Assessment of oxidative status and genotoxicity in photocopier operators: a pilot study

Autores
Kleinsorge, Elisa; Erben, Melina; Galan, Maria Gimena; Barisón, Caterina; Gonsebatt, Mara Eugenia; Simoniello, Maria Fernanda
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Occupational exposure to photocopiers has been indicated as being responsible for a number of health complaints, particularly effects on the respiratory, immunological, and nervous systems. In this study, we investigated oxidative and genotoxic damage in photocopier operators by assessing catalase activity (CAT), reduced vs. oxidized glutathione ratio (GSH/GSSG), level of lipid peroxidation (TBARS), damage index by Comet assay (DICA), and buccal cells with micronuclei (BCMN). Our results reveal that the TBARS levels in operators were increased (27%; p<0.05) but that no significant alterations to GSH/GSSG or CAT activity were observed. The DICA and the number of BCMN were significantly increased (134% and 100%, respectively; p<0.05) in the exposed group. There was a significant association between the time in months spent at work and DNA damage in lymphocytes (rs=0.720; p<0.001) and buccal cell with MN (rs=0.538; p<0.001). Because laser printers and photocopiers have become increasingly used, it is important to control human exposure using reliable biomarkers.
Fil: Kleinsorge, Elisa. Universidad Nacional del Litoral; Argentina
Fil: Erben, Melina. Universidad Nacional del Litoral; Argentina
Fil: Galan, Maria Gimena. Universidad Nacional del Litoral; Argentina
Fil: Barisón, Caterina. Universidad Nacional del Litoral; Argentina
Fil: Gonsebatt, Mara Eugenia. Instituto de Investigaciones Biomedicas de la Unam; México
Fil: Simoniello, Maria Fernanda. Universidad Nacional del Litoral; Argentina. Universidad de Buenos Aires; Argentina
Materia
BUCCAL MICRONUCLEUS
COMET ASSAY
OXIDATIVE STRESS
PHOTOCOPIER OPERATORS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96489
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/96489
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Assessment of oxidative status and genotoxicity in photocopier operators: a pilot studyKleinsorge, ElisaErben, MelinaGalan, Maria GimenaBarisón, CaterinaGonsebatt, Mara EugeniaSimoniello, Maria FernandaBUCCAL MICRONUCLEUSCOMET ASSAYOXIDATIVE STRESSPHOTOCOPIER OPERATORShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Occupational exposure to photocopiers has been indicated as being responsible for a number of health complaints, particularly effects on the respiratory, immunological, and nervous systems. In this study, we investigated oxidative and genotoxic damage in photocopier operators by assessing catalase activity (CAT), reduced vs. oxidized glutathione ratio (GSH/GSSG), level of lipid peroxidation (TBARS), damage index by Comet assay (DICA), and buccal cells with micronuclei (BCMN). Our results reveal that the TBARS levels in operators were increased (27%; p<0.05) but that no significant alterations to GSH/GSSG or CAT activity were observed. The DICA and the number of BCMN were significantly increased (134% and 100%, respectively; p<0.05) in the exposed group. There was a significant association between the time in months spent at work and DNA damage in lymphocytes (rs=0.720; p<0.001) and buccal cell with MN (rs=0.538; p<0.001). Because laser printers and photocopiers have become increasingly used, it is important to control human exposure using reliable biomarkers.Fil: Kleinsorge, Elisa. Universidad Nacional del Litoral; ArgentinaFil: Erben, Melina. Universidad Nacional del Litoral; ArgentinaFil: Galan, Maria Gimena. Universidad Nacional del Litoral; ArgentinaFil: Barisón, Caterina. Universidad Nacional del Litoral; ArgentinaFil: Gonsebatt, Mara Eugenia. Instituto de Investigaciones Biomedicas de la Unam; MéxicoFil: Simoniello, Maria Fernanda. Universidad Nacional del Litoral; Argentina. Universidad de Buenos Aires; ArgentinaTaylor & Francis Ltd2011-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96489Kleinsorge, Elisa; Erben, Melina; Galan, Maria Gimena; Barisón, Caterina; Gonsebatt, Mara Eugenia; et al.; Assessment of oxidative status and genotoxicity in photocopier operators: a pilot study; Taylor & Francis Ltd; Biomarkers; 16; 8; 12-2011; 642-6481354-750XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://informahealthcare.com/doi/abs/10.3109/1354750X.2011.620744info:eu-repo/semantics/altIdentifier/doi/10.3109/1354750X.2011.620744info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:23Zoai:ri.conicet.gov.ar:11336/96489instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:23.359CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Assessment of oxidative status and genotoxicity in photocopier operators: a pilot study
title Assessment of oxidative status and genotoxicity in photocopier operators: a pilot study
spellingShingle Assessment of oxidative status and genotoxicity in photocopier operators: a pilot study
