Neonatal innate immunity response in invasive candidiasis

Autores
Suárez, J. A. G.; Nunes Calumby, Rodrigo José; Silva, D. P.; Barbosa, V. T.; Maranhão, F. C. A.; Moreira, I. F.; Melhem, M. S. C.; Moreira, R. T. F.
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Infections caused by Candida spp. are frequent in critically hospitalized patients, especially among premature neonates, representing one of the most common healthcare-related infections. Although there is considerable production of current knowledge about the mechanisms of immune response, aspects involved in the newborn's innate defense are not fully understood. The aim of this study was to describe the innate immune mechanisms involved in the defense of neonates against invasive candidiasis. This is an integrative literature review from the Scopus, Scifinder, Medline, Web of Science databases and the electronic libraries ScienceDirect and Scielo, in the period between 2002 and 2020, with rescue based on primary descriptor Immunity Innate plus secondary descriptors Candidiasis Invasive AND Infant Newborn. We have observed the involvement of various mechanisms in the neonatal response against invasive candidiasis, including the recognition, signaling, recruitment, and initiation of an effective immune response. These mechanisms encompass the presence of antimicrobial peptides, phagocytosis, synthesis of reactive oxygen species, inflammatory mediators, and complex cell signaling systems mediated by Pattern Recognition Receptors (PRRs). With this study, it is expected to contribute to the expansion of knowledge about the immunological mechanisms involved in the innate immune response of the newborn against disseminated infections caused by Candida species, and in the same sense, highlight the importance of this knowledge as a reflex in the decrease in mortality in the neonatal period.
Fil: Suárez, J. A. G.. Universidade Federal de Ouro Preto; Brasil
Fil: Nunes Calumby, Rodrigo José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Centro de Estudios Fotosintéticos y Bioquímicos. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Estudios Fotosintéticos y Bioquímicos; Argentina. Universidade Federal de Alagoas; Brasil
Fil: Silva, D. P.. Universidade Federal de Alagoas; Brasil
Fil: Barbosa, V. T.. Universidade Federal de Alagoas; Brasil
Fil: Maranhão, F. C. A.. Universidade Federal de Alagoas; Brasil
Fil: Moreira, I. F.. Universidade Federal de Alagoas; Brasil
Fil: Melhem, M. S. C.. Universidade Federal do Mato Grosso do Sul; Brasil
Fil: Moreira, R. T. F.. Universidade Federal do Mato Grosso do Sul; Brasil. Universidade Federal de Alagoas; Brasil
Materia
Immunity innate
Candidiasis invasive
Infant newborn
Neonatal infections
Immune defense
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/258302
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/258302
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Neonatal innate immunity response in invasive candidiasisSuárez, J. A. G.Nunes Calumby, Rodrigo JoséSilva, D. P.Barbosa, V. T.Maranhão, F. C. A.Moreira, I. F.Melhem, M. S. C.Moreira, R. T. F.Immunity innateCandidiasis invasiveInfant newbornNeonatal infectionsImmune defensehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Infections caused by Candida spp. are frequent in critically hospitalized patients, especially among premature neonates, representing one of the most common healthcare-related infections. Although there is considerable production of current knowledge about the mechanisms of immune response, aspects involved in the newborn's innate defense are not fully understood. The aim of this study was to describe the innate immune mechanisms involved in the defense of neonates against invasive candidiasis. This is an integrative literature review from the Scopus, Scifinder, Medline, Web of Science databases and the electronic libraries ScienceDirect and Scielo, in the period between 2002 and 2020, with rescue based on primary descriptor Immunity Innate plus secondary descriptors Candidiasis Invasive AND Infant Newborn. We have observed the involvement of various mechanisms in the neonatal response against invasive candidiasis, including the recognition, signaling, recruitment, and initiation of an effective immune response. These mechanisms encompass the presence of antimicrobial peptides, phagocytosis, synthesis of reactive oxygen species, inflammatory mediators, and complex cell signaling systems mediated by Pattern Recognition Receptors (PRRs). With this study, it is expected to contribute to the expansion of knowledge about the immunological mechanisms involved in the innate immune response of the newborn against disseminated infections caused by Candida species, and in the same sense, highlight the importance of this knowledge as a reflex in the decrease in mortality in the neonatal period.Fil: Suárez, J. A. G.. Universidade Federal de Ouro Preto; BrasilFil: Nunes Calumby, Rodrigo José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Centro de Estudios Fotosintéticos y Bioquímicos. