Effects of kefir fractions on innate immunity

Autores
Vinderola, Celso Gabriel; Perdigon, Gabriela del Valle; Duarte, Jairo; Thangavel, Deepa; Farnworth, Edward; Matar, Chantal
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Innate immunity that protects against pathogens in the tissues and circulation is the first line of defense in the immune reaction, where macrophages have a critical role in directing the fate of the infection. We recently demonstrated that kefir modulates the immune response in mice, increasing the number of IgA + cells in the intestinal and bronchial mucosa and the phagocytic activity of peritoneal and pulmonary macrophages. The aim of this study was to further characterize the immunomodulating capacity of the two fractions of kefir (F1: Solids including bacteria and F2: Liquid supernatant), by studying the cytokines produced by cells from the innate immune system: Peritoneal macrophages and the adherent cells from Peyer's patches. BALB/c mice were fed either kefir solid fraction (F1) or kefir supernatant (F2) for 2, 5 or 7 consecutive days. The number of cytokine (IL-1α, IFNγ, TNFα, IL-6 and IL-10) producing cells was determined on peritoneal macrophages and adherent cells from Peyer's patches. Both kefir fractions (F1 and F2) induced similar cytokine profiles on peritoneal macrophages (only TNFα and IL-6 were up-regulated). All cytokines studied on adherent cells from Peyer's patches were enhanced after F1 and F2 feeding, except for IFNγ after F2 administration. Moreover, the percentage of IL-10 + cells induced by fraction F2 on adherent cells from Peyer's patches was significantly higher than the one induced by fraction F1. Different components of kefir have an in vivo role as oral biotherapeutic substances capable of stimulating immune cells of the innate immune system, to down-regulate the Th2 immune phenotype or to promote cell-mediated immune responses against tumours and also against intracellular pathogenic infections.
Fil: Vinderola, Celso Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina. Universite de Moncton; Canadá
Fil: Perdigon, Gabriela del Valle. Universidad Nacional de Tucumán; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Duarte, Jairo. Universite de Moncton; Canadá
Fil: Thangavel, Deepa. Universite de Moncton; Canadá
Fil: Farnworth, Edward. Agriculture Et Agroalimentaire Canada; Canadá
Fil: Matar, Chantal. Universite de Moncton; Canadá
Materia
Cytokines
Immunomodulation
Innate Immunity
Kefir
Macrophages
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/36576
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/36576
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of kefir fractions on innate immunityVinderola, Celso GabrielPerdigon, Gabriela del ValleDuarte, JairoThangavel, DeepaFarnworth, EdwardMatar, ChantalCytokinesImmunomodulationInnate ImmunityKefirMacrophageshttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2Innate immunity that protects against pathogens in the tissues and circulation is the first line of defense in the immune reaction, where macrophages have a critical role in directing the fate of the infection. We recently demonstrated that kefir modulates the immune response in mice, increasing the number of IgA + cells in the intestinal and bronchial mucosa and the phagocytic activity of peritoneal and pulmonary macrophages. The aim of this study was to further characterize the immunomodulating capacity of the two fractions of kefir (F1: Solids including bacteria and F2: Liquid supernatant), by studying the cytokines produced by cells from the innate immune system: Peritoneal macrophages and the adherent cells from Peyer's patches. BALB/c mice were fed either kefir solid fraction (F1) or kefir supernatant (F2) for 2, 5 or 7 consecutive days. The number of cytokine (IL-1α, IFNγ, TNFα, IL-6 and IL-10) producing cells was determined on peritoneal macrophages and adherent cells from Peyer's patches. Both kefir fractions (F1 and F2) induced similar cytokine profiles on peritoneal macrophages (only TNFα and IL-6 were up-regulated). All cytokines studied on adherent cells from Peyer's patches were enhanced after F1 and F2 feeding, except for IFNγ after F2 administration. Moreover, the percentage of IL-10 + cells induced by fraction F2 on adherent cells from Peyer's patches was significantly higher than the one induced by fraction F1. Different components of kefir have an in vivo role as oral biotherapeutic substances capable of stimulating immune cells of the innate immune system, to down-regulate the Th2 immune phenotype or to promote cell-mediated immune responses against tumours and also against intracellular pathogenic infections.Fil: Vinderola, Celso Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina. Universite de Moncton; CanadáFil: Perdigon, Gabriela del Valle. Universidad Nacional de Tucumán; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; ArgentinaFil: Duarte, Jairo. Universite de Moncton; CanadáFil: Thangavel, Deepa. Universite de Moncton; CanadáFil: Farnworth, Edward. Agriculture Et Agroalimentaire Canada; CanadáFil: Matar, Chantal. Universite de Moncton; CanadáElsevier Gmbh2006-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/36576Vinderola, Celso Gabriel; Perdigon, Gabriela del Valle; Duarte, Jairo; Thangavel, Deepa; Farnworth, Edward; et al.; Effects of kefir fractions on innate immunity; Elsevier Gmbh; Immunobiology; 211; 3; 4-2006; 149-1560171-2985CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.imbio.2005.08.005info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0171298506000118info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:40:37Zoai:ri.conicet.gov.ar:11336/36576instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:40:37.558CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of kefir fractions on innate immunity
title Effects of kefir fractions on innate immunity
spellingShingle Effects of kefir fractions on innate immunity
Vinderola, Celso Gabriel
