The native fruit geoffroea decorticans from arid northern Chile: phenolic composition, antioxidant activities and in vitro inhibition of pro-inflammatory and metabolic syndrome-ass...

Autores
Jiménez Aspee, Felipe; Theoduloz, Cristina; Soriano, María del Pilar C.; Ugalde Arbizu, Maider; Alberto, Maria Rosa; Zampini, Iris Catiana; Isla, Maria Ines; Simirgiotis, Mario J.; Schmeda Hirschmann, Guillermo
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The native tree Geoffroea decorticans (cha ar) grows in the arid lands of northern Chile. It has been used as a food plant since prehistoric times. Phenolic-enriched extracts (PEEs) of Chilean cha ar fruits were assessed for their chemical composition, antioxidant properties and inhibition of pro-inflammatory and metabolic syndrome-associated enzymes. Phenolic profiles were determined by HPLC-DAD-MS/MS. The PEEs of G. decorticans showed a strong effect towards the enzymes COX-1/COX-2, with inhibition percentages ranging from inactive to 92.1% and inactive to 76.0% at 50 µg PEE/mL, respectively. The IC50 values of the PEEs towards lipoxygenase and phospholipase A2 inhibitory activity were between 43.6–96.8 and 98.9–156.0 µg PEE/mL, respectively. Samples inhibited α-glucosidase (IC50 0.8–7.3 µg PEE/mL) and lipase (9.9 to 100 µg PEE/mL). However, samples did not inhibit α-amylase. The HPLC-DAD-MS analysis of the PEEs allowed the tentative identification of 53 compounds, mainly flavonol glycosides and procyanidins. The procyanidin content of the Chilean G. decorticans pulp was positively correlated with the antioxidant activity and the inhibition of the enzyme α-glucosidase. These results indicate that the Chilean cha ar fruit contains bioactive polyphenols with functional properties.
Fil: Jiménez Aspee, Felipe. Universidad de Talca; Chile
Fil: Theoduloz, Cristina. Universidad de Talca; Chile
Fil: Soriano, María del Pilar C.. Universidad de Talca; Chile
Fil: Ugalde Arbizu, Maider. Universidad de Talca; Chile
Fil: Alberto, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Zampini, Iris Catiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Simirgiotis, Mario J.. Universidad Austral de Chile; Chile
Fil: Schmeda Hirschmann, Guillermo. Universidad de Talca; Chile
Materia
ANTI-INFLAMMATORY ACTIVITY
ANTIOXIDANT CAPACITY
GEOFFROEA DECORTICANS
HPLC-DAD-ESI-MS
METABOLIC SYNDROME-ASSOCIATED ENZYMES
PHENOLIC COMPOSITION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/50654
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/50654
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The native fruit geoffroea decorticans from arid northern Chile: phenolic composition, antioxidant activities and in vitro inhibition of pro-inflammatory and metabolic syndrome-associated enzymesJiménez Aspee, FelipeTheoduloz, CristinaSoriano, María del Pilar C.Ugalde Arbizu, MaiderAlberto, Maria RosaZampini, Iris CatianaIsla, Maria InesSimirgiotis, Mario J.Schmeda Hirschmann, GuillermoANTI-INFLAMMATORY ACTIVITYANTIOXIDANT CAPACITYGEOFFROEA DECORTICANSHPLC-DAD-ESI-MSMETABOLIC SYNDROME-ASSOCIATED ENZYMESPHENOLIC COMPOSITIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The native tree Geoffroea decorticans (cha ar) grows in the arid lands of northern Chile. It has been used as a food plant since prehistoric times. Phenolic-enriched extracts (PEEs) of Chilean cha ar fruits were assessed for their chemical composition, antioxidant properties and inhibition of pro-inflammatory and metabolic syndrome-associated enzymes. Phenolic profiles were determined by HPLC-DAD-MS/MS. The PEEs of G. decorticans showed a strong effect towards the enzymes COX-1/COX-2, with inhibition percentages ranging from inactive to 92.1% and inactive to 76.0% at 50 µg PEE/mL, respectively. The IC50 values of the PEEs towards lipoxygenase and phospholipase A2 inhibitory activity were between 43.6–96.8 and 98.9–156.0 µg PEE/mL, respectively. Samples inhibited α-glucosidase (IC50 0.8–7.3 µg PEE/mL) and lipase (9.9 to 100 µg PEE/mL). However, samples did not inhibit α-amylase. The HPLC-DAD-MS analysis of the PEEs allowed the tentative identification of 53 compounds, mainly flavonol