Fungal biofilms as a valuable target for the discovery of natural products that cope with the resistance of medically important fungi—Latest findings

Autores
Butassi, Estefanía; Svetaz, Laura Andrea; Carpinella, Maria Cecilia; Efferth, Thomas; Zacchino, Susana Alicia Stella
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The development of new antifungal agents that target biofilms is an urgent need. Natural products, mainly from the plant kingdom, represent an invaluable source of these entities. The present review provides an update (2017–May 2021) on the available information on essential oils, propolis, extracts from plants, algae, lichens and microorganisms, compounds from different natural sources and nanosystems containing natural products with the capacity to in vitro or in vivo modulate fungal biofilms. The search yielded 42 articles; seven involved essential oils, two Brazilian propolis, six plant extracts and one of each, extracts from lichens and algae/cyanobacteria. Twenty articles deal with the antibiofilm effect of pure natural compounds, with 10 of them including studies of the mechanism of action and five dealing with natural compounds included in nanosystems. Thirty‐seven manuscripts evaluated Candida spp. biofilms and two tested Fusarium and Cryptococcus spp. Only one manuscript involved Aspergillus fumigatus. From the data presented here, it is clear that the search of natural products with activity against fungal biofilms has been a highly active area of research in recent years. However, it also reveals the necessity of deepening the studies by (i) evaluating the effect of natural products on biofilms formed by the newly emerged and worrisome health‐care associated fungi, C. auris, as well as on other non‐albicans Candida spp., Cryptococcus sp. and filamentous fungi; (ii) elucidating the mechanisms of action of the most active natural products; (iii) increasing the in vivo testing.
Fil: Butassi, Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Svetaz, Laura Andrea. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Carpinella, Maria Cecilia. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; Argentina
Fil: Efferth, Thomas. Johannes Gutenberg Universitat Mainz; Alemania
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
Materia
ANTIFUNGAL RESISTANCE
CANDIDA SPP
CRYPTOCOCCUS SPP
FILAMENTOUS FUNGI
FUNGAL BIOFILM
FUSARIUM SPP
MECHANISMS OF ANTIBIOFILM ACTION
NATURAL PRODUCTS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/153564
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Fungal biofilms as a valuable target for the discovery of natural products that cope with the resistance of medically important fungi—Latest findingsButassi, EstefaníaSvetaz, Laura AndreaCarpinella, Maria CeciliaEfferth, ThomasZacchino, Susana Alicia StellaANTIFUNGAL RESISTANCECANDIDA SPPCRYPTOCOCCUS SPPFILAMENTOUS FUNGIFUNGAL BIOFILMFUSARIUM SPPMECHANISMS OF ANTIBIOFILM ACTIONNATURAL PRODUCTShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The development of new antifungal agents that target biofilms is an urgent need. Natural products, mainly from the plant kingdom, represent an invaluable source of these entities. The present review provides an update (2017–May 2021) on the available information on essential oils, propolis, extracts from plants, algae, lichens and microorganisms, compounds from different natural sources and nanosystems containing natural products with the capacity to in vitro or in vivo modulate fungal biofilms. The search yielded 42 articles; seven involved essential oils, two Brazilian propolis, six plant extracts and one of each, extracts from lichens and algae/cyanobacteria. Twenty articles deal with the antibiofilm effect of pure natural compounds, with 10 of them including studies of the mechanism of action and five dealing with natural compounds included in nanosystems. Thirty‐seven manuscripts evaluated Candida spp. biofilms and two tested Fusarium and Cryptococcus spp. Only one manuscript involved Aspergillus fumigatus. From the data presented here, it is clear that the search of natural products with activity against fungal biofilms has been a highly active area of research in recent years. However, it also reveals the necessity of deepening the studies by (i) evaluating the effect of natural products on biofilms formed by the newly emerged and worrisome health‐care associated fungi, C. auris, as well as on other non‐albicans Candida spp., Cryptococcus sp. and filamentous fungi; (ii) elucidating the mechanisms of action of the most active natural products; (iii) increasing the in vivo testing.Fil: Butassi, Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Svetaz, Laura Andrea. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Carpinella, Maria Cecilia. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; ArgentinaFil: Efferth, Thomas. Johannes Gutenberg Universitat Mainz; AlemaniaFil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; ArgentinaMultidisciplinary Digital Publishing Institute2021-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/153564Butassi, Estefanía; Svetaz, Laura Andrea; Carpinella, Maria Cecilia; Efferth, Thomas; Zacchino, Susana Alicia Stella; Fungal biofilms as a valuable target for the discovery of natural products that cope with the resistance of medically important fungi—Latest findings; Multidisciplinary Digital Publishing Institute; Antibiotics; 10; 9; 9-2021; 1-312079-63822079-6382CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-6382/10/9/1053info:eu-repo/semantics/altIdentifier/doi/10.3390/antibiotics10091053info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:57Zoai:ri.conicet.gov.ar:11336/153564instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:57.917CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Fungal biofilms as a valuable target for the discovery of natural products that cope with the resistance of medically important fungi—Latest findings
title Fungal biofilms as a valuable target for the discovery of natural products that cope with the resistance of medically important fungi—Latest findings
spellingShingle Fungal biofilms as a valuable target for the discovery of natural products that cope with the resistance of medically important fungi—Latest findings
Butassi, Estefanía
ANTIFUNGAL RESISTANCE
CANDIDA SPP
CRYPTOCOCCUS SPP
FILAMENTOUS FUNGI
FUNGAL BIOFILM
FUSARIUM SPP
MECHANISMS OF ANTIBIOFILM ACTION
