The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci
- Autores
- D'Aeth, Joshua C.; van der Linden, Mark P. G.; McGee, Lesley; de Lencastre, Herminia; Turner, Paul; Song, Jae Hoon; Lo, Stephanie W.; Gladstone, Rebecca A.; Sá Leão, Raquel; Ko, Kwan Soo; Hanage, William P.; Breiman, Robert F.; Beall, Bernard; Bentley, Stephen D.; Croucher, Nicholas J.; Faccone, Diego Francisco; The GPS Consortium
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant S. pneumoniae lineages PMEN3 and PMEN9. A single PMEN3 clade spread globally, evading vaccine-induced immunity through frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. Both lineages repeatedly integrated Tn916-type and Tn1207.1- type elements, conferring tetracycline and macrolide resistance, respectively, through homologous recombination importing sequences originating in other species. A species-wide dataset found over 100 instances of such interspecific acquisitions of resistance cassettes and flanking homologous arms. Phylodynamic analysis of the most commonly sampled Tn1207.1-type insertion in PMEN9, originating from a commensal and disrupting a competence gene, suggested its expansion across Germany was driven by a high ratio of macrolide-to-b-lactam consumption. Hence, selection from antibiotic consumption was sufficient for these atypically large recombinations to overcome species boundaries across the pneumococcal chromosome.
Fil: D'Aeth, Joshua C.. Imperial College London; Reino Unido
Fil: van der Linden, Mark P. G.. Uniklinik RWTH Aachen; Alemania
Fil: McGee, Lesley. Centers for Disease Control and Prevention; Estados Unidos
Fil: de Lencastre, Herminia. Universidade Nova de Lisboa; Portugal. The Rockefeller University; Estados Unidos
Fil: Turner, Paul. Angkor Hospital for Children; Camboya. University of Oxford; Reino Unido
Fil: Song, Jae Hoon. Sungkyunkwan University School of Medicine; Corea del Sur
Fil: Lo, Stephanie W.. Wellcome Genome Campus; Reino Unido
Fil: Gladstone, Rebecca A.. Wellcome Genome Campus; Reino Unido
Fil: Sá Leão, Raquel. Universidade Nova de Lisboa; Portugal
Fil: Ko, Kwan Soo. Sungkyunkwan University School of Medicine; Corea del Sur
Fil: Hanage, William P.. Harvard University. Harvard School of Public Health; Estados Unidos
Fil: Breiman, Robert F.. University of Emory; Estados Unidos
Fil: Beall, Bernard. Centers for Disease Control and Prevention; Estados Unidos
Fil: Bentley, Stephen D.. Wellcome Genome Campus; Reino Unido
Fil: Croucher, Nicholas J.. Imperial College London; Reino Unido
Fil: Faccone, Diego Francisco. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: The GPS Consortium. The GPS Consortium; Estados Unidos - Materia
-
STREPTOCOCCUS PNEUMONIAE
ANTIBIOTIC
RECOMBINATION
EVOLUTION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/167401
Ver los metadatos del registro completo
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The role of interspecies recombination in the evolution of antibiotic-resistant pneumococciD'Aeth, Joshua C.van der Linden, Mark P. G.McGee, Lesleyde Lencastre, HerminiaTurner, PaulSong, Jae HoonLo, Stephanie W.Gladstone, Rebecca A.Sá Leão, RaquelKo, Kwan SooHanage, William P.Breiman, Robert F.Beall, BernardBentley, Stephen D.Croucher, Nicholas J.Faccone, Diego FranciscoThe GPS ConsortiumSTREPTOCOCCUS PNEUMONIAEANTIBIOTICRECOMBINATIONEVOLUTIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant S. pneumoniae lineages PMEN3 and PMEN9. A single PMEN3 clade spread globally, evading vaccine-induced immunity through frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. Both lineages repeatedly integrated Tn916-type and Tn1207.1- type elements, conferring tetracycline and macrolide resistance, respectively, through homologous recombination importing sequences originating in other species. A species-wide dataset found over 100 instances of such interspecific acquisitions of resistance cassettes and flanking homologous arms. Phylodynamic analysis of the most commonly sampled Tn1207.1-type insertion in PMEN9, originating from a commensal and disrupting a competence gene, suggested its expansion across Germany was driven by a high ratio of macrolide-to-b-lactam