On the Stability of BOLD fMRI Correlations

Autores
Laumann, Timothy O.; Snyder, Abraham Z.; Mitra, Anish; Gordon, Evan M.; Gratton, Caterina; Adeyemo, Babatunde; Gilmore, Adrian W.; Nelson, Steven M.; Berg, Jeff J.; Greene, Deanna J.; McCarthy, John E.; Tagliazucchi, Enzo Rodolfo; Laufs, Helmut; Schlaggar, Bradley L.; Dosenbach, Nico U. F.; Petersen, Steven E.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Measurement of correlations between brain regions (functional connectivity) using blood oxygen level dependent (BOLD) fMRI has proven to be a powerful tool for studying the functional organization of the brain. Recently, dynamic functional connectivity has emerged as a major topic in the resting-state BOLD fMRI literature. Here, using simulations and multiple sets of empirical observations, we confirm that imposed task states can alter the correlation structure of BOLD activity. However, we find that observations of "dynamic" BOLD correlations during the resting state are largely explained by sampling variability. Beyond sampling variability, the largest part of observed "dynamics" during rest is attributable to head motion. An additional component of dynamic variability during rest is attributable to fluctuating sleep state. Thus, aside from the preceding explanatory factors, a single correlation structure - as opposed to a sequence of distinct correlation structures - may adequately describe the resting state as measured by BOLD fMRI. These results suggest that resting-state BOLD correlations do not primarily reflect moment-to-moment changes in cognitive content. Rather, resting-state BOLD correlations may predominantly reflect processes concerned with the maintenance of the long-term stability of the brain's functional organization.
Fil: Laumann, Timothy O.. Washington University School of Medicine; Estados Unidos
Fil: Snyder, Abraham Z.. Washington University School of Medicine; Estados Unidos
Fil: Mitra, Anish. Washington University School of Medicine; Estados Unidos
Fil: Gordon, Evan M.. VISN 17 Center of Excellence for Research on Returning War Veterans; Estados Unidos. University of Texas at Dallas; Estados Unidos
Fil: Gratton, Caterina. Washington University School of Medicine; Estados Unidos
Fil: Adeyemo, Babatunde. Washington University School of Medicine; Estados Unidos
Fil: Gilmore, Adrian W.. Washington University in St. Louis; Estados Unidos
Fil: Nelson, Steven M.. VISN 17 Center of Excellence for Research on Returning War Veterans; Estados Unidos. University of Texas at Dallas; Estados Unidos
Fil: Berg, Jeff J.. Washington University in St. Louis; Estados Unidos
Fil: Greene, Deanna J.. Washington University School of Medicine; Estados Unidos
Fil: McCarthy, John E.. Washington University in St. Louis; Estados Unidos
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Christian-Albrechts-Universitat zu Kiel; Alemania. Goethe-Universitat Frankfurt am Main; Alemania
Fil: Laufs, Helmut. Goethe-Universitat Frankfurt am Main; Alemania. Christian-Albrechts-Universitat zu Kiel; Alemania
Fil: Schlaggar, Bradley L.. Washington University School of Medicine; Estados Unidos
Fil: Dosenbach, Nico U. F.. Washington University School of Medicine; Estados Unidos
Fil: Petersen, Steven E.. Washington University School of Medicine; Estados Unidos. Washington University in St. Louis; Estados Unidos
Materia
Bold Fmri
Dynamics
Functional Connectivity
Nonstationarity
Resting State
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/55154
Acceder
id CONICETDig_fb73362385321f8b571b08df052db4b2
oai_identifier_str oai:ri.conicet.gov.ar:11336/55154
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling On the Stability of BOLD fMRI CorrelationsLaumann, Timothy O.Snyder, Abraham Z.Mitra, AnishGordon, Evan M.Gratton, CaterinaAdeyemo, BabatundeGilmore, Adrian W.Nelson, Steven M.Berg, Jeff J.Greene, Deanna J.McCarthy, John E.Tagliazucchi, Enzo RodolfoLaufs, HelmutSchlaggar, Bradley L.Dosenbach, Nico U. F.Petersen, Steven E.Bold FmriDynamicsFunctional ConnectivityNonstationarityResting Statehttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Measurement of correlations between brain regions (functional connectivity) using blood oxygen level dependent (BOLD) fMRI has proven to be a powerful tool for studying the functional organization of the brain. Recently, dynamic functional connectivity has emerged as a major topic in the resting-state BOLD fMRI literature. Here, using simulations and multiple sets of empirical observations, we confirm that imposed task states can alter the correlation structure of BOLD activity. However, we