Putative novel cps loci in a large global collection of pneumococci

Autores: van Tonder, Andries; Gladstone, Rebecca A.; Lo, Stephanie W.; Nahm, Moon H.; du Plessis, Mignon; Cornick, Jennifer; Kwambana Adams, Brenda; Madhi, Shabir A.; Hawkins, Paulina A.; Benisty, Rachel; Dagan, Ron; Everett, Dean; Antonio, Martin; Klugman, Keith P.; von Gottberg, Anne; Breiman, Robert F.; McGee, Lesley; Bentley, Stephen D.; Faccone, Diego Francisco
Año de publicación: 2019
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: The pneumococcus produces a polysaccharide capsule, encoded by the cps locus, that provides protection against phagocytosis and determines serotype. Nearly 100 serotypes have been identified with new serotypes still being discovered, especially in previously understudied regions. Here we present an analysis of the cps loci of more than 18 000 genomes from the Global Pneumococcal Sequencing (GPS) project with the aim of identifying novel cps loci with the potential to produce previously unrecognized capsule structures. Serotypes were assigned using whole genome sequence data and 66 of the approximately 100 known serotypes were included in the final dataset. Closer examination of each serotype’s sequences identified nine putative novel cps loci (9X, 11X, 16X, 18X1, 18X2, 18X3, 29X, 33X and 36X) found in ~2.6 % of the genomes. The large number and global distribution of GPS genomes provided an unprecedented opportunity to identify novel cps loci and consider their phylogenetic and geographical distribution. Nine putative novel cps loci were identified and examples of each will undergo subsequent structural and immunological analysis.
Fil: van Tonder, Andries. Wellcome Genome Campus;
Fil: Gladstone, Rebecca A.. Wellcome Genome Campus;
Fil: Lo, Stephanie W.. Wellcome Genome Campus;
Fil: Nahm, Moon H.. University Of Alabama At Birmingahm. School Of Medicine; Estados Unidos
Fil: du Plessis, Mignon. National Institute For Communicable Diseases; Sudáfrica. University of the Witwatersrand; Sudáfrica
Fil: Cornick, Jennifer. Malawi Liverpool Wellcome Trust; Malaui
Fil: Kwambana Adams, Brenda. Vaccines And Immunity Theme; Gambia
Fil: Madhi, Shabir A.. University of the Witwatersrand; Sudáfrica
Fil: Hawkins, Paulina A.. University Of Emory. Rollins School Of Public Health; Estados Unidos
Fil: Benisty, Rachel. Ben Gurion University of the Negev; Israel
Fil: Dagan, Ron. Ben Gurion University of the Negev; Israel
Fil: Everett, Dean. University of Edinburgh; Reino Unido
Fil: Antonio, Martin. Vaccines And Immunity Theme; Gambia
Fil: Klugman, Keith P.. University Of Emory. Rollins School Of Public Health; Estados Unidos
Fil: von Gottberg, Anne. National Institute For Communicable Diseases; Sudáfrica. University of the Witwatersrand; Sudáfrica
Fil: Breiman, Robert F.. University Of Emory. Rollins School Of Public Health; Estados Unidos. University of Edinburgh; Reino Unido
Fil: McGee, Lesley. Centers for Disease Control and Prevention; Estados Unidos
Fil: Bentley, Stephen D.. Wellcome Genome Campus; . University Of Emory. Emory College Of Arts And Sciences.; Estados Unidos
Fil: Faccone, Diego Francisco. Administracion Nacional de Laboratorios E Institutos de Salud "dr. Carlos G. Malbran". Instituto Nacional de Epidemiologia. Departamento de Investigacion.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia: CPS LOCUS
PNEUMOCOCCUS
POLYSACCHARIDE CAPSULE
SEROTYPE
STREPTOCOCCUS PNEUMONIAE
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/131269

Acceder

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network_name_str	CONICET Digital (CONICET)