consumption. Hence, selection from antibiotic consumption was sufficient for these atypically large recombinations to overcome species boundaries across the pneumococcal chromosome.Fil: D'Aeth, Joshua C.. Imperial College London; Reino UnidoFil: van der Linden, Mark P. G.. Uniklinik RWTH Aachen; AlemaniaFil: McGee, Lesley. Centers for Disease Control and Prevention; Estados UnidosFil: de Lencastre, Herminia. Universidade Nova de Lisboa; Portugal. The Rockefeller University; Estados UnidosFil: Turner, Paul. Angkor Hospital for Children; Camboya. University of Oxford; Reino UnidoFil: Song, Jae Hoon. Sungkyunkwan University School of Medicine; Corea del SurFil: Lo, Stephanie W.. Wellcome Genome Campus; Reino UnidoFil: Gladstone, Rebecca A.. Wellcome Genome Campus; Reino UnidoFil: Sá Leão, Raquel. Universidade Nova de Lisboa; PortugalFil: Ko, Kwan Soo. Sungkyunkwan University School of Medicine; Corea del SurFil: Hanage, William P.. Harvard University. Harvard School of Public Health; Estados UnidosFil: Breiman, Robert F.. University of Emory; Estados UnidosFil: Beall, Bernard. Centers for Disease Control and Prevention; Estados UnidosFil: Bentley, Stephen D.. Wellcome Genome Campus; Reino UnidoFil: Croucher, Nicholas J.. Imperial College London; Reino UnidoFil: Faccone, Diego Francisco. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: The GPS Consortium. The GPS Consortium; Estados UnidoseLife Sciences Publications Ltd2021-07-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/167401D'Aeth, Joshua C.; van der Linden, Mark P. G.; McGee, Lesley; de Lencastre, Herminia; Turner, Paul; et al.; The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci; eLife Sciences Publications Ltd; eLife; 10; 14-7-2021; 1-352050-084X2050-084XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/articles/67113info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.67113info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:03:36Zoai:ri.conicet.gov.ar:11336/167401instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:03:37.008CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci |
title |
The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci |
spellingShingle |
The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci D'Aeth, Joshua C. STREPTOCOCCUS PNEUMONIAE ANTIBIOTIC RECOMBINATION EVOLUTION |
title_short |
The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci |
title_full |
The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci |
title_fullStr |
The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci |
title_full_unstemmed |
The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci |
title_sort |
The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci |
dc.creator.none.fl_str_mv |
D'Aeth, Joshua C. van der Linden, Mark P. G. McGee, Lesley de Lencastre, Herminia Turner, Paul Song, Jae Hoon Lo, Stephanie W. Gladstone, Rebecca A. Sá Leão, Raquel Ko, Kwan Soo Hanage, William P. Breiman, Robert F. Beall, Bernard Bentley, Stephen D. Croucher, Nicholas J. Faccone, Diego Francisco The GPS Consortium |
author |
D'Aeth, Joshua C. |
author_facet |
D'Aeth, Joshua C. van der Linden, Mark P. G. McGee, Lesley de Lencastre, Herminia Turner, Paul Song, Jae Hoon Lo, Stephanie W. Gladstone, Rebecca A. Sá Leão, Raquel Ko, Kwan Soo Hanage, William P. Breiman, Robert F. Beall, Bernard Bentley, Stephen D. Croucher, Nicholas J. Faccone, Diego Francisco The GPS Consortium |
author_role |
author |
author2 |
van der Linden, Mark P. G. McGee, Lesley de Lencastre, Herminia Turner, Paul Song, Jae Hoon Lo, Stephanie W. Gladstone, Rebecca A. Sá Leão, Raquel Ko, Kwan Soo Hanage, William P. Breiman, Robert F. Beall, Bernard Bentley, Stephen D. Croucher, Nicholas J. Faccone, Diego Francisco The GPS Consortium |
author2_role |
author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
STREPTOCOCCUS PNEUMONIAE ANTIBIOTIC RECOMBINATION EVOLUTION |
topic |