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Estudios Fotosintéticos y Bioquímicos; Argentina. Universidade Federal de Alagoas; BrasilFil: Silva, D. P.. Universidade Federal de Alagoas; BrasilFil: Barbosa, V. T.. Universidade Federal de Alagoas; BrasilFil: Maranhão, F. C. A.. Universidade Federal de Alagoas; BrasilFil: Moreira, I. F.. Universidade Federal de Alagoas; BrasilFil: Melhem, M. S. C.. Universidade Federal do Mato Grosso do Sul; BrasilFil: Moreira, R. T. F.. Universidade Federal do Mato Grosso do Sul; Brasil. Universidade Federal de Alagoas; BrasilInstituto Internacional de Ecología2024-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/258302Suárez, J. A. G.; Nunes Calumby, Rodrigo José; Silva, D. P.; Barbosa, V. T.; Maranhão, F. C. A.; et al.; Neonatal innate immunity response in invasive candidiasis; Instituto Internacional de Ecología; Brazilian Journal of Biology; 84; 5-2024; 1-101519-69841678-4375CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842024000100703&tlng=eninfo:eu-repo/semantics/altIdentifier/doi/10.1590/1519-6984.275155info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:21:37Zoai:ri.conicet.gov.ar:11336/258302instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:21:37.559CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neonatal innate immunity response in invasive candidiasis
title Neonatal innate immunity response in invasive candidiasis
spellingShingle Neonatal innate immunity response in invasive candidiasis
Suárez, J. A. G.
Immunity innate
Candidiasis invasive
Infant newborn
Neonatal infections
Immune defense
title_short Neonatal innate immunity response in invasive candidiasis
title_full Neonatal innate immunity response in invasive candidiasis
title_fullStr Neonatal innate immunity response in invasive candidiasis
title_full_unstemmed Neonatal innate immunity response in invasive candidiasis
title_sort Neonatal innate immunity response in invasive candidiasis
dc.creator.none.fl_str_mv Suárez, J. A. G.
Nunes Calumby, Rodrigo José
Silva, D. P.
Barbosa, V. T.
Maranhão, F. C. A.
Moreira, I. F.
Melhem, M. S. C.
Moreira, R. T. F.
author Suárez, J. A. G.
author_facet Suárez, J. A. G.
Nunes Calumby, Rodrigo José
Silva, D. P.
Barbosa, V. T.
Maranhão, F. C. A.
Moreira, I. F.
Melhem, M. S. C.
Moreira, R. T. F.
author_role author
author2 Nunes Calumby, Rodrigo José
Silva, D. P.
Barbosa, V. T.
Maranhão, F. C. A.
Moreira, I. F.
Melhem, M. S. C.
Moreira, R. T. F.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Immunity innate
Candidiasis invasive
Infant newborn
Neonatal infections
Immune defense
topic Immunity innate
Candidiasis invasive
Infant newborn
Neonatal infections
Immune defense
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Infections caused by Candida spp. are frequent in critically hospitalized patients, especially among premature neonates, representing one of the most common healthcare-related infections. Although there is considerable production of current knowledge about the mechanisms of immune response, aspects involved in the newborn's innate defense are not fully understood. The aim of this study was to describe the innate immune mechanisms involved in the defense of neonates against invasive candidiasis. This is an integrative literature review from the Scopus, Scifinder, Medline, Web of Science databases and the electronic libraries ScienceDirect and Scielo, in the period between 2002 and 2020, with rescue based on primary descriptor Immunity Innate plus secondary descriptors Candidiasis Invasive AND Infant Newborn. We have observed the involvement of various mechanisms in the neonatal response against invasive candidiasis, including the recognition, signaling, recruitment, and initiation of an effective immune response. These mechanisms encompass the presence of antimicrobial peptides, phagocytosis, synthesis of reactive oxygen species, inflammatory mediators, and complex cell signaling systems mediated by Pattern Recognition Receptors (PRRs). With this study, it is expected to contribute to the expansion of knowledge about the immunological mechanisms involved in the innate immune response of the newborn against disseminated infections caused by Candida species, and in the same sense, highlight the importance of this knowledge as a reflex in the decrease in mortality in the neonatal period.
