Invasive Candidiasis: Update and Current Challenges in the Management of This Mycosis in South America

Autores
Riera, Fernando Oscar; Caeiro, Juan Pablo; Angiolini, Sofia Carla; Vigezzi, Cecilia; Rodriguez, Emilse; Icely, Paula Alejandra; Sotomayor, Claudia Elena
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Invasive candidiasis encompassing Candida bloodstream infections and deep-seated candidiasis can become a persistent health problem. These infections are caused by Candida species and have high morbidity and mortality rates. Species distribution, access to diagnosis, treatment and mortality are different around the world. The mortality rate is high in South America (30–70%), and Candida albicans is the most prevalent species in this region. However, a global epidemiological shift to non-albicans species has been observed. In this group, C. parapsilosis is the species most frequently detected, followed by C. tropicalis, and at a slower rate, C. glabrata, which has also increased, in addition to the emerging C. auris, resistance to several drugs. This article summarizes relevant aspects of candidemia pathogenesis, such as the mechanisms of fungal invasion, immune response, and the impact of genetic defects that increase host susceptibility to developing the infection. We also discuss relevant aspects of treatment and future challenges in South America.
Fil: Riera, Fernando Oscar. Sanatorio Allende; Argentina
Fil: Caeiro, Juan Pablo. Hospital Privado Universitario de Córdoba; Argentina
Fil: Angiolini, Sofia Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Vigezzi, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Rodriguez, Emilse. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Icely, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Sotomayor, Claudia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Materia
CANDIDEMIA
INVASIVE CANDIDIASIS
RISK FACTORS
SOUTH AMERICA
TREATMENT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/216878
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/216878
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Invasive Candidiasis: Update and Current Challenges in the Management of This Mycosis in South AmericaRiera, Fernando OscarCaeiro, Juan PabloAngiolini, Sofia CarlaVigezzi, CeciliaRodriguez, EmilseIcely, Paula AlejandraSotomayor, Claudia ElenaCANDIDEMIAINVASIVE CANDIDIASISRISK FACTORSSOUTH AMERICATREATMENThttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Invasive candidiasis encompassing Candida bloodstream infections and deep-seated candidiasis can become a persistent health problem. These infections are caused by Candida species and have high morbidity and mortality rates. Species distribution, access to diagnosis, treatment and mortality are different around the world. The mortality rate is high in South America (30–70%), and Candida albicans is the most prevalent species in this region. However, a global epidemiological shift to non-albicans species has been observed. In this group, C. parapsilosis is the species most frequently detected, followed by C. tropicalis, and at a slower rate, C. glabrata, which has also increased, in addition to the emerging C. auris, resistance to several drugs. This article summarizes relevant aspects of candidemia pathogenesis, such as the mechanisms of fungal invasion, immune response, and the impact of genetic defects that increase host susceptibility to developing the infection. We also discuss relevant aspects of treatment and future challenges in South America.Fil: Riera, Fernando Oscar. Sanatorio Allende; ArgentinaFil: Caeiro, Juan Pablo. Hospital Privado Universitario de Córdoba; ArgentinaFil: Angiolini, Sofia Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Vigezzi, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Rodriguez, Emilse. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Icely, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Sotomayor, Claudia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaMDPI2022-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/216878Riera, Fernando Oscar; Caeiro, Juan Pablo; Angiolini, Sofia Carla; Vigezzi, Cecilia; Rodriguez, Emilse; et al.; Invasive Candidiasis: Update and Current Challenges in the Management of This Mycosis in South America; MDPI; Antibiotics; 11; 7; 6-2022; 877-8932079-6382CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/antibiotics11070877info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:10:00Zoai:ri.conicet.gov.ar:11336/216878instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:10:01.274CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Invasive Candidiasis: Update and Current Challenges in the Management of This Mycosis in South America
title Invasive Candidiasis: Update and Current Challenges in the Management of This Mycosis in South America
spellingShingle Invasive Candidiasis: Update and Current Challenges in the Management of This Mycosis in South America