spelling	Putative novel cps loci in a large global collection of pneumococcivan Tonder, AndriesGladstone, Rebecca A.Lo, Stephanie W.Nahm, Moon H.du Plessis, MignonCornick, JenniferKwambana Adams, BrendaMadhi, Shabir A.Hawkins, Paulina A.Benisty, RachelDagan, RonEverett, DeanAntonio, MartinKlugman, Keith P.von Gottberg, AnneBreiman, Robert F.McGee, LesleyBentley, Stephen D.Faccone, Diego FranciscoCPS LOCUSPNEUMOCOCCUSPOLYSACCHARIDE CAPSULESEROTYPESTREPTOCOCCUS PNEUMONIAEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The pneumococcus produces a polysaccharide capsule, encoded by the cps locus, that provides protection against phagocytosis and determines serotype. Nearly 100 serotypes have been identified with new serotypes still being discovered, especially in previously understudied regions. Here we present an analysis of the cps loci of more than 18 000 genomes from the Global Pneumococcal Sequencing (GPS) project with the aim of identifying novel cps loci with the potential to produce previously unrecognized capsule structures. Serotypes were assigned using whole genome sequence data and 66 of the approximately 100 known serotypes were included in the final dataset. Closer examination of each serotype’s sequences identified nine putative novel cps loci (9X, 11X, 16X, 18X1, 18X2, 18X3, 29X, 33X and 36X) found in ~2.6 % of the genomes. The large number and global distribution of GPS genomes provided an unprecedented opportunity to identify novel cps loci and consider their phylogenetic and geographical distribution. Nine putative novel cps loci were identified and examples of each will undergo subsequent structural and immunological analysis.Fil: van Tonder, Andries. Wellcome Genome Campus;Fil: Gladstone, Rebecca A.. Wellcome Genome Campus;Fil: Lo, Stephanie W.. Wellcome Genome Campus;Fil: Nahm, Moon H.. University Of Alabama At Birmingahm. School Of Medicine; Estados UnidosFil: du Plessis, Mignon. National Institute For Communicable Diseases; Sudáfrica. University of the Witwatersrand; SudáfricaFil: Cornick, Jennifer. Malawi Liverpool Wellcome Trust; MalauiFil: Kwambana Adams, Brenda. Vaccines And Immunity Theme; GambiaFil: Madhi, Shabir A.. University of the Witwatersrand; SudáfricaFil: Hawkins, Paulina A.. University Of Emory. Rollins School Of Public Health; Estados UnidosFil: Benisty, Rachel. Ben Gurion University of the Negev; IsraelFil: Dagan, Ron. Ben Gurion University of the Negev; IsraelFil: Everett, Dean. University of Edinburgh; Reino UnidoFil: Antonio, Martin. Vaccines And Immunity Theme; GambiaFil: Klugman, Keith P.. University Of Emory. Rollins School Of Public Health; Estados UnidosFil: von Gottberg, Anne. National Institute For Communicable Diseases; Sudáfrica. University of the Witwatersrand; SudáfricaFil: Breiman, Robert F.. University Of Emory. Rollins School Of Public Health; Estados Unidos. University of Edinburgh; Reino UnidoFil: McGee, Lesley. Centers for Disease Control and Prevention; Estados UnidosFil: Bentley, Stephen D.. Wellcome Genome Campus; . University Of Emory. Emory College Of Arts And Sciences.; Estados UnidosFil: Faccone, Diego Francisco. Administracion Nacional de Laboratorios E Institutos de Salud "dr. Carlos G. Malbran". Instituto Nacional de Epidemiologia. Departamento de Investigacion.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMicrobiology Society2019-06-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/131269van Tonder, Andries; Gladstone, Rebecca A.; Lo, Stephanie W.; Nahm, Moon H.; du Plessis, Mignon; et al.; Putative novel cps loci in a large global collection of pneumococci; Microbiology Society; Microbial Genomics; 5; 7; 11-6-2019; 1-162057-5858CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.000274.v1info:eu-repo/semantics/altIdentifier/doi/10.1099/mgen.0.000274info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:57:44Zoai:ri.conicet.gov.ar:11336/131269instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:57:44.674CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	Putative novel cps loci in a large global collection of pneumococci