NATURAL PRODUCTS
title_short Fungal biofilms as a valuable target for the discovery of natural products that cope with the resistance of medically important fungi—Latest findings
title_full Fungal biofilms as a valuable target for the discovery of natural products that cope with the resistance of medically important fungi—Latest findings
title_fullStr Fungal biofilms as a valuable target for the discovery of natural products that cope with the resistance of medically important fungi—Latest findings
title_full_unstemmed Fungal biofilms as a valuable target for the discovery of natural products that cope with the resistance of medically important fungi—Latest findings
title_sort Fungal biofilms as a valuable target for the discovery of natural products that cope with the resistance of medically important fungi—Latest findings
dc.creator.none.fl_str_mv Butassi, Estefanía
Svetaz, Laura Andrea
Carpinella, Maria Cecilia
Efferth, Thomas
Zacchino, Susana Alicia Stella
author Butassi, Estefanía
author_facet Butassi, Estefanía
Svetaz, Laura Andrea
Carpinella, Maria Cecilia
Efferth, Thomas
Zacchino, Susana Alicia Stella
author_role author
author2 Svetaz, Laura Andrea
Carpinella, Maria Cecilia
Efferth, Thomas
Zacchino, Susana Alicia Stella
author2_role author
author
author
author
dc.subject.none.fl_str_mv ANTIFUNGAL RESISTANCE
CANDIDA SPP
CRYPTOCOCCUS SPP
FILAMENTOUS FUNGI
FUNGAL BIOFILM
FUSARIUM SPP
MECHANISMS OF ANTIBIOFILM ACTION
NATURAL PRODUCTS
topic ANTIFUNGAL RESISTANCE
CANDIDA SPP
CRYPTOCOCCUS SPP
FILAMENTOUS FUNGI
FUNGAL BIOFILM
FUSARIUM SPP
MECHANISMS OF ANTIBIOFILM ACTION
NATURAL PRODUCTS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The development of new antifungal agents that target biofilms is an urgent need. Natural products, mainly from the plant kingdom, represent an invaluable source of these entities. The present review provides an update (2017–May 2021) on the available information on essential oils, propolis, extracts from plants, algae, lichens and microorganisms, compounds from different natural sources and nanosystems containing natural products with the capacity to in vitro or in vivo modulate fungal biofilms. The search yielded 42 articles; seven involved essential oils, two Brazilian propolis, six plant extracts and one of each, extracts from lichens and algae/cyanobacteria. Twenty articles deal with the antibiofilm effect of pure natural compounds, with 10 of them including studies of the mechanism of action and five dealing with natural compounds included in nanosystems. Thirty‐seven manuscripts evaluated Candida spp. biofilms and two tested Fusarium and Cryptococcus spp. Only one manuscript involved Aspergillus fumigatus. From the data presented here, it is clear that the search of natural products with activity against fungal biofilms has been a highly active area of research in recent years. However, it also reveals the necessity of deepening the studies by (i) evaluating the effect of natural products on biofilms formed by the newly emerged and worrisome health‐care associated fungi, C. auris, as well as on other non‐albicans Candida spp., Cryptococcus sp. and filamentous fungi; (ii) elucidating the mechanisms of action of the most active natural products; (iii) increasing the in vivo testing.
Fil: Butassi, Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Svetaz, Laura Andrea. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Carpinella, Maria Cecilia. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; Argentina
Fil: Efferth, Thomas. Johannes Gutenberg Universitat Mainz; Alemania
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
description The development of new antifungal agents that target biofilms is an urgent need. Natural products, mainly from the plant kingdom, represent an invaluable source of these entities. The present review provides an update (2017–May 2021) on the available information on essential oils, propolis, extracts from plants, algae, lichens and microorganisms, compounds from different natural sources and nanosystems containing natural products with the capacity to in vitro or in vivo modulate fungal biofilms. The search yielded 42 articles; seven involved essential oils, two Brazilian propolis, six plant extracts and one of each, extracts from lichens and algae/cyanobacteria. Twenty articles deal with the antibiofilm effect of pure natural compounds, with 10 of them including studies of the mechanism of action and five dealing with natural compounds included in nanosystems. Thirty‐seven manuscripts evaluated Candida spp. biofilms and two tested Fusarium and Cryptococcus spp. Only one manuscript involved Aspergillus fumigatus. From the data presented here, it is clear that the search of natural products with activity against fungal biofilms has been a highly active area of research in recent years. However, it also reveals the necessity of deepening the studies by (i) evaluating the effect of natural products on biofilms formed by the newly emerged and worrisome health‐care associated fungi, C. auris, as well as on other non‐albicans Candida spp., Cryptococcus sp. and filamentous fungi; (ii) elucidating the mechanisms of action of the most active natural products; (iii) increasing the in vivo testing.
publishDate 2021
dc.date.none.fl_str_mv 2021-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/153564
Butassi, Estefanía; Svetaz, Laura Andrea; Carpinella, Maria Cecilia; Efferth, Thomas; Zacchino, Susana Alicia Stella; Fungal biofilms as a valuable target for the discovery of natural products that cope with the resistance of medically important fungi—Latest findings; Multidisciplinary Digital Publishing Institute; Antibiotics; 10; 9; 9-2021; 1-31
2079-6382
2079-6382
CONICET Digital
CONICET
url http://hdl.handle.net/11336/153564
identifier_str_mv Butassi, Estefanía; Svetaz, Laura Andrea; Carpinella, Maria Cecilia; Efferth, Thomas; Zacchino, Susana Alicia Stella; Fungal biofilms as a valuable target for the discovery of natural products that cope with the resistance of medically important fungi—Latest findings; Multidisciplinary Digital Publishing Institute; Antibiotics; 10; 9; 9-2021; 1-31
2079-6382
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-6382/10/9/1053
info:eu-repo/semantics/altIdentifier/doi/10.3390/antibiotics10091053
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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