find that observations of "dynamic" BOLD correlations during the resting state are largely explained by sampling variability. Beyond sampling variability, the largest part of observed "dynamics" during rest is attributable to head motion. An additional component of dynamic variability during rest is attributable to fluctuating sleep state. Thus, aside from the preceding explanatory factors, a single correlation structure - as opposed to a sequence of distinct correlation structures - may adequately describe the resting state as measured by BOLD fMRI. These results suggest that resting-state BOLD correlations do not primarily reflect moment-to-moment changes in cognitive content. Rather, resting-state BOLD correlations may predominantly reflect processes concerned with the maintenance of the long-term stability of the brain's functional organization.Fil: Laumann, Timothy O.. Washington University School of Medicine; Estados UnidosFil: Snyder, Abraham Z.. Washington University School of Medicine; Estados UnidosFil: Mitra, Anish. Washington University School of Medicine; Estados UnidosFil: Gordon, Evan M.. VISN 17 Center of Excellence for Research on Returning War Veterans; Estados Unidos. University of Texas at Dallas; Estados UnidosFil: Gratton, Caterina. Washington University School of Medicine; Estados UnidosFil: Adeyemo, Babatunde. Washington University School of Medicine; Estados UnidosFil: Gilmore, Adrian W.. Washington University in St. Louis; Estados UnidosFil: Nelson, Steven M.. VISN 17 Center of Excellence for Research on Returning War Veterans; Estados Unidos. University of Texas at Dallas; Estados UnidosFil: Berg, Jeff J.. Washington University in St. Louis; Estados UnidosFil: Greene, Deanna J.. Washington University School of Medicine; Estados UnidosFil: McCarthy, John E.. Washington University in St. Louis; Estados UnidosFil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Christian-Albrechts-Universitat zu Kiel; Alemania. Goethe-Universitat Frankfurt am Main; AlemaniaFil: Laufs, Helmut. Goethe-Universitat Frankfurt am Main; Alemania. Christian-Albrechts-Universitat zu Kiel; AlemaniaFil: Schlaggar, Bradley L.. Washington University School of Medicine; Estados UnidosFil: Dosenbach, Nico U. F.. Washington University School of Medicine; Estados UnidosFil: Petersen, Steven E.. Washington University School of Medicine; Estados Unidos. Washington University in St. Louis; Estados UnidosOxford Univ Press Inc2017-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/55154Laumann, Timothy O.; Snyder, Abraham Z.; Mitra, Anish; Gordon, Evan M.; Gratton, Caterina; et al.; On the Stability of BOLD fMRI Correlations; Oxford Univ Press Inc; Cerebral Cortex; 27; 10; 10-2017; 4719-47321047-3211CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/cercor/bhw265info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/cercor/article-abstract/27/10/4719/3060865?redirectedFrom=fulltextinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:37Zoai:ri.conicet.gov.ar:11336/55154instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:37.383CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv On the Stability of BOLD fMRI Correlations
title On the Stability of BOLD fMRI Correlations
spellingShingle On the Stability of BOLD fMRI Correlations
Laumann, Timothy O.
Bold Fmri
Dynamics
Functional Connectivity
Nonstationarity
Resting State
title_short On the Stability of BOLD fMRI Correlations
title_full On the Stability of BOLD fMRI Correlations
title_fullStr On the Stability of BOLD fMRI Correlations
title_full_unstemmed On the Stability of BOLD fMRI Correlations
title_sort On the Stability of BOLD fMRI Correlations
dc.creator.none.fl_str_mv Laumann, Timothy O.
Snyder, Abraham Z.
Mitra, Anish
Gordon, Evan M.
Gratton, Caterina
Adeyemo, Babatunde
Gilmore, Adrian W.
Nelson, Steven M.
Berg, Jeff J.
Greene, Deanna J.
McCarthy, John E.
Tagliazucchi, Enzo Rodolfo
Laufs, Helmut
Schlaggar, Bradley L.
Dosenbach, Nico U. F.
Petersen, Steven E.
author Laumann, Timothy O.
author_facet Laumann, Timothy O.
Snyder, Abraham Z.
Mitra, Anish
Gordon, Evan M.
Gratton, Caterina
Adeyemo, Babatunde
Gilmore, Adrian W.
Nelson, Steven M.
Berg, Jeff J.
Greene, Deanna J.
McCarthy, John E.
Tagliazucchi, Enzo Rodolfo
Laufs, Helmut
Schlaggar, Bradley L.
Dosenbach, Nico U. F.
Petersen, Steven E.
author_role author
author2 Snyder, Abraham Z.
Mitra, Anish
Gordon, Evan M.
Gratton, Caterina
Adeyemo, Babatunde
Gilmore, Adrian W.
Nelson, Steven M.
Berg, Jeff J.
Greene, Deanna J.
McCarthy, John E.
Tagliazucchi, Enzo Rodolfo
Laufs, Helmut
Schlaggar, Bradley L.
Dosenbach, Nico U. F.
