Enhanced Repertoire of Brain Dynamical States During the Psychedelic Experience

Autores
Tagliazucchi, Enzo Rodolfo; Carhart Harris, Robin L.; Leech, Robert; Nutt, David; Chialvo, Dante Renato
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Abstract: The study of rapid changes in brain dynamics and functional connectivity (FC) is of increasing interest in neuroimaging. Brain states departing from normal waking consciousness are expected to be accompanied by alterations in the aforementioned dynamics. In particular, the psychedelic experience produced by psilocybin (a substance found in “magic mushrooms”) is characterized by unconstrained cognition and profound alterations in the perception of time, space and selfhood. Considering the spontaneous and subjective manifestation of these effects, we hypothesize that neural correlates of the psychedelic experience can be found in the dynamics and variability of spontaneous brain activity fluctuations and connectivity, measurable with functional Magnetic Resonance Imaging (fMRI). Fifteen healthy subjects were scanned before, during and after intravenous infusion of psilocybin and an inert placebo. Blood-Oxygen Level Dependent (BOLD) temporal variability was assessed computing the variance and total spectral power, resulting in increased signal variability bilaterally in the hippocampi and anterior cingulate cortex. Changes in BOLD signal spectral behavior (including spectral scaling exponents) affected exclusively higher brain systems such as the default mode, executive control, and dorsal attention networks. A novel framework enabled us to track different connectivity states explored by the brain during rest. This approach revealed a wider repertoire of connectivity states post-psilocybin than during control conditions. Together, the present results provide a comprehensive account of the effects of psilocybin on dynamical behavior in the human brain at a macroscopic level and may have implications for our understanding of the unconstrained, hyper-associative quality of consciousness in the psychedelic state
Fil: Tagliazucchi, Enzo Rodolfo. Goethe Universitat Frankfurt; Alemania
Fil: Carhart Harris, Robin L.. Imperial College London. Londres; Reino Unido
Fil: Leech, Robert. Imperial College London. Londres; Reino Unido
Fil: Nutt, David. Imperial College London. Londres; Reino Unido
Fil: Chialvo, Dante Renato. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Psilocybin
Fmri
Functional Connectivity
Resting State
Psychedelic State
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/30264
Acceder
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spelling Enhanced Repertoire of Brain Dynamical States During the Psychedelic ExperienceTagliazucchi, Enzo RodolfoCarhart Harris, Robin L.Leech, RobertNutt, DavidChialvo, Dante RenatoPsilocybinFmriFunctional ConnectivityResting StatePsychedelic StateAbstract: The study of rapid changes in brain dynamics and functional connectivity (FC) is of increasing interest in neuroimaging. Brain states departing from normal waking consciousness are expected to be accompanied by alterations in the aforementioned dynamics. In particular, the psychedelic experience produced by psilocybin (a substance found in “magic mushrooms”) is characterized by unconstrained cognition and profound alterations in the perception of time, space and selfhood. Considering the spontaneous and subjective manifestation of these effects, we hypothesize that neural correlates of the psychedelic experience can be found in the dynamics and variability of spontaneous brain activity fluctuations and connectivity, measurable with functional Magnetic Resonance Imaging (fMRI). Fifteen healthy subjects were scanned before, during and after intravenous infusion of psilocybin and an inert placebo. Blood-Oxygen Level Dependent (BOLD) temporal variability was assessed computing the variance and total spectral power, resulting in increased signal variability bilaterally in the hippocampi and anterior cingulate cortex. Changes in BOLD signal spectral behavior (including spectral scaling exponents) affected exclusively higher brain systems such as the default mode, executive control, and dorsal attention networks. A novel framework enabled us to track different connectivity states explored by the brain during rest. This approach revealed a wider repertoire of connectivity states post-psilocybin than during control conditions. Together, the present results provide a comprehensive account of the effects of psilocybin on dynamical behavior in the human brain at a macroscopic level and may have implications for our understanding of the unconstrained, hyper-associative quality of consciousness in the psychedelic stateFil: Tagliazucchi, Enzo Rodolfo. Goethe Universitat Frankfurt; AlemaniaFil: Carhart Harris, Robin L.. Imperial College London. Londres; Reino UnidoFil: Leech, Robert. Imperial College London. Londres; Reino UnidoFil: Nutt, David. Imperial College London. Londres; Reino UnidoFil: Chialvo, Dante Renato. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley-liss, Div John Wiley & Sons Inc2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/30264Tagliazucchi, Enzo Rodolfo; Carhart Harris, Robin L.; Leech, Robert; Nutt, David; Chialvo, Dante Renato; Enhanced Repertoire of Brain Dynamical States During the Psychedelic Experience; Wiley-liss, Div John Wiley & Sons Inc; Human Brain Mapping; 35; 11; 7-2014; 5442-54561065-9471CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/hbm.22562/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1002/hbm.22562info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:08:48Zoai:ri.conicet.gov.ar:11336/30264instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:08:48.569CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Enhanced Repertoire of Brain Dynamical States During the Psychedelic Experience
title Enhanced Repertoire of Brain Dynamical States During the Psychedelic Experience
spellingShingle Enhanced Repertoire of Brain Dynamical States During the Psychedelic Experience
Tagliazucchi, Enzo Rodolfo
Psilocybin
Fmri
Functional Connectivity
Resting State
Psychedelic State
title_short Enhanced Repertoire of Brain Dynamical States During the Psychedelic Experience
title_full Enhanced Repertoire of Brain Dynamical States During the Psychedelic Experience
title_fullStr Enhanced Repertoire of Brain Dynamical States During the Psychedelic Experience
title_full_unstemmed Enhanced Repertoire of Brain Dynamical States During the Psychedelic Experience
title_sort Enhanced Repertoire of Brain Dynamical States During the Psychedelic Experience
dc.creator.none.fl_str_mv Tagliazucchi, Enzo Rodolfo
Carhart Harris, Robin L.
