Anti-inflammatory Activity and Antioxidant Potential of Aqueous Extracts from Stem Bark of Geoffroea decorticans

Autores
Jofré, Mariana; Fusco, María; Favier, Laura; Teves, Mauricio; Rotelli, Alejandra Ester; Pedernera, Ana; Pelzer, Lilian; Ortega, Claudia; Cifuente, Diego Alberto
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the present work we investigated, for the first time, the anti-inflammatory activity and the antioxidant properties ofaqueous and ethanolic extracts, obtained from stem bark of Geoffroea decorticans (Gill. ex Hook. et Arn.) Burk. (Fabaceae). G.decorticans, commonly known as ?chañar? or ?chañarcillo?, is a traditional argentinean plant used as emollient, balsamic, antitussive,expectorant and anti-inflammatory. The stem bark was collected from San Francisco del Monte de Oro, San Luis, Argentina.Anti-inflammatory activity was evaluated by carrageenan-induced paw edema in rats. Antioxidant activity was tested using1,1-Diphenyl-2-picrylhydrazyl radical-scavenging activity (DPPH), 2,2´-Azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radicalscavenging activity (ABTS) and ferric ion-reducing power (RP-Fe) assays. Aqueous extract 10% p/v showed anti-inflammatory activity (3h, 48% inhibition, 5h 37% inhibition and 7h 17% inhibition) and antioxidant activity (DPPH, IC50 (mg/mL) = 0.098 ± 0.032; ABTS, IC50 (mg/mL) = 0.022 ± 0.343, RP-Fe IC50 (mg/mL) = 1.124 ± 0.146). In the other hand, the ethanolic extract 5% p/v, presented anti-inflammatory activity (3h, 34% inhibition, 5h 38% inhibition and 7h 35% inhibition) and antioxidant activity (DPPH, IC50 (mg/mL) = 0.133 ± 0.027; ABTS, IC50 (mg/mL) = 0.086 ± 0.262, RP-Fe IC50 (mg/mL) = 7.089 ± 0.104). These results suggest that, also fruits, the aqueous and ethanolic extracts from the stem bark of G. decorticans present significant anti-inflammatory activity and antioxidant properties.
Fil: Jofré, Mariana. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; Argentina
Fil: Fusco, María. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; Argentina
Fil: Favier, Laura. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Area de Química Orgánica; Argentina
Fil: Teves, Mauricio. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; Argentina
Fil: Rotelli, Alejandra Ester. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; Argentina
Fil: Pedernera, Ana. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; Argentina
Fil: Pelzer, Lilian. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; Argentina
Fil: Ortega, Claudia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; Argentina
Fil: Cifuente, Diego Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; Argentina
Materia
ANTI-INFLAMMATORY BIOACTIVITY bioactivity
ANTIOXIDANT PROPERTIES
GEOFFROEA DECORTICANS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/66602
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/66602
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Anti-inflammatory Activity and Antioxidant Potential of Aqueous Extracts from Stem Bark of Geoffroea decorticansJofré, MarianaFusco, MaríaFavier, LauraTeves, MauricioRotelli, Alejandra EsterPedernera, AnaPelzer, LilianOrtega, ClaudiaCifuente, Diego AlbertoANTI-INFLAMMATORY BIOACTIVITY bioactivityANTIOXIDANT PROPERTIESGEOFFROEA DECORTICANShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In the present work we investigated, for the first time, the anti-inflammatory activity and the antioxidant properties ofaqueous and ethanolic extracts, obtained from stem bark of Geoffroea decorticans (Gill. ex Hook. et Arn.) Burk. (Fabaceae). G.decorticans, commonly known as ?chañar? or ?chañarcillo?, is a traditional argentinean plant used as emollient, balsamic, antitussive,expectorant and anti-inflammatory. The stem bark was collected from San Francisco del Monte de Oro, San Luis, Argentina.Anti-inflammatory activity was evaluated by carrageenan-induced paw edema in rats. Antioxidant activity was tested using1,1-Diphenyl-2-picrylhydrazyl radical-scavenging activity (DPPH), 2,2´-Azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radicalscavenging activity (ABTS) and ferric ion-reducing power (RP-Fe) assays. Aqueous extract 10% p/v showed anti-inflammatory activity (3h, 48% inhibition, 5h 37% inhibition and 7h 17% inhibition) and antioxidant activity (DPPH, IC50 (mg/mL) = 0.098 ± 0.032; ABTS, IC50 (mg/mL) = 0.022 ± 0.343, RP-Fe IC50 (mg/mL) = 1.124 ± 0.146). In the other hand, the ethanolic extract 5% p/v, presented anti-inflammatory activity (3h, 34% inhibition, 5h 38% inhibition and 7h 35% inhibition) and antioxidant activity (DPPH, IC50 (mg/mL) = 0.133 ± 0.027; ABTS, IC50 (mg/mL) = 0.086 ± 0.262, RP-Fe IC50 (mg/mL) = 7.089 ± 0.104). These results suggest that, also fruits, the aqueous and ethanolic extracts from the stem bark of G. decorticans present significant anti-inflammatory activity and antioxidant properties.Fil: Jofré, Mariana. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; ArgentinaFil: Fusco, María. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; ArgentinaFil: Favier, Laura. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Area de Química Orgánica; ArgentinaFil: Teves, Mauricio. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; ArgentinaFil: Rotelli, Alejandra Ester. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; ArgentinaFil: Pedernera, Ana. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; ArgentinaFil: Pelzer, Lilian. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; ArgentinaFil: Ortega, Claudia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; ArgentinaFil: Cifuente, Diego Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; ArgentinaDavid Publishing2017-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/66602Jofré, Mariana; Fusco, María; Favier, Laura; Teves, Mauricio; Rotelli, Alejandra Ester; et al.; Anti-inflammatory Activity and Antioxidant Potential of Aqueous Extracts from Stem Bark of Geoffroea decorticans; David Publishing; Journal of Pharmacy and Pharmacology; 5; 10; 10-2017; 703-7072328-2150CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.17265/2328-2150/2017.10.001info:eu-repo/semantics/altIdentifier/url/http://www.davidpublisher.com/index.php/Home/Article/index?id=32893.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:49Zoai:ri.conicet.gov.ar:11336/66602instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:49.968CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Anti-inflammatory Activity and Antioxidant Potential of Aqueous Extracts from Stem Bark of Geoffroea decorticans
title Anti-inflammatory Activity and Antioxidant Potential of Aqueous Extracts from Stem Bark of Geoffroea decorticans
spellingShingle Anti-inflammatory Activity and Antioxidant Potential of Aqueous Extracts from Stem Bark of Geoffroea decorticans
Jofré, Mariana
ANTI-INFLAMMATORY BIOACTIVITY bioactivity
ANTIOXIDANT PROPERTIES
GEOFFROEA DECORTICANS
title_short Anti-inflammatory Activity and Antioxidant Potential of Aqueous Extracts from Stem Bark of Geoffroea decorticans
title_full Anti-inflammatory Activity and Antioxidant Potential of Aqueous Extracts from Stem Bark of Geoffroea decorticans
title_fullStr Anti-inflammatory Activity and Antioxidant Potential of Aqueous Extracts from Stem Bark of Geoffroea decorticans
title_full_unstemmed Anti-inflammatory Activity and Antioxidant Potential of Aqueous Extracts from Stem Bark of Geoffroea decorticans
title_sort Anti-inflammatory Activity and Antioxidant Potential of Aqueous Extracts from Stem Bark of Geoffroea decorticans
dc.creator.none.fl_str_mv Jofré, Mariana
Fusco, María
Favier, Laura
Teves, Mauricio
Rotelli, Alejandra Ester
Pedernera, Ana
Pelzer, Lilian
Ortega, Claudia
Cifuente, Diego Alberto
author Jofré, Mariana
author_facet Jofré, Mariana
Fusco, María
Favier, Laura
Teves, Mauricio
Rotelli, Alejandra Ester
Pedernera, Ana
Pelzer, Lilian
Ortega, Claudia
Cifuente, Diego Alberto
author_role author
author2 Fusco, María
Favier, Laura
Teves, Mauricio
Rotelli, Alejandra Ester
Pedernera, Ana
Pelzer, Lilian
Ortega, Claudia
Cifuente, Diego Alberto
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTI-INFLAMMATORY BIOACTIVITY bioactivity
ANTIOXIDANT PROPERTIES
GEOFFROEA DECORTICANS
topic ANTI-INFLAMMATORY BIOACTIVITY bioactivity
ANTIOXIDANT PROPERTIES
GEOFFROEA DECORTICANS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In the present work we investigated, for the first time, the anti-inflammatory activity and the antioxidant properties ofaqueous and ethanolic extracts, obtained from stem bark of Geoffroea decorticans (Gill. ex Hook. et Arn.) Burk. (Fabaceae). G.decorticans, commonly known as ?chañar? or ?chañarcillo?, is a traditional argentinean plant used as emollient, balsamic, antitussive,expectorant and anti-inflammatory. The stem bark was collected from San Francisco del Monte de Oro, San Luis, Argentina.Anti-inflammatory activity was evaluated by carrageenan-induced paw edema in rats. Antioxidant activity was tested using1,1-Diphenyl-2-picrylhydrazyl radical-scavenging activity (DPPH), 2,2´-Azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radicalscavenging activity (ABTS) and ferric ion-reducing power (RP-Fe) assays. Aqueous extract 10% p/v showed anti-inflammatory activity (3h, 48% inhibition, 5h 37% inhibition and 7h 17% inhibition) and antioxidant activity (DPPH, IC50 (mg/mL) = 0.098 ± 0.032; ABTS, IC50 (mg/mL) = 0.022 ± 0.343, RP-Fe IC50 (mg/mL) = 1.124 ± 0.146). In the other hand, the ethanolic extract 5% p/v, presented anti-inflammatory activity (3h, 34% inhibition, 5h 38% inhibition and 7h 35% inhibition) and antioxidant activity (DPPH, IC50 (mg/mL) = 0.133 ± 0.027; ABTS, IC50 (mg/mL) = 0.086 ± 0.262, RP-Fe IC50 (mg/mL) = 7.089 ± 0.104). These results suggest that, also fruits, the aqueous and ethanolic extracts from the stem bark of G. decorticans present significant anti-inflammatory activity and antioxidant properties.
