The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci

Autores
D'Aeth, Joshua C.; van der Linden, Mark P. G.; McGee, Lesley; de Lencastre, Herminia; Turner, Paul; Song, Jae Hoon; Lo, Stephanie W.; Gladstone, Rebecca A.; Sá Leão, Raquel; Ko, Kwan Soo; Hanage, William P.; Breiman, Robert F.; Beall, Bernard; Bentley, Stephen D.; Croucher, Nicholas J.; Faccone, Diego Francisco; The GPS Consortium
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant S. pneumoniae lineages PMEN3 and PMEN9. A single PMEN3 clade spread globally, evading vaccine-induced immunity through frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. Both lineages repeatedly integrated Tn916-type and Tn1207.1- type elements, conferring tetracycline and macrolide resistance, respectively, through homologous recombination importing sequences originating in other species. A species-wide dataset found over 100 instances of such interspecific acquisitions of resistance cassettes and flanking homologous arms. Phylodynamic analysis of the most commonly sampled Tn1207.1-type insertion in PMEN9, originating from a commensal and disrupting a competence gene, suggested its expansion across Germany was driven by a high ratio of macrolide-to-b-lactam consumption. Hence, selection from antibiotic consumption was sufficient for these atypically large recombinations to overcome species boundaries across the pneumococcal chromosome.
Fil: D'Aeth, Joshua C.. Imperial College London; Reino Unido
Fil: van der Linden, Mark P. G.. Uniklinik RWTH Aachen; Alemania
Fil: McGee, Lesley. Centers for Disease Control and Prevention; Estados Unidos
Fil: de Lencastre, Herminia. Universidade Nova de Lisboa; Portugal. The Rockefeller University; Estados Unidos
Fil: Turner, Paul. Angkor Hospital for Children; Camboya. University of Oxford; Reino Unido
Fil: Song, Jae Hoon. Sungkyunkwan University School of Medicine; Corea del Sur
Fil: Lo, Stephanie W.. Wellcome Genome Campus; Reino Unido
Fil: Gladstone, Rebecca A.. Wellcome Genome Campus; Reino Unido
Fil: Sá Leão, Raquel. Universidade Nova de Lisboa; Portugal
Fil: Ko, Kwan Soo. Sungkyunkwan University School of Medicine; Corea del Sur
Fil: Hanage, William P.. Harvard University. Harvard School of Public Health; Estados Unidos
Fil: Breiman, Robert F.. University of Emory; Estados Unidos
Fil: Beall, Bernard. Centers for Disease Control and Prevention; Estados Unidos
Fil: Bentley, Stephen D.. Wellcome Genome Campus; Reino Unido
Fil: Croucher, Nicholas J.. Imperial College London; Reino Unido
Fil: Faccone, Diego Francisco. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: The GPS Consortium. The GPS Consortium; Estados Unidos
Materia
STREPTOCOCCUS PNEUMONIAE
ANTIBIOTIC
RECOMBINATION
EVOLUTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/167401
Acceder
id CONICETDig_6cb90862d1d25ac258440edc25a5c5d2
oai_identifier_str oai:ri.conicet.gov.ar:11336/167401
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The role of interspecies recombination in the evolution of antibiotic-resistant pneumococciD'Aeth, Joshua C.van der Linden, Mark P. G.McGee, Lesleyde Lencastre, HerminiaTurner, PaulSong, Jae HoonLo, Stephanie W.Gladstone, Rebecca A.Sá Leão, RaquelKo, Kwan SooHanage, William P.Breiman, Robert F.Beall, BernardBentley, Stephen D.Croucher, Nicholas J.Faccone, Diego FranciscoThe GPS ConsortiumSTREPTOCOCCUS PNEUMONIAEANTIBIOTICRECOMBINATIONEVOLUTIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant S. pneumoniae lineages PMEN3 and PMEN9. A single PMEN3 clade spread globally, evading vaccine-induced immunity through frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. Both lineages repeatedly integrated Tn916-type and Tn1207.1- type elements, conferring tetracycline and macrolide resistance, respectively, through homologous recombination importing sequences originating in other species. A species-wide dataset found over 100 instances of such interspecific acquisitions of resistance