Leech, Robert
Nutt, David
Chialvo, Dante Renato
author Tagliazucchi, Enzo Rodolfo
author_facet Tagliazucchi, Enzo Rodolfo
Carhart Harris, Robin L.
Leech, Robert
Nutt, David
Chialvo, Dante Renato
author_role author
author2 Carhart Harris, Robin L.
Leech, Robert
Nutt, David
Chialvo, Dante Renato
author2_role author
author
author
author
dc.subject.none.fl_str_mv Psilocybin
Fmri
Functional Connectivity
Resting State
Psychedelic State
topic Psilocybin
Fmri
Functional Connectivity
Resting State
Psychedelic State
dc.description.none.fl_txt_mv Abstract: The study of rapid changes in brain dynamics and functional connectivity (FC) is of increasing interest in neuroimaging. Brain states departing from normal waking consciousness are expected to be accompanied by alterations in the aforementioned dynamics. In particular, the psychedelic experience produced by psilocybin (a substance found in “magic mushrooms”) is characterized by unconstrained cognition and profound alterations in the perception of time, space and selfhood. Considering the spontaneous and subjective manifestation of these effects, we hypothesize that neural correlates of the psychedelic experience can be found in the dynamics and variability of spontaneous brain activity fluctuations and connectivity, measurable with functional Magnetic Resonance Imaging (fMRI). Fifteen healthy subjects were scanned before, during and after intravenous infusion of psilocybin and an inert placebo. Blood-Oxygen Level Dependent (BOLD) temporal variability was assessed computing the variance and total spectral power, resulting in increased signal variability bilaterally in the hippocampi and anterior cingulate cortex. Changes in BOLD signal spectral behavior (including spectral scaling exponents) affected exclusively higher brain systems such as the default mode, executive control, and dorsal attention networks. A novel framework enabled us to track different connectivity states explored by the brain during rest. This approach revealed a wider repertoire of connectivity states post-psilocybin than during control conditions. Together, the present results provide a comprehensive account of the effects of psilocybin on dynamical behavior in the human brain at a macroscopic level and may have implications for our understanding of the unconstrained, hyper-associative quality of consciousness in the psychedelic state
Fil: Tagliazucchi, Enzo Rodolfo. Goethe Universitat Frankfurt; Alemania
Fil: Carhart Harris, Robin L.. Imperial College London. Londres; Reino Unido
Fil: Leech, Robert. Imperial College London. Londres; Reino Unido
Fil: Nutt, David. Imperial College London. Londres; Reino Unido
Fil: Chialvo, Dante Renato. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Abstract: The study of rapid changes in brain dynamics and functional connectivity (FC) is of increasing interest in neuroimaging. Brain states departing from normal waking consciousness are expected to be accompanied by alterations in the aforementioned dynamics. In particular, the psychedelic experience produced by psilocybin (a substance found in “magic mushrooms”) is characterized by unconstrained cognition and profound alterations in the perception of time, space and selfhood. Considering the spontaneous and subjective manifestation of these effects, we hypothesize that neural correlates of the psychedelic experience can be found in the dynamics and variability of spontaneous brain activity fluctuations and connectivity, measurable with functional Magnetic Resonance Imaging (fMRI). Fifteen healthy subjects were scanned before, during and after intravenous infusion of psilocybin and an inert placebo. Blood-Oxygen Level Dependent (BOLD) temporal variability was assessed computing the variance and total spectral power, resulting in increased signal variability bilaterally in the hippocampi and anterior cingulate cortex. Changes in BOLD signal spectral behavior (including spectral scaling exponents) affected exclusively higher brain systems such as the default mode, executive control, and dorsal attention networks. A novel framework enabled us to track different connectivity states explored by the brain during rest. This approach revealed a wider repertoire of connectivity states post-psilocybin than during control conditions. Together, the present results provide a comprehensive account of the effects of psilocybin on dynamical behavior in the human brain at a macroscopic level and may have implications for our understanding of the unconstrained, hyper-associative quality of consciousness in the psychedelic state
publishDate 2014
dc.date.none.fl_str_mv 2014-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/30264
Tagliazucchi, Enzo Rodolfo; Carhart Harris, Robin L.; Leech, Robert; Nutt, David; Chialvo, Dante Renato; Enhanced Repertoire of Brain Dynamical States During the Psychedelic Experience; Wiley-liss, Div John Wiley & Sons Inc; Human Brain Mapping; 35; 11; 7-2014; 5442-5456
1065-9471
CONICET Digital
CONICET
url http://hdl.handle.net/11336/30264
identifier_str_mv Tagliazucchi, Enzo Rodolfo; Carhart Harris, Robin L.; Leech, Robert; Nutt, David; Chialvo, Dante Renato; Enhanced Repertoire of Brain Dynamical States During the Psychedelic Experience; Wiley-liss, Div John Wiley & Sons Inc; Human Brain Mapping; 35; 11; 7-2014; 5442-5456
1065-9471
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/hbm.22562/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1002/hbm.22562
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.885934

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