Kleinsorge, Elisa
BUCCAL MICRONUCLEUS
COMET ASSAY
OXIDATIVE STRESS
PHOTOCOPIER OPERATORS
title_short Assessment of oxidative status and genotoxicity in photocopier operators: a pilot study
title_full Assessment of oxidative status and genotoxicity in photocopier operators: a pilot study
title_fullStr Assessment of oxidative status and genotoxicity in photocopier operators: a pilot study
title_full_unstemmed Assessment of oxidative status and genotoxicity in photocopier operators: a pilot study
title_sort Assessment of oxidative status and genotoxicity in photocopier operators: a pilot study
dc.creator.none.fl_str_mv Kleinsorge, Elisa
Erben, Melina
Galan, Maria Gimena
Barisón, Caterina
Gonsebatt, Mara Eugenia
Simoniello, Maria Fernanda
author Kleinsorge, Elisa
author_facet Kleinsorge, Elisa
Erben, Melina
Galan, Maria Gimena
Barisón, Caterina
Gonsebatt, Mara Eugenia
Simoniello, Maria Fernanda
author_role author
author2 Erben, Melina
Galan, Maria Gimena
Barisón, Caterina
Gonsebatt, Mara Eugenia
Simoniello, Maria Fernanda
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv BUCCAL MICRONUCLEUS
COMET ASSAY
OXIDATIVE STRESS
PHOTOCOPIER OPERATORS
topic BUCCAL MICRONUCLEUS
COMET ASSAY
OXIDATIVE STRESS
PHOTOCOPIER OPERATORS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Occupational exposure to photocopiers has been indicated as being responsible for a number of health complaints, particularly effects on the respiratory, immunological, and nervous systems. In this study, we investigated oxidative and genotoxic damage in photocopier operators by assessing catalase activity (CAT), reduced vs. oxidized glutathione ratio (GSH/GSSG), level of lipid peroxidation (TBARS), damage index by Comet assay (DICA), and buccal cells with micronuclei (BCMN). Our results reveal that the TBARS levels in operators were increased (27%; p<0.05) but that no significant alterations to GSH/GSSG or CAT activity were observed. The DICA and the number of BCMN were significantly increased (134% and 100%, respectively; p<0.05) in the exposed group. There was a significant association between the time in months spent at work and DNA damage in lymphocytes (rs=0.720; p<0.001) and buccal cell with MN (rs=0.538; p<0.001). Because laser printers and photocopiers have become increasingly used, it is important to control human exposure using reliable biomarkers.
Fil: Kleinsorge, Elisa. Universidad Nacional del Litoral; Argentina
Fil: Erben, Melina. Universidad Nacional del Litoral; Argentina
Fil: Galan, Maria Gimena. Universidad Nacional del Litoral; Argentina
Fil: Barisón, Caterina. Universidad Nacional del Litoral; Argentina
Fil: Gonsebatt, Mara Eugenia. Instituto de Investigaciones Biomedicas de la Unam; México
Fil: Simoniello, Maria Fernanda. Universidad Nacional del Litoral; Argentina. Universidad de Buenos Aires; Argentina
description Occupational exposure to photocopiers has been indicated as being responsible for a number of health complaints, particularly effects on the respiratory, immunological, and nervous systems. In this study, we investigated oxidative and genotoxic damage in photocopier operators by assessing catalase activity (CAT), reduced vs. oxidized glutathione ratio (GSH/GSSG), level of lipid peroxidation (TBARS), damage index by Comet assay (DICA), and buccal cells with micronuclei (BCMN). Our results reveal that the TBARS levels in operators were increased (27%; p<0.05) but that no significant alterations to GSH/GSSG or CAT activity were observed. The DICA and the number of BCMN were significantly increased (134% and 100%, respectively; p<0.05) in the exposed group. There was a significant association between the time in months spent at work and DNA damage in lymphocytes (rs=0.720; p<0.001) and buccal cell with MN (rs=0.538; p<0.001). Because laser printers and photocopiers have become increasingly used, it is important to control human exposure using reliable biomarkers.
publishDate 2011
dc.date.none.fl_str_mv 2011-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96489
Kleinsorge, Elisa; Erben, Melina; Galan, Maria Gimena; Barisón, Caterina; Gonsebatt, Mara Eugenia; et al.; Assessment of oxidative status and genotoxicity in photocopier operators: a pilot study; Taylor & Francis Ltd; Biomarkers; 16; 8; 12-2011; 642-648
1354-750X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96489
identifier_str_mv Kleinsorge, Elisa; Erben, Melina; Galan, Maria Gimena; Barisón, Caterina; Gonsebatt, Mara Eugenia; et al.; Assessment of oxidative status and genotoxicity in photocopier operators: a pilot study; Taylor & Francis Ltd; Biomarkers; 16; 8; 12-2011; 642-648
1354-750X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://informahealthcare.com/doi/abs/10.3109/1354750X.2011.620744
info:eu-repo/semantics/altIdentifier/doi/10.3109/1354750X.2011.620744
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269282895921152
score 13.13397

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