Riera, Fernando Oscar
CANDIDEMIA
INVASIVE CANDIDIASIS
RISK FACTORS
SOUTH AMERICA
TREATMENT
title_short Invasive Candidiasis: Update and Current Challenges in the Management of This Mycosis in South America
title_full Invasive Candidiasis: Update and Current Challenges in the Management of This Mycosis in South America
title_fullStr Invasive Candidiasis: Update and Current Challenges in the Management of This Mycosis in South America
title_full_unstemmed Invasive Candidiasis: Update and Current Challenges in the Management of This Mycosis in South America
title_sort Invasive Candidiasis: Update and Current Challenges in the Management of This Mycosis in South America
dc.creator.none.fl_str_mv Riera, Fernando Oscar
Caeiro, Juan Pablo
Angiolini, Sofia Carla
Vigezzi, Cecilia
Rodriguez, Emilse
Icely, Paula Alejandra
Sotomayor, Claudia Elena
author Riera, Fernando Oscar
author_facet Riera, Fernando Oscar
Caeiro, Juan Pablo
Angiolini, Sofia Carla
Vigezzi, Cecilia
Rodriguez, Emilse
Icely, Paula Alejandra
Sotomayor, Claudia Elena
author_role author
author2 Caeiro, Juan Pablo
Angiolini, Sofia Carla
Vigezzi, Cecilia
Rodriguez, Emilse
Icely, Paula Alejandra
Sotomayor, Claudia Elena
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CANDIDEMIA
INVASIVE CANDIDIASIS
RISK FACTORS
SOUTH AMERICA
TREATMENT
topic CANDIDEMIA
INVASIVE CANDIDIASIS
RISK FACTORS
SOUTH AMERICA
TREATMENT
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Invasive candidiasis encompassing Candida bloodstream infections and deep-seated candidiasis can become a persistent health problem. These infections are caused by Candida species and have high morbidity and mortality rates. Species distribution, access to diagnosis, treatment and mortality are different around the world. The mortality rate is high in South America (30–70%), and Candida albicans is the most prevalent species in this region. However, a global epidemiological shift to non-albicans species has been observed. In this group, C. parapsilosis is the species most frequently detected, followed by C. tropicalis, and at a slower rate, C. glabrata, which has also increased, in addition to the emerging C. auris, resistance to several drugs. This article summarizes relevant aspects of candidemia pathogenesis, such as the mechanisms of fungal invasion, immune response, and the impact of genetic defects that increase host susceptibility to developing the infection. We also discuss relevant aspects of treatment and future challenges in South America.
Fil: Riera, Fernando Oscar. Sanatorio Allende; Argentina
Fil: Caeiro, Juan Pablo. Hospital Privado Universitario de Córdoba; Argentina
Fil: Angiolini, Sofia Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Vigezzi, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Rodriguez, Emilse. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Icely, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Sotomayor, Claudia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
description Invasive candidiasis encompassing Candida bloodstream infections and deep-seated candidiasis can become a persistent health problem. These infections are caused by Candida species and have high morbidity and mortality rates. Species distribution, access to diagnosis, treatment and mortality are different around the world. The mortality rate is high in South America (30–70%), and Candida albicans is the most prevalent species in this region. However, a global epidemiological shift to non-albicans species has been observed. In this group, C. parapsilosis is the species most frequently detected, followed by C. tropicalis, and at a slower rate, C. glabrata, which has also increased, in addition to the emerging C. auris, resistance to several drugs. This article summarizes relevant aspects of candidemia pathogenesis, such as the mechanisms of fungal invasion, immune response, and the impact of genetic defects that increase host susceptibility to developing the infection. We also discuss relevant aspects of treatment and future challenges in South America.
publishDate 2022
dc.date.none.fl_str_mv 2022-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/216878
Riera, Fernando Oscar; Caeiro, Juan Pablo; Angiolini, Sofia Carla; Vigezzi, Cecilia; Rodriguez, Emilse; et al.; Invasive Candidiasis: Update and Current Challenges in the Management of This Mycosis in South America; MDPI; Antibiotics; 11; 7; 6-2022; 877-893
2079-6382
CONICET Digital
CONICET
url http://hdl.handle.net/11336/216878
identifier_str_mv Riera, Fernando Oscar; Caeiro, Juan Pablo; Angiolini, Sofia Carla; Vigezzi, Cecilia; Rodriguez, Emilse; et al.; Invasive Candidiasis: Update and Current Challenges in the Management of This Mycosis in South America; MDPI; Antibiotics; 11; 7; 6-2022; 877-893
2079-6382
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/antibiotics11070877
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.199325

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