title	Putative novel cps loci in a large global collection of pneumococci
spellingShingle	Putative novel cps loci in a large global collection of pneumococci van Tonder, Andries CPS LOCUS PNEUMOCOCCUS POLYSACCHARIDE CAPSULE SEROTYPE STREPTOCOCCUS PNEUMONIAE
title_short	Putative novel cps loci in a large global collection of pneumococci
title_full	Putative novel cps loci in a large global collection of pneumococci
title_fullStr	Putative novel cps loci in a large global collection of pneumococci
title_full_unstemmed	Putative novel cps loci in a large global collection of pneumococci
title_sort	Putative novel cps loci in a large global collection of pneumococci
dc.creator.none.fl_str_mv	van Tonder, Andries Gladstone, Rebecca A. Lo, Stephanie W. Nahm, Moon H. du Plessis, Mignon Cornick, Jennifer Kwambana Adams, Brenda Madhi, Shabir A. Hawkins, Paulina A. Benisty, Rachel Dagan, Ron Everett, Dean Antonio, Martin Klugman, Keith P. von Gottberg, Anne Breiman, Robert F. McGee, Lesley Bentley, Stephen D. Faccone, Diego Francisco
author	van Tonder, Andries
author_facet	van Tonder, Andries Gladstone, Rebecca A. Lo, Stephanie W. Nahm, Moon H. du Plessis, Mignon Cornick, Jennifer Kwambana Adams, Brenda Madhi, Shabir A. Hawkins, Paulina A. Benisty, Rachel Dagan, Ron Everett, Dean Antonio, Martin Klugman, Keith P. von Gottberg, Anne Breiman, Robert F. McGee, Lesley Bentley, Stephen D. Faccone, Diego Francisco
author_role	author
author2	Gladstone, Rebecca A. Lo, Stephanie W. Nahm, Moon H. du Plessis, Mignon Cornick, Jennifer Kwambana Adams, Brenda Madhi, Shabir A. Hawkins, Paulina A. Benisty, Rachel Dagan, Ron Everett, Dean Antonio, Martin Klugman, Keith P. von Gottberg, Anne Breiman, Robert F. McGee, Lesley Bentley, Stephen D. Faccone, Diego Francisco
author2_role	author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	CPS LOCUS PNEUMOCOCCUS POLYSACCHARIDE CAPSULE SEROTYPE STREPTOCOCCUS PNEUMONIAE
topic	CPS LOCUS PNEUMOCOCCUS POLYSACCHARIDE CAPSULE SEROTYPE STREPTOCOCCUS PNEUMONIAE
purl_subject.fl_str_mv	https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv	The pneumococcus produces a polysaccharide capsule, encoded by the cps locus, that provides protection against phagocytosis and determines serotype. Nearly 100 serotypes have been identified with new serotypes still being discovered, especially in previously understudied regions. Here we present an analysis of the cps loci of more than 18 000 genomes from the Global Pneumococcal Sequencing (GPS) project with the aim of identifying novel cps loci with the potential to produce previously unrecognized capsule structures. Serotypes were assigned using whole genome sequence data and 66 of the approximately 100 known serotypes were included in the final dataset. Closer examination of each serotype’s sequences identified nine putative novel cps loci (9X, 11X, 16X, 18X1, 18X2, 18X3, 29X, 33X and 36X) found in ~2.6 % of the genomes. The large number and global distribution of GPS genomes provided an unprecedented opportunity to identify novel cps loci and consider their phylogenetic and geographical distribution. Nine putative novel cps loci were identified and examples of each will undergo subsequent structural and immunological analysis. Fil: van Tonder, Andries. Wellcome Genome Campus; Fil: Gladstone, Rebecca A.. Wellcome Genome Campus; Fil: Lo, Stephanie W.. Wellcome Genome Campus; Fil: Nahm, Moon H.. University Of Alabama At Birmingahm. School Of Medicine; Estados Unidos Fil: du Plessis, Mignon. National Institute For Communicable Diseases; Sudáfrica. University of the Witwatersrand; Sudáfrica Fil: Cornick, Jennifer. Malawi Liverpool Wellcome Trust; Malaui Fil: Kwambana Adams, Brenda. Vaccines And Immunity Theme; Gambia