cassettes and flanking homologous arms. Phylodynamic analysis of the most commonly sampled Tn1207.1-type insertion in PMEN9, originating from a commensal and disrupting a competence gene, suggested its expansion across Germany was driven by a high ratio of macrolide-to-b-lactam consumption. Hence, selection from antibiotic consumption was sufficient for these atypically large recombinations to overcome species boundaries across the pneumococcal chromosome.Fil: D'Aeth, Joshua C.. Imperial College London; Reino UnidoFil: van der Linden, Mark P. G.. Uniklinik RWTH Aachen; AlemaniaFil: McGee, Lesley. Centers for Disease Control and Prevention; Estados UnidosFil: de Lencastre, Herminia. Universidade Nova de Lisboa; Portugal. The Rockefeller University; Estados UnidosFil: Turner, Paul. Angkor Hospital for Children; Camboya. University of Oxford; Reino UnidoFil: Song, Jae Hoon. Sungkyunkwan University School of Medicine; Corea del SurFil: Lo, Stephanie W.. Wellcome Genome Campus; Reino UnidoFil: Gladstone, Rebecca A.. Wellcome Genome Campus; Reino UnidoFil: Sá Leão, Raquel. Universidade Nova de Lisboa; PortugalFil: Ko, Kwan Soo. Sungkyunkwan University School of Medicine; Corea del SurFil: Hanage, William P.. Harvard University. Harvard School of Public Health; Estados UnidosFil: Breiman, Robert F.. University of Emory; Estados UnidosFil: Beall, Bernard. Centers for Disease Control and Prevention; Estados UnidosFil: Bentley, Stephen D.. Wellcome Genome Campus; Reino UnidoFil: Croucher, Nicholas J.. Imperial College London; Reino UnidoFil: Faccone, Diego Francisco. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: The GPS Consortium. The GPS Consortium; Estados UnidoseLife Sciences Publications Ltd2021-07-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/167401D'Aeth, Joshua C.; van der Linden, Mark P. G.; McGee, Lesley; de Lencastre, Herminia; Turner, Paul; et al.; The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci; eLife Sciences Publications Ltd; eLife; 10; 14-7-2021; 1-352050-084X2050-084XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/articles/67113info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.67113info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:33:22Zoai:ri.conicet.gov.ar:11336/167401instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:33:22.82CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci
title The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci
spellingShingle The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci
D'Aeth, Joshua C.
STREPTOCOCCUS PNEUMONIAE
ANTIBIOTIC
RECOMBINATION
EVOLUTION
title_short The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci
title_full The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci
title_fullStr The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci
title_full_unstemmed The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci
title_sort The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci
dc.creator.none.fl_str_mv D'Aeth, Joshua C.
van der Linden, Mark P. G.
McGee, Lesley
de Lencastre, Herminia
Turner, Paul
Song, Jae Hoon
Lo, Stephanie W.
Gladstone, Rebecca A.
Sá Leão, Raquel
Ko, Kwan Soo
Hanage, William P.
Breiman, Robert F.
Beall, Bernard
Bentley, Stephen D.
Croucher, Nicholas J.
Faccone, Diego Francisco
The GPS Consortium
author D'Aeth, Joshua C.
author_facet D'Aeth, Joshua C.
van der Linden, Mark P. G.
McGee, Lesley
de Lencastre, Herminia
Turner, Paul
Song, Jae Hoon
Lo, Stephanie W.
Gladstone, Rebecca A.
Sá Leão, Raquel
Ko, Kwan Soo
Hanage, William P.
Breiman, Robert F.
Beall, Bernard
Bentley, Stephen D.
Croucher, Nicholas J.
Faccone, Diego Francisco
The GPS Consortium
author_role author
author2 van der Linden, Mark P. G.
McGee, Lesley
de Lencastre, Herminia
Turner, Paul
Song, Jae Hoon
Lo, Stephanie W.
Gladstone, Rebecca A.
Sá Leão, Raquel
Ko, Kwan Soo
Hanage, William P.
Breiman, Robert F.
Beall, Bernard
Bentley, Stephen D.
Croucher, Nicholas J.