Fil: Jofré, Mariana. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; Argentina
Fil: Fusco, María. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; Argentina
Fil: Favier, Laura. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Area de Química Orgánica; Argentina
Fil: Teves, Mauricio. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; Argentina
Fil: Rotelli, Alejandra Ester. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; Argentina
Fil: Pedernera, Ana. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; Argentina
Fil: Pelzer, Lilian. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; Argentina
Fil: Ortega, Claudia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; Argentina
Fil: Cifuente, Diego Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Area de Farmacognosia; Argentina
description In the present work we investigated, for the first time, the anti-inflammatory activity and the antioxidant properties ofaqueous and ethanolic extracts, obtained from stem bark of Geoffroea decorticans (Gill. ex Hook. et Arn.) Burk. (Fabaceae). G.decorticans, commonly known as ?chañar? or ?chañarcillo?, is a traditional argentinean plant used as emollient, balsamic, antitussive,expectorant and anti-inflammatory. The stem bark was collected from San Francisco del Monte de Oro, San Luis, Argentina.Anti-inflammatory activity was evaluated by carrageenan-induced paw edema in rats. Antioxidant activity was tested using1,1-Diphenyl-2-picrylhydrazyl radical-scavenging activity (DPPH), 2,2´-Azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radicalscavenging activity (ABTS) and ferric ion-reducing power (RP-Fe) assays. Aqueous extract 10% p/v showed anti-inflammatory activity (3h, 48% inhibition, 5h 37% inhibition and 7h 17% inhibition) and antioxidant activity (DPPH, IC50 (mg/mL) = 0.098 ± 0.032; ABTS, IC50 (mg/mL) = 0.022 ± 0.343, RP-Fe IC50 (mg/mL) = 1.124 ± 0.146). In the other hand, the ethanolic extract 5% p/v, presented anti-inflammatory activity (3h, 34% inhibition, 5h 38% inhibition and 7h 35% inhibition) and antioxidant activity (DPPH, IC50 (mg/mL) = 0.133 ± 0.027; ABTS, IC50 (mg/mL) = 0.086 ± 0.262, RP-Fe IC50 (mg/mL) = 7.089 ± 0.104). These results suggest that, also fruits, the aqueous and ethanolic extracts from the stem bark of G. decorticans present significant anti-inflammatory activity and antioxidant properties.
publishDate 2017
dc.date.none.fl_str_mv 2017-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/66602
Jofré, Mariana; Fusco, María; Favier, Laura; Teves, Mauricio; Rotelli, Alejandra Ester; et al.; Anti-inflammatory Activity and Antioxidant Potential of Aqueous Extracts from Stem Bark of Geoffroea decorticans; David Publishing; Journal of Pharmacy and Pharmacology; 5; 10; 10-2017; 703-707
2328-2150
CONICET Digital
CONICET
url http://hdl.handle.net/11336/66602
identifier_str_mv Jofré, Mariana; Fusco, María; Favier, Laura; Teves, Mauricio; Rotelli, Alejandra Ester; et al.; Anti-inflammatory Activity and Antioxidant Potential of Aqueous Extracts from Stem Bark of Geoffroea decorticans; David Publishing; Journal of Pharmacy and Pharmacology; 5; 10; 10-2017; 703-707
2328-2150
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.17265/2328-2150/2017.10.001
info:eu-repo/semantics/altIdentifier/url/http://www.davidpublisher.com/index.php/Home/Article/index?id=32893.html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv David Publishing
publisher.none.fl_str_mv David Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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