STREPTOCOCCUS PNEUMONIAE ANTIBIOTIC RECOMBINATION EVOLUTION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant S. pneumoniae lineages PMEN3 and PMEN9. A single PMEN3 clade spread globally, evading vaccine-induced immunity through frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. Both lineages repeatedly integrated Tn916-type and Tn1207.1- type elements, conferring tetracycline and macrolide resistance, respectively, through homologous recombination importing sequences originating in other species. A species-wide dataset found over 100 instances of such interspecific acquisitions of resistance cassettes and flanking homologous arms. Phylodynamic analysis of the most commonly sampled Tn1207.1-type insertion in PMEN9, originating from a commensal and disrupting a competence gene, suggested its expansion across Germany was driven by a high ratio of macrolide-to-b-lactam consumption. Hence, selection from antibiotic consumption was sufficient for these atypically large recombinations to overcome species boundaries across the pneumococcal chromosome. Fil: D'Aeth, Joshua C.. Imperial College London; Reino Unido Fil: van der Linden, Mark P. G.. Uniklinik RWTH Aachen; Alemania Fil: McGee, Lesley. Centers for Disease Control and Prevention; Estados Unidos Fil: de Lencastre, Herminia. Universidade Nova de Lisboa; Portugal. The Rockefeller University; Estados Unidos Fil: Turner, Paul. Angkor Hospital for Children; Camboya. University of Oxford; Reino Unido Fil: Song, Jae Hoon. Sungkyunkwan University School of Medicine; Corea del Sur Fil: Lo, Stephanie W.. Wellcome Genome Campus; Reino Unido Fil: Gladstone, Rebecca A.. Wellcome Genome Campus; Reino Unido Fil: Sá Leão, Raquel. Universidade Nova de Lisboa; Portugal Fil: Ko, Kwan Soo. Sungkyunkwan University School of Medicine; Corea del Sur Fil: Hanage, William P.. Harvard University. Harvard School of Public Health; Estados Unidos Fil: Breiman, Robert F.. University of Emory; Estados Unidos Fil: Beall, Bernard. Centers for Disease Control and Prevention; Estados Unidos Fil: Bentley, Stephen D.. Wellcome Genome Campus; Reino Unido Fil: Croucher, Nicholas J.. Imperial College London; Reino Unido Fil: Faccone, Diego Francisco. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: The GPS Consortium. The GPS Consortium; Estados Unidos |
description |
Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant S. pneumoniae lineages PMEN3 and PMEN9. A single PMEN3 clade spread globally, evading vaccine-induced immunity through frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. Both lineages repeatedly integrated Tn916-type and Tn1207.1- type elements, conferring tetracycline and macrolide resistance, respectively, through homologous recombination importing sequences originating in other species. A species-wide dataset found over 100 instances of such interspecific acquisitions of resistance cassettes and flanking homologous arms. Phylodynamic analysis of the most commonly sampled Tn1207.1-type insertion in PMEN9, originating from a commensal and disrupting a competence gene, suggested its expansion across Germany was driven by a high ratio of macrolide-to-b-lactam consumption. Hence, selection from antibiotic consumption was sufficient for these atypically large recombinations to overcome species boundaries across the pneumococcal chromosome. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-14 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/167401 D'Aeth, Joshua C.; van der Linden, Mark P. G.; McGee, Lesley; de Lencastre, Herminia; Turner, Paul; et al.; The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci; eLife Sciences Publications Ltd; eLife; 10; 14-7-2021; 1-35 2050-084X 2050-084X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/167401 |
identifier_str_mv |
D'Aeth, Joshua C.; van der Linden, Mark P. G.; McGee, Lesley; de Lencastre, Herminia; Turner, Paul; et al.; The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci; eLife Sciences Publications Ltd; eLife; 10; 14-7-2021; 1-35 2050-084X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/articles/67113 info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.67113 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
eLife Sciences Publications Ltd |
publisher.none.fl_str_mv |
eLife Sciences Publications Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613854064017408 |
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13.070432 |