Faccone, Diego Francisco
The GPS Consortium
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv STREPTOCOCCUS PNEUMONIAE
ANTIBIOTIC
RECOMBINATION
EVOLUTION
topic STREPTOCOCCUS PNEUMONIAE
ANTIBIOTIC
RECOMBINATION
EVOLUTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant S. pneumoniae lineages PMEN3 and PMEN9. A single PMEN3 clade spread globally, evading vaccine-induced immunity through frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. Both lineages repeatedly integrated Tn916-type and Tn1207.1- type elements, conferring tetracycline and macrolide resistance, respectively, through homologous recombination importing sequences originating in other species. A species-wide dataset found over 100 instances of such interspecific acquisitions of resistance cassettes and flanking homologous arms. Phylodynamic analysis of the most commonly sampled Tn1207.1-type insertion in PMEN9, originating from a commensal and disrupting a competence gene, suggested its expansion across Germany was driven by a high ratio of macrolide-to-b-lactam consumption. Hence, selection from antibiotic consumption was sufficient for these atypically large recombinations to overcome species boundaries across the pneumococcal chromosome.
Fil: D'Aeth, Joshua C.. Imperial College London; Reino Unido
Fil: van der Linden, Mark P. G.. Uniklinik RWTH Aachen; Alemania
Fil: McGee, Lesley. Centers for Disease Control and Prevention; Estados Unidos
Fil: de Lencastre, Herminia. Universidade Nova de Lisboa; Portugal. The Rockefeller University; Estados Unidos
Fil: Turner, Paul. Angkor Hospital for Children; Camboya. University of Oxford; Reino Unido
Fil: Song, Jae Hoon. Sungkyunkwan University School of Medicine; Corea del Sur
Fil: Lo, Stephanie W.. Wellcome Genome Campus; Reino Unido
Fil: Gladstone, Rebecca A.. Wellcome Genome Campus; Reino Unido
Fil: Sá Leão, Raquel. Universidade Nova de Lisboa; Portugal
Fil: Ko, Kwan Soo. Sungkyunkwan University School of Medicine; Corea del Sur
Fil: Hanage, William P.. Harvard University. Harvard School of Public Health; Estados Unidos
Fil: Breiman, Robert F.. University of Emory; Estados Unidos
Fil: Beall, Bernard. Centers for Disease Control and Prevention; Estados Unidos
Fil: Bentley, Stephen D.. Wellcome Genome Campus; Reino Unido
Fil: Croucher, Nicholas J.. Imperial College London; Reino Unido
Fil: Faccone, Diego Francisco. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: The GPS Consortium. The GPS Consortium; Estados Unidos
description Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant S. pneumoniae lineages PMEN3 and PMEN9. A single PMEN3 clade spread globally, evading vaccine-induced immunity through frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. Both lineages repeatedly integrated Tn916-type and Tn1207.1- type elements, conferring tetracycline and macrolide resistance, respectively, through homologous recombination importing sequences originating in other species. A species-wide dataset found over 100 instances of such interspecific acquisitions of resistance cassettes and flanking homologous arms. Phylodynamic analysis of the most commonly sampled Tn1207.1-type insertion in PMEN9, originating from a commensal and disrupting a competence gene, suggested its expansion across Germany was driven by a high ratio of macrolide-to-b-lactam consumption. Hence, selection from antibiotic consumption was sufficient for these atypically large recombinations to overcome species boundaries across the pneumococcal chromosome.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-14
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/167401
D'Aeth, Joshua C.; van der Linden, Mark P. G.; McGee, Lesley; de Lencastre, Herminia; Turner, Paul; et al.; The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci; eLife Sciences Publications Ltd; eLife; 10; 14-7-2021; 1-35
2050-084X
2050-084X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/167401
identifier_str_mv D'Aeth, Joshua C.; van der Linden, Mark P. G.; McGee, Lesley; de Lencastre, Herminia; Turner, Paul; et al.; The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci; eLife Sciences Publications Ltd; eLife; 10; 14-7-2021; 1-35
2050-084X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/articles/67113
info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.67113
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv eLife Sciences Publications Ltd
publisher.none.fl_str_mv eLife Sciences Publications Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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