glycosides and procyanidins. The procyanidin content of the Chilean G. decorticans pulp was positively correlated with the antioxidant activity and the inhibition of the enzyme α-glucosidase. These results indicate that the Chilean cha ar fruit contains bioactive polyphenols with functional properties.Fil: Jiménez Aspee, Felipe. Universidad de Talca; ChileFil: Theoduloz, Cristina. Universidad de Talca; ChileFil: Soriano, María del Pilar C.. Universidad de Talca; ChileFil: Ugalde Arbizu, Maider. Universidad de Talca; ChileFil: Alberto, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Zampini, Iris Catiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Simirgiotis, Mario J.. Universidad Austral de Chile; ChileFil: Schmeda Hirschmann, Guillermo. Universidad de Talca; ChileMolecular Diversity Preservation International2017-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/50654Jiménez Aspee, Felipe; Theoduloz, Cristina; Soriano, María del Pilar C.; Ugalde Arbizu, Maider; Alberto, Maria Rosa; et al.; The native fruit geoffroea decorticans from arid northern Chile: phenolic composition, antioxidant activities and in vitro inhibition of pro-inflammatory and metabolic syndrome-associated enzymes; Molecular Diversity Preservation International; Molecules; 22; 9; 9-2017; 1-18; 15651420-3049CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/molecules22091565info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1420-3049/22/9/1565info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:39Zoai:ri.conicet.gov.ar:11336/50654instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:39.67CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The native fruit geoffroea decorticans from arid northern Chile: phenolic composition, antioxidant activities and in vitro inhibition of pro-inflammatory and metabolic syndrome-associated enzymes
title The native fruit geoffroea decorticans from arid northern Chile: phenolic composition, antioxidant activities and in vitro inhibition of pro-inflammatory and metabolic syndrome-associated enzymes
spellingShingle The native fruit geoffroea decorticans from arid northern Chile: phenolic composition, antioxidant activities and in vitro inhibition of pro-inflammatory and metabolic syndrome-associated enzymes
Jiménez Aspee, Felipe
ANTI-INFLAMMATORY ACTIVITY
ANTIOXIDANT CAPACITY
GEOFFROEA DECORTICANS
HPLC-DAD-ESI-MS
METABOLIC SYNDROME-ASSOCIATED ENZYMES
PHENOLIC COMPOSITION
title_short The native fruit geoffroea decorticans from arid northern Chile: phenolic composition, antioxidant activities and in vitro inhibition of pro-inflammatory and metabolic syndrome-associated enzymes
title_full The native fruit geoffroea decorticans from arid northern Chile: phenolic composition, antioxidant activities and in vitro inhibition of pro-inflammatory and metabolic syndrome-associated enzymes
title_fullStr The native fruit geoffroea decorticans from arid northern Chile: phenolic composition, antioxidant activities and in vitro inhibition of pro-inflammatory and metabolic syndrome-associated enzymes
title_full_unstemmed The native fruit geoffroea decorticans from arid northern Chile: phenolic composition, antioxidant activities and in vitro inhibition of pro-inflammatory and metabolic syndrome-associated enzymes
title_sort The native fruit geoffroea decorticans from arid northern Chile: phenolic composition, antioxidant activities and in vitro inhibition of pro-inflammatory and metabolic syndrome-associated enzymes
dc.creator.none.fl_str_mv Jiménez Aspee, Felipe
Theoduloz, Cristina
Soriano, María del Pilar C.
Ugalde Arbizu, Maider
Alberto, Maria Rosa
Zampini, Iris Catiana
Isla, Maria Ines
Simirgiotis, Mario J.
Schmeda Hirschmann, Guillermo
author Jiménez Aspee, Felipe
author_facet Jiménez Aspee, Felipe
Theoduloz, Cristina
Soriano, María del Pilar C.
Ugalde Arbizu, Maider
Alberto, Maria Rosa
Zampini, Iris Catiana
Isla, Maria Ines
Simirgiotis, Mario J.
Schmeda Hirschmann, Guillermo
author_role author
author2 Theoduloz, Cristina
Soriano, María del Pilar C.
Ugalde Arbizu, Maider
Alberto, Maria Rosa
Zampini, Iris Catiana
Isla, Maria Ines
Simirgiotis, Mario J.
