibition
Cognition
Schizophrenia
Correlation
Individual Difference
Learning
Prepulse Inhibition
Sensorinotor Gating
title_short Prepulse inhibition predicts working memory performance while startle habituation predicts spatial reference memory retention in C57BL/6 mice
title_full Prepulse inhibition predicts working memory performance while startle habituation predicts spatial reference memory retention in C57BL/6 mice
title_fullStr Prepulse inhibition predicts working memory performance while startle habituation predicts spatial reference memory retention in C57BL/6 mice
title_full_unstemmed Prepulse inhibition predicts working memory performance while startle habituation predicts spatial reference memory retention in C57BL/6 mice
title_sort Prepulse inhibition predicts working memory performance while startle habituation predicts spatial reference memory retention in C57BL/6 mice
dc.creator.none.fl_str_mv Singer, Phillipp
Hauser, Jonas
Lopez Llano, Luis
Peleg Raibstein, Daria
Feldon, Joram
Gargiulo, Pascual Angel
Yee, Benjamin K.
author Singer, Phillipp
author_facet Singer, Phillipp
Hauser, Jonas
Lopez Llano, Luis
Peleg Raibstein, Daria
Feldon, Joram
Gargiulo, Pascual Angel
Yee, Benjamin K.
author_role author
author2 Hauser, Jonas
Lopez Llano, Luis
Peleg Raibstein, Daria
Feldon, Joram
Gargiulo, Pascual Angel
Yee, Benjamin K.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Pre-Pulse
Inhibition
Cognition
Schizophrenia
Correlation
Individual Difference
Learning
Prepulse Inhibition
Sensorinotor Gating
topic Pre-Pulse
Inhibition
Cognition
Schizophrenia
Correlation
Individual Difference
Learning
Prepulse Inhibition
Sensorinotor Gating
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Prepulse inhibition (PPI) of the acoustic startle reflex refers to the attenuation of the startle response to an intense pulse stimulus when it is shortly preceded by a weak non-startling prepulse stimulus. It is a well-established high-throughput translational measure of pre-attentive sensory gating, and its impairment is detected in several neuropsychiatric diseases including schizophrenia. It has been hypothesized that PPI might be associated with, or predictive of, cognitive deficiency in such diseases, and therefore provide an efficient assay for screening drugs with potential pro-cognitive efficacy. Free from any predetermined disease models, the present study evaluated in a homogeneous cohort of inbred C57BL/6 mice the presence of a statistical link between PPI expression and cognitive performance. Performance indices in a spatial reference memory test and a working memory test conducted in the Morris water maze, and contextual fear conditioning were correlated against pre-existing baseline PPI expression. A specific correlative link between working memory and PPI induced by weak (but not strong) prepulse was revealed. In addition, a correlation between habituation of the startle reflex and reference memory was identified for the first time: a stronger overt habituation effect was associated with superior spatial search accuracy. The PPI paradigm thus provides two independent predictors of dissociable cognitive traits in normal C57BL/6 mice; and they might serve as potential markers for high-throughput evaluation of potential cognitive enhancers, especially in the context of schizophrenia where deficits in startle habituation and PPI co-exist.
Fil: Singer, Phillipp. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; Suiza
Fil: Hauser, Jonas. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; Suiza
Fil: Lopez Llano, Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Peleg Raibstein, Daria. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; Suiza
Fil: Feldon, Joram. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; Suiza
Fil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Yee, Benjamin K.. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; Suiza
description Prepulse inhibition (PPI) of the acoustic startle reflex refers to the attenuation of the startle response to an intense pulse stimulus when it is shortly preceded by a weak non-startling prepulse stimulus. It is a well-established high-throughput translational measure of pre-attentive sensory gating, and its impairment is detected in several neuropsychiatric diseases including schizophrenia. It has been hypothesized that PPI might be associated with, or predictive of, cognitive deficiency in such diseases, and therefore provide an efficient assay for screening drugs with potential pro-cognitive efficacy. Free from any predetermined disease models, the present study evaluated in a homogeneous cohort of inbred C57BL/6 mice the presence of a statistical link between PPI expression and cognitive performance. Performance indices in a spatial reference memory test and a working memory test conducted in the Morris water maze, and contextual fear conditioning were correlated against pre-existing baseline PPI expression. A specific correlative link between working memory and PPI induced by weak (but not strong) prepulse was revealed. In addition, a correlation between habituation of the startle reflex and reference memory was identified for the first time: a stronger overt habituation effect was associated with superior spatial search accuracy. The PPI paradigm thus provides two independent predictors of dissociable cognitive traits in normal C57BL/6 mice; and they might serve as potential markers for high-throughput evaluation of potential cognitive enhancers, especially in the context of schizophrenia where deficits in startle habituation and PPI co-exist.
publishDate 2013
dc.date.none.fl_str_mv 2013-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/18163
Singer, Phillipp; Hauser, Jonas; Lopez Llano, Luis; Peleg Raibstein, Daria; Feldon, Joram; et al.; Prepulse inhibition predicts working memory performance while startle habituation predicts spatial reference memory retention in C57BL/6 mice; Elsevier Science; Behavioural Brain Research; 242; 1-2013; 166-177
0166-4328
CONICET Digital
CONICET
url http://hdl.handle.net/11336/18163
identifier_str_mv Singer, Phillipp; Hauser, Jonas; Lopez Llano, Luis; Peleg Raibstein, Daria; Feldon, Joram; et al.; Prepulse inhibition predicts working memory performance while startle habituation predicts spatial reference memory retention in C57BL/6 mice; Elsevier Science; Behavioural Brain Research; 242; 1-2013; 166-177
0166-4328
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2012.12.011
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0166432812007930
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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