Advances in therapy for the prevention of HIV transmission from mother to child

Autores
Moretton, Marcela Analía; Bertera, Facundo Martin; Lagomarsino, Eduardo; Riedel, Jennifer Denise; Chiappetta, Diego Andrés; Höcht, Christian
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Actually, ~17.8 million women and 1.8 million children (<15 years) are currently infected with the Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS). Particularly, the majority of pediatric infections (>90%) resulted from ‘HIV mother-to-child transmission’ (MTCT), both in pregnancy, labour, delivery and later by breastfeeding. Due to its high pediatric incidence, MTCT represents a public health concern. 15 Areas covered: In this review, we focus on available treatments and antiretroviral drugs recommended by the World Health Organization, and the main clinical investigations in antiretroviral pharmacotherapy to prevent the MTCT. Expert opinion: The MTCT has been improved dramatically in the last few years mainly due to prophylactic perinatal antiretroviral therapy for pregnant women living with HIV. However, there is 20 still a milestone to reach since HIV MTCT remains as a public health challenge associated with MTCT though breastfeeding (post-natal transmission). In this context, different strategies could be employed as an attempt to reduce pediatric HIV infections. One of them involves the improvement of patient adherence to the HIV therapy. One possible solution is the development of novel long-acting formulations for prophylaxis of mothers and children, and a second possible solution is increase the inclusion of 25 mothers and infants in care programs to more effectively prevent the vertical transmission.
Fil: Moretton, Marcela Analía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Bertera, Facundo Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Lagomarsino, Eduardo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Riedel, Jennifer Denise. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Chiappetta, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Höcht, Christian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Materia
Hiv Mother-To-Child Transmission
Antiretroviral Pharmacotherapy
Prevention
Pregnancy
Breastfeeding
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/47775
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Advances in therapy for the prevention of HIV transmission from mother to childMoretton, Marcela AnalíaBertera, Facundo MartinLagomarsino, EduardoRiedel, Jennifer DeniseChiappetta, Diego AndrésHöcht, ChristianHiv Mother-To-Child TransmissionAntiretroviral PharmacotherapyPreventionPregnancyBreastfeedinghttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction: Actually, ~17.8 million women and 1.8 million children (<15 years) are currently infected with the Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS). Particularly, the majority of pediatric infections (>90%) resulted from ‘HIV mother-to-child transmission’ (MTCT), both in pregnancy, labour, delivery and later by breastfeeding. Due to its high pediatric incidence, MTCT represents a public health concern. 15 Areas covered: In this review, we focus on available treatments and antiretroviral drugs recommended by the World Health Organization, and the main clinical investigations in antiretroviral pharmacotherapy to prevent the MTCT. Expert opinion: The MTCT has been improved dramatically in the last few years mainly due to prophylactic perinatal antiretroviral therapy for pregnant women living with HIV. However, there is 20 still a milestone to reach since HIV MTCT remains as a public health challenge associated with MTCT though breastfeeding (post-natal transmission). In this context, different strategies could be employed as an attempt to reduce pediatric HIV infections. One of them involves the improvement of patient adherence to the HIV therapy. One possible solution is the development of novel long-acting formulations for prophylaxis of mothers and children, and a second possible solution is increase the inclusion of 25 mothers and infants in care programs to more effectively prevent the vertical transmission.Fil: Moretton, Marcela Analía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Bertera, Facundo Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Lagomarsino, Eduardo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Riedel, Jennifer Denise. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Chiappetta, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Höcht, Christian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaInforma Healthcare2017-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47775Moretton, Marcela Analía; Bertera, Facundo Martin; Lagomarsino, Eduardo; Riedel, Jennifer Denise; Chiappetta, Diego Andrés; et al.; Advances in therapy for the prevention of HIV transmission from mother to child; Informa Healthcare; Expert Opinion on Pharmacotherapy; 18; 7; 4-2017; 657-6661465-6566CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/14656566.2017.1316369info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/14656566.2017.1316369info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:29Zoai:ri.conicet.gov.ar:11336/47775instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:29.889CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Advances in therapy for the prevention of HIV transmission from mother to child
title Advances in therapy for the prevention of HIV transmission from mother to child
spellingShingle Advances in therapy for the prevention of HIV transmission from mother to child
Moretton, Marcela Analía
Hiv Mother-To-Child Transmission
Antiretroviral Pharmacotherapy
Prevention
Pregnancy
Breastfeeding