Schmeda Hirschmann, Guillermo
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTI-INFLAMMATORY ACTIVITY
ANTIOXIDANT CAPACITY
GEOFFROEA DECORTICANS
HPLC-DAD-ESI-MS
METABOLIC SYNDROME-ASSOCIATED ENZYMES
PHENOLIC COMPOSITION
topic ANTI-INFLAMMATORY ACTIVITY
ANTIOXIDANT CAPACITY
GEOFFROEA DECORTICANS
HPLC-DAD-ESI-MS
METABOLIC SYNDROME-ASSOCIATED ENZYMES
PHENOLIC COMPOSITION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The native tree Geoffroea decorticans (cha ar) grows in the arid lands of northern Chile. It has been used as a food plant since prehistoric times. Phenolic-enriched extracts (PEEs) of Chilean cha ar fruits were assessed for their chemical composition, antioxidant properties and inhibition of pro-inflammatory and metabolic syndrome-associated enzymes. Phenolic profiles were determined by HPLC-DAD-MS/MS. The PEEs of G. decorticans showed a strong effect towards the enzymes COX-1/COX-2, with inhibition percentages ranging from inactive to 92.1% and inactive to 76.0% at 50 µg PEE/mL, respectively. The IC50 values of the PEEs towards lipoxygenase and phospholipase A2 inhibitory activity were between 43.6–96.8 and 98.9–156.0 µg PEE/mL, respectively. Samples inhibited α-glucosidase (IC50 0.8–7.3 µg PEE/mL) and lipase (9.9 to 100 µg PEE/mL). However, samples did not inhibit α-amylase. The HPLC-DAD-MS analysis of the PEEs allowed the tentative identification of 53 compounds, mainly flavonol glycosides and procyanidins. The procyanidin content of the Chilean G. decorticans pulp was positively correlated with the antioxidant activity and the inhibition of the enzyme α-glucosidase. These results indicate that the Chilean cha ar fruit contains bioactive polyphenols with functional properties.
Fil: Jiménez Aspee, Felipe. Universidad de Talca; Chile
Fil: Theoduloz, Cristina. Universidad de Talca; Chile
Fil: Soriano, María del Pilar C.. Universidad de Talca; Chile
Fil: Ugalde Arbizu, Maider. Universidad de Talca; Chile
Fil: Alberto, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Zampini, Iris Catiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Simirgiotis, Mario J.. Universidad Austral de Chile; Chile
Fil: Schmeda Hirschmann, Guillermo. Universidad de Talca; Chile
description The native tree Geoffroea decorticans (cha ar) grows in the arid lands of northern Chile. It has been used as a food plant since prehistoric times. Phenolic-enriched extracts (PEEs) of Chilean cha ar fruits were assessed for their chemical composition, antioxidant properties and inhibition of pro-inflammatory and metabolic syndrome-associated enzymes. Phenolic profiles were determined by HPLC-DAD-MS/MS. The PEEs of G. decorticans showed a strong effect towards the enzymes COX-1/COX-2, with inhibition percentages ranging from inactive to 92.1% and inactive to 76.0% at 50 µg PEE/mL, respectively. The IC50 values of the PEEs towards lipoxygenase and phospholipase A2 inhibitory activity were between 43.6–96.8 and 98.9–156.0 µg PEE/mL, respectively. Samples inhibited α-glucosidase (IC50 0.8–7.3 µg PEE/mL) and lipase (9.9 to 100 µg PEE/mL). However, samples did not inhibit α-amylase. The HPLC-DAD-MS analysis of the PEEs allowed the tentative identification of 53 compounds, mainly flavonol glycosides and procyanidins. The procyanidin content of the Chilean G. decorticans pulp was positively correlated with the antioxidant activity and the inhibition of the enzyme α-glucosidase. These results indicate that the Chilean cha ar fruit contains bioactive polyphenols with functional properties.
publishDate 2017
dc.date.none.fl_str_mv 2017-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/50654
Jiménez Aspee, Felipe; Theoduloz, Cristina; Soriano, María del Pilar C.; Ugalde Arbizu, Maider; Alberto, Maria Rosa; et al.; The native fruit geoffroea decorticans from arid northern Chile: phenolic composition, antioxidant activities and in vitro inhibition of pro-inflammatory and metabolic syndrome-associated enzymes; Molecular Diversity Preservation International; Molecules; 22; 9; 9-2017; 1-18; 1565
1420-3049
CONICET Digital
CONICET
url http://hdl.handle.net/11336/50654
identifier_str_mv Jiménez Aspee, Felipe; Theoduloz, Cristina; Soriano, María del Pilar C.; Ugalde Arbizu, Maider; Alberto, Maria Rosa; et al.; The native fruit geoffroea decorticans from arid northern Chile: phenolic composition, antioxidant activities and in vitro inhibition of pro-inflammatory and metabolic syndrome-associated enzymes; Molecular Diversity Preservation International; Molecules; 22; 9; 9-2017; 1-18; 1565
1420-3049
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules22091565
info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1420-3049/22/9/1565
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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