In vitro interactions of antifungal agents against Fusarium spp. clinical isolates

Autores
Córdoba, Susana Beatríz; Rodero, Laura; Vivot, Walter Oscar; Abrantes, Rubén; Davel, Graciela Odelsia; Vitale, Roxana Gabriela
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The in vitro activities of amphotericinB(AMB), itraconazole (ITC), voriconazole (VCZ) and terbinafine (TBF) alone and in the combinationsAMB+ VCZ, TBF + ITC and TBF + VCZ were evaluated against 29 clinical isolates of Fusarium spp. (15 Fusarium solani, 7 Fusariumoxysporum, 2 Fusarium decemcellulare, 2 Fusarium dimerum and 3 other Fusarium spp.). Minimum inhibitory concentrations were determinedusing the method of the Clinical and Laboratory Standards Institute and the interaction activity was calculated using the fractional inhibitoryconcentration index. The four antifungal drugs tested alone showed very limited activity against most of the isolates. In contrast, the combinationTBF + VCZshowed synergy for 21 isolates. The combinationAMB+ VCZshowed synergism for only five strains.Nointeraction or antagonismwas observed among the remaining strains. TBF + ITC showed no interaction for 18 strains. The in vitro antifungal activity of the drugs aloneand in combination varied for different species. These results corroborate previous in vitro studies in which the combination TBF + VCZshowed synergy against Fusarium spp., although further studies are needed to elucidate its potential usefulness for therapy.
Fil: Córdoba, Susana Beatríz. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Rodero, Laura. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina
Fil: Vivot, Walter Oscar. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Abrantes, Rubén. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Davel, Graciela Odelsia. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Vitale, Roxana Gabriela. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Fusarium spp
Antifungal susceptibility
Antifungal interactions
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/244604
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/244604
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling In vitro interactions of antifungal agents against Fusarium spp. clinical isolatesCórdoba, Susana BeatrízRodero, LauraVivot, Walter OscarAbrantes, RubénDavel, Graciela OdelsiaVitale, Roxana GabrielaFusarium sppAntifungal susceptibilityAntifungal interactionshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The in vitro activities of amphotericinB(AMB), itraconazole (ITC), voriconazole (VCZ) and terbinafine (TBF) alone and in the combinationsAMB+ VCZ, TBF + ITC and TBF + VCZ were evaluated against 29 clinical isolates of Fusarium spp. (15 Fusarium solani, 7 Fusariumoxysporum, 2 Fusarium decemcellulare, 2 Fusarium dimerum and 3 other Fusarium spp.). Minimum inhibitory concentrations were determinedusing the method of the Clinical and Laboratory Standards Institute and the interaction activity was calculated using the fractional inhibitoryconcentration index. The four antifungal drugs tested alone showed very limited activity against most of the isolates. In contrast, the combinationTBF + VCZshowed synergy for 21 isolates. The combinationAMB+ VCZshowed synergism for only five strains.Nointeraction or antagonismwas observed among the remaining strains. TBF + ITC showed no interaction for 18 strains. The in vitro antifungal activity of the drugs aloneand in combination varied for different species. These results corroborate previous in vitro studies in which the combination TBF + VCZshowed synergy against Fusarium spp., although further studies are needed to elucidate its potential usefulness for therapy.Fil: Córdoba, Susana Beatríz. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Rodero, Laura. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; ArgentinaFil: Vivot, Walter Oscar. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Abrantes, Rubén. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Davel, Graciela Odelsia. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Vitale, Roxana Gabriela. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Science2008-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/244604Córdoba, Susana Beatríz; Rodero, Laura; Vivot, Walter Oscar; Abrantes, Rubén; Davel, Graciela Odelsia; et al.; In vitro interactions of antifungal agents against Fusarium spp. clinical isolates; Elsevier Science; International Journal of Antimicrobial Agents; 31; 2; 2-2008; 171-1740924-8579CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0924857907004761info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijantimicag.2007.09.005info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:56Zoai:ri.conicet.gov.ar:11336/244604instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:57.291CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv In vitro interactions of antifungal agents against Fusarium spp. clinical isolates
title In vitro interactions of antifungal agents against Fusarium spp. clinical isolates
spellingShingle In vitro interactions of antifungal agents against Fusarium spp. clinical isolates