title_short Advances in therapy for the prevention of HIV transmission from mother to child
title_full Advances in therapy for the prevention of HIV transmission from mother to child
title_fullStr Advances in therapy for the prevention of HIV transmission from mother to child
title_full_unstemmed Advances in therapy for the prevention of HIV transmission from mother to child
title_sort Advances in therapy for the prevention of HIV transmission from mother to child
dc.creator.none.fl_str_mv Moretton, Marcela Analía
Bertera, Facundo Martin
Lagomarsino, Eduardo
Riedel, Jennifer Denise
Chiappetta, Diego Andrés
Höcht, Christian
author Moretton, Marcela Analía
author_facet Moretton, Marcela Analía
Bertera, Facundo Martin
Lagomarsino, Eduardo
Riedel, Jennifer Denise
Chiappetta, Diego Andrés
Höcht, Christian
author_role author
author2 Bertera, Facundo Martin
Lagomarsino, Eduardo
Riedel, Jennifer Denise
Chiappetta, Diego Andrés
Höcht, Christian
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Hiv Mother-To-Child Transmission
Antiretroviral Pharmacotherapy
Prevention
Pregnancy
Breastfeeding
topic Hiv Mother-To-Child Transmission
Antiretroviral Pharmacotherapy
Prevention
Pregnancy
Breastfeeding
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: Actually, ~17.8 million women and 1.8 million children (<15 years) are currently infected with the Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS). Particularly, the majority of pediatric infections (>90%) resulted from ‘HIV mother-to-child transmission’ (MTCT), both in pregnancy, labour, delivery and later by breastfeeding. Due to its high pediatric incidence, MTCT represents a public health concern. 15 Areas covered: In this review, we focus on available treatments and antiretroviral drugs recommended by the World Health Organization, and the main clinical investigations in antiretroviral pharmacotherapy to prevent the MTCT. Expert opinion: The MTCT has been improved dramatically in the last few years mainly due to prophylactic perinatal antiretroviral therapy for pregnant women living with HIV. However, there is 20 still a milestone to reach since HIV MTCT remains as a public health challenge associated with MTCT though breastfeeding (post-natal transmission). In this context, different strategies could be employed as an attempt to reduce pediatric HIV infections. One of them involves the improvement of patient adherence to the HIV therapy. One possible solution is the development of novel long-acting formulations for prophylaxis of mothers and children, and a second possible solution is increase the inclusion of 25 mothers and infants in care programs to more effectively prevent the vertical transmission.
Fil: Moretton, Marcela Analía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Bertera, Facundo Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Lagomarsino, Eduardo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Riedel, Jennifer Denise. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Chiappetta, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Höcht, Christian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
description Introduction: Actually, ~17.8 million women and 1.8 million children (<15 years) are currently infected with the Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS). Particularly, the majority of pediatric infections (>90%) resulted from ‘HIV mother-to-child transmission’ (MTCT), both in pregnancy, labour, delivery and later by breastfeeding. Due to its high pediatric incidence, MTCT represents a public health concern. 15 Areas covered: In this review, we focus on available treatments and antiretroviral drugs recommended by the World Health Organization, and the main clinical investigations in antiretroviral pharmacotherapy to prevent the MTCT. Expert opinion: The MTCT has been improved dramatically in the last few years mainly due to prophylactic perinatal antiretroviral therapy for pregnant women living with HIV. However, there is 20 still a milestone to reach since HIV MTCT remains as a public health challenge associated with MTCT though breastfeeding (post-natal transmission). In this context, different strategies could be employed as an attempt to reduce pediatric HIV infections. One of them involves the improvement of patient adherence to the HIV therapy. One possible solution is the development of novel long-acting formulations for prophylaxis of mothers and children, and a second possible solution is increase the inclusion of 25 mothers and infants in care programs to more effectively prevent the vertical transmission.
publishDate 2017
dc.date.none.fl_str_mv 2017-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/47775
Moretton, Marcela Analía; Bertera, Facundo Martin; Lagomarsino, Eduardo; Riedel, Jennifer Denise; Chiappetta, Diego Andrés; et al.; Advances in therapy for the prevention of HIV transmission from mother to child; Informa Healthcare; Expert Opinion on Pharmacotherapy; 18; 7; 4-2017; 657-666
1465-6566
CONICET Digital
CONICET
url http://hdl.handle.net/11336/47775
identifier_str_mv Moretton, Marcela Analía; Bertera, Facundo Martin; Lagomarsino, Eduardo; Riedel, Jennifer Denise; Chiappetta, Diego Andrés; et al.; Advances in therapy for the prevention of HIV transmission from mother to child; Informa Healthcare; Expert Opinion on Pharmacotherapy; 18; 7; 4-2017; 657-666
1465-6566
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/14656566.2017.1316369
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/14656566.2017.1316369
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Informa Healthcare
publisher.none.fl_str_mv Informa Healthcare
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268926457675776
score 13.13397

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