Fil: Suárez, J. A. G.. Universidade Federal de Ouro Preto; Brasil
Fil: Nunes Calumby, Rodrigo José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Centro de Estudios Fotosintéticos y Bioquímicos. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Estudios Fotosintéticos y Bioquímicos; Argentina. Universidade Federal de Alagoas; Brasil
Fil: Silva, D. P.. Universidade Federal de Alagoas; Brasil
Fil: Barbosa, V. T.. Universidade Federal de Alagoas; Brasil
Fil: Maranhão, F. C. A.. Universidade Federal de Alagoas; Brasil
Fil: Moreira, I. F.. Universidade Federal de Alagoas; Brasil
Fil: Melhem, M. S. C.. Universidade Federal do Mato Grosso do Sul; Brasil
Fil: Moreira, R. T. F.. Universidade Federal do Mato Grosso do Sul; Brasil. Universidade Federal de Alagoas; Brasil
description Infections caused by Candida spp. are frequent in critically hospitalized patients, especially among premature neonates, representing one of the most common healthcare-related infections. Although there is considerable production of current knowledge about the mechanisms of immune response, aspects involved in the newborn's innate defense are not fully understood. The aim of this study was to describe the innate immune mechanisms involved in the defense of neonates against invasive candidiasis. This is an integrative literature review from the Scopus, Scifinder, Medline, Web of Science databases and the electronic libraries ScienceDirect and Scielo, in the period between 2002 and 2020, with rescue based on primary descriptor Immunity Innate plus secondary descriptors Candidiasis Invasive AND Infant Newborn. We have observed the involvement of various mechanisms in the neonatal response against invasive candidiasis, including the recognition, signaling, recruitment, and initiation of an effective immune response. These mechanisms encompass the presence of antimicrobial peptides, phagocytosis, synthesis of reactive oxygen species, inflammatory mediators, and complex cell signaling systems mediated by Pattern Recognition Receptors (PRRs). With this study, it is expected to contribute to the expansion of knowledge about the immunological mechanisms involved in the innate immune response of the newborn against disseminated infections caused by Candida species, and in the same sense, highlight the importance of this knowledge as a reflex in the decrease in mortality in the neonatal period.
publishDate 2024
dc.date.none.fl_str_mv 2024-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/258302
Suárez, J. A. G.; Nunes Calumby, Rodrigo José; Silva, D. P.; Barbosa, V. T.; Maranhão, F. C. A.; et al.; Neonatal innate immunity response in invasive candidiasis; Instituto Internacional de Ecología; Brazilian Journal of Biology; 84; 5-2024; 1-10
1519-6984
1678-4375
CONICET Digital
CONICET
url http://hdl.handle.net/11336/258302
identifier_str_mv Suárez, J. A. G.; Nunes Calumby, Rodrigo José; Silva, D. P.; Barbosa, V. T.; Maranhão, F. C. A.; et al.; Neonatal innate immunity response in invasive candidiasis; Instituto Internacional de Ecología; Brazilian Journal of Biology; 84; 5-2024; 1-10
1519-6984
1678-4375
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842024000100703&tlng=en
info:eu-repo/semantics/altIdentifier/doi/10.1590/1519-6984.275155
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Instituto Internacional de Ecología
publisher.none.fl_str_mv Instituto Internacional de Ecología
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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