Córdoba, Susana Beatríz
Fusarium spp
Antifungal susceptibility
Antifungal interactions
title_short In vitro interactions of antifungal agents against Fusarium spp. clinical isolates
title_full In vitro interactions of antifungal agents against Fusarium spp. clinical isolates
title_fullStr In vitro interactions of antifungal agents against Fusarium spp. clinical isolates
title_full_unstemmed In vitro interactions of antifungal agents against Fusarium spp. clinical isolates
title_sort In vitro interactions of antifungal agents against Fusarium spp. clinical isolates
dc.creator.none.fl_str_mv Córdoba, Susana Beatríz
Rodero, Laura
Vivot, Walter Oscar
Abrantes, Rubén
Davel, Graciela Odelsia
Vitale, Roxana Gabriela
author Córdoba, Susana Beatríz
author_facet Córdoba, Susana Beatríz
Rodero, Laura
Vivot, Walter Oscar
Abrantes, Rubén
Davel, Graciela Odelsia
Vitale, Roxana Gabriela
author_role author
author2 Rodero, Laura
Vivot, Walter Oscar
Abrantes, Rubén
Davel, Graciela Odelsia
Vitale, Roxana Gabriela
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Fusarium spp
Antifungal susceptibility
Antifungal interactions
topic Fusarium spp
Antifungal susceptibility
Antifungal interactions
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The in vitro activities of amphotericinB(AMB), itraconazole (ITC), voriconazole (VCZ) and terbinafine (TBF) alone and in the combinationsAMB+ VCZ, TBF + ITC and TBF + VCZ were evaluated against 29 clinical isolates of Fusarium spp. (15 Fusarium solani, 7 Fusariumoxysporum, 2 Fusarium decemcellulare, 2 Fusarium dimerum and 3 other Fusarium spp.). Minimum inhibitory concentrations were determinedusing the method of the Clinical and Laboratory Standards Institute and the interaction activity was calculated using the fractional inhibitoryconcentration index. The four antifungal drugs tested alone showed very limited activity against most of the isolates. In contrast, the combinationTBF + VCZshowed synergy for 21 isolates. The combinationAMB+ VCZshowed synergism for only five strains.Nointeraction or antagonismwas observed among the remaining strains. TBF + ITC showed no interaction for 18 strains. The in vitro antifungal activity of the drugs aloneand in combination varied for different species. These results corroborate previous in vitro studies in which the combination TBF + VCZshowed synergy against Fusarium spp., although further studies are needed to elucidate its potential usefulness for therapy.
Fil: Córdoba, Susana Beatríz. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Rodero, Laura. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina
Fil: Vivot, Walter Oscar. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Abrantes, Rubén. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Davel, Graciela Odelsia. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Vitale, Roxana Gabriela. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The in vitro activities of amphotericinB(AMB), itraconazole (ITC), voriconazole (VCZ) and terbinafine (TBF) alone and in the combinationsAMB+ VCZ, TBF + ITC and TBF + VCZ were evaluated against 29 clinical isolates of Fusarium spp. (15 Fusarium solani, 7 Fusariumoxysporum, 2 Fusarium decemcellulare, 2 Fusarium dimerum and 3 other Fusarium spp.). Minimum inhibitory concentrations were determinedusing the method of the Clinical and Laboratory Standards Institute and the interaction activity was calculated using the fractional inhibitoryconcentration index. The four antifungal drugs tested alone showed very limited activity against most of the isolates. In contrast, the combinationTBF + VCZshowed synergy for 21 isolates. The combinationAMB+ VCZshowed synergism for only five strains.Nointeraction or antagonismwas observed among the remaining strains. TBF + ITC showed no interaction for 18 strains. The in vitro antifungal activity of the drugs aloneand in combination varied for different species. These results corroborate previous in vitro studies in which the combination TBF + VCZshowed synergy against Fusarium spp., although further studies are needed to elucidate its potential usefulness for therapy.
publishDate 2008
dc.date.none.fl_str_mv 2008-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/244604
Córdoba, Susana Beatríz; Rodero, Laura; Vivot, Walter Oscar; Abrantes, Rubén; Davel, Graciela Odelsia; et al.; In vitro interactions of antifungal agents against Fusarium spp. clinical isolates; Elsevier Science; International Journal of Antimicrobial Agents; 31; 2; 2-2008; 171-174
0924-8579
CONICET Digital
CONICET
url http://hdl.handle.net/11336/244604
identifier_str_mv Córdoba, Susana Beatríz; Rodero, Laura; Vivot, Walter Oscar; Abrantes, Rubén; Davel, Graciela Odelsia; et al.; In vitro interactions of antifungal agents against Fusarium spp. clinical isolates; Elsevier Science; International Journal of Antimicrobial Agents; 31; 2; 2-2008; 171-174
0924-8579
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0924857907004761
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijantimicag.2007.09.005
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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