Fil: Madhi, Shabir A.. University of the Witwatersrand; Sudáfrica Fil: Hawkins, Paulina A.. University Of Emory. Rollins School Of Public Health; Estados Unidos Fil: Benisty, Rachel. Ben Gurion University of the Negev; Israel Fil: Dagan, Ron. Ben Gurion University of the Negev; Israel Fil: Everett, Dean. University of Edinburgh; Reino Unido Fil: Antonio, Martin. Vaccines And Immunity Theme; Gambia Fil: Klugman, Keith P.. University Of Emory. Rollins School Of Public Health; Estados Unidos Fil: von Gottberg, Anne. National Institute For Communicable Diseases; Sudáfrica. University of the Witwatersrand; Sudáfrica Fil: Breiman, Robert F.. University Of Emory. Rollins School Of Public Health; Estados Unidos. University of Edinburgh; Reino Unido Fil: McGee, Lesley. Centers for Disease Control and Prevention; Estados Unidos Fil: Bentley, Stephen D.. Wellcome Genome Campus; . University Of Emory. Emory College Of Arts And Sciences.; Estados Unidos Fil: Faccone, Diego Francisco. Administracion Nacional de Laboratorios E Institutos de Salud "dr. Carlos G. Malbran". Instituto Nacional de Epidemiologia. Departamento de Investigacion.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description	The pneumococcus produces a polysaccharide capsule, encoded by the cps locus, that provides protection against phagocytosis and determines serotype. Nearly 100 serotypes have been identified with new serotypes still being discovered, especially in previously understudied regions. Here we present an analysis of the cps loci of more than 18 000 genomes from the Global Pneumococcal Sequencing (GPS) project with the aim of identifying novel cps loci with the potential to produce previously unrecognized capsule structures. Serotypes were assigned using whole genome sequence data and 66 of the approximately 100 known serotypes were included in the final dataset. Closer examination of each serotype’s sequences identified nine putative novel cps loci (9X, 11X, 16X, 18X1, 18X2, 18X3, 29X, 33X and 36X) found in ~2.6 % of the genomes. The large number and global distribution of GPS genomes provided an unprecedented opportunity to identify novel cps loci and consider their phylogenetic and geographical distribution. Nine putative novel cps loci were identified and examples of each will undergo subsequent structural and immunological analysis.
publishDate	2019
dc.date.none.fl_str_mv	2019-06-11
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/131269 van Tonder, Andries; Gladstone, Rebecca A.; Lo, Stephanie W.; Nahm, Moon H.; du Plessis, Mignon; et al.; Putative novel cps loci in a large global collection of pneumococci; Microbiology Society; Microbial Genomics; 5; 7; 11-6-2019; 1-16 2057-5858 CONICET Digital CONICET
url	http://hdl.handle.net/11336/131269
identifier_str_mv	van Tonder, Andries; Gladstone, Rebecca A.; Lo, Stephanie W.; Nahm, Moon H.; du Plessis, Mignon; et al.; Putative novel cps loci in a large global collection of pneumococci; Microbiology Society; Microbial Genomics; 5; 7; 11-6-2019; 1-16 2057-5858 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/url/https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.000274.v1 info:eu-repo/semantics/altIdentifier/doi/10.1099/mgen.0.000274
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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dc.publisher.none.fl_str_mv	Microbiology Society
publisher.none.fl_str_mv	Microbiology Society
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reponame_str	CONICET Digital (CONICET)
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repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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Putative novel cps loci in a large global collection of pneumococci

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