Cytokines
Immunomodulation
Innate Immunity
Kefir
Macrophages
title_short Effects of kefir fractions on innate immunity
title_full Effects of kefir fractions on innate immunity
title_fullStr Effects of kefir fractions on innate immunity
title_full_unstemmed Effects of kefir fractions on innate immunity
title_sort Effects of kefir fractions on innate immunity
dc.creator.none.fl_str_mv Vinderola, Celso Gabriel
Perdigon, Gabriela del Valle
Duarte, Jairo
Thangavel, Deepa
Farnworth, Edward
Matar, Chantal
author Vinderola, Celso Gabriel
author_facet Vinderola, Celso Gabriel
Perdigon, Gabriela del Valle
Duarte, Jairo
Thangavel, Deepa
Farnworth, Edward
Matar, Chantal
author_role author
author2 Perdigon, Gabriela del Valle
Duarte, Jairo
Thangavel, Deepa
Farnworth, Edward
Matar, Chantal
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Cytokines
Immunomodulation
Innate Immunity
Kefir
Macrophages
topic Cytokines
Immunomodulation
Innate Immunity
Kefir
Macrophages
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Innate immunity that protects against pathogens in the tissues and circulation is the first line of defense in the immune reaction, where macrophages have a critical role in directing the fate of the infection. We recently demonstrated that kefir modulates the immune response in mice, increasing the number of IgA + cells in the intestinal and bronchial mucosa and the phagocytic activity of peritoneal and pulmonary macrophages. The aim of this study was to further characterize the immunomodulating capacity of the two fractions of kefir (F1: Solids including bacteria and F2: Liquid supernatant), by studying the cytokines produced by cells from the innate immune system: Peritoneal macrophages and the adherent cells from Peyer's patches. BALB/c mice were fed either kefir solid fraction (F1) or kefir supernatant (F2) for 2, 5 or 7 consecutive days. The number of cytokine (IL-1α, IFNγ, TNFα, IL-6 and IL-10) producing cells was determined on peritoneal macrophages and adherent cells from Peyer's patches. Both kefir fractions (F1 and F2) induced similar cytokine profiles on peritoneal macrophages (only TNFα and IL-6 were up-regulated). All cytokines studied on adherent cells from Peyer's patches were enhanced after F1 and F2 feeding, except for IFNγ after F2 administration. Moreover, the percentage of IL-10 + cells induced by fraction F2 on adherent cells from Peyer's patches was significantly higher than the one induced by fraction F1. Different components of kefir have an in vivo role as oral biotherapeutic substances capable of stimulating immune cells of the innate immune system, to down-regulate the Th2 immune phenotype or to promote cell-mediated immune responses against tumours and also against intracellular pathogenic infections.
Fil: Vinderola, Celso Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina. Universite de Moncton; Canadá
Fil: Perdigon, Gabriela del Valle. Universidad Nacional de Tucumán; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Duarte, Jairo. Universite de Moncton; Canadá
Fil: Thangavel, Deepa. Universite de Moncton; Canadá
Fil: Farnworth, Edward. Agriculture Et Agroalimentaire Canada; Canadá
Fil: Matar, Chantal. Universite de Moncton; Canadá
description Innate immunity that protects against pathogens in the tissues and circulation is the first line of defense in the immune reaction, where macrophages have a critical role in directing the fate of the infection. We recently demonstrated that kefir modulates the immune response in mice, increasing the number of IgA + cells in the intestinal and bronchial mucosa and the phagocytic activity of peritoneal and pulmonary macrophages. The aim of this study was to further characterize the immunomodulating capacity of the two fractions of kefir (F1: Solids including bacteria and F2: Liquid supernatant), by studying the cytokines produced by cells from the innate immune system: Peritoneal macrophages and the adherent cells from Peyer's patches. BALB/c mice were fed either kefir solid fraction (F1) or kefir supernatant (F2) for 2, 5 or 7 consecutive days. The number of cytokine (IL-1α, IFNγ, TNFα, IL-6 and IL-10) producing cells was determined on peritoneal macrophages and adherent cells from Peyer's patches. Both kefir fractions (F1 and F2) induced similar cytokine profiles on peritoneal macrophages (only TNFα and IL-6 were up-regulated). All cytokines studied on adherent cells from Peyer's patches were enhanced after F1 and F2 feeding, except for IFNγ after F2 administration. Moreover, the percentage of IL-10 + cells induced by fraction F2 on adherent cells from Peyer's patches was significantly higher than the one induced by fraction F1. Different components of kefir have an in vivo role as oral biotherapeutic substances capable of stimulating immune cells of the innate immune system, to down-regulate the Th2 immune phenotype or to promote cell-mediated immune responses against tumours and also against intracellular pathogenic infections.
publishDate 2006
dc.date.none.fl_str_mv 2006-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/36576
Vinderola, Celso Gabriel; Perdigon, Gabriela del Valle; Duarte, Jairo; Thangavel, Deepa; Farnworth, Edward; et al.; Effects of kefir fractions on innate immunity; Elsevier Gmbh; Immunobiology; 211; 3; 4-2006; 149-156
0171-2985
CONICET Digital
CONICET
url http://hdl.handle.net/11336/36576
identifier_str_mv Vinderola, Celso Gabriel; Perdigon, Gabriela del Valle; Duarte, Jairo; Thangavel, Deepa; Farnworth, Edward; et al.; Effects of kefir fractions on innate immunity; Elsevier Gmbh; Immunobiology; 211; 3; 4-2006; 149-156
0171-2985
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.imbio.2005.08.005
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0171298506000118
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Gmbh
publisher.none.fl_str_mv Elsevier Gmbh
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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