Petersen, Steven E.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bold Fmri
Dynamics
Functional Connectivity
Nonstationarity
Resting State
topic Bold Fmri
Dynamics
Functional Connectivity
Nonstationarity
Resting State
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Measurement of correlations between brain regions (functional connectivity) using blood oxygen level dependent (BOLD) fMRI has proven to be a powerful tool for studying the functional organization of the brain. Recently, dynamic functional connectivity has emerged as a major topic in the resting-state BOLD fMRI literature. Here, using simulations and multiple sets of empirical observations, we confirm that imposed task states can alter the correlation structure of BOLD activity. However, we find that observations of "dynamic" BOLD correlations during the resting state are largely explained by sampling variability. Beyond sampling variability, the largest part of observed "dynamics" during rest is attributable to head motion. An additional component of dynamic variability during rest is attributable to fluctuating sleep state. Thus, aside from the preceding explanatory factors, a single correlation structure - as opposed to a sequence of distinct correlation structures - may adequately describe the resting state as measured by BOLD fMRI. These results suggest that resting-state BOLD correlations do not primarily reflect moment-to-moment changes in cognitive content. Rather, resting-state BOLD correlations may predominantly reflect processes concerned with the maintenance of the long-term stability of the brain's functional organization.
Fil: Laumann, Timothy O.. Washington University School of Medicine; Estados Unidos
Fil: Snyder, Abraham Z.. Washington University School of Medicine; Estados Unidos
Fil: Mitra, Anish. Washington University School of Medicine; Estados Unidos
Fil: Gordon, Evan M.. VISN 17 Center of Excellence for Research on Returning War Veterans; Estados Unidos. University of Texas at Dallas; Estados Unidos
Fil: Gratton, Caterina. Washington University School of Medicine; Estados Unidos
Fil: Adeyemo, Babatunde. Washington University School of Medicine; Estados Unidos
Fil: Gilmore, Adrian W.. Washington University in St. Louis; Estados Unidos
Fil: Nelson, Steven M.. VISN 17 Center of Excellence for Research on Returning War Veterans; Estados Unidos. University of Texas at Dallas; Estados Unidos
Fil: Berg, Jeff J.. Washington University in St. Louis; Estados Unidos
Fil: Greene, Deanna J.. Washington University School of Medicine; Estados Unidos
Fil: McCarthy, John E.. Washington University in St. Louis; Estados Unidos
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Christian-Albrechts-Universitat zu Kiel; Alemania. Goethe-Universitat Frankfurt am Main; Alemania
Fil: Laufs, Helmut. Goethe-Universitat Frankfurt am Main; Alemania. Christian-Albrechts-Universitat zu Kiel; Alemania
Fil: Schlaggar, Bradley L.. Washington University School of Medicine; Estados Unidos
Fil: Dosenbach, Nico U. F.. Washington University School of Medicine; Estados Unidos
Fil: Petersen, Steven E.. Washington University School of Medicine; Estados Unidos. Washington University in St. Louis; Estados Unidos
description Measurement of correlations between brain regions (functional connectivity) using blood oxygen level dependent (BOLD) fMRI has proven to be a powerful tool for studying the functional organization of the brain. Recently, dynamic functional connectivity has emerged as a major topic in the resting-state BOLD fMRI literature. Here, using simulations and multiple sets of empirical observations, we confirm that imposed task states can alter the correlation structure of BOLD activity. However, we find that observations of "dynamic" BOLD correlations during the resting state are largely explained by sampling variability. Beyond sampling variability, the largest part of observed "dynamics" during rest is attributable to head motion. An additional component of dynamic variability during rest is attributable to fluctuating sleep state. Thus, aside from the preceding explanatory factors, a single correlation structure - as opposed to a sequence of distinct correlation structures - may adequately describe the resting state as measured by BOLD fMRI. These results suggest that resting-state BOLD correlations do not primarily reflect moment-to-moment changes in cognitive content. Rather, resting-state BOLD correlations may predominantly reflect processes concerned with the maintenance of the long-term stability of the brain's functional organization.
publishDate 2017
dc.date.none.fl_str_mv 2017-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/55154
Laumann, Timothy O.; Snyder, Abraham Z.; Mitra, Anish; Gordon, Evan M.; Gratton, Caterina; et al.; On the Stability of BOLD fMRI Correlations; Oxford Univ Press Inc; Cerebral Cortex; 27; 10; 10-2017; 4719-4732
1047-3211
CONICET Digital
CONICET
url http://hdl.handle.net/11336/55154
identifier_str_mv Laumann, Timothy O.; Snyder, Abraham Z.; Mitra, Anish; Gordon, Evan M.; Gratton, Caterina; et al.; On the Stability of BOLD fMRI Correlations; Oxford Univ Press Inc; Cerebral Cortex; 27; 10; 10-2017; 4719-4732
1047-3211
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/cercor/bhw265
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/cercor/article-abstract/27/10/4719/3060865?redirectedFrom=fulltext
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford Univ Press Inc
publisher.none.fl_str_mv Oxford Univ Press Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268678462111744
score